Tag: M.W=250-300

Ozgiray, Erkin; Sogutlu, Fatma; Biray Avci, Cigir published the artcile< Chk1/2 inhibitor AZD7762 enhances the susceptibility of IDH-mutant brain cancer cells to temozolomide>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is AZD7762; DNA damage response; IDH-mutant glioma; Polploidy; Temozolomide.

Abstract: The IDH mutation initially exhibits chemosensitive properties, progression-free survival cannot be achieved in the later grades, and malignant transformation occurs as a result of TMZ-induced hypermutation profile and adaptation to this profile. In this study, we evaluated the potential of the combination of TMZ and AZD7762 at mol. level, to increase the anticancer activity of TMZ in IDH-mutant U87-mg cells. We used the WST-1 test to evaluate cytotoxic effect of TMZ and AZD7762 combination with dose-effect and isobologram curves. The effects of the inhibitory and effective concentrations of the combination on apoptosis, cell cycle and γ-H2AX phosphorylation were analyzed with flow cytometry. The expression of genes responsible for the DNA damage response was analyzed with qRT-PCR. The combination showed a synergistic effect with high dose reduction index. Single and combined administrations of TMZ and AZD7762 increased in G2/M arrest from 24 to 48 h, and cells in the G2/M phase shifted towards octaploidy at 72 h. While no double-strand breaks were detected after TMZ treatment, AZD7762 and combination treatments caused a significant increase in γ-H2AX phosphorylation and increased apoptotic stimulation towards 72 h although TMZ did not cause apoptotic effect in IDH-mutant U87-mg cells. The genes controlling the apoptosis were determined to be upregulated in all three groups, and genes regarding cell cycle checkpoints were downregulated. Targeting Chk1/2 with AZD7762 simultaneously with TMZ may be a potential therapeutic strategy for both increasing the sensitivity of IDH-mutant glioma cells to TMZ and reducing the dose of TMZ. Graphical abstract: In IDH-mutant glioma cells, AZD7762, the Chk1/2 inhibitor, can increase the efficacy of Temozolomide by (i) increasing mitotic chaos, and (ii) inhibiting double-strand break repair, (iii) thereby inducing cell death. [graphic not available: see fulltext]

Medical Oncology (New York, NY, United States) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anilkumar, Parambath; Lawson, Taylor B.; Abbina, Srinivas; Makela, Janne T. A.; Sabatelle, Robert C.; Takeuchi, Lily E.; Snyder, Brian D.; Grinstaff, Mark W.; Kizhakkedathu, Jayachandran N. published the artcile< Mega macromolecules as single molecule lubricants for hard and soft surfaces>, Category: esters-buliding-blocks, the main research area is mega hyperbranched polyglycerol mol lubricant hard soft surface.

A longstanding goal in science and engineering is to mimic the size, structure, and functionality present in biol. with synthetic analogs. Today, synthetic globular polymers of several million mol. weight are unknown, and, yet, these structures are expected to exhibit unanticipated properties due to their size, compactness, and low inter-chain interactions. Here we report the gram-scale synthesis of dendritic polymers, mega hyperbranched polyglycerols (mega HPGs), in million daltons. The mega HPGs are highly water soluble, soft, nanometer-scale single polymer particles that exhibit low intrinsic viscosities. Further, the mega HPGs are lubricants acting as interposed single mol. ball bearings to reduce the coefficient of friction between both hard and soft natural surfaces in a size dependent manner. We attribute this result to their globular and single particle nature together with its exceptional hydration. Collectively, these results set the stage for new opportunities in the design, synthesis, and evaluation of mega polymers.

Nature Communications published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Press, Loren P.; Kosanovich, Alex J.; McCulloch, Billy J.; Ozerov, Oleg V. published the artcile< High-Turnover Aromatic C-H Borylation Catalyzed by POCOP-Type Pincer Complexes of Iridium>, HPLC of Formula: 112-63-0, the main research area is borylation arene pinacolate iridium pincer complex catalyst mechanism; crystal structure mol iridium pincer complex preparation borylation catalyst.

The catalytic C-H borylation of arenes with HBpin (pin = pinacolate) using POCOP-type pincer complexes of Ir has been demonstrated, with turnover numbers exceeding 10,000 in some cases. The selectivity of C-H activation was based on steric preferences and largely mirrored that found in other Ir borylation catalysts. Catalysis in the (POCOP)Ir system depends on the presence of stoichiometric quantities of sacrificial olefin, which is hydrogenated to consume the H2 equivalents generated in the borylation of C-H bonds with HBpin. Smaller olefins such as ethylene or 1-hexene were more advantageous to catalysis than sterically encumbered tert-butylethylene (TBE). Olefin hydroboration is a competing side reaction. The synthesis and isolation of multiple complexes potentially relevant to catalysis permitted examination of several key elementary reactions. These experiments indicate that the C-H activation step in catalysis ostensibly involves oxidative addition of an aromatic C-H bond to the three-coordinate (POCOP)Ir species. The olefin is mechanistically critical to gain access to this 14-electron, monovalent Ir intermediate. C-H activation at Ir(I) here is in contrast to the olefin-free catalysis with state-of-the-art Ir complexes supported by neutral bidentate ligands, where the C-H activating step is understood to involve trivalent Ir-boryl intermediates.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Canale, Vittorio; Kotanska, Magdalena; Dziubina, Anna; Stefaniak, Matylda; Siwek, Agata; Starowicz, Gabriela; Marciniec, Krzysztof; Kasza, Patryk; Satala, Grzegorz; Duszynska, Beata; Bantreil, Xavier; Lamaty, Frederic; Bednarski, Marek; Sapa, Jacek; Zajdel, Pawel published the artcile< Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties>, Related Products of 112-63-0, the main research area is dihydrobenzofuranoxy ethyl piperidine preparation antidepressant activity green chem SAR; 5-HT7 receptor antagonist; depression; forced swim test; medicinal mechanochemistry; α2 adrenoceptor antagonist.

The complex pathophysiol. of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacol. blockade ofα2-adrenoceptor might be beneficial for the treatment of depressive symptoms by increasing both norepinephrine and serotonin levels in certain brain areas. The antidepressant properties of 5-HT7 receptor antagonists have been widely demonstrated in a large set of animal models. Considering the potential therapeutic advantages in targeting both α2-adrenoceptors and 5-HT7 receptors, a small series of arylsulfonamide derivatives of (dihydrobenzofuranoxy)ethyl piperidines I (Ar = 4-fluorophenyl, naphthalen-1-yl, isoquinolin-4-yl, etc.; m = 0,1) as dually active ligands were designed. Following green chem. principles, the designed compounds were synthesized entirely using a sustainable mechanochem. approach. The identified compound I (Ar = 5-chloro-2-fluorophenyl (II)) behaved as a potent α2A/5-HT7 receptor antagonist and displayed moderate-to-high selectivity over α1-adrenoceptor subtypes and selected serotonin and dopaminergic receptors. Finally, (II) improved performance of mice in the forced swim test, displaying similar potency to the reference drug mirtazapine.

Molecules published new progress about 5-HT antagonists. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Corder, Ria D.; Gadi, Sashi V.; Vachieri, Robert B.; Jayes, Friederike L.; Cullen, John M.; Khan, Saad A.; Taylor, Darlene K. published the artcile< Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion>, Reference of 112-63-0, the main research area is collagenase treatment rheol uterine fibroid digestion; Collagenase; Drug delivery; Histology; Rheology; Uterine fibroids.

Uterine fibroids are stiff, benign tumors containing excessive, disordered collagens that occur in 70-80% of women before age 50 and cause bleeding and pain. Collagenase Clostridium histolyticum (CCH) is a bacterial enzyme capable of digesting the collagens present in fibroids. By combining CCH with injectable drug delivery systems to enhance effectiveness, a new class of treatments could be developed to reduce the stiffness of fibroids, preventing the need for surgical removal and preserving fertility. In this work, we achieved localization of CCH via phys. entrapment by co-injecting a thermoresponsive pNIPAM-based polymeric delivery system called LiquoGel (LQG), which undergoes a sol-gel transition upon heating. Toxicity study results for LQG injected s.c. into mice demonstrate that LQG does not induce lesions or other adverse effects. We then used rheol. to quantify the effects of localized CCH injections on the modulus and viscoelasticity of uterine fibroids, which exhibit gel-like behavior, through ex vivo and in vivo digestion studies. Ex vivo CCH injections reduce the tissue modulus by over two orders of magnitude and co-injection of LQG enhances this effect. Rheol. results from an in vivo digestion study in mice show a significant reduction in tissue modulus and increase in tissue viscoelasticity 7 days after a single injection of LQG+CCH. Parallel histol. staining validates that the observed rheol. changes correspond to an increase in collagen lysis after treatment by LQG+CCH. These results show promise for development of injectable and localized enzymic therapies for uterine fibroids and other dense tumors. Uterine fibroids are stiff, benign tumors containing high collagen levels that cause bleeding and pain in women. Fertility-preserving and minimally-invasive treatments to soften fibroids are needed as an alternative to surgical removal via hysterectomy. We demonstrate through ex vivo and in vivo studies that co-injecting a thermoresponsive polymer delivery system (LQG) alongside a bacterial collagenase (CCH) enzyme significantly increases treatment effectiveness at softening fibroids through CCH localization. We use rheol. to measure the modulus and viscoelasticity of fibroids and histol. to show that fibroid softening corresponds to a decrease in collagen after treatment with LQG+CCH. These results highlight the utility of rheol. at quantifying tissue properties and present a promising injectable therapy for fibroids and other dense tumors.

Acta Biomaterialia published new progress about Biological digestion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Hao; Zhang, Lei; Yue, Shizhong; Yu, Suzhu; Wei, Jun; Ouyang, Jianyong published the artcile< Enhancement in the Mechanical Stretchability of PEDOT:PSS Films by Compounds of Multiple Hydroxyl Groups for Their Application as Transparent Stretchable Conductors>, COA of Formula: C19H34O2, the main research area is PEDOT PSS film compound hydroxyl group transparent stretchable conductor.

It is of significance to develop stretchable conductors for flexible electronics. Although intrinsically conducting polymers like poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) can exhibit high conductivity, they have limited mech. stretchability because of the rigid conjugated backbone and strong interchain interaction. Here, we report the significant enhancement in the mech. stretchability of PEDOT:PSS films by adding a compound of two or more hydroxyl groups like glycerol, malic acid, 1,2,6-hexanetriol, or triethylene glycol. The elongation at break can be enhanced from <10% of pristine PEDOT:PSS films to >50%. The enhancement in the mech. stretchability is less significant when other compounds with only one hydroxyl or no hydroxyl group are used. The effect of the compounds with multiple hydroxyl groups on the stretchability of PEDOT:PSS is related to the Hansen solubility parameter (HSP) δh. A compound with a higher δh value can give rise to a more significant plasticization of PEDOT:PSS. The mechanism is attributed to the destruction of hydrogen bonds among the chains of poly(styrenesulfonic acid) (PSSH) by the compounds of multiple hydroxyl groups. This effectively lowers the interchain interaction among the PSSH and thus increases the mech. stretchability of PEDOT:PSS. Simultaneously, these compounds can induce secondary doping to saliently enhance the conductivity of PEDOT:PSS films. The highly stretchable and highly conductive PEDOT:PSS films can be used as transparent stretchable conductors.

Macromolecules (Washington, DC, United States) published new progress about Conducting polymers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kawai, Junya; Ota, Masahiro; Ohki, Hitoshi; Toki, Tadashi; Suzuki, Makoto; Shimada, Takashi; Matsui, Satoshi; Inoue, Hidekazu; Sugihara, Chika; Matsuhashi, Norikazu; Matsui, Yumi; Takaishi, Sachiko; Nakayama, Kiyoshi published the artcile< Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is inhibitor isoenzyme selective SBDD tricyclic coumarin MTHFD2.

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isoenzyme-selective MTHFD2 inhibitor is highly attractive for potential use in cancer treatment. Herein, we disclose a novel isoenzyme-selective MTHFD2 inhibitor DS44960156, with a tricyclic coumarin scaffold, which was initially discovered via high-throughput screening (HTS) and improved using structure-based drug design (SBDD). DS44960156 would offer a good starting point for further optimization based on the following features: (1) unprecedented selectivity (>18-fold) for MTHFD2 over MTHFD1, (2) a mol. weight of less than 400, and (3) good ligand efficiency (LE).

ACS Medicinal Chemistry Letters published new progress about Drug design (structure-based drug design). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ji, Junwei; Day, Anil published the artcile< Construction of highly error-prone DNA polymerase for developing organelle mutation systems>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DNA polymerase substitution mutation chloroplast mitochondria plant protozoa.

A novel family of DNA polymerases replicates organelle genomes in a wide distribution of taxa encompassing plants and protozoans. Making error-prone mutator versions of gamma DNA polymerases revolutionised our understanding of animal mitochondrial genomes but similar advances have not been made for the organelle DNA polymerases present in plant mitochondria and chloroplasts. We tested the fidelities of error prone tobacco organelle DNA polymerases using a novel pos. selection method involving replication of the phage lambda cI repressor gene. Unlike gamma DNA polymerases, ablation of 3′-5′ exonuclease function resulted in a modest 5-8-fold error rate increase. Combining exonuclease deficiency with a polymerization domain substitution raised the organelle DNA polymerase error rate by 140-fold relative to the wild type enzyme. This high error rate compares favorably with error-rates of mutator versions of animal gamma DNA polymerases. The error prone organelle DNA polymerase introduced mutations at multiple locations ranging from two to seven sites in half of the mutant cI genes studied. Single base substitutions predominated including frequent A:A (template: dNMP) mispairings. High error rate and semi-dominance to the wild type enzyme in vitro make the error prone organelle DNA polymerase suitable for elevating mutation rates in chloroplasts and mitochondria.

Nucleic Acids Research published new progress about cDNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kleinbeck, Florian; Toste, F. Dean published the artcile< Gold(I)-Catalyzed Enantioselective Ring Expansion of Allenylcyclopropanols>, Synthetic Route of 112-63-0, the main research area is allenylcyclopropanol preparation chiral gold catalyst preparation ring expansion; cyclobutanone vinyl derivative stereoselective preparation crystal structure.

The asym. gold(I)-catalyzed ring expansion of 1-allenylcyclopropanols is described. The method provides synthetically valuable cyclobutanones with a vinyl-substituted quaternary stereogenic center in high enantioselectivities and yields. The method shows a broad substrate scope, tolerating protected alcs. and amines, alkenes, unsaturated esters, and acetals. The reaction is easily adjustable to large-scale synthesis, leading to product formation without significant loss of selectivity or yield with only 0.5 mol% catalyst loading.

Journal of the American Chemical Society published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Wenchao; Liu, Huili; Li, Fashe; Wang, Hua; Ma, Xin; Li, Jingjing; Zhou, Li; Xiao, Quan published the artcile< Effects of unsaturated fatty acid methyl esters on the oxidation stability of biodiesel determined by gas chromatography-mass spectrometry and information entropy methods>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is fatty acid methyl ester oxidation gas chromatog mass spectrometry.

To explore the trend of fatty acid Me esters (FAMEs) during the oxidation process of biodiesel, this study uses gas chromatog. – mass spectrometry (GC-MS) combined with information entropy theory to propose a new method to analyze the effect of FAMEs on the stability of biodiesel (especially with different amounts of unsaturated FAMEs). The induction periods of the main FAMEs in biodiesel were determined by the Rancimat method. The results showed that the longest induction period of Me stearate was 248 h, while the induction of Me linoleate was only 0.12 h. Accelerated oxidation of biodiesel, using GC-MS anal. showed that the oxidation trends of FAMEs was different. The oxidation rate of Me linoleate was the fastest. A math. equation was proposed to calculate the trend of FAMEs. The results showed that during the 5 h accelerated an oxidation process, the content of Me linoleate decreased from 28.35% to 2.10%, while the content of Me oleate decreased by 18.21%. Using information entropy, the weighting coefficients of FAMEs in the oxidation process of biodiesel were calculated The weighting coefficient of Me linoleate was as high as 0.6797. Me linoleate was the main reason why biodiesel was easily oxidized.

Renewable Energy published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics