On January 5, 2012, Brownstein, Michael J. published a patent.Recommanded Product: 53838-27-0 The title of the patent was β-Lactam derivatives as vasopressin V1a antagonists and their preparation and use for the treatment of post traumatic stress disorder. And the patent contained the following:
The invention relates to β-lactam derivatives of formula I, which are vasopressin V1a antagonists and which are useful in the treatment of post traumatic stress disorder. Compounds of formula I wherein A is carboxylic acid, ester and amide; B is carboxylic acid, ester, alc., etc.; R1 is H and C1-6 alkyl; R2 is H, alkyl, alkenyl, etc.; R3 is amino, amido, acylamido, etc.; R4 is alkyl, alkenyl, alkynyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their vasopressin V1a antagonistic activity and binding affinity. From the assay, it was determined that compound II exhibited a binding affinity IC50 value of 35 nM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Recommanded Product: 53838-27-0
The Article related to beta lactam preparation vasopressin v1a antagonist, lactam beta preparation treatment post traumatic stress disorder, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Recommanded Product: 53838-27-0
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