On December 16, 2021, Cleary, Leah; Fleury, Melissa; Pei, Zhonghua published a patent.Computed Properties of 141940-37-6 The title of the patent was Preparation of quinolinone derivatives as methionine adenosyltransferase 2a inhibitors for treatment of cancer. And the patent contained the following:
Disclosed herein are certain quinolinone derivatives of I that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Compounds of formula I [wherein V = Ph or 5 to 6 membered heteroaryl; Z = CH or N; R1, R2, and R5 independently = H, cyano, halo, C1-6alkyl, etc.; each R3 independently = halo, C1-4alkyl, C1-4haloalkyl, etc.; R4 = H, halo, C1-6alkyl, C6-10aryl, etc.; Y2 = bond or C1-4alkylene; n = 0, 1, or 2] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for MAT2A inhibitory activity from which II exhibited an IC50 in the range of â?10 nM to < 200 nM. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6
The Article related to quinolinone derivative preparation methionine adenosyltransferase 2a inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 141940-37-6
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