18595-14-7, A common heterocyclic compound, 18595-14-7, name is Methyl 4-amino-3-methylbenzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of methyl 4-amino-5-methylbenzoate (85) (2.48 g, 15 mmol) in 25 mL of AcOH, NBS (3.0 g, 17 mmol)was added portionwise, the mixture was stirred for 1 h, diluted with water, extracted with DCM, washed with a saturated NaHCO3 solution, dried over a2S04, and rotovapped to yield 3.66 g of methyl 4-amino-3-bromo-5-methylbenzoate (86). XH NMR (CDC13, 400 MHz) delta 8.03 (s, 1H), 7.71 (s, 1H), 4.50 (brs, 2H), 3.87 (s, 3H), 2.25 (s, 3H).
The synthetic route of 18595-14-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IVACHTCHENKO, Alexandre, Vasilievich; ALLA CHEM, LLC; IVASHCHENKO, Andrey, Alexandrovich; SAVCHUK, Nikolay, Filippovich; MITKIN, Oleg, Dmitrievich; (98 pag.)WO2017/39791; (2017); A1;,
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