On December 21, 2000, Bjore, Annika; Bjorsne, Magnus; Halvarsson, Torbjorn; Hoffmann, Kurt-jurgen; Samuelsson, Bertil; Strandlund, Gert published a patent.Electric Literature of 227940-70-7 The title of the patent was Preparation of new bispidines useful in the treatment of cardiac arrhythmias. And the patent contained the following:
Bispidines, such as I [R1 = alkyl, arylalkyl, etc.; R2, R3 = H, OH, alkyl, etc.; R2R3 = O; R4, R5a, R5b = H, alkyl; R6 = OH, CN, NO2, NH2, halogen, etc.; X = O, S; A, B = bond, linking group, such as alkylene, etc.; D = H, OH, alkyl, aminoalkyl, etc.], were prepared for pharmaceutical use in the treatment of cardiac arrhythmias, in particular atrial and ventricular arrhythmias. Thus, bispidine II was prepared in multistep synthetic sequence starting from Et 4-oxo-1-piperidinecarboxylate, epichlorohydrin, and 4-cyanophenol. The prepared bispidines were tested for primary electrophysiol. effects in anesthetized guinea pigs. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Electric Literature of 227940-70-7
The Article related to bispidine preparation cardiac arrhythmia treatment, antiarrhythmic bispidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Electric Literature of 227940-70-7
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