Tag: M.W=250-300

Santschi, Nico; Nauser, Thomas published the artcile< Rate of single electron reduction of Togni's reagent>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Togni reagent single electron reduction rate.

We report on the rate of reduction of a popular electrophilic trifluoromethylating agent, Togni’s reagent (T-CF3), with solvated electrons (e-aq) generated by pulse radiolysis. By means of competition experiments against Me viologen (MV2+) and direct observation of the decay of e-aq we determined k(T-CF3 + e-aq) ≈ 2 × 1010 M-1 s-1. To the best of our knowledge, this constitutes the first report on a reduction of T-CF3 with an unambiguously clear outer-sphere mechanism. Furthermore, we studied the oxidation of 2-(2-iodophenyl)propan-2-ol (ROH) by peroxyl-radicals to a presumably cyclic iodanyl radical RI·. This species RI· was not detected during the reduction of T-CF3 with e-aq and therefore, this reduction does not proceed via heterolytic I-CF3 bond cleavage to CF3- and RI·. More likely, a CF3 radical is formed, as was observed in numerous synthesis studies reported to date.

Journal of Fluorine Chemistry published new progress about Intermediates Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), FORM (Formation, Nonpreparative), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kayahara, Eiichi; Yamada, Hiroto; Yamago, Shigeru published the artcile< Generation of Carbanions through Stibine-Metal and Bismuthine-Metal Exchange Reactions and Its Applications to Precision Synthesis of ω-End-Functionalized Polymers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stibine metal exchange reaction carbanion generation; polyhydroxyethyl methacrylate terminal functionalization stibine metal exchange reaction; polyisopropylacrylamide terminal functionalization stibine metal exchange reaction; polybutyl acrylate terminal functionalization stibine metal exchange reaction; PMMA terminal functionalization stibine metal exchange reaction; magnesium stibine exchange reaction carbanion generation; zinc stibine exchange reaction carbanion generation; bismuthine metal exchange reaction carbanion generation; lithium stibine exchange reaction carbanion generation.

Generation of carbanions from organostibines and organobismuthines through heteroatom-metal exchange reactions was examined from synthetic and mechanistic viewpoints. The exchange reaction proceeded spontaneously upon treatment with various organometallic reagents, such as alkyllithiums, tetraalkylzincates, and alkylmagnesium halides to afford the corresponding carbanions quant. Due to the high reactivity of these heteroatom compounds, the exchange reactions took place exclusively even in the presence of various polar functional groups, which potentially react with organometallic species. The advantage of this method was exemplified by the end-group transformation of living polymers that bear these heteroatom species at the ω-polymer end, prepared by using organostibine- and bismuthine-mediated living radical polymerizations Various polymers that bear polar functional groups and acidic hydrogen-for example, poly(Me methacrylate), poly(Bu acrylate), poly(N-iso-Pr acrylamide), and poly(2-hydroxyethyl methacrylate)-could be used in the exchange reactions, and subsequent trapping with electrophiles afforded the corresponding polymers with controlled mol. weights, mol. weight distributions, and end-group functionalities. Competition experiments showed that organostibines and organobismuthines were among the most reactive heteroatom compounds towards organometallic reagents and that their high reactivity was responsible for the high chemoselectivity in the exchange reaction.

Chemistry – A European Journal published new progress about Carbanions Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kajimoto, Tetsuya; Hidaka, Mitsuharu; Shoyama, Kayoko; Nohara, Toshihiro published the artcile< Iridoids from Scrophularia ningpoensis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iridoid Scrophularia root structure.

Three new compounds (e.g., I and II) were isolated from Scrophulariae Radix, the dried root of S. ningpoensis, together with the known compounds harpagide and harpagoside. The structure of one was shown to be similar to acetoside and angoroside A; the other two were characterized as iridial derivatives by spectroscopic means.

Phytochemistry published new progress about Scrophularia ningpoensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Liangliang; Oestreich, Martin published the artcile< Diastereotopic Group-Selective Intramolecular Aldol Reactions Initiated by Enantioselective Conjugate Silylation: Diastereodivergence Controlled by the Silicon Nucleophile>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silyl benzoyl dihydroxyoctahydroindenone preparation isomerization crystal structure; crystal structure silyl benzoyl dihydroxyoctahydroindenone; mol structure silyl benzoyl dihydroxyoctahydroindenone; aryloxopentenyl cyclopentanedione enantioselective copper catalyzed silylation aldol cyclization; indenone silyl benzoyl preparation.

A reaction sequence consisting of enantioselective Cu-catalyzed conjugate silylation and diastereotopic group-selective aldol cyclization is reported. The diastereoselectivity of the intramol. aldol reaction depends on the Si nucleophile used, either Me2PhSiZnX·2LiX (trans) or Me2PhSiBpin (cis). The more basic Zn reagent and as such the very basic reaction medium also enable thermodynamically driven cis-to-trans isomerization by a retro-aldol-aldol process. A broad range of electron-withdrawing groups including electron-deficient heterocycles is compatible with the different procedures developed.

ACS Catalysis published new progress about Aldehydes, hydroxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasheed, Hafiz Majid; Wahid, Fazli; Ikram, Muhammad; Qaisar, Muhammad; Shah, Abdul Jabbar; Khan, Taous published the artcile< Chemical profiling and anti-breast cancer potential of hexane fraction of Sphaeranthus indicus flowers>, Related Products of 112-63-0, the main research area is Sphaeranthus flower extract anticancer breast cancer.

The current study aimed to determine the phytochems. and anti-breast cancer potential of Sphaeranthus indicus. S. indicus flowers were extracted with methanol followed by fractionation using n-hexane. For the chem. composition of n-hexane fraction, qual. phytochem. and GC-MS anal. were performed. The anti-proliferative activity was measured by MTT assay, whereas, cytotoxic and proapoptotic effects in MCF-7 (breast cancer) cells were determined using propidium iodide, 4,6-diamidino-2-phenylindole, dichlorofluorescin diacetate, and JC-1 staining through fluorescent microscopy. The phytochem. anal. indicated presence of phytosterols, oils and resins in the nhexane fraction. GC-MS anal. showed that n-hexane fraction comprises of 11 compounds including Me esters of caprylic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and behanic acid. The tested fraction showed remarkable cytotoxic activity against breast cancer (MCF-7) cells while it was found less toxic towards non-cancerous (BHK-21) cells. Furthermore, morphol. assessment through fluorescent microscopy revealed cytotoxic and apoptotic effects by improved cell membrane permeability, increased reactive oxygen species level, compromised mitochondrial activity and condensation of chromatin network. Conclusion: The n-hexane fraction of S. indicus contains phytosterols, oils and fatty acid Me esters and produced apoptotic effect against breast cancer cells.

Tropical Journal of Pharmaceutical Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nyakas, Marta; Fleten, Karianne Giller; Haugen, Mads Haugland; Engedal, Nikolai; Sveen, Christina; Farstad, Inger Nina; Floerenes, Vivi Ann; Prasmickaite, Lina; Maelandsmo, Gunhild Mari; Seip, Kotryna published the artcile< AXL inhibition improves BRAF-targeted treatment in melanoma>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is BGB324 vemurafenib anticancer agent AXL BRAF proteome metastatic melanoma.

More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype, attributed with AXL high mol. profile in melanoma, has been recently linked to such event, limiting treatment efficacy. In the current study, we investigated the therapeutic potential of the AXL inhibitor (AXLi) BGB324 alone or in combination with the clin. relevant BRAF inhibitor (BRAFi) vemurafenib. Firstly, AXL was shown to be expressed in majority of melanoma lymph node metastases. When treated ex vivo, the largest reduction in cell viability was observed when the two drugs were combined. In addition, a therapeutic benefit of adding AXLi to the BRAF-targeted therapy was observed in pre-clin. AXL high melanoma models in vitro and in vivo. When searching for mechanistic insights, AXLi was found to potentiate BRAFi-induced apoptosis, stimulate ferroptosis and inhibit autophagy. Altogether, our findings propose AXLi as a promising treatment in combination with standard therapy to improve therapeutic outcome in metastatic melanoma.

Scientific Reports published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (BRAF). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qin, Lu-Yun; Guan, Peng; Wang, Jian-Xin; Chen, Yu; Zhao, Ya-Shuo; Yang, Sheng-Chang; Guo, Ya-Jing; Wang, Na; Ji, En-Sheng published the artcile< Therapeutic potential of astragaloside IV against Adriamycin-induced renal damage in rats via ferroptosis>, Computed Properties of 347174-05-4, the main research area is renal damage ferroptosis astragaloside IV therapeutic potential; Adriamycin; astragaloside Ⅳ; ferroptosis; iron metabolism; kidney.

Adriamycin (ADR) has been utilized to treat cancer for several decades. However, ADR-induced renal injury is one of the most common side effects accompanying ADR therapy. In the present study, we revealed that astragaloside IV (ASIV) was beneficial for renal injury caused by Adriamycin. We demonstrated that ASIV significantly ameliorated kidney injury, improved renal dysfunction, reduced oxidative stress, alleviated iron accumulation, and inhibited the induction of ferroptosis by ADR. ASIV also rescued the intracellular levels of nuclear factor-erythroid-2-related factor 2 (Nrf2) and promoted nuclear translocation of Nrf2. These protective effects of ASIV on renal injury might be attained through the ASIV-induced activation of the Pi3K/Akt signaling pathway. In vitro, the treatment of the HK-2 cells with fer-1 or deferoxamine mesylate obviously improved cell viability during Adriamycin administration. On the other hand, the protective role of ASIV can be abrogated by RSL3 to some extent. Moreover, ASIV lowered the expression of transferrin receptor 1 and divalent metal transporter 1 while enhancing the expression of ferropotin 1 and glutathione peroxidase 4 in ADR administrated cells, the effects of which were akin to those of deferoxamine mesylate. Furthermore, ASIV increased the phosphorylation of Pi3K, Akt, and the expression of Nrf2 and glutathione peroxidase 4 compared to HK-2 cells stimulated by ADR. However, Pi3K inhibitor LY294002 abrogated these activations. In conclusion, ferroptosis may involve in ADR-induced nephrotoxicity, and ASIV might protect nephrocytes against ADR-induced ferroptosis, perhaps via activations of the Pi3K/Akt and Nrf2 signaling pathways.

Frontiers in Pharmacology published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Computed Properties of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Svec, Riley L.; McKee, Sydney A.; Berry, Matthew R.; Kelly, Aya M.; Fan, Timothy M.; Hergenrother, Paul J. published the artcile< Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is imidazotetrazin derivative preparation temozolomide resistant glioblastoma.

Glioblastoma (GBM) is the most lethal primary brain tumor. Currently, frontline treatment for primary GBM includes the DNA-methylating drug temozolomide (TMZ, of the imidazotetrazine class), while the optimal treatment for recurrent GBM remains under investigation. Despite its widespread use, a majority of GBM patients do not respond to TMZ therapy; expression of the O6-methylguanine DNA methyltransferase (MGMT) enzyme and loss of mismatch repair (MMR) function as the principal clin. modes of resistance to TMZ. Here, we describe a novel imidazotetrazine designed to evade resistance by MGMT while retaining suitable hydrolytic stability, allowing for effective prodrug activation and biodistribution. This dual-substituted compound, called CPZ, exhibits activity against cancer cells irresp. of MGMT expression and MMR status. CPZ has greater blood-brain barrier penetrance and comparable hematol. toxicity relative to TMZ, while also matching its maximum tolerated dose in mice when dosed once-per-day over five days. The activity of CPZ is independent of the two principal mechanisms suppressing the effectiveness of TMZ, making it a promising new candidate for the treatment of GBM, especially those that are TMZ-resistant.

ACS Chemical Biology published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Min, Qing-Qiang; Li, Na; Chen, Guang-Le; Liu, Feng published the artcile< Copper-catalysed C(sp3)-N coupling initiated by selective C-C bond cleavage of cyclobutanone oxime esters>, Category: esters-buliding-blocks, the main research area is arylaminobutanenitrile preparation chemoselective; cyclobutanone oxime ester aryl amine bond cleavage amination copper.

Herein, an efficient copper-catalyzed selective C-C bond cleavage/amination of cyclobutanone oxime esters is reported. This reaction protocol is operationally simple and conducted at ambient temperature, allowing access to a wide range of functionalized 4-(arylamino)butanenitriles in moderate to excellent yields. This transformation shows high chemo-selectivity and wide functional-group compatibility and can be easily scaled up to the gram level with a useful yield. A mechanism involving copper-catalyzed capture of alkyl radical intermediates by amine nucleophiles is proposed.

Organic Chemistry Frontiers published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Dae-Yon; Kim, In-Jung; Jun, Chul-Ho published the artcile< Synthesis of cycloalkanones from dienes and allylamines through C-H and C-C bond activation catalyzed by a rhodium(I) complex>, SDS of cas: 112-63-0, the main research area is cycloalkanone preparation alkadiene allylamine rhodium catalyzed carbon hydrogen activation; phenylpropenyl pyridinamine alkadiene rhodium catalyzed activation cycloalkanone preparation.

An allylic amine, 3-methyl-N-(3-phenyl-2-propenyl)-2-pyridinamine (I), is used as a masked form of formaldehyde in the rhodium-catalyzed cyclization of dienes. The reaction provides access to various cycloalkanones through chelation-assisted C-H-bond and C-C-bond activation. The di-μ-chlorotetrakis[(1,2-η)-cyclooctene]dirhodium/tricyclohexylphosphine-catalyzed reaction of I with [[(1-ethenyl-3-butenyl)oxy]methyl]benzene gave 4-(phenylmethoxy)cycloheptanone (II) and 2-methyl-4-(phenylmethoxy)cyclohexanone (III) (84% overall yield; 67:33 ratio). Also, allylic amines that have no coordination site could be applied to this reaction; for example, N-(3-Phenyl-2-propenyl)benzenamine reacted with [[(1-ethenyl-3-butenyl)oxy]methyl]benzene in the presence of 3-methyl-2-pyridinamine catalyzed by di-μ-chlorotetrakis[(1,2-η)-cyclooctene]dirhodium/tricyclohexylphosphine gave II and III (72% overall yield; 53:47 ratio).

Angewandte Chemie, International Edition published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics