Month: November 2022

On August 23, 2018, Zhou, Guo Qiang published a patent.SDS of cas: 1198284-94-4 The title of the patent was Preparation of diazaspirodecanyl pyrimidines useful as SSAO inhibitors. And the patent contained the following:

The invention provides compound of formula I and pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds Example compound (E)-I�HCl was prepared by BOC-deprotection of tert-Bu N-[(E)-3-fluoro-2-[[2-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-5-yl]oxymethyl]allyl]carbamate. The invention compounds were evaluated for their SSAO inhibitory activities. From the assay, it was determined that compound I(E)-I�HCl exhibited IC50 value of less than 60 nM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).SDS of cas: 1198284-94-4

The Article related to diazaspirodecanyl pyrimidine preparation ssao inhibitor nonalcoholic steatohepatitis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 16, 2021, Cleary, Leah; Fleury, Melissa; Pei, Zhonghua published a patent.Computed Properties of 141940-37-6 The title of the patent was Preparation of quinolinone derivatives as methionine adenosyltransferase 2a inhibitors for treatment of cancer. And the patent contained the following:

Disclosed herein are certain quinolinone derivatives of I that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Compounds of formula I [wherein V = Ph or 5 to 6 membered heteroaryl; Z = CH or N; R1, R2, and R5 independently = H, cyano, halo, C1-6alkyl, etc.; each R3 independently = halo, C1-4alkyl, C1-4haloalkyl, etc.; R4 = H, halo, C1-6alkyl, C6-10aryl, etc.; Y2 = bond or C1-4alkylene; n = 0, 1, or 2] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for MAT2A inhibitory activity from which II exhibited an IC50 in the range of �10 nM to < 200 nM. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to quinolinone derivative preparation methionine adenosyltransferase 2a inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2016, Ioannidis, Stephanos; Talbot, Adam Charles; Follows, Bruce; Buckmelter, Alexandre Joseph; Wang, Minghua; Campbell, Ann-Marie; Schmidt, Darby Rye; Guerin, David Joseph; Caravella, Justin A.; Diebold, R. Bruce; Ericsson, Anna; Lancia, David, Jr. published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors. And the patent contained the following:

The invention relates to inhibitors of ubiquitin-specific protease 7 (USP7) of formula I useful in the treatment of cancers, neurodegenerative diseases, immunol. disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases. I [wherein X1 = C, S, or S(O); X2 = CH, CD, C-halo, etc.; R1 = H, D, -OH, etc.; R2 = (C1-C8) alkyl, aryl, heteroaryl, etc.; each R3 independently = D, aryl, heteroaryl, etc.; R4 = (C1-C6) alkyl, CD3, heteroaryl etc.; R5 and R5′ independently = H, D, (C1-C6) alkyl, (C2-C6) alkenyl, etc.; R6 = H, D, (C1-C6) alkyl, etc.; m = 0, 1, or 2; n = 0, 1, 2, or 3] or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer, thereof, are claimed and exemplified. II was prepared via a multistep process (preparation given). I were evaluated for USP7 inhibitor activity using a Ubitquin-Rhodamine 110 assay (data provided). The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Category: esters-buliding-blocks

The Article related to pyrrolopyrimidine pyrazolopyrimidine preparation ubiquitin specific protease inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 25, 2016, Diogo, Joao C. F.; Avelino, Helena M. N. T.; Caetano, Fernando J. P.; Fareleira, Joao M. N. A.; Wakeham, William A. published an article.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Tris(2-ethylhexyl) trimellitate (TOTM) as a potential industrial reference fluid for viscosity at high temperatures and high pressures: New viscosity, density and surface tension measurements. And the article contained the following:

Tris(2-ethylhexyl) trimellitate (TOTM) was recently suggested as a reference fluid for industrial use associated with high viscosity at elevated temperature and pressure. Viscosity and d. data have already been published on one sample covering the temperature range (303-373) K and at pressures up to about 65 MPa. The viscosity covered a range from about (9 to 460) mPa s. In the present article we study several other characteristics of TOTM that must be available if it were to be adopted as a standard First, we present values for the viscosity and d. obtained with a different sample of TOTM to examine the important feature of consistency among different samples. Vibrating-wire viscosity measurements were performed at pressures from (5 to 100) MPa, along 6 isotherms between (303 and 373) K. D. measurements were carried out from (293 to 373) K up to 68 MPa, along 4 isotherms, using an Anton Paar DMA HP vibrating U-tube densimeter. Secondly, we report a study of the effect of water contamination on the viscosity of TOTM, performed using an Ubbelhode viscometer under atm. pressure. Finally, in order to support the use of TOTM as a reference liquid for the calibration of capillary viscometers, values of its surface tension, obtained by the pendant drop method, are provided. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to trisethylhexyl trimellitate viscosity density surface tension high temperature pressure, Phase Equilibriums, Chemical Equilibriums, and Solutions: Electrolytic Solutions and other aspects.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 29, 2007, Hashimoto, Kazuki; Nakamura, Tomoaki; Nakamura, Kei; Tojo, Shingo; Kurimoto, Ayumu; Isobe, Yoshiaki; Wada, Hiroki; Bonnert, Roger published a patent.Electric Literature of 142327-44-4 The title of the patent was Preparation of adenine derivatives as TLR7 agonists. And the patent contained the following:

Title compounds I [R1 = halo, (un)substituted alkyl, (un)substituted alkenyl, etc.; R2 = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; X = O, S, NR4, etc.; with the proviso that if R1 is halo, X is a single bond; R4 = H, alkyl; A1 = (un)substituted, (un)saturated nitrogenous heterocycle containing hetero atoms selected from N, O and S; A2 = (un)substituted aromatic carbocycle, (un)substituted aromatic heterocycle; L3 = (un)substituted alkylene, single bond; L1, L2 = alkylene (1-3 methylene in alkylene may be replaced with O, S, NR5, etc.), single bond; R5 = H, (un)substituted alkyl, (un)substituted cycloalkyl, etc.] or their pharmaceutically acceptable salts were prepared For example, de-tert-butoxycarbonylation of 2-butoxy-9-[(1-[3-[N-(tert-butoxycarbonyl)-N-methylamino]propyl]piperidin-4-yl)methyl]-8-methoxyadenine, e.g., prepared from 4-hydroxymethylpiperidine-1-carboxylic acid tert-Bu ester in 3 steps, followed by reductive amination with 3-formylphenylacetic acid Me ester and treatment with sulfuric acid afforded compound II. In toll-like receptor 7 (TLR7) binding assays, the EC50 value of compound III was 74.5 nM. Compounds I are claimed useful for the treatment of asthma, COPD, etc. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4

The Article related to adenine preparation tlr7 agonist, asthma copd treatment adenine preparation tlr7 agonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 142327-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 6, 2005, Kurimoto, Ayumu; Hashimoto, Kazuki; Isobe, Yoshiaki; Brough, Stephen; Millichip, Ian; Wada, Hiroki; Bonnert, Roger; McInally, Thomas published a patent.Formula: C10H10O3 The title of the patent was Preparation of 8-oxoadenine compounds as immunomodulators. And the patent contained the following:

Title compounds I [ring A = aromatic carbocycle, etc.; R = halo, etc.; n = 0-2; Z1 = (un)substituted alkylene, etc.; X2 = O, etc.; Y1, Y2, Y3 = alkylene, etc.; X1 = O, etc.; R2 = H, (un)substituted alkyl, etc.; R1 = H, OH, etc.] were prepared For example, bromination of 2-butoxy-9-[2-(3-methoxycarbonylphenoxy)ethyl]adenine, e.g., prepared from Me 3-hydroxybenzoate in 2 steps, using Br2 followed by treatment with NaOH afforded compound II. In interferon induction assays (in vitro), the min. effective concentration of compound II was 0.3 nM. Compounds I are claimed useful for the treatment of cancer, allergy, etc. Formulation is given. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Formula: C10H10O3

The Article related to oxoadenine preparation immunomodulator, antitumor antiallergic agent oxoadenine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C10H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 25, 2020, Zhang, Xingxian; He, Kailun; Wang, Wenbing published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of lenalidomide derivatives as antitumor agents. And the patent contained the following:

The invention discloses a preparation of lenalidomide derivative with general formula I as antitumor agents [wherein A = (CH2CH2X)n, n = 1 to 6; X = O or CH2]. For example, compound I (n = 2, X = O) was prepared in a multi-step synthesis. The title compounds have good antitumor activity and EGFR protein degradation level, which can be used to prepare antitumor agents. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Category: esters-buliding-blocks

The Article related to substitution iodization hydrolysis amidation preparation lenalidomide pyrimidine antitumor human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhat, Subrahmanya Ishwar; Das, U. K.; Trivedi, Darshak R. published an article in 2015, the title of the article was An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition.Computed Properties of 707-07-3 And the article contains the following content:

An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst was developed. 2,4-disubstituted quinazolines were synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method had advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction was proposed based on the spectral characterization and single crystal X-ray anal. of isolated intermediate. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Computed Properties of 707-07-3

The Article related to aminoaryl ketone orthoester ammonium acetate three component reaction, quinazoline preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 22, 1997, Bessard, Ives; Stucky, Gerhard published a patent.Product Details of 121129-31-5 The title of the patent was Process for the preparation of substituted pyrimidines. And the patent contained the following:

Pyrimidines I [R1 = OCHR4COR5, 2-oxo-3-tetrahydrofuryl, 2-oxo-3-tetrahydropyranyl, (un)substituted Ph, pyridyl; R2, R3 = H, alkyl, alkoxy, (un)substituted NH2; R4 = H, alkyl, aryl, aralkyl, CO2H, acyl, alkoxycarbonyl; R5 = OH, alkoxy, aryloxy, alkyl] were prepared by treating I [R1 = halogen] with HOR1 in presence of a sulfinate in a one- or two-step reaction. Thus, 2-chloro-4,6-dimethoxypyrimidine was treated with Me3CCH(OH)CO2Me and MeSO2Na to give 82.7% I [R1 = OCH(CMe3)CO2Me, R2, R3 = OMe]. The experimental process involved the reaction of Methyl 2-hydroxy-3,3-dimethylbutanoate(cas: 121129-31-5).Product Details of 121129-31-5

The Article related to alkoxypyrimidine preparation, halopyrimidine alkoxylation sulfinate, pyrimidine halo alkoxylation sulfinate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 121129-31-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Makuuchi, K.; Hagiwara, M. published an article in 1984, the title of the article was Radiation vulcanization of natural rubber latex with polyfunctional monomers – II.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) And the article contains the following content:

Natural rubber latexes were vulcanized by γ-rays with 2 polyfunctional monomers, neopentyl glycol diacrylate (I) [2223-82-7] and neopentyl glycol dimethacrylate (II) [1985-51-9]. In comparison with I, II was more soluble in rubber particles, but it was less effective as an accelerating agent for the vulcanization because of the smaller rate of polymerization On the other hand, the colloidal stability of the latex containing I was low because it was localized on the surface of rubber particles due to its poor solubility in the particles. The solubility of I was improved by adding I with solvents. The maximum tensile strength of the irradiated latex film was 350 kg/cm2 at 3 Mrad. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to natural rubber diacrylate vulcanization accelerator, dimethacrylate vulcanization accelerator natural rubber, Synthetic Elastomers and Natural Rubber: Vulcanization, Curing, and Crosslinking and other aspects.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics