Tag: 200-300

On April 26, 2012, Badiger, Sangamesh; Behnke, Dirk; Betschart, Claudia; Cotesta, Simona; Hintermann, Samuel; Ofner, Silvio; Pandit, Chetan; Roy, Bernard Lucien published a patent.Synthetic Route of 1198284-94-4 The title of the patent was Preparation of diazaspiro[5.5]undecanes as orexin receptor inhibitors. And the patent contained the following:

The title compounds I [A = (un)substituted 5-6 membered aromatic ring which contain 1-4 heteroatoms selected from N, O and S; m, n = 0-6; R1, R2 = halo alkyl, cycloalkyl, etc.; X1 = C(O) and X2 = N(LB); or X1 = N(LB) and X2 = C(O); L = C(R6)2; R6 = H, alkyl, cycloalkyl, etc.; or two R6 together with the carbon atom to which they are bound form cycloalkyl; B = (un)substituted 5-6 membered monocyclic or 8-10 membered fused bicyclic aromatic ring which may contain 1-4 heteroatoms selected from N, O and S], useful as orexin receptor inhibitors, were prepared E.g., a multi-step synthesis of II, starting from 2,9-diazaspiro[5.5]undecan-1-one trifluoroacetate and 2-chloro-4,6-dimethylpyrimidine, was described. Exemplified compounds I were tested for inhibiting human orexin 1 and human orexin 2 receptors (data given). Pharmaceutical composition comprising the compound I was disclosed. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Synthetic Route of 1198284-94-4

The Article related to diazaspiroundecane preparation orexin receptor inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 11, 2020, Hu, Yonghan; Wu, Dongdong; Peng, Wei; Lu, Liang; Li, Xin; Zhang, Xiuchun; Wang, Ruzhi; Zhu, Sheng; Huang, Bin; Liu, Tao; Zhu, Jinlian; Wu, Yuchuan published a patent.Recommanded Product: 1198284-94-4 The title of the patent was Heterocyclic compound, application and pharmaceutical composition and application. And the patent contained the following:

The invention disclosed a kind of heterocyclic compound, its preparation method and application. The claimed compound is shown in structure I (R1 = H, F, difluoromethyl, OMe, cyclopropyl, etc.; Y1 = N or CH; Y2 = N, CH, C(F), etc.; R9 = H, Me, or difluoromethyl; X1 = N, CH, C(OH), etc.; s,t = 0 or 1; X3 = N; X2 = CH2, or C(O); X4 = hetero atom containing fragment forming heterocycle; X6 = C(O), or CH2. CHR; R = C1-4 alkyl; X5 = N or CH; R6 = H, halo, cyclopropyl, etc.; R7 = H or halo; R8 = (un)substituted C1-4 alkyl, halo, cyclopropyl, oe H). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used as RET kinase inhibitor for treating and preventing diseases mediated by abnormal expression of RET such as cancers (papillary thyroid carcinoma, medullary thyroid carcinoma, pheochromocytoma, pancreatic ductal adenocarcinoma, multiple endocrine tumors (also for example MEN2A or MEN2B), breast cancer (also for example metastatic breast cancer), testicular cancer, small cell lung cancer, Non-small cell lung cancer, chronic bone marrow mononuclear leukemia, colon cancer, rectal cancer, ovarian cancer, or salivary adenocarcinoma). The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Recommanded Product: 1198284-94-4

The Article related to heterocyclic compound preparation ret kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 15, 2021, Sasaki, Takashi; Tsuzuki, Yuya; Nakane, Tatsuki published an article.Electric Literature of 118-55-8 The title of the article was A Dynamically Correlated Network Model for the Collective Dynamics in Glass-Forming Molecular Liquids and Polymers. And the article contained the following:

The non-Arrhenius behavior of segmental dynamics in glass-forming liquids is one of the most profound mysteries in soft matter physics. In this article, the authors propose a dynamically correlated network (DCN) model to understand the growing behavior of dynamically correlated regions during cooling, which leads to the viscous slowdown of supercooled liquids The fundamental concept of the model is that the cooperative region of collective motions has a network structure that consists of string-like parts, and networks of various sizes interpenetrate each other. Each segment undergoes dynamical coupling with its neighboring segments via a finite binding energy. Monte Carlo simulations showed that the fractal dimension of the DCNs generated at different temperatures increased and their size distribution became broader with decreasing temperature The segmental relaxation time was evaluated based on a power law with four different exponents for the activation energy of rearrangement with respect to the DCN size. The results of the present DCN model are consistent with the exptl. results for various materials of mol. and polymeric liquids The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Electric Literature of 118-55-8

The Article related to mol liquid polymer collective dynamics dynamically correlated network model, dynamically correlated network, dynamics, relaxation time, simulation, supercooled liquids, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Electric Literature of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2018, Veluri, Jagan Mohan Reddy; Mustoori, Sairam; Yeruva, Srinivasulu Reddy; Tapas, Barui; Jyothishwaran, Jyothishwaran; Kanduri, Venkata Sada Siva Rao; Furkhan, Tajamul; Malolanarasimhan, Krishnan; Murugan, Ravichandran Narayanasamy; Kedari, Chaitanyakumar; Vasker, Rakesh Goud; Desai, Sahejad published a patent.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Process for preparation, recovery and purification of lirapeptide as a ubiquitin fusion protein and it’s subsequent conversion to liraglutide. And the patent contained the following:

The present application relates to a process for the preparation of peptides or proteins or derivatives thereof by expression of synthetic oligonucleotide encoding desired protein or peptide in prokaryotic cell as ubiquitin fusion construct. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to lirapeptide sequence ubiquitin fusion protein liraglutide conversion, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 11, 2021, Mei, Baicheng; Zhou, Yuxing; Schweizer, Kenneth S. published an article.Category: esters-buliding-blocks The title of the article was Long Wavelength Thermal Density Fluctuations in Molecular and Polymer Glass-Forming Liquids: Experimental and Theoretical Analysis under Isobaric Conditions. And the article contained the following:

We establish via an in-depth anal. of exptl. data that the dimensionless compressibility (proportional to the dimensionless amplitude of long wavelength thermal d. fluctuations) of one-component normal and supercooled liquids of chem. complex nonpolar and weakly polar mols. and polymers follows extremely well a surprisingly simple and general temperature dependence over an exceptionally wide range of pressures and temperatures A theor. basis for this behavior is shown to exist in the venerable van der Waals model and its more modern interpretations. Although associated hydrogen bonding (and to a lesser degree strongly polar) liquids display modestly more complex behavior, rather simple temperature and pressure dependences are also discovered. A new approach to collapse the temperature- and pressure-dependent dimensionless compressibility data onto a master curve is formulated that differs from the empirical thermodn. scaling approach. As a practical matter, we also find that the dimensionless compressibility scales well as an inverse power law with temperature with an exponent that is system dependent and decreases with pressure. At very high pressures and low temperatures, the thermal liquid behavior appears to approach (but not reach) a repulsion-dominated random close packing limit. All these findings are relevant to our recent theor. work on the problem of activated relaxation and vitrification of supercooled mol. and polymeric liquids The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Category: esters-buliding-blocks

The Article related to thermal density fluctuation mol polymer glass liquid isobaric, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kalachandra, S.; Kusy, R. P. published an article in 1991, the title of the article was Comparison of water sorption by methacrylate and dimethacrylate monomers and their corresponding polymers.Product Details of 1985-51-9 And the article contains the following content:

Water sorption of some glycol dimethacrylates (GDM) and alkyl methacrylates (AM) was determined by Karl-Fischer anal. After γ-irradiation, the corresponding polymers were characterized in terms of percentage water uptake (gravimetrically), diffusion coefficient (D), and contact angle (θ) measurements. Water sorption of the polymers approximated Fick’s law. Ignoring the double bond contribution, the weight per cent O content (WPO), which was indicative of hydrophilic character of these materials, was calculated and correlated with the total O content present in each monomer mol. A linear relationship between the WPO and percentage water uptake was observed in a series of 4 GDM’s and 8 linear AM’s. Their corresponding polymers conformed to a linear correlation between the WPO and θ. On the basis of its WPO, bisphenol A-bis(2-hydroxypropyl) methacrylate sorbed less water than expected because an intramol. H bond was present. The rapid initial rates observed in soft Me methacrylate polymers were attributed to the water soluble impurities present in the matrix. The D values of the networks based on difunctional methacrylates were generally lower than Me methacrylates presumably because of the highly crosslinked nature of the former. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Product Details of 1985-51-9

The Article related to water sorption methacrylate monomer polymer, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Product Details of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 16, 2021, Cleary, Leah; Fleury, Melissa; Pei, Zhonghua published a patent.Computed Properties of 141940-37-6 The title of the patent was Preparation of quinolinone derivatives as methionine adenosyltransferase 2a inhibitors for treatment of cancer. And the patent contained the following:

Disclosed herein are certain quinolinone derivatives of I that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Compounds of formula I [wherein V = Ph or 5 to 6 membered heteroaryl; Z = CH or N; R1, R2, and R5 independently = H, cyano, halo, C1-6alkyl, etc.; each R3 independently = halo, C1-4alkyl, C1-4haloalkyl, etc.; R4 = H, halo, C1-6alkyl, C6-10aryl, etc.; Y2 = bond or C1-4alkylene; n = 0, 1, or 2] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for MAT2A inhibitory activity from which II exhibited an IC50 in the range of �10 nM to < 200 nM. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to quinolinone derivative preparation methionine adenosyltransferase 2a inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 23, 2018, Zhou, Guo Qiang published a patent.SDS of cas: 1198284-94-4 The title of the patent was Preparation of diazaspirodecanyl pyrimidines useful as SSAO inhibitors. And the patent contained the following:

The invention provides compound of formula I and pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds Example compound (E)-I�HCl was prepared by BOC-deprotection of tert-Bu N-[(E)-3-fluoro-2-[[2-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-5-yl]oxymethyl]allyl]carbamate. The invention compounds were evaluated for their SSAO inhibitory activities. From the assay, it was determined that compound I(E)-I�HCl exhibited IC50 value of less than 60 nM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).SDS of cas: 1198284-94-4

The Article related to diazaspirodecanyl pyrimidine preparation ssao inhibitor nonalcoholic steatohepatitis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 23, 2018, Fan, Mengyang; Qin, Luoheng; Wei, Yi; Zhou, Guoqiang; Zhou, Jingye published a patent.Product Details of 1198284-94-4 The title of the patent was Preparation of aminopyrimidine compounds useful as semicarbazide-sensitive amino oxidase (SSAO) inhibitors. And the patent contained the following:

The invention provides compounds of the formula I (wherein R1 is substituted piperidinyl, substituted 2,8-diazaspiro[4.5]decan-1-one, substituted piperazinyl, etc.) and pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds Example compound II�HCl was prepared by BOC-deprotection of tert-Bu N-[(E)-3-fluoro-2-[[2-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-5-yl]oxymethyl]allyl]carbamate. The invention compounds were evaluated for their SSAO inhibitory activities (some data given). The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Product Details of 1198284-94-4

The Article related to aminopyrimidine semicarbazide sensitive amino oxidase inhibitor liver disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 23, 2018, Fan, Mengyang; Qin, Luoheng; Wei, Yi; Zhou, Guoqiang; Zhou, Jingye published a patent.Synthetic Route of 1198284-94-4 The title of the patent was Preparation of aminopyrimidine compounds as SSAO inhibitors. And the patent contained the following:

The invention provides compounds of the formula I (wherein R1 is substituted piperidinyl, substituted 2,8-diazaspiro[4.5]decan-1-one, substituted piperazinyl, etc.) and pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds Example compound II�HCl was prepared by BOC-deprotection of tert-Bu N-[(E)-3-fluoro-2-[[2-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-5-yl]oxymethyl]allyl]carbamate. The invention compounds were evaluated for their SSAO inhibitory activities (some data given). The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Synthetic Route of 1198284-94-4

The Article related to aminopyrimidine preparation ssao inhibitor nonalcoholic steatohepatitis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics