Tag: M.W=250-300

Liu, Xinliang; Qi, Kai; Gong, Yi; Long, Xiang; Zhu, Shuqiang; Lu, Feng; Lin, Kun; Xu, Jianjun published the artcile< Ferulic Acid Alleviates Myocardial Ischemia Reperfusion Injury Via Upregulating AMPKα2 Expression-Mediated Ferroptosis Depression>, Formula: C15H22N2O2, the main research area is myocardial ischemia reperfusion injury ferulic acid ferroptosis cardioprotective.

Ferroptosis, a recently discovered form of regulated cell death that is characterized by iron accumulation and excessive reactive oxygen species generation, has been favored by most researchers. Increasing evidence suggest that ferulic acid (FA) could exert marked effects to myocardial ischemia reperfusion (I/R) injury, although the understanding of its mol. mechanism is still limited. In our study, the myocardial I/R injury model was established to explore the relationship between I/R injury and ferroptosis. First, we successfully constructed myocardial I/R injury model with changes in ST segment, increased creatine phosphokinase, lactate dehydrogenase activities, and N-Terminal Pro Brain Natriuretic Peptide content, and a significantly larger infarct size. Then, the increased levels of the Ptgs2 mRNA, Fe2+ accumulation, and a decreased reduced glutathione/oxidized glutathione disulfide ratio were detected in ischemia-reperfusion-injured heart, which is highly consistent with ferroptosis. However, these effects were significantly improved after FA treatment. Based on these results, FA increased the activities of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, decreased the malondialdehyde level, ameliorated the production of reactive oxygen species, and promoted the generation of ATP. These effects of FA are similar to those of the ferroptosis inhibitor ferrostatin-1. Upregulation of AMPKα2 and Glutathione Peroxidase 4 expression were also observed in the FA group. Compound C, a specific AMP (AMP)-activated protein kinase inhibitor, significantly blocked the protective effect of FA. These findings underlined that FA inhibits ferroptosis by upregulating the expression of AMPKα2 and serves as a cardioprotective strategy.

Journal of Cardiovascular Pharmacology published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ham, Jin Su; Park, Bohyun; Son, Mina; Roque, Jose B.; Jurczyk, Justin; Yeung, Charles S.; Baik, Mu-Hyun; Sarpong, Richmond published the artcile< C-H/C-C Functionalization Approach to N-Fused Heterocycles from Saturated Azacycles>, SDS of cas: 112-63-0, the main research area is indolizidine preparation diastereoselective; hydroxy lactam preparation diastereoselective rhodium catalyst; ketoamide preparation Norrish Yang photochem.

The synthesis of substituted indolizidines and related N-fused bicycles e.g., 1R,2S,8aS/1R,2R,8aS-I from simple phenyl(2-piperidinyl)methanone hydrochloride through sequential C-H and C-C bond functionalizations was reported. Inspired by the Norrish-Yang Type II reaction, C-H functionalization of azacycles is achieved by forming α-hydroxy-β-lactams e.g., II from precursor α-ketoamide derivatives RC(O)C(O)C6H5 (R = piperidin-1-yl, morpholin-4-yl, 3-azaspiro[5.5]undecan-3-yl, etc.) under mild, visible light conditions. Selective cleavage of the distal C(sp2)-C(sp3) bond in α-hydroxy-β-lactams e.g., II using a Rh-complex leads to α-acyl intermediates which undergo sequential Rh-catalyzed decarbonylation, 1,4-addition to an electrophile, and aldol cyclization, to afford N-fused bicycles including indolizidines. Computational studies provide mechanistic insight into the observed positional selectivity of C-C cleavage, which depends strongly on the groups bound to Rh trans to the phosphine ligand.

Journal of the American Chemical Society published new progress about 1,4-Addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russell, Glen A.; Ros, Francisco; Hershberger, J.; Tashtoush, Hasan published the artcile< Electron transfer processes. 30. Participation of anions of dialkyl phosphites and thiophosphites in aliphatic SRN1 reactions>, COA of Formula: C19H34O2, the main research area is phosphite nitrous compound reaction; thiophosphite nitrous compound reaction; nitrous compound phosphite reaction; phosphonate nitroalkyl; thiophosphonate nitroalkyl; phosphate alkyl.

Dialkyl phosphite or thiophosphite anions react with 2-chloro- or 2-(p-tolylsulfonyl)-2-nitropropane, p-nitrobenzyl chloride, and α,α-dimethyl-p-nitrobenzyl chloride to form, in a free radical chain process, the α-nitroalkyl or p-nitrobenzyl phosphonates or thiophosphonates which may be reduced to the amino derivatives 2,2-Dinitropropane reacts with dialkyl phoshite or di-Me thiophosphite ions to form the dialkyl phosphate or thiophosphate esters of acetone oxime. The relative reactivities of a series of anions towards (O2N)Me2C•, p-O2C6H4CH2• and p-O2NC6H4CMe2• are reported.

Journal of Organic Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valea, Ana; Sandru, Florica; Petca, Aida; Dumitrascu, Mihai Cristian; Carsote, Mara; Petca, Razvan-Cosmin; Ghemigian, Adina published the artcile< Aggressive prolactinoma (review)>, COA of Formula: C19H34O2, the main research area is review prolactin succinate dehydrogenase AIP temozolomide ipilimumab aggressive prolactinoma; aggressive pituitary tumor; aggressive prolactinoma; cabergoline; hypophysectomy; menses; menstrual cycle; pituitary carcinoma; prolactin; prolactinoma; temozolomide.

A review. Aggressive prolactinoma (APRL) is a subgroup of aggressive pituitary tumors (accounting for 10% of all hypophyseal neoplasia) which are defined by: invasion based on radiol. and/or histol. features, a higher proliferation profile when compared to typical adenomas and rapidly developing resistance to standard medication/protocols in addition to an increased risk of early recurrence. This is a narrative review focusing on APRL in terms of both presentation and management. Upon admission, the suggestive features may include increased serum prolactin with a large tumor diameter (mainly >4 cm), male sex, early age at diagnosis (<20 years), and genetic predisposition [multiple endocrine neoplasia type 1 (MEN1), aryl hydrocarbon receptor interacting protein (AIP), succinate dehydrogenase (SDHx) gene mutations]. Potential prognostic factors are indicated by assessment of E-cadherin, matrix metalloproteinase (MMP)-9, and vascular endothelial growth factor (VEGF) status. Furthermore, during management, APRL may be associated with dopamine agonist (DA) resistance (described in 10-20% of all prolactinomas), post-hypophysectomy relapse, mitotic count >2, Ki-67 proliferation index ≥3%, the need for radiotherapy, lack of response in terms of controlling prolactin levels and tumor growth despite multimodal therapy. However, none of these as an isolated element serves as a surrogate of APRL diagnosis. A fourth-line therapy is necessary with temozolomide, an oral alkylating chemotherapeutic agent, that may induce tumor reduction and serum prolactin reduction in 75% of cases but only 8% have a normalization of prolactin levels. Controversies surrounding the duration of therapy still exist; also regarding the fifth-line therapy, post-temozolomide intervention. Recent data suggest alternatives such as somatostatin analogs (pasireotide), checkpoint inhibitors (ipilimumab, nivolumab), tyrosine kinase inhibitors (TKIs) (lapatinib), and mTOR inhibitors (everolimus). APRL represents a complex condition that is still challenging, and multimodal therapy is essential.

Experimental and Therapeutic Medicine published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (AIP). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Uribe-Echeverria, Teresa; Beiras, Ricardo published the artcile< Acute toxicity of bioplastic leachates to Paracentrotus lividus sea urchin larvae>, Application of C19H34O2, the main research area is Paracentrotus lividus acute toxicity bioplastic leachates; Additives; Bioplastic; Ecotoxicology; Larval bioassay; Microplastic; Paracentrotus lividus; Polyhydroxybutyrate; Polylactic acid.

In an attempt to ensure that bioplastics, progressively replacing petrochem.-derived plastics, do not release any harmful compound to the environment, the study assessed the toxic effects of three innovative bioplastic products: polyhydroxybutyrate resin (PHB), polylactic acid cups (PLA) and a polylactic acid/polyhydroxyalkanoate 3D printing filament (PLA/PHA), together with a synthetic polyvinyl chloride (PVC) toy in Paracentrotus lividus sea urchin larvae. PVC toy was the most toxic material, likely due to the added plasticizers; remarkably, even if PHB is conceived as a nontoxic polymer, it showed a slight toxicity and Gas Chromatog.-Mass Spectometry anal. (GC-MS) revealed the presence of a wide range of additives. Conversely, PLA cups and PLA/PHA filament were innocuous for the larvae, a pos. outcome for these renewable solutions Proven that additives are also used in some bioplastic formulations, they should be carefully addressed to ensure that they are as safe as regarded.

Marine Environmental Research published new progress about Acute toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles published the artcile< Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research>, Electric Literature of 112-63-0, the main research area is azaindole PLX4720 PLX4032 preparation BRAF inhibitor microwave irradiation.

We report dramatically improved total syntheses of two highly selective V600EBRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without compromising yield. In addition to providing a gram-scale route to these compounds for preclin. oncol. research, we anticipate this approach could accelerate the synthesis of azaindoles in high-throughput, library-based formats.

Tetrahedron Letters published new progress about Microwave irradiation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wilson, Kenneth J.; Illig, Carl R.; Chen, Jinsheng; Wall, Mark J.; Ballentine, Shelley K.; Des Jarlais, Renee L.; Chen, Yanmin; Schubert, Carsten; Donatelli, Robert; Petrounia, Ioanna; Crysler, Carl S.; Molloy, Christopher J.; Chaikin, Margery A.; Manthey, Carl L.; Player, Mark R.; Tomczuk, Bruce E.; Meegalla, Sanath K. published the artcile< Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors>, Application of C19H34O2, the main research area is imidazolecarboxamide cyclohexenylaryl nitrile preparation ion channel activity FMS inhibitor.

A series of saturated and aromatic 4-heterocycles of reduced basicity I (R1 = Ph, 4-H2NC6H4, 2-pyridyl, 2,6-dioxo-4-piperidinyl, 2-oxo-3,4,5,6-tetrahydro-1H-pyrimidin-5-yl, etc.; R2 = H, Me) was prepared and evaluated in an attempt to improve the bioavailability of FMS kinase inhibitors and the cardiovascular safety profile over lead arylamide I (R1 = 4-piperidinyl; R2 = H), which possessed ion channel activity. The resultant compounds retained excellent potency and exhibited diminished ion channel activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smyth, Elizabeth; Cozens, Kelly; Griffiths, Daniel; Clark, Kathryn L; Ewings, Sean; Petty, Russell; Underwood, Tim; Fitzgerald, Rebecca C; Tanner, James; Giger, Olivier; Anand, Shubha; Griffiths, Gareth published the artcile< ELEVATE - evaluating Temozolomide and Nivolumab in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma with MGMT methylation: study protocol for a single arm phase II trial.>, Related Products of 112-63-0, the main research area is Immunotherapy; MGMT methylated; Oesophagogastric adenocarcinoma; Phase II.

BACKGROUND: For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients will relapse and die. Many UK patients present with advanced disease which is already inoperable or metastatic at diagnosis. For these patients, standard care chemotherapy only offers them survival of less than a year. Nivolumab, a checkpoint blockade inhibitor, has been found to work in some advanced cancers. It is proposed, for those where immunotherapy hasn’t worked, that these immunologically evasive tumours need to be sensitized to immunotherapy drugs to allow them to act. METHODS: ELEVATE is a single arm phase II trial testing the overall response to nivolumab following temozolomide treatment in patients with advanced unresectable previously treated adenocarcinoma which is O6-methylguanine-DNA-methyltransferase (MGMT) methylated. 18 patients are being recruited from UK secondary care sites. To be eligible, participants must have been treated with at least 3 months of platinum and fluoropyrimidine chemotherapy. Participants will receive 50 mg/m2 temozolomide continuously for 3 months. If their disease progresses during the 3 months, they will stop temozolomide and start nivolumab at a dose of 240mg every 2 weeks. If there is no progression after 3 months the participant will continue taking temozolomide in combination with nivolumab. All treatment will stop once the participant progresses on nivolumab. The primary endpoint is the best overall response to nivolumab, using both Response Evaluation Criteria in Solid Tumours version 1.1 and immunotherapy modified Response Evaluation Criteria in Solid Tumours. Secondary endpoints include progression-free survival, overall survival, and quality of life. DISCUSSION: ELEVATE will provide evidence for whether giving nivolumab after temozolomide in patients with previously treated advanced oesophagogastric adenocarcinoma is safe and biologically effective prior to future randomised trials. TRIAL REGISTRATIONS: EudraCT Number: 2020-004771-41 (issued 01 October 2020); ISCRTN11398887 (registered 14 July 2021).

BMC cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Zhixian; Sun, Zhe; Xu, Chengping; Zhang, Aiqin; Xiang, Jun; Fan, Haojun published the artcile< A self-matting waterborne polyurethane coating with admirable abrasion-resistance>, Application of C19H34O2, the main research area is waterborne polyurethane coating abrasion resistance.

Due to the paradox between abrasion-resistance and extinction, the development of a self-matting waterborne polyurethane (SMWPU) coating accompanied by excellent abrasion-resistance is still a challenge. Herein, a kind of hydroxyalkyl-terminated polysiloxane modified SMWPU was prepared and employed for matting leather/synthetic leather finishing. Simultaneously, the influences of hydrophilic chain extender and polysiloxane loadings on the matting effect and abrasion resistance of the coating were investigated in detail. The results indicated that the gloss of the coating was closely related to the hydrophilic chain extender content, and a stable emulsion and optimal matting effect could be achieved when a 1.6 weight% (based on solid content) hydrophilic chain extender was employed. With the introduction of polysiloxane, the silicon element content on the coating surface increased from 0% to 9.26%, just as expected, and an enhanced abrasion resistance of the coating was obtained. Specifically, the coating weight loss ratio was reduced from 2.36 weight% to 0.41 weight%, and obvious surface damage did not occur after 500 abrasions. Although the surface roughness and matting effect of the coating decreased slightly due to the introduction of silicone, the gloss of the modified coating was less than 1.5° (60° incidence angle), still exhibiting an excellent matting effect. Another interesting result was the elevation of anti-hot-pressing, compared with that of the unmodified one, and the gloss of the modified coating showed no changes under a 10 MPa, 150°C hot-pressing condition.

RSC Advances published new progress about Abrasion resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balakrishnan, Remya; Nallaperumal, Agasthiyalingom Meenakshi; Manu, Saraswathy Kesava Pillai; Varghese, Lity Alen; Sekkar, Venkataraman published the artcile< DSC assisted kinetic analysis on the urethane network formation between castor oil based ester polyol and poly(methylene di phenyl isocyanate) (pMDI)>, Electric Literature of 112-63-0, the main research area is castor oil polyol pMDI urethane network formation kinetics.

Kinetics of the reaction between castor oil based ester polyol (CEP) and poly(methylene di Ph isocyanate) (pMDI) was studied adopting differential scanning calorimetry (DSC). DSC scans were recorded at various heating rates, viz.: 5, 10, 15 and 20 K.min-1. Hydroxyl and isocyanato compounds were taken at stoichiometric ratio [r=[NCO/OH]=1] Both single heating rate methods (Coats-Redfern, Chatterjee-Conrad) and multiple heating rate based iso-conversional methods (Ozawa, Freidman and Kissinger) were adopted to calculate the kinetic parameters. DSC thermograms consist of two exothermic peaks at temperatures 343 and 393 K, for all heating rates. Kinetic parameters were calculated using input parameters deduced from DSC thermogram. The reaction was assumed to be second order and the corresponding second order equations were applied for evaluating the kinetic parameters.

International Journal of Polymer Analysis and Characterization published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics