Month: December 2022

Saravanakumar, Kandasamy published the artcileNucleolin targeted delivery of aptamer tagged Trichoderma derived crude protein coated gold nanoparticles for improved cytotoxicity in cancer cells, Related Products of esters-buliding-blocks, the main research area is nucleolin Trichoderma protein coated gold nanoparticles cytotoxicity cancer.

The present work demonstrates how the fungal crude protein extract (FE) mediated gold nanoparticles (AuNPs) functionalized with aptamer (APT) improved cytotoxicity in human lung cancer cell line (A549) and brain tumor cell line (LN229). The agarose gel electrophoresis (AGE) confirmed the conjugation of APT in FE-AuNPs. The FTIR results revealed the involvement of FE in the amalgamation of FE-AuNPs. FE-AuNPs (λmax 521 nm) had Z-average size of 19.72 ± 0.26 d. nm and PDI of 0.58 ± 0.01 with a zeta potential of -22.20 mV, whereas APT-FE-AuNPs (λmax521 nm) had the Z-average size of 167.63 ± 1.40 d. nm and PDI of 0.21 ± 0.01 with a zeta potential of -36.36 mV. Both synthesized nanoparticles exhibited less cytotoxicity in normal NIH3T3 cells, while the APT-FE-AuNPs (λmax 521 nm) showed significant cytotoxicity in A549 and LN229 cells. The cells treated with APT-FE-AuNPs (λmax 521 nm) displayed higher percentage of early apoptosis (6.97%), apoptosis (7.08%), and necrosis (6.63%) than those treated with bare or APT-FE-AuNPs (λmax 565 nm) in A549 cells. The results demonstrated that the DNA aptamer (AS1411) tagged with FE-AuNPs (λmax 521 nm) increased their accumulation in cancer cells, which triggered nucleolin targeted cell cytotoxicity through nucleus damage and induction of oxidative stress.

Process Biochemistry (Oxford, United Kingdom) published new progress about Amalgamation. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhaskar, K. published the artcileAnalysis of Cymbopogon Citratus, Pinus sylvestris and Syzygium cumini biodiesel feedstocks for its fatty acid composition, Quality Control of 929-77-1, the main research area is biodiesel feedstock fatty acid branching combustion.

Rapid depletion of fossil fuel and increased demand for petroleum products in energy and transportation sector motivated the researchers to find a substitution for petroleum diesel. Biodiesel is one among the alternate to this crisis. Biodiesel is a combined mixture of fatty acid alkyl esters obtained by the reaction of triglycerides of vegetable or animal origin with alc. in the presence of a catalyst. The fatty acid profile influences the overall properties of the biodiesel. The properties of individual fatty acid depend on the occurrence of double bonds, fatty acid chain length and branching. Better understanding of the fatty acid composition and correlating the fuel properties is of utmost importance in improving the optimal performance. In the present study, feedstocks of Cymbopogon citratus, Pinus sylvestris and Syzygium cumini is analyzed for its fatty acid composition study using Gas Chromatog. assisted with mass spectrometry. Based on GC-MS Anal., fifteen types of fatty acids in Cymbopogon citratus, Pinus sylvestris and Syzygium cumini oil Me esters were analyzed and defined; all these esters are amalgamations of saturated and unsaturated fatty acids. The variation in fatty acid compositions affects the properties of the esters. GC-MS synthesis showed that Me, Et esters free from dirt for the three feedstocks. Few impurities like mainly mono-, di- and triglycerides were found.

Materials Today: Proceedings published new progress about Amalgamation. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Quality Control of 929-77-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xiao-Yue published the artcilepara-Selective arylation and alkenylation of monosubstituted arenes using thianthrene S-oxide as a transient mediator, Product Details of C9H10O2, the main research area is biaryl preparation.

Using thianthrene S-oxide (TTSO) as a transient mediator, para-arylation and alkenylation of mono-substituted arenes was demonstrated to get biaryls via a para-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction featured a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenylation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Product Details of C9H10O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diantina, S. published the artcileSeed viability and fatty acid profiles of five orchid species before and after ageing, Application In Synthesis of 929-77-1, the main research area is seed viability fatty acid profile orchid species ageing; Epiphytic Dendrobium; fatty acid methyl esters (FAMEs); gas chromatography (GC); seed lipids; seed storage; terrestrial orchids.

Changes in seed lipid composition during ageing are associated with seed viability loss in many plant species. However, due to their small seed size, this has not been previously explored in orchids. We characterized and compared the seed viability and fatty acid profiles of five orchid species before and after ageing: one tropical epiphytic orchid from Indonesia (Dendrobium strebloceras), and four temperate species from New Zealand, D. cunninghamii (epiphytic), and Gastrodia cunninghamii, Pterostylis banksii and Thelymitra nervosa (terrestrial). Seeds were aged under controlled laboratory conditions (3-mo storage at 60% RH and 20°C). Seed viability was tested before and after ageing using tetrazolium chloride staining. Fatty acid Me esters from fresh and aged seeds were extracted through trans-esterification, and then analyzed using gas chromatog.-mass spectrometry. All species had high initial viability (>80%) and experienced significant viability loss after ageing. The saturated, polyunsaturated, monounsaturated and total fatty acid content decreased with ageing in all species, but this reduction was only significant for D. strebloceras, D. cunninghamii and G. cunninghamii. Our results suggest that fatty acid degradation is a typical response to ageing in orchids, albeit with species variation in magnitude, but the link between fatty acid degradation and viability was not elucidated. Pterostylis banksii exemplified this variation; it showed marked viability loss despite not having a significant reduction in its fatty acid content after ageing. More research is required to identify the effect of ageing on fatty acid composition in orchids, and its contribution to seed viability loss.

Plant Biology (Berlin, Germany) published new progress about Aging, plant. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Application In Synthesis of 929-77-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aplander, Karolina published the artcileMolecular Wipes: Application to Epidemic Keratoconjuctivitis, COA of Formula: C28H37NO9, the main research area is topical skin wipe keratoconjunctivitis pentacosadiynoic acid polyethylene glycol.

Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. It was found previously that EKC-causing Ads use sialic acid as a cellular receptor and demonstrated that soluble, sialic acid-containing mols. can prevent infection. In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC50 = 0.9 μM) and Ad infectivity (IC50 = 0.7 μM). The mechanism of action is to aggregate virus particles and thereby prevent them from binding to ocular cells. Such formulations may be used for topical treatment of adenovirus-caused EKC.

Journal of Medicinal Chemistry published new progress about Adenoviridae. 882847-32-7 belongs to class esters-buliding-blocks, name is 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid, and the molecular formula is C28H37NO9, COA of Formula: C28H37NO9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lan, Yi-Bin published the artcileCharacterization and differentiation of key odor-active compounds of ‘Beibinghong’ icewine and dry wine by gas chromatography-olfactometry and aroma reconstitution, Formula: C10H20O2, the main research area is icewine aroma gas chromatog olfactometry; Aroma reconstitution; GC-O; Icewine; PLSR; Quantitative descriptive analysis; ‘Beibinghongâ€?

Freezing-thawing events contribute to the unique aroma profile of icewines. Differences in key odor-active volatile compounds between ‘Beibinghong’ (Vitis amurensis × V. vinifera) icewines and dry wines were investigated by gas chromatog.-olfactometry and gas chromatog.-mass spectrometry. Acceptable agreement between the olfactometric and quant. results was obtained. ‘Beibinghong’ icewine was characterized by high concentrations of volatile phenols, lactones, (E)-β-damascenone, and phenylacetaldehyde, which were associated with on-vine freezing-thawing events in grape. Low concentrations of higher alc. acetates and Et esters of fatty acids were attributed to hyperosmotic stress during fermentation The overall aroma of icewine could be mimicked by reconstitution containing 44 identified volatiles. Partial least squares regression anal. demonstrated that the concentrations of these volatile compounds determined the distinct sensory profiles of icewines, which have higher intensities of honey/sweet, smoky, caramel, dried fruit, apricot/peach, and floral aromas, and lower intensities of fresh fruity and herbaceous notes in comparison with dry wines.

Food Chemistry published new progress about Wine analysis. 106-32-1 belongs to class esters-buliding-blocks, name is Ethyl octanoate, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parpinello, Giuseppina Paola published the artcileComparison of Sangiovese wines obtained from stabilized organic and biodynamic vineyard management systems, Recommanded Product: Ethyl 3-hydroxybutanoate, the main research area is Sangiovese wine organic biodynamic vineyard management; Bioactive compounds; Biodynamic; Organic; Sensory evaluation; Volatiles compounds; Wine sustainability.

Sangiovese red wines produced from organic (ORG) and biodynamic (BDN) vineyards over two consecutive vintages (2011 and 2012) were compared for chem. and sensory parameters to investigate a sustainable approach to grape production The effects of management practice, vintage, and their interaction were investigated. The ORG wines showed higher total acidity and lower volatile acidity and pH. Although trained panelists highlighted some differences in astringency and odor complexity between ORG and BDN wines, consumers had no preference. The concentrations of anthocyanins, phenolic and cinnamic acids, and flavonols, as well as color components, did not differ-contrary to results from the conversion period from ORG to BDN (2009 and 2010) in the same vineyard (Parpinello, Rombola,́ Simoni, & Versari, 2015). Together, these two studies demonstrate that ORG and BDN wine characteristics tend to be similar after the first year of conversion, indicating that the BDN method can produce high-quality Sangiovese wine.

Food Chemistry published new progress about Wine analysis. 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Recommanded Product: Ethyl 3-hydroxybutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmad, Ejaz published the artcileSynthesis and application of TiO2-supported phosphotungstic acid for ethyl levulinate production, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is ethyl levulinate synthesis titania supported phosphotungstic acid catalyst.

The present study investigates synthesis, characterization, and application of TiO2 supported Keggin phosphotungstic acid in biorenewable transformations. In particular, 10 wt%, 20 wt%, 30 wt% and 40 wt% Keggin phosphotungstic acid was loaded over TiO2 support via wet impregnation method to prepare EPTN-1, EPTN-2, EPTN-3, and EPTN-4 catalysts, resp. After this, synthesized catalysts were tested in a microwave reactor to measure reactivity trend in order HPW > EPTN-4 > EPTN-3 > EPTN-2 > EPTN-1. A maximum 95% levulinic acid (LA) conversion was measured in the presence of 72 mg EPTN-4 catalyst, two mmol LA in 1:42 LA: EtOH (ethanol) molar ratio at 393 K in 120 min at a stirring speed of 300 rpm. No significant loss in heterogenized EPTN-4 catalyst was measured after five application cycles. A detailed characterization of synthesized catalyst showed that the Keggin structure remained intact after heterogenization.

Materials Science for Energy Technologies published new progress about Particle size. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mocny, Piotr published the artcileSynthesis of Loop Poly(Methyl Methacrylate) Brushes via Chain-End Postpolymerization Modification, Application In Synthesis of 86549-27-1, the main research area is polymethyl methacrylate brush postpolymn.

Polymer brushes are typically densely grafted assemblies of polymer chains that are tethered via one end group to a solid substrate. Anchoring linear polymer chains via both end groups to a surface results in loop-type polymer brushes. Although loop polymer brushes have been shown to be able to outperform their linear, single-chain-end tethered analogs, for example, with respect to the prevention of biofouling or reducing friction, this brush architecture has received only relatively limited attention. Loop-type polymer brushes are mostly prepared following grafting-onto approaches using α,ω-heterobifunctional polymers. Grafting-from strategies, so far, have been rarely explored, but could further expand the range of accessible polymer mol. weights and brush grafting densities and allow the preparation of surface-attached polymer loops from a wider scope of monomers. This manuscript reports an alternative grafting-from strategy for the preparation of loop-type poly(Me methacrylate) (PMMA) brushes. The strategy presented here starts with the preparation of linear polymer grafts using conventional surface-initiated atom transfer radical polymerization The free chain-ends of the linear PMMA grafts are modified with an allyl group and subsequently subjected to a metathesis reaction to induce loop closure. The formation of the loop PMMA brushes was monitored by gel permeation chromatog. anal. after cleavage of the polymer from the silica nanoparticles.

Macromolecules (Washington, DC, United States) published new progress about Nanoparticles. 86549-27-1 belongs to class esters-buliding-blocks, name is Ethyl 2,2-dimethylpent-4-enoate, and the molecular formula is C9H16O2, Application In Synthesis of 86549-27-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barbaro, Pierluigi published the artcileSustainable Catalytic Synthesis for a Bio-Based Alternative to the Reach-Restricted N-Methyl-2-Pyrrolidone, Formula: C7H12O3, the main research area is aquivion support platinum heterogeneous catalyst preparation nanostructure; ethyl levulinate heptylamine platinum catalyst one pot reductive amination; methyl pyrrolidone preparation.

A variety of bifunctional catalysts are prepared combining immobilized metal nanoparticles and acid solid materials featuring Lewis or Bronsted acidity was reported. The catalytic systems are tested in the reductive amination of bio-derived levulinates with primary amines, using hydrogen as clean reducing agent, to obtain N-substituted-5-methyl-2-pyrrolidones, which were proposed as substitutes for the widely used, REACH-restricted solvent N-methyl-2-pyrrolidone. The overall process was studied in depth to identify the best combination of metal and acid functionalities to be used in one-pot and one stage. Pt immobilized onto the Bronsted solid acid Aquivion is shown to be the most efficient catalyst, with a productivity of N-heptyl-5-methyl-2-pyrrolidone of 7.9 mmolgcat-1 h-1 reached at full conversion and 98.6% selectivity, under 120°C, 4 bar H2 pressure and solvent-free conditions.

Advanced Sustainable Systems published new progress about Nanoparticles. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics