Tag: M.W=250-300

Rakkan, Thanaphorn; Chana, Netnapa; Chirapongsatonkul, Nion; U-taynapun, Kittichon; Sangkharak, Kanokphorn published the artcile< Screening and Identification of Newly Isolated Basic Red 9-Degrading Bacteria from Textile Wastewater and Their Ability to Produce Medium-Co-Long-Chain-Length Polyhydroxyalkanoates>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Enterobacter basic red biodegradation wastewater treatment.

Newly isolated Basic Red 9-degrading bacteria were isolated from textile wastewater using a pretreatment method. Nine strains were isolated; however, only five strains accumulated polyhydroxyalkanoates (PHAs). Thereafter, PHA-producing strains were identified through 16S rDNA sequencing anal. and phylogenetic evaluation and were found to belong to Enterobacter with 100% identification. The five isolated strains were incubated with a PHAs-producing medium containing 100 mg/l Basic Red 9 (BR9) to study decolorization efficiency, and PHAs production Enterobacter sp. strains TS3 and TS1L effectively decolorized the BR9 dye with degradation rates of 63.43% and 79.15%, resp. PHAs production from TS3 and TS1L was also observed to be 75.34% and 72.32% of dry cell weight (DCW), resp. Furthermore, Enterobacter sp. strains TS3 and TS1L accumulated medium-co-long-chain-length PHAs (mcl-co-lcl PHAs). This is the first report using Enterobacter strains to degrade BR9 dyes from textile wastewater and to assess their ability to produce mcl-co-lcl PHAs.

Journal of Polymers and the Environment published new progress about Bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nazarov, I. N.; Semenovskii, A. V. published the artcile< Bromomethylation of aromatic compounds>, Related Products of 112-63-0, the main research area is .

Passage of HBr into 150 ml. MePh, 15 g. paraformaldehyde, 8.5 g. ZnCl2, and a little P 1 hr. at 50° gave after washing with NaHCO3 and H2O, 58% mixed MeC6H4CH2Br isomers (I), b10 82-90°, and some diaryl derivatives b13 145-50°. Passage of HBr into 150 ml. CCl4, 15 g. paraformaldehyde, and 10 g. ZnCl2 with a little P for 35 min. and dropwise addition of 53 g. EtPh at 50° in a continuous stream of HBr over 1.3 hrs. similarly gave 48.3% mixed EtC6H4CH2Br (II), b7.5 96-100°. Passage of HBr 6 hrs. into 90 ml. concentrated HBr, 70 g. MePh, 30 g. paraformaldehyde, and a little P, followed by 19 hrs. at 50° gave, after washing, 71.3% mixed MeC6H4CH2Br, b23 112-20°; similarly, EtPh gave 85% mixed EtC6H4CH2Br, b10 101-4°, while iso-PrPh gave 78% mixed iso-PrC6H4CH2Br (III), b20 126-30°. Hydrolysis of I gave mixed o- and p-MeC6H4CH2OH, b12 106-10°; II gave the corresponding Et analogs, b12 120-4° and III gave mixed iso-Pr analogs, b12 121-5°. The hydrolyses were run with chalk in hot H2O 24 hrs. Oxidation of the alcs. with CrO3 gave mixtures of o- and p-C6H4(CO2H)2; oxidation with 10% HNO3 in an autoclave at 200° gave the same products, in which the p-isomers predominated.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Bromomethylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maeda, Kyogo; Uemura, Yohei; Chun, Wang-Jae; Satter, Shazia Sharmin; Nakajima, Kiyotaka; Manaka, Yuichi; Motokura, Ken published the artcile< Controllable Factors of Supported Ir Complex Catalysis for Aromatic C-H Borylation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is borylation catalyst silica immobilized iridium complex tertiary amine preparation; direct borylation aromatic compound CH activation preparation arylboronic ester.

We have developed a catalyst in which an Ir complex and tertiary amine organic functionalities are coimmobilized on the silica surface. The catalytic activity for aromatic C-H borylation was significantly affected by (i) the linker length of the Ir-bipyridine complex, (ii) the coimmobilized organic functionality, and (iii) the substituents on the aromatic substrate compounds The fine-tuned supported catalyst showed higher activity than the homogeneous Ir-bipyridine complex when using a specific substrate such as benzonitrile. We elucidated this property by conducting solid-state NMR, FT-IR, XAFS, and in situ FT-IR anal.

ACS Catalysis published new progress about Aromatic substitution reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gerlach, Samantha L.; Dunlop, Rachael A.; Metcalf, James S.; Banack, Sandra A.; Cox, Paul Alan published the artcile< Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide>, Application In Synthesis of 112-63-0, the main research area is cyclotides chemosensitizer glioblastoma temozolomide.

Glioblastoma multiforme (GBM) is the most aggressive cancer originating in the brain, with a median survival of 12 mo. Most patients do not respond to or develop resistance to the only effective chemotherapeutic drug, temozolomide (TMZ), used to treat gliomas. Novel treatment methods are critically needed. Cyclotides are plant peptides that may be promising adjuvants to TMZ chemotherapy. They exhibit antitumor activity and chemosensitize cells to doxorubicin in breast cancer studies. During this research, we optimized cyclotide isolation techniques, and several cyclotides (CyO2, CyO13, kalata B1, and varv peptide A) exhibited dose-dependent cytotoxicity in MTT assays with IC50 values of 2.15-7.92 μM against human brain astrocytoma cells (U-87 MG) and human bone marrow derived neuroblastoma cells (SH-SY5Y). CyO2 and varv peptide A increased TMZ-induced cell death in U-87 MG cultures alone and when coexposed with CyO2 or varv peptide A plus TMZ. Phase contrast microscopy of glioblastoma cells exposed to cyclotides alone and coexposed to TMZ indicated shrunken, granular cells with blebbing, and the most pronounced effects were observed with coexposure treatments of cyclotides and TMZ. Cumulative results provide the proof-of-concept that cyclotides may enhance TMZ chemotherapy, and in vivo pharmacokinetic investigations of cyclotides are warranted with respect to GBM.

Journal of Natural Products published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Rui; Cheng, Jun; Song, Wenlu; Qiu, Yi; Guo, Hao; Yang, Weijuan published the artcile< Physicochemical characterizations of microalgal methyl esters extracted with hexane and refined by vacuum distillation at different temperatures>, Related Products of 112-63-0, the main research area is hexane microalgal methyl ester vacuum distillation.

To prepare quality biodiesel from microalgal lipids in pilot-scale reactors, Me esters from microalgal cells were extracted with hexane after direct transesterification and then refined by vacuum distillation The refined Me esters were comprehensively characterized via gas chromatog.-mass spectrometry, Fourier transform IR spectroscopy, NMR, and thermogravimetric anal. The Me ester refined at 255°C-259°C was found to be the ideal fuel with a high fatty acid Me ester content of 94.6%, a low combustion activation energy of 42.1 kJ/mol, and a proper carbon-chain length distributed in C14-C18. Impurities extracted with hexane, such as alkanes and short-chain esters, were separated at 105°C-254°C owing to their low polarity and mol. weight Highly unsaturated Me esters with a long carbon-chain were collected at 260°C-280°C owing to their high b.p. Separation of alkanes, short-chain esters, and highly unsaturated Me esters through vacuum distillation effectively improved the properties of the Me esters extracted with hexane as a fuel and enhanced the economic feasibility of microalgal lipids.

Fuel published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verma, Vipin Kumar; Prakash, Om; Kumar, R. Shiva Raj; Rani, Kumari Vandana; Sehgal, Neeta published the artcile< Water hyacinth (Eichhornia crassipes) leaves enhances disease resistance in Channa punctata from Vibrio harveyi infection>, Electric Literature of 112-63-0, the main research area is Channa Vibrio Eichhornia infection leaf disease resistance.

Channa punctata, Indian spotted snakehead, has a great economic value in south and south-east Asia being an important protein source for humans. Fish cultures are affected due to various bacterial and viral infections. Vibrio harveyi is a fish pathogenic bacteria which causes several outbreaks throughout the world and leads to huge mortalities. In this study, leaves of Eichhornia crassipes (water hyacinth) were used to investigate its immunostimulatory potential in Channa punctata. The immunostimulatory effects of water hyacinth leaves were studied in fish fed with 2.5% and 5% supplementary feed (exptl. groups) in comparison to normal feed (control groups). Gas chromatog. mass spectrometry (GC-MS) anal. of E. crassipes methanol extract showed presence of various components which have immunostimulatory, antioxidant, antibacterial, and anti-inflammatory activities. The antibacterial activity, antioxidant potential, and presence of phenol and flavonoids in methanol and ethanol extracts supported its use in fish feed. The healthy acclimatized fish were challenged with V. harveyi weekly. Liver function tests, alk. phosphatase levels, and Ig content in the exptl. groups were improved with respect to those in the pos. control group. The spleen and head kidney were obtained at the final day of experiment, and macrophages were isolated; higher percentage of phagocytosis and phagocytic index indicated enhanced cell-mediated immune response in fish due to supplemented feed. Plant-infused feed with leaves of E. crassipes can be recommended as a regular feed supplement to enhance fish immunity and disease resistance against the V. harveyi infection.

Journal of Basic & Applied Zoology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balmaseda, Aitor; Rozes, Nicolas; Bordons, Albert; Reguant, Cristina published the artcile< Molecular adaptation response of Oenococcus oeni in non-Saccharomyces fermented wines: A comparative multi-omics approach>, Formula: C19H34O2, the main research area is Saccharomyces Metschnikowia Torulaspora Oenococcus carbohydrate amino acid Hsp20 wine; Malolactic fermentation; Non-Saccharomyces; Oenococcus oeni; Proteomics; Transcriptomics; Wine.

Oenococcus oeni is the main agent responsible for malolactic fermentation (MLF) in wine. This usually takes place in red wines after alc. fermentation (AF) carried out by Saccharomyces cerevisiae. In recent years, there is an increasing interest in using non-Saccharomyces yeast, usually in combination with S. cerevisiae, to improve wine quality. Current studies report a stimulatory effect of non-Saccharomyces on MLF, generally related to a decrease in the inhibitor compounds found in wine. In this work, we followed a comparative multi-omics approach, including transcriptomic and proteomic anal., to study the mol. adaptation of O. oeni in wines fermented with Torulaspora delbrueckii and Metschnikowia pulcherrima, two of the most frequently used non-Saccharomyces, in sequential inoculation with S. cerevisiae. We compared the results to the adaptation of O. oeni in S. cerevisiae wine to determine the main changes arising from the use of non-Saccharomyces. The duration of MLF was shortened when using non-Saccharomyces, to half the time with T. delbrueckii and to a quarter with M. pulcherrima. In this work, we observed for the first time how O. oeni responds at mol. level to the changes brought about by non-Saccharomyces. We showed a differential adaptation of O. oeni in the wines studied. In this regard, the main mol. functions affected were amino acid and carbohydrate transport and metabolism, from which peptide metabolism appeared as a key feature under wine-like conditions. We also showed that the abundance of Hsp20, a well-known stress protein, depended on the duration time. Thus, the use of non-Saccharomyces reduced the abundance of Hsp20, which could mean a less stressful wine-like condition for O. oeni.

International Journal of Food Microbiology published new progress about Adaptation, microbial. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chan, Pui Ying; Phillips, Melissa M.; Ellis, Stephen; Johnston, Amanda; Feng, Xiaoxing; Arora, Amit; Hay, Gordon; Cohen, Victoria M. L.; Sagoo, Mandeep S.; Bomalaski, John S.; Sheaff, Michael T.; Szlosarek, Peter W. published the artcile< A Phase 1 study of ADI-PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1-negative metastatic uveal melanoma>, COA of Formula: C19H34O2, the main research area is pemetrexed cisplatin ADIPEG20 anticancer agent metastatic uveal melanoma; ADI-PEG20; ASS1; arginine auxotrophy; cisplatin; pemetrexed; uveal melanoma.

Metastatic uveal melanoma (UM) is a devastating disease with few treatment options. We evaluated the safety, tolerability and preliminary activity of arginine depletion using pegylated arginine deiminase (ADI-PEG20; pegargiminase) combined with pemetrexed (Pem) and cisplatin (Cis) chemotherapy in a phase 1 dose-expansion study of patients with argininosuccinate synthetase (ASS1)-deficient metastatic UM. Eligible patients received up to six cycles of Pem (500 mg/m2) and Cis (75 mg/m2) every 3 wk plus weekly i.m. ADI (36 mg/m2), followed by maintenance ADI until progression (NCT02029690). Ten of fourteen ASS1-deficient patients with UM liver metastases and a median of one line of prior immunotherapy received ADIPemCis. Only one ≥ grade 3 adverse event of febrile neutropenia was reported. Seven patients had stable disease with a median progression-free survival of 3.0 mo (range, 1.3-8.1) and a median overall survival of 11.5 mo (range, 3.2-36.9). Despite anti-ADI-PEG20 antibody emergence, plasma arginine concentrations remained suppressed by 18 wk with a reciprocal increase in plasma citrulline. Tumor rebiopsies at progression revealed ASS1 re-expression as an escape mechanism. ADIPemCis was well tolerated with modest disease stabilization in metastatic UM. Further investigation of arginine deprivation is indicated in UM including combinations with immune checkpoint blockade and addnl. anti-metabolite strategies.

Pigment Cell & Melanoma Research published new progress about Antimetabolites. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Krajewska, Anna M.; Powers, John J. published the artcile< Isolation of naturally occurring capsaicinoids by reversed-phase low-pressure liquid chromatography>, Synthetic Route of 112-63-0, the main research area is low pressure liquid chromatog capsaicinoid; reversed phase liquid chromatog capsaicinoid.

A reversed-phase low-pressure liquid chromatog. method is described for isolation of major capsaicinoids, i.e., capsaicin  [404-86-4], dihydrocapsaicin  [19408-84-5], nordihydrocapsaicin  [28789-35-7], and homodihydrocapsaicin  [20279-06-5]. The stationary phase was octadecyl-silica (40 μm), the mobile phase was MeOH-H2O, and N from a cylinder served as a driving force for the mobile phase. To sep. nordihydrocapsaicin and capsaicin, an intermediate bromination step with pyridinium bromide perbromide  [39416-48-3] was required. This method is simple and less costly than preparative-scale HPLC.

Journal of Chromatography published new progress about Capsaicinoids Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Urbanczyk, Malgorzata; Jewginski, Michal; Krzciuk-Gula, Joanna; Gora, Jerzy; Latajka, Rafal; Sewald, Norbert published the artcile< Synthesis and conformational preferences of short analogs of antifreeze glycopeptides (AFGP)>, Electric Literature of 4098-06-0, the main research area is antifreeze glycopeptide analog synthesis conformation hydrogen bond cluster NMR; threonine glycosylation azido galactosyl chloride reduction; solid phase peptide synthesis acetylation antifreeze activity; NMR; PP II; antifreeze glycopeptides; conformational preferences; solid phase synthesis.

Antifreeze glycoproteins are a class of biol. agents which enable living at temperatures below the f.p. of the body fluids. Antifreeze glycopeptides usually consist of repeating tripeptide unit (-Ala-Ala-Thr*-), glycosylated at the threonine side chain. However, on the microscopic level, the mechanism of action of these compounds remains unclear. As previous research has shown, antifreeze activity of antifreeze glycopeptides strongly relies on the overall conformation of the mol. as well an on the stereochem. of amino acid residues. The desired monoglycosylated analogs with acetylated amino termini and the carboxy termini in form of N-methylamide have been synthesized. Conformational NMR (NMR) studies of the designed analogs have shown a strong influence of the stereochem. of amino acid residues on the peptide chain stability, which could be connected to the antifreeze activity of these compounds A better understanding of the mechanism of action of antifreeze glycopeptides would allow applying these materials, e.g., in food industry and biomedicine.

Beilstein Journal of Organic Chemistry published new progress about Acetylation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Electric Literature of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics