154825-97-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 154825-97-5 name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 50 mL two neck flask were added methyl 2- (4-bromophenyl) -2-methylpropionate (689 mg, 2.68 mmol) , (R) -tert-butyl 3-oxohexahydroimidazo [1, 5-a] pyrazine-7 (1H) -carboxylate (630 mg, 2.61mmol) , Pd2(dba)3(180 mg, 0.19 mmol) , 2-di-tert-butylphosphino-2′, 4′, 6′-triisopropylbiphenyl (550 mg, 1.26 mmol) , Cs2CO3(173 mg, 0.53 mmol) and 1, 4-dioxane (25 mL) , the mixture was stirred at 90 for 12 hours. After the reaction was completed, the mixture was cooled to rt and filtered. The filter cake was washed with EtOAc (25 mL) . To the filtrate were added EtOAc (75 mL) and water (50 mL) , the mixture was shaken and separated into layers. The water layer was extracted with ethyl acetate (50 mL) . The combined organic phases were dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (V/V) = 1.2/1) to give the title compound as a white solid (200 mg, 17.88%) . MS (ESI, pos. ion) m/z: 440.1 [M+Na]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, and friends who are interested can also refer to it.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Xinchang; REN, Qingyun; YAN, Guanghua; GOLDMANN, Siegfried; ZHANG, Yingjun; (253 pag.)WO2019/76310; (2019); A1;,
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