On October 6, 2005, Kurimoto, Ayumu; Hashimoto, Kazuki; Isobe, Yoshiaki; Brough, Stephen; Millichip, Ian; Wada, Hiroki; Bonnert, Roger; McInally, Thomas published a patent.Formula: C10H10O3 The title of the patent was Preparation of 8-oxoadenine compounds as immunomodulators. And the patent contained the following:
Title compounds I [ring A = aromatic carbocycle, etc.; R = halo, etc.; n = 0-2; Z1 = (un)substituted alkylene, etc.; X2 = O, etc.; Y1, Y2, Y3 = alkylene, etc.; X1 = O, etc.; R2 = H, (un)substituted alkyl, etc.; R1 = H, OH, etc.] were prepared For example, bromination of 2-butoxy-9-[2-(3-methoxycarbonylphenoxy)ethyl]adenine, e.g., prepared from Me 3-hydroxybenzoate in 2 steps, using Br2 followed by treatment with NaOH afforded compound II. In interferon induction assays (in vitro), the min. effective concentration of compound II was 0.3 nM. Compounds I are claimed useful for the treatment of cancer, allergy, etc. Formulation is given. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Formula: C10H10O3
The Article related to oxoadenine preparation immunomodulator, antitumor antiallergic agent oxoadenine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C10H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics