Tag: M.W=250-300

Karnjanakom, Surachai; Maneechakr, Panya; Samart, Chanatip; Kongparakul, Suwadee; Guan, Guoqing; Bayu, Asep published the artcile< Direct conversion of sugar into ethyl levulinate catalyzed by selective heterogeneous acid under co-solvent system>, Computed Properties of 112-63-0, the main research area is sugar ethyl levulinate catalyzed acid solvent system.

The direct synthesis of Et levulinate (EL) from sucrose was investigated under co-solvent of THF/ethanol over stable/active heterogeneous acid catalyst. Several Lewis acid-metal oxides were doped onto Bronsted acid-sulfonated carbon (SC) and the results found that Zn-SC exhibited highest activity for production of EL from sucrose conversion of 100% with a selectivity of 72.1%. The catalytic mechanism for conversion of sucrose into EL and other products was investigated through significant effects such as catalyst type, co-solvent and ultrasonic application. The catalyst reusability test exhibited high stability for five cycles and then dramatically decreased without any regeneration process.

Catalysis Communications published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jubo; Quan, Yu; Lv, Jian; Gong, Shouping; Ren, Pengyu published the artcile< Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT /Wnt/β-catenin pathway>, Application In Synthesis of 112-63-0, the main research area is FAM83D antitumor glioblastoma; AKT; FAM83D; Wnt; glioblastoma.

Up-regulation of family with sequence similarity 83 member D (FAM83D) has been acknowledged as a vital contributor for the carcinogenesis of numerous cancers. The relevance of FAM83D in glioblastoma (GBM), however, is not well understood. This current work aimed to determine the possible roles and mechanisms of FAM83D in GBM. By analyzing The Cancer Genome Atlas (TCGA) data, we found dramatic increases in FAM83D expression in GBM tissue. We also observed elevated levels of FAM83D in the clin. specimens of GBM. In vitro data showed that silencing FAM83D resulted in remarkable antitumor effects via inhibiting the proliferation, invasion and epithelial-mesenchymal transition of GBM cells. Moreover, the knockdown of FAM83D improved sensitivity to the chemotherapy drug temozolomide. In-depth mechanism research revealed that the silencing of FAM83D strikingly decreased the phosphorylation levels of AKT and glycogen synthase kinase-3β, and prohibited activation of the Wnt/β-catenin pathway. The suppression of AKT abolished FAM83D-mediated activation of the Wnt/β-catenin pathway. The re-expression of β-catenin reversed FAM83D-silencing-induced antitumor effects in GBM cells. In addition, GBM cells with FAM83D silencing exhibited reduced tumorigenic potential in vivo. Overall, the data from this work show that the inhibition of FAM83D displays antitumor effects in GBM via down-regulation of the AKT/Wnt/β-catenin pathway and propose FAM83D as a new therapeutic target for GBM.

Environmental Toxicology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Tingshun; Mou, Chengli; Li, Baosheng; Smetankova, Marie; Song, Bao-An; Chi, Yonggui Robin published the artcile< N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes>, Quality Control of 112-63-0, the main research area is heterocyclic carbene catalyzed domino reaction LUMO activation diunsatd enal; multisubstituted arene preparation chemoselective regioselective; ylidenephthalide preparation chemoselective regioselective; unsaturated aldehyde domino reaction heterocyclic carbene NHC organocatalyst.

An N-heterocyclic carbene (NHC) catalyzed domino reaction triggered by a δ-LUMO activation of α,β-γ,δ-diunsatd. enal has been developed for the formal [4 + 2] construction of multisubstituted arenes and 3-ylidenephthalide. These two products, formed in a highly chemo- and regioselective manner, were obtained via different catalytic pathways due to a simple change of the substrate. The activation of the remote δ-carbon of unsaturated aldehydes expands the synthetic potentials of NHC organocatalysis.

Journal of the American Chemical Society published new progress about Addition reaction catalysts (Michael addition). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thompson, Alicia L. S.; Kabalka, George W.; Akula, Murthy R.; Huffman, John W. published the artcile< The conversion of phenols to the corresponding aryl halides under mild conditions>, Electric Literature of 112-63-0, the main research area is aryl triflate preparation Pd catalyzed borylation copper promoted bromination; phenol sulfonylation Pd catalyzed borylation sodium promoted iodination; halide aryl preparation.

Mild, novel procedures were developed for the syntheses of aryl halides from the corresponding phenols in modest to good yields via boronate ester intermediates. E.g., Phenol reacted with Tf2O/py/CH2Cl2 to give PhOTf intermediate which subsequently reacted with bis(neopentyl glycolato)diboron in the presence of PdCl2 catalyst/KOAc/dppf/dioxane at 80° to give a neopentylboronate ester which then reacts with NaI/chloramine-T to give PhI in 58% yield.

Synthesis published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yanxia; Fan, Xiaodi; Ma, Kun; Wang, Kaili; Tian, Caidie; Li, Min; Gong, Linjuan published the artcile< Bushen Culuan decoction ameliorates premature ovarian insufficiency by acting on the Nrf2/ ARE signaling pathway to alleviate oxidative stress>, Quality Control of 112-63-0, the main research area is premature ovarian insufficiency Nrf2 ARE oxidative stress BCD; Bushen Culuan Decoction; Nrf2/ARE; Tripterygium wilfordii polyglycosidium; oxidative stress; premature ovarian insufficiency.

Premature ovarian insufficiency (POI) can result in lower fertility and shorten the female reproductive span. Bushen-Culuan Decoction (BCD) is a traditional Chinese medication utilized for treating POI for many years. We previously observed that BCD protects against further deterioration of the ovarian reserve of POI patients, however, the underlying mechanism has not been well studied. Our investigation seeks to evaluate the effect of BCD on POI induced by Tripterygium wilfordii polyglycosidium (TWP) and the likely mechanistic pathways, which we hypothesize may involve the Nrf2/ARE pathway. The body weights, estrous cycle, serum hormone levels, histol. follicular anal. and quantification, levels of oxidative stress biomarkers in the ovarian tissue of POI mice models were evaluated. Western blotting and RT-PCR enabled quantification of the components of the Nrf2/ARE pathway. Our results showed that BCD restored hormonal profiles and estrous cycles of POI mice similar to those observed in healthy controls. BCD reduced the numbers of atretic follicles while increasing the number of primordial follicles. BCD facilitated lower 8-OHdG and MDA levels while increasing levels of key antioxidant enzymes including GSH-Px, CAT, and SOD. Furthermore, TWP increased Bach 1, Nrf2, and Keap 1 expressions at the translational level, while decreased that of HO-1. BCD treatment also promoted nuclear translocation rates of Bach 1 and Nrf2, suppressed Keap 1 protein expression, as well as raised HO-1 protein expression. Taken together, BCD likely augments ovarian reserve by activating the Nrf2/ARE signaling pathway, which stimulated higher levels of antioxidants and suppressed oxidative stress. BCD may be an important therapeutic compound in POI.

Frontiers in Pharmacology published new progress about Angelica sinensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Teng, Zhiyan; Zheng, Weiwei; Jiang, Shufang; Hong, Seung-Beom; Zhu, Zhujun; Zang, Yunxiang published the artcile< Role of melatonin in promoting plant growth by regulating carbon assimilation and ATP accumulation>, COA of Formula: C19H34O2, the main research area is transcriptome adenosine triphosphate carbon melatonin plant growth; ATP accumulation; Carbon assimilation; Melatonin; Plant growth.

Melatonin (MT) is a phytohormone important in mediating diverse plant growth processes. In this study, we performed transcriptomic, qRT-PCR, physiol. and biochem. analyses of Brassica rapa seedlings in order to understand how MT promotes plant growth. The results showed that exogenous MT increased the rate of cyclic electron flow around photosystem (PS) I, fluorescence quantum yield, and electron transport efficiency between PSII and PSI to promote the vegetative growth of B. rapa seedlings without affecting oxidative stress level, as compared to control. However, MT treatment significantly reduced photosynthetic rate (Pn), transpiration rate (Tr), and stomatal conductance (Gs) by 2.25-, 1.23- and 3.50-fold at 0.05 level, resp. This occurred in parallel with the down-regulation of the genes for carbon fixation in photosynthetic organisms in a KEGG pathway enrichment. More accelerated plant growth despite the reduced photosynthesis rate and the enhanced electron transport rate suggested that NADPH and ATP (ATP) were preferentially diverted into other anabolic reactions than the Calvin cycle upon MT application. MT treatment increased ATP level and facilitated carbon assimilation into primary metabolism that led to a significant enhancement of soluble protein, sucrose, and fructose, but a significant decrease in glucose content. MT-induced carbon assimilation into primary metabolism was driven by up-regulation of the genes for glutathione metabolism, Krebs cycle, ribosome, and DNA replication in a KEGG pathway enrichment, as well as down-regulation of the genes for secondary metabolites. Our results provide an insight into MT-mediated metabolic adjustments triggered by coordinate changes in a wide range of gene expression profiles to help improve the plant functionality.

Plant Science (Shannon, Ireland) published new progress about Brassica oleracea capitata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanaka, Koichi; Shiraishi, Ryusuke; Toda, Fumio published the artcile< A new method for stereoselective bromination of stilbene and chalcone in a water suspension medium>, Computed Properties of 112-63-0, the main research area is stereoselective bromination stilbene chalcone water suspension.

Bromination reactions of (E)-stilbene and (E)-chalcone in a water suspension medium proceeded efficiently and stereoselectively, the reaction products were collected easily by filtration.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Bromination, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yunxin; Song, Yan; He, Na; Cheng, Fei; Jiao, Xiaojiao; Lai, Guoqiao; Hua, Xilin; Yang, Xiongfa published the artcile< High efficiency and low migration hyperbranched silicone contain macrophotoinitiators for UV-cured transparent coatings>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silicone macrophotoinitiator UV transparent coating tensile strength; UV-cured coating; hyperbranched silicone containing macrophotoinitiators; migration; the tensile strength.

A kind of hyperbranched silicone containing macrophotoinitiators (HBSMIs) were synthesized from 2-hydroxy-2-methyl-1-Ph propanone (HMPP) and the UV-curing behaviors of HBSMIs were investigated in UV-cured transparent polyurethane-acrylate (PUA) coatings. HBSMIs show higher UV-initiating efficiency than HMPP. The migration of HBSMIs from the UV-cured coatings can be as low as 1.7-6.0 wt%, which is obviously lower than the migration of HMPP. There is a remarkable improvement of the tensile strength of the UV-cured materials initiated by HBSMI in comparison to that of the materials prepared with the same PUA initiated by HMPP. Especially for the UV-cured materials prepared from PUA with 20 wt% 1,1,1-tris(hydroxymethyl)propane (TMP), the tensile strength and the strain at break increased from 6.81 MPa to 12.14 MPa and from 43.0% to 71.9%, resp. The fraction of improvement for the tensile strength and the strain at break is as high as 78.9% and 67.2%, resp. The coatings prepared with HBSMI also have better UV resistance ability than those coatings prepared with HMPP because they turn slightly yellow when they are aged by UV for about 15 min while the coating prepared with 4 wt% of HMPP will turn yellow only aged by UV for 2 min. These results suggest that preparation hyperbranched silicone containing macrophotoinitiators will be one of the good strategies to improve the curing efficiency of the UV-curing system, reduce the migration of UV initiator from cured material, improve the mech. and UV resistance performance of UV-cured materials.

Polymers (Basel, Switzerland) published new progress about Diffusion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bahekar, Rajesh H.; Jain, Mukul R.; Goel, Ashish; Patel, Dipam N.; Prajapati, Vijay M.; Gupta, Arun A.; Jadav, Pradip A.; Patel, Pankaj R. published the artcile< Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines>, Product Details of C19H34O2, the main research area is antidiabetic indolyl thienopyridinyl pyrrolopyridinyl guanidine preparation SAR.

Sulfonylureas stimulate insulin secretion independent of the blood glucose concentration and therefore cause hypoglycemia in type 2 diabetic patients. Over the last years, a number of aryl-imidazoline derivatives have been identified that stimulate insulin secretion in a glucose-dependent manner. In the present study, we have developed three series of substituted N-(thieno[2,3-b]pyridin-3-yl)-guanidine (2a-l), N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidine (3a-l), and N-(1H-indol-3-yl)-guanidine (4a-l) as new class of antidiabetic agents. In vitro glucose-dependent insulinotropic activity of test compounds 2a-l, 3a-l, and 4a-l was evaluated using RIN5F (Rat Insulinoma cell) based assay. All the test compounds showed concentration-dependent insulin secretion, only in presence of glucose load (16.7 mmol). Some of the test compounds (2c, 3c, and 4c) from each series were found to be equipotent to BL 11282 (standard aryl-imidazoline), which indicated that the guanidine group acts as a bioisostere of imidazoline ring system.

Bioorganic & Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yogita; Rao, B. Srinivasa; Subrahmanyam, Ch.; Lingaiah, N. published the artcile< The selective conversion of furfuryl alcohol to ethyl levulinate over Zr-modified tungstophosphoric acid supported on β-zeolites>, Application of C19H34O2, the main research area is ethyl levulinate furfuryl alc zirconium tungstophosphoric acid zeolite catalyst.

Catalysts of zirconium-exchanged proton-containing tungstophosphoric acid (TPA) supported on β-zeolites were prepared by an impregnation method for the selective alcoholysis of furfuryl alc. into Et levulinate. The prepared catalysts were characterized by different spectroscopic techniques. The results indicated the existence of a Keggin ion structure of TPA after its modification with Zr ions and successive dispersion on β-zeolites. The introduction of Zr in TPA generated Lewis acidic sites in the catalyst. Pyridine-adsorbed FT-IR confirmed the presence of both Bronsted and Lewis acidic sites in catalysts. The catalytic activity for the alcoholysis of furfuryl alc. depends on the strength of both Bronsted and Lewis acids of the catalyst. Among these catalysts, 20%Zr0.75TPA/β-zeolite was active for the alcoholysis of furfuryl alc. with a 96% yield of Et levulinate. Optimal conditions were established to obtain maximum yield. A plausible reaction mechanism was also proposed. The catalyst was reused without any appreciable loss of activity.

New Journal of Chemistry published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics