Tag: 200-300

On July 8, 2021, Luo, Long; Nguyen, Hien M. published a patent.Application In Synthesis of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate The title of the patent was Alternating current electrolysis for use in organic synthesis. And the patent contained the following:

The current disclosure provides a.c. based systems and methods to develop chem. compounds, such as drug mols. using electrochem. in organic synthesis. The experimental process involved the reaction of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate(cas: 1414887-27-6).Application In Synthesis of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate

The Article related to alternating current electrolysis organic synthesis, Electrochemistry: Nonindustrial Electrochemical Syntheses and Preparations and other aspects.Application In Synthesis of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 21, 2021, Wang, Hui; Vendrame, Lorenzo; Fliedel, Christophe; Chen, Si; Gayet, Florence; D’Agosto, Franck; Lansalot, Muriel; Manoury, Eric; Poli, Rinaldo published an article.Related Products of 2358-84-1 The title of the article was Triphenylphosphine-Functionalized Core-Cross-Linked Micelles and Nanogels with a Polycationic Outer Shell: Synthesis and Application in Rhodium-Catalyzed Biphasic Hydrogenations. And the article contained the following:

Unimol. amphiphilic nanoreactors with a poly(4-vinyl-N-methylpyridinium iodide) (P4VPMe+I-) polycationic outer shell and two different architectures (core-crosslinked micelles, CCM, and nanogels, NG), with narrow size distributions around 130-150 nm in diameter, were synthesized by RAFT polymerization from an R0-4VPMe+I-140-b-S50-SC(S)SPr macroRAFT agent by either chain extension with a long (300 monomer units) hydrophobic polystyrene-based block followed by crosslinking with diethylene glycol dimethacrylate (DEGDMA) for the CCM particles, or by simultaneous chain extension and crosslinking for the NG particles. A core-anchored triphenylphosphine (TPP) ligand functionality was introduced by using 4-diphenylphosphinostyrene (DPPS) as a comonomer (5-20% mol mol-1) in the chain extension (for CCM) or chain extension/crosslinking (for NG) step. The products were directly obtained as stable colloidal dispersions in water (latexes). After loading with [RhCl(COD)]2 to yield [RhCl(COD)(TPP@CCM)] or [RhCl(COD)(TPP@NG)], resp., the polymers were used as polymeric nanoreactors in Rh-catalyzed aqueous biphasic hydrogenation of the model substrates styrene and 1-octene, either neat (for styrene) or in an organic solvent (toluene or 1-nonanol). All hydrogenations were rapid (TOF up to 300 h-1) at 25°C and 20 bar of H2 pressure, the biphasic mixture rapidly decanted at the end of the reaction (<2 min), the Rh loss was negligible (<0.1 ppm in the recovered organic phase), and the catalyst phase could be recycled 10 times without significant loss of catalytic activity. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Related Products of 2358-84-1

The Article related to triphenylphosphine micelle nanogel polycationic rhodium catalyst hydrogenation, nanostructures, polycations, polymers, rhodium, self-assembly, surfactants, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Related Products of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 24, 2020, Wang, Hui; Vendrame, Lorenzo; Fliedel, Christophe; Chen, Si; Gayet, Florence; Manoury, Eric; Zhang, Xuewei; DAgosto, Franck; Lansalot, Muriel; Poli, Rinaldo published an article.COA of Formula: C12H18O5 The title of the article was Core-Cross-Linked Micelles Made by RAFT Polymerization with a Polycationic Outer Shell Based on Poly(1-methyl-4-vinylpyridinium). And the article contained the following:

A convergent synthesis of amphiphilic polymers with a polystyrene (PS) core and a polyelectrolytic poly(1-methyl-4-vinylpyridinium iodide) (P4VPMe+I-) shell is reported. The polymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization in water using a trithiocarbonate chain transfer agent [R0-SC(S)SPr, R0 = -C(Me)(CN)CH2CH2COOH]. Two types of particle structure, both having a spherical morphol. and diameters in the 85-150 nm range, have been obtained as stable latexes with polymer content up to 10% in weight The first structure consists of core-crosslinked micelles (CCMs), where amphiphilic P4VPMe+I–b-PS arms are cross-linked at the hydrophobic end by the use of diethylene glycol dimethacrylate. The Coulombic repulsion between the outer shells of the precursor micelles ensures the absence of macrogelation during the crosslinking step. The second structure consists of nanogels (NGs), where the entire hydrophobic core is crosslinked during the last step of simultaneous chain extension and crosslinking of a P4VPMe+I–b-PS intermediate with a short PS block. The lack of radical polymerization for the 4VPMe+I- monomer and the lack of chain extension with styrene for a R0-P4VPMe+I–SC(S)SPr intermediate were circumvented by the synthesis of R0-P4VP-b-PS-SC(S)SPr containing a short PS block by sequential RAFT polymerization of 4-vinylpyridine (4VP) and styrene, followed by quant. cationization of the P4VP block by MeI and subsequent sequential (for the CCMs) or simultaneous (for the NGs) chain extension and crosslinking. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to core crosslinked micelle raft polymerization cationic polyvinylpyridine polystyrene diblock, nanogel polyvinylpyridine polystyrene diblock, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 7, 2019, Bhaumik, Atanu; Peterson, Gregory I.; Kang, Cheol; Choi, Tae-Lim published an article.Computed Properties of 2873-29-2 The title of the article was Controlled Living Cascade Polymerization To Make Fully Degradable Sugar-Based Polymers from D-Glucose and D-Galactose. And the article contained the following:

Monomers derived from glucose and galactose, which contain an endocyclic alkene (in the sugar ring) and a terminal alkyne, underwent a cascade polymerization to prepare new polymers with the ring-opened sugar incorporated into the polymer backbone. Polymerizations were well-controlled, as demonstrated by a linear increase in mol. weight with monomer-to-initiator ratio and generally narrow mol. weight dispersity values. The living nature of the polymerization was supported by the preparation of a block copolymer from two different sugar-based monomers. The resulting polymers were also fully degradable. They underwent fast and complete depolymerization to small mols. under acidic conditions. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to degradable monosaccharide polymer cascade polymerization synthesis, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ieawsuwan, Winai; Ruchirawat, Somsak published an article in 2019, the title of the article was An efficient silver tetrafluoroborate-catalyzed cycloisomerization of ynamides.Synthetic Route of 141940-37-6 And the article contains the following content:

A silver catalyzed-cycloisomerization of N-Boc protected ynamides was developed under mild reaction conditions to provide a wide range of oxazolones I [R1 = (CH2)8OTIPS, Ph, 4-FC6H4, etc.; R2 = Ph, 4-ClC6H4, (CH2)2Ph, etc.] in good to excellent yields. Moreover, the acid-promoted Pictet-Spengler cyclization of oxazolones I was described to furnish the corresponding trans-oxazolidones II [R3 = H, OMe; R4 = R5 = OMe] in moderate yields. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Synthetic Route of 141940-37-6

The Article related to oxazolidone preparation diastereoselective, oxazolone preparation pictet spengler cyclization acid mediated, protected ynamide cycloisomerization silver catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Synthetic Route of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 5, 2012, Brownstein, Michael J. published a patent.Recommanded Product: 53838-27-0 The title of the patent was β-Lactam derivatives as vasopressin V1a antagonists and their preparation and use for the treatment of post traumatic stress disorder. And the patent contained the following:

The invention relates to β-lactam derivatives of formula I, which are vasopressin V1a antagonists and which are useful in the treatment of post traumatic stress disorder. Compounds of formula I wherein A is carboxylic acid, ester and amide; B is carboxylic acid, ester, alc., etc.; R1 is H and C1-6 alkyl; R2 is H, alkyl, alkenyl, etc.; R3 is amino, amido, acylamido, etc.; R4 is alkyl, alkenyl, alkynyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their vasopressin V1a antagonistic activity and binding affinity. From the assay, it was determined that compound II exhibited a binding affinity IC50 value of 35 nM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Recommanded Product: 53838-27-0

The Article related to beta lactam preparation vasopressin v1a antagonist, lactam beta preparation treatment post traumatic stress disorder, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Recommanded Product: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 4, 1999, Hardy, Jean-Claude; Bouquerel, Jean; Nemecek, Patrick; Peyronel, Jean-Francois published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of thiazolobenzazepines and analogs as anticonvulsants and glutamate antagonists. And the patent contained the following:

Title compounds [I; R2 = H or alkyl; R6R3 = (CH2)4, (CH2)3CO, (CH2)3O, etc.; R7 = polyfluoroalkyl(oxy); Z = S or Se] were prepared Thus, N-protected Et 2-amino-5-trifluoromethoxybenzoate was N-alkylated by Br(CH2)3CO2Et and the product cyclized to give, in 3 addnl. steps, benzazepine II which was cyclocondensed with KSCN to give I [R2 = H, R6R3 = CH(OH)(CH2)3, R7 = OCF3, Z = S]. Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolobenzazepine preparation anticonvulsant glutamate antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 3, 1998, Hardy, Jean-claude; Bouquerel, Jean; Nemecek, Patrick; Aloup, Jean-claude; Mignani, Serge; Peyronel, Jean-francois published a patent.Application of 141940-37-6 The title of the patent was Preparation of 2-iminothiazolo[5,4,3-ij]quinolines and analogs as glutamatergic antagonists. And the patent contained the following:

Title compounds [I; R1 = H or alkyl; R6 = fluoroalkyl, -alkoxy, -alkylthio; R7 = H or alkyl, CH2OH, CH2NH2, alkylsulfonylmethyl, etc. only when Z = CH2CH2; Z = CH2CH2, CH(OH)CF2, COCH2, SO0-2CH2, etc.; Z1 = S or Se] were prepared Thus, 4-(F3CO)C6H4NH2 was cyclocondensed with HOCH(CH2OH)2 and the hydrogenated product cyclocondensed with KCNS to give I (R2 = R7 = H, R6 = OCF3, Z = CH2CH2, Z1 = S). Data for biol. activity of I were given. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application of 141940-37-6

The Article related to iminothiazoloquinoline preparation glutamatergic antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 22, 2010, Sugita, Kazuyuki; Ota, Masahiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or their pharmacol. acceptable salts], etc., were prepared For example, reaction of Et [(trans)-7-chloro-5-[3-methoxy-2-(trifluoromethyl)phenyl]-2-thioxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetate (preparation given) with NH2NH2·H2O followed by cyclization with trifluoroacetic anhydride, separation using chiral HPLC and hydrolysis afforded (4R,6R)-I. In squalene synthase inhibition assays, the IC50 value of (4R,6R)-I was 0.88 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. Pharmaceutical composition comprising (4R,6R)-I is disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 8, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics