Synthetic Route of 14062-25-0, These common heterocyclic compound, 14062-25-0, name is Ethyl 2-(4-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2.0 M LDA in heptane/THF/ethylbenzene (6.0 mL, 12 mmol) was slowly added to a solution of ethyl (4-bromophenyl)acetate (2.43 g, 10.0 mmol) in THF (20 mL) at -78 C. and then the mixture was stirred for 30 min. Methyl iodide (0.93 mL, 15 mmol) was added at -78 C. and then the reaction was stirred for an additional 30 min. Saturated NH4Cl aq. was added to quench the reaction. The mixture was extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexane (0-10%) to afford the desired product (2.0 g).
The synthetic route of 14062-25-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YAO, Wenqing; ZHANG, Colin; XU, Meizhong; ZHUO, Jincong; HE, Chunhong; US2012/165305; (2012); A1;,
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