Tag: M.W=250-300

Yang, Xingjie; Jiang, Xubao; Bashir, Muhammad Sohail; Kong, Xiang Zheng published the artcile< Preparation of Highly Uniform Polyurethane Microspheres by Precipitation Polymerization and Pd Immobilization on Their Surface and Their Catalytic Activity in 4-Nitrophenol Reduction and Dye Degradation>, Reference of 112-63-0, the main research area is palladium immobilized polyurethane microsphere catalyst nitrophenol reduction dye degradation.

Polyurethanes (PUNs) have been widely used in many fields. However, there are few reports on their microsphere preparation through precipitation polymerization Herein, uniform PUN microspheres are prepared by precipitation polymerization of toluene diisocyanate and trimethylolpropane, without any surfactant and stabilizer. Under optimized conditions, monomers are fully polymerized within 2 h at a monomer concentration as high as 25.0 wt %, with a high yield of the microspheres (96.9%). By loading Pd on their surface, composite microspheres Pd@PUN are obtained and used as catalysts. 4-Nitrophenol is completely reduced within 1 min, with a kinetic constant of 4.96 min-1, significantly higher than many reported Pd-loaded catalysts, and with comparable reusability. Used in degradation of dye mols., the catalytic performance is practically unchanged after 20 recycled uses. This work provides a simple method for the preparation of highly uniform PUN microspheres with a high yield and their Pd-loaded catalysts, both of great potential for various applications.

Industrial & Engineering Chemistry Research published new progress about Catalytic wastewater treatment. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trost, Barry; Krische, Michael J. published the artcile< Palladium-Catalyzed Enyne Cycloisomerization Reaction in an Asymmetric Approach to the Picrotoxane Sesquiterpenes. 2. Second-Generation Total Syntheses of Corianin, Picrotoxinin, Picrotin, and Methyl Picrotoxate>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is palladium catalyzed enyne cycloisomerization picrotoxane sesquiterpene synthesis; asym synthesis corianin picrotoxinin picrotin methyl picrotoxate; bisdibenzophospholylpropane ligand palladium catalyst enyne cycloisomerization; diphenylphosphinobenzoic acid ligand palladium catalyst enyne cycloisomerization.

An alternative, more efficient synthesis of the picrotoxane core by palladium-catalyzed cycloisomerization of an enyne requires the design of a new catalyst system based upon 1,3-bis(dibenzophospholyl)propane and 2-(diphenylphosphino)benzoic acid as ligands. Thus, unlike thermal processes which leave little opportunity to address failed reactions, the transition-metal-catalyzed reaction provides opportunities for catalyst modification to overcome limitations. In this way, a seven-step synthesis of the picrotoxane core from carvone emerges. The formation of the bislactone depends critically on the ring substitution pattern. A myriad of selective transannular cyclizations occur as a function of this substitution pattern. The bislactone serves as a pivotal intermediate to picrotoxinin (I), picrotin (II), and corianin (III). During the course of the manipulation of the oxidation pattern to create the correct bislactone, an intermediate generated also provides access to Me picrotoxate (IV). An improved sequence from the bislactone to corianin compared to the first generation evolves-in part derived from enhanced control of stereoselectivity in the functionalization of the double bond in the cyclohexenyl portion of the picrotoxane skeleton. Later in the sequence, a hydroxyl-directed chemoselective lactone reduction is employed using lithium triacetoxyborohydride. In the course of these studies, two reactions that involve substitution with retention of configuration occur in high yield as a result of the remarkable reactivity of this densely functionalized ring system.

Journal of the American Chemical Society published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Haocheng; Zhang, Weixuan; Yin, Xu; Wu, Yuling; Du, Chao; Zhao, Weigang; Zhao, Li; Liu, Cuirong published the artcile< TMP-based hyperbranched polyurethane elastomer (HBPUE) packaging material applied to anodic bonding>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polyurethane elastomer packaging material anodic bonding.

In this work, hyperbranched polyurethane elastomer (HBPUE) electrolyte and aluminum foil (Al) were joined together by anodic bonding. It provides a possibility for packaging of flexible devices to use anodic bonding. The HBPUEs were designed and prepared via prepolymerization method cured at room temperature using polypropylene glycol (PPG), toluene-2,4-diisocyanate(TDI), lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and the varying ratios of trimethylolpropane (TMP)/1,4-butanediol (BDO). All HBPUEs prepared exhibited low glass transition temperature (Tg) and good thermal stability. The highly branched structures increase the proportion of amorphous phase of HBPUEs, resulting in a high ionic conductivity with a highest value of 2.38 x 10-4 S cm-1 at 70°C when adding TMP and BDO at the ratio of 0.45:0.45 (HBPUE3). There are no obvious diffraction peaks of the LiTFSI in the XRD patterns, indicating that LiTFSI was dissolved in polyurethane matrix completely. XRD results show that the structures of PEO-PUEs are amorphous. The HBPUEs prepared have good mech. properties that can be used as packaging material. After bonded, the microstructures of the bonded interface between HBPUE and Al with a clear intermediate bonding layer could be observed by the cross-sectional SEM images, and the elements diffused were also detected by the energy-dispersive spectrometer (EDS), indicating that the HBPUEs and Al were bonded together successfully. The maximum tensile strength for HBPUE3/Al was up to 1.15 MPa. All results demonstrated that the HBPUEs prepared would be a promising packaging material for flexible devices applied to anodic bonding.

Chemical Papers published new progress about Anodic bonding. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Re, Rebecca N.; Proessdorf, Johanna C.; La Clair, James J.; Subileau, Maeva; Burkart, Michael D. published the artcile< Tailoring chemoenzymic oxidation via in situ peracids>, Synthetic Route of 4098-06-0, the main research area is chemoenzymic oxidation peracid olefin lipid epoxidation.

Epoxidation chem. often suffers from the challenging handling of peracids and thus requires in situ preparation Here, we describe a two-phase enzymic system that allows the effective generation of peracids and directly translate their activity to the epoxidation of olefins. We demonstrate the approach by application to lipid and olefin epoxidation as well as sulfide oxidation These methods offer useful applications to synthetic modifications and scalable green processes.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Jingke; Chen, Dezhao; Pan, Fenghua; Luo, Youshou published the artcile< Artificial neural system prediction of aryl fluoride yields in nucleophilic fluorinations>, Related Products of 112-63-0, the main research area is artificial neural network prediction aryl fluoride; halogen exchange fluorination reaction computer modeling.

Multilayered Feed-Forward Networks were employed to model on halogen-exchange fluorination reactions and predict the aryl fluoride product yields.

Journal of Fluorine Chemistry published new progress about Computer program (Artificial neural system). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Jinhua; Lin, Shengyou; Lin, Zechen; Lin, Xianlei; Shen, Yuezhong; Su, Jingyang published the artcile< PPM1A as a key target of the application of Jiawei-Maxing-Shigan decoction for the attenuation of radiation-induced epithelial-mesenchymal transition in type II alveolar epithelial cells>, SDS of cas: 112-63-0, the main research area is type II alveolar epithelial cell mesenchymal transition radiation; Jiawei Maxing Shigan decoction PPM1A; Jiawei‑Maxing‑Shigan decoction; Radiation‑induced injury; TGF‑β1/Smad signaling; epithelial‑mesenchymal transition; protein phosphatase Mg2+/Mn2+‑dependent 1A.

Radiation-induced lung tissue injury is an important reason for the limited application of radiotherapy on thoracic malignancies. Previously, we reported that administration of Jiawei-Maxing-Shigan decoction (JMSD) attenuated the radiation-induced epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AECs) via TGF-β/Smad signaling. The present study aimed to examine the role of protein phosphatase Mg2+/Mn2+-dependent 1A (PPM1A) in the anti-EMT activity of JMSD on AECs. The components in the aqueous extract of JMSD were identified by high-performance liquid chromatog. coupled with electrospray mass spectrometry. Primary rat type II AECs were treated with radiation (60Co γ-ray at 8 Gy) and JMSD-medicated serum. PPM1A was overexpressed and knocked down in the AECs via lentivirus transduction and the effects of JMSD administration on the key proteins related to TGF-β1/Smad signaling were measured by western blotting. It was found that radiation decreased the PPM1A expression in the AECs and JMSD-medicated serum upregulated the PPM1A expressions in the radiation-induced AECs. PPM1A overexpression increased the E-cadherin level but decreased the phosphorylated (p-)Smad2/3, vimentin and α-smooth muscle actin (α-SMA) levels in the AECs. By contrast, the PPM1A knockdown decreased the E-cadherin level and increased the p-Smad2/3, vimentin and α-SMA levels in the AECs and these effects could be blocked by SB431542 (TGF-β1/Smad signaling inhibitor). JMSD administration increased the E-cadherin level and decreased the p-Smad2/3, vimentin and α-SMA levels in the AECs; however, these effects could be blocked by siPPM1A-2. In conclusion, PPM1A is a key target of JMSD administration for the attenuation of the radiation-induced EMT in primary type II AECs via the TGF-β1/Smad pathway.

Molecular Medicine Reports published new progress about Apricot. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramakrishna, Kankanala; Biswas, Jyoti Prasad; Jana, Sadhan; Achar, Tapas Kumar; Porey, Sandip; Maiti, Debabrata published the artcile< Coordination Assisted Distal C-H Alkylation of Fused Heterocycles>, Application of C19H34O2, the main research area is oxoalkylquinoline regioselective preparation; oxoalkylthiazole benzothiazole benzoxazole regioselective preparation; quinoline allyl alc regioselective alkylation palladium catalyst; C−H activation; alkylation; bifunctional; heterocycles; non-covalent.

Distal C-H bond functionalization of heterocycles remained extremely challenging with covalently attached directing groups (DG). Lack of proper site for DG attachment and inherent catalyst poisoning by heterocycles demand alternate routes for site selective functionalization of their distal C-H bonds. Utilizing non-productive coordinating property to hold the heterocycle into the cavity of a template system in a host-guest manner, we report distal C-H alkylation (C-5 of quinoline and thiazole, C-7 of benzothiazole and benzoxazole) of heterocycles. Upon complexation with heterocyclic substrate, nitrile DG in template directs the metal catalyst towards close vicinity of the specific distal C-H bond of the heterocycles. Our hypothesized pathway has been supported by various X-ray crystallog. characterized intermediates.

Angewandte Chemie, International Edition published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Zhaoxia; Huang, Jialiang; Luo, Jianbin; Hu, Deng; Yin, Zibin published the artcile< Performance enhancement and emission reduction of a diesel engine fueled with different biodiesel-diesel blending fuel based on the multi-parameter optimization theory>, Category: esters-buliding-blocks, the main research area is diesel engine fuel emission reduction optimization theory.

In this work, the biodiesel-diesel blending fuels (B20, B30 and B40) and pure diesel fuel (B0) were employed to investigate the effects of intake pressure and EGR ratio on the performance and emission characteristics of diesel engine. The 3D model is developed by the AVL-Fire coupled Chemkin code. In addition, an improved chem. kinetics mechanism of 134 species and 475 reactions is employed to simulate the fuel combustion process. The results show that the improved model improves the calculation accuracy and the high intake pressure and oxygen content in biodiesel are beneficial for the improvements of performance and emission characteristics. However, the NO emission increases. On the contrary, the EGR effectively reduces NOx emission. Finally, the performance and emission characteristics of diesel engine are optimized by the orthogonal principal component-optimization method. Moreover, the NOx mass fraction is reduced by 78.6% and the engine power is decreased by 5.60%. Therefore, the reasonable parameter is beneficial for alleviating the conflict between performance and emission characteristics of diesel engine.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lv, Zhangming; Shen, Jiayun; Gao, Xuejiao; Ruan, Yonglan; Ling, Jinying; Sun, Rongwei; Dai, Jingya; Fan, Haizhen; Cheng, Xiaolan; Cao, Peng published the artcile< Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Huangqi Guizhi Wuwu neuroprotective agent peripheral neuropathy; Huangqi Guizhi Wuwu decoction; Inflammation; Network pharmacology; Oxidative stress; Paclitaxel; Peripheral neuropathy.

Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clin. problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-induced neurotoxicity. However, its effect on PIPN remains unknown. In this study, we aim to investigate the therapeutic effect and the underlying mechanisms of HGWD against PIPN with pharmacol. experiment and network pharmacol. Male Wistar rats were used to establish an animal model of PIPN and treated with different doses of HGWD for 3 wk. Mech. allodynia, thermal hyperalgesia and body weight were measured to evaluate the therapeutic effect of HGWD on PIPN rats. On the day of the sacrifice, blood, DRGs, sciatic nerve, and hind-paw intra-plantar skins were collected to assess neuroprotective effect of HGWD on PIPN. Next, network pharmacol. was performed to decipher the potential active components and mol. mechanisms of HGWD, as were further verified by western blotting analyses in PIPN rats. Finally, the effect of HGWD on the chemotherapeutic activity of paclitaxel was evaluated in vitro and in vivo. In rats with PIPN, HGWD reversed mech. allodynia, thermal hyperalgesia, and ameliorated neuronal damage. Moreover, HGWD significantly increased the level of nerve growth factor, dramatically reduced IL-1β, IL-6, TNF-α levels and oxidative stress. Network pharmacol. anal. revealed 30 active ingredients in HGWD and 158 candidate targets. Integrated pathway anal. identified PI3K/Akt and toll-like receptor as two main pathways responsible for the neuroprotective effect of HGWD. Further exptl. validation demonstrated that HGWD expectedly inhibited the protein expression of TLR4, MyD88, IKKα, and p-NF-κB, and promoted PI3K, p-Akt, Nrf2, and HO-1 level in dorsal root ganglia. Last but not least, HGWD did not interfere with the antitumor activity of paclitaxel both in in vitro and in vivo models. These combined data showed that HGWD could inhibit paclitaxel-evoked inflammatory and oxidative responses in peripheral nervous system viaTLR4/NF-κB and PI3K/Akt-Nrf2 pathways involvement. The neuroprotective property of HGWD on PIPN provides fundamental support to the potential application of HGWD for counteracting the side effects of paclitaxel during chemotherapy.

Chinese Medicine (London, United Kingdom) published new progress about Body weight. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Omonov, Tolibjon S.; Patel, Vinay R.; Curtis, Jonathan M. published the artcile< Biobased Thermosets from Epoxidized Linseed Oil and its Methyl Esters>, Application of C19H34O2, the main research area is biobased thermoset epoxidized linseed oil methyl ester.

This work describes a model biobased epoxy thermoset resin incorporating epoxidized linseed oil fatty acid Me esters (ELOMEs) with trimellitic anhydride (TMA) as a curing agent. Unlike epoxidized linseed oil (ELO), ELOME acts as a solvent at moderate temperatures and can dissolve the curing agent. Thermosets were prepared using a range of molar ratios of ELOME, or ELOME/ELO mixtures, to TMA. It was found that the storage moduli and glass-transition temperatures of the resulting thermosets increase with the increasing concentration of the curing agent due to enhanced crosslinking. On the other hand, the dynamic mech. anal. demonstrated that an increase in the curing agent content, especially above the stoichiometric ratios of reactive moieties, hinders the formation of the crosslinked network when an excessive amount of TMA esters of ELOME are formed. These consume a large proportion of the available epoxy moieties and consequently limit further crosslinking and polymer network growth. The glass-transition temperature (Tg) of these resins was between 80 and 86°C, depending on the stoichiometric ratio of the reactive moieties. In thermoset systems prepared with ELOME/ELO mixtures, an improvement in the thermomech. properties (increase of Tg up to 102°C) was observed, which was associated with the increase in crosslinking d. resulting from the branched triacylglycerol structure of epoxidized linseed oil.

ACS Applied Polymer Materials published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics