On December 21, 2000, Alstermark, Christer; Andersson, Kjell; Bjore, Annika; Bjorsne, Magnus; Lindstedt, Alstermark Eva-Lotte; Nilsson, Goran; Polla, Magnus; Strandlund, Gert; Ortengren, Ylva published a patent.COA of Formula: C19H26N2O3 The title of the patent was Preparation of new bispidines useful in the treatment of cardiac arrhythmias. And the patent contained the following:
Bispidines, such as I [R3 = H, alkyl; R4 = H, alkyl, alkoxy; NR3R4 = heterocyclyl; R5 = H, halogen, alkyl, alkoxy, acyloxy, alkylsulfonyloxy, carbamoyl, etc.; R6 = H, alkyl; R5R6 = O; R7 = alkyl, aryl, heterocyclyl; A, B = bond, linking group, such as alkylene, etc.], were prepared for pharmaceutical use in the treatment of cardiac arrhythmias, in particular atrial and ventricular arrhythmias. Thus, bispidine II was prepared with 51% yield by amidation of (S)-4-[3-(3,7-diazabicyclo[3.3.1]non-3-yl)-2-hydroxypropoxy]benzonitrile with Et isocyanate. The prepared bispidines were tested for primary electrophysiol. effects in anesthetized guinea pigs. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).COA of Formula: C19H26N2O3
The Article related to bispidine preparation cardiac arrhythmia treatment, antiarrhythmic bispidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.COA of Formula: C19H26N2O3
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