Tag: M.W=250-300

Jiatsa Mbouna, Cedric Derick; Tchatat Tali, Brice Mariscal; Tsouh Fokou, Patrick Valere; Madiesse Kemgne, Eugenie Aimee; Keumoe, Rodrigue; Toghueo Kouipou, Rufin Marie; Yamthe Tchokouaha, Lauve Rachel; Tchuente Tchuenmogne, Marthe Aimee; Kenou, Donald Kagho; Sahal, Dinkar; Boyom, Fabrice Fekam published the artcile< Specific sub fractions from Terminalia mantaly (H. Perrier) extracts potently inhibit Plasmodium falciparum rings, merozoite egress and invasion>, Product Details of C19H34O2, the main research area is Terminalia Plasmodium antiplasmodial phytochem profiling; Antiplasmodial; Intraerythrocytic stage–specific inhibition; Phytochemical profiling; Plasmodium falciparum; Terminalia mantaly.

Terminalia mantaly (H. Perrier) and Terminalia superba (Engl. & Diels) are sources of treatment for various diseases, including malaria and/or related symptoms in parts of Southwestern Cameroon. However, there is limited information on the extent of the antiplasmodial potential of their extracts The present study was designed to investigate the antiplasmodial potential of chromatog. sub fractions (SFs) from promising fractions of Terminalia mantaly (Tm) [TmsbwChl, the chloroform fraction from water extract of Tm, IC50 (μg/mL) PfINDO: 0.56, Pf3D7: 1.12; SI > 357 (HEK/PfINDO) & 178 (HEK/Pf3D7)] and Terminalia superba (Ts) [TsrmEA, the Et acetate fraction from methanolic extract of Ts, IC50 (μg/mL) PfINDO: 1.82, Pf3D7: 1.65; SI > 109 (HEK/PfINDO) & 121 (HEK/Pf3D7)] obtained from previous studies. The SFs were tested against Plasmodium falciparum 3D7 (Pf3D7-chloroquine sensitive) and INDO (PfINDO-chloroquine resistant) strains in culture. Also, the phytochem. profile of potent SFs was determined and finally, the inhibition of the asexual blood stages of Plasmodium falciparum by the SFs with the highest promise was assessed. Selected SFs were submitted to a second bio-guided fractionation using silica gel column chromatog. The partial phytochem. composition of potent antiplasmodial SFs was determined using gas chromatog. coupled to mass spectrometry (GC-MS). The SYBR Green I-based fluorescence microtiter plate assay was used to monitor the growth of Plasmodium falciparum parasites in culture in the presence or absence of extracts Microscopy and flow cytometry counting was used to assess the Plasmodium falciparum stage-specific inhibition and post-drug exposure growth suppression by highly potent extracts Twenty-one of the 39 SFs afforded from TmsbwChl showed activity (IC50: 0.29-4.74 μg/mL) against both Pf3D7 and PfINDO strains. Of note, eight SFs namely, Tm25, Tm28-30, Tm34-36 and Tm38, exerted highly potent antiplasmodial activity (IC50 < 1 μg/mL) with IC50PfINDO: 0.41-0.84 μg/mL and IC50Pf3D7: 0.29-0.68 μg/mL. They also displayed very high selectivity (50 < SIPfINDO, SIPf3D7 > 344) on the two Plasmodial strains. On the other hand, 7 SFs (SFs Ts03, Ts04, Ts06, Ts09, Ts10, Ts12 and Ts13) from TsrmEA showed promising inhibitory potential against both parasite strains (IC50: 2.01-5.14 μg/mL). Sub fraction Tm36 (IC50PfINDO: 0.41 μg/mL, SIPfINDO > 243; IC50Pf3D7: 0.29 μg/mL, SIPf3D7 > 344) showed the highest promise. The GC-MS anal. of the 8 selected SFs led to the identification of 99 phytometabolites, with D-limonene (2), benzaldehyde (12), carvone (13), caryophyllene (35), hexadecanoic acid, Me ester (74) and 9-octadecenoic acid, Me ester (82) being the main constituents. Sub fractions Tm28, Tm29, Tm30, Tm36 and Tm38 inhibited all the three intraerythrocytic stages of P. falciparum, with strong potency against ring stage development, merozoite egress and invasion processes. This study has identified highly potent antiplasmodial SFs from Terminalia mantaly with significant activity on the intraerythrocytic development of Plasmodium falciparum. These SFs qualify as promising sources of novel antiplasmodial lead compounds Further purification and characterization studies are expected to unravel mol. targets in rings and merozoites.

Journal of Ethnopharmacology published new progress about Antimalarials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Renaud, Roger N.; Champagne, Philippe J. published the artcile< Electrochemical oxidation of trifluoroacetic acid in an organic substrate. III. In the presence of substituted malonic acid half esters and unsaturated carboxylic acid esters>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is electrochem oxidation trifluoroacetate; fluoroacetate oxidation malonate ester; acetate trifluoro electrochem oxidation; ester unsaturated oxidation trifluoroacetate.

The electrochem. oxidation of substituted malonic acid half esters was studied in the presence of F3CCO2H. Some crossed Kolbe products were obtained together with some unsaturated carboalkoxy compounds, trifluoromethylated adducts to the double bond, and trifluoromethylated dimers. The electrolysis of F3CCO2H in the presence of olefinic carboalkoxy compounds was also studied.

Canadian Journal of Chemistry published new progress about Oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chatterjee, Abhishek; Bhadane, Manish; Manjali, Jifmi Jose; Dasgupta, Archya; Epari, Sridhar; Sahay, Ayushi; Patil, Vijay; Moiyadi, Aliasgar; Shetty, Prakash; Gupta, Tejpal published the artcile< Optimizing Postoperative Adjuvant Therapy in Elderly Patients with Newly Diagnosed Glioblastoma: Single-Institution Audit of Clinical Outcomes from a Tertiary-Care Comprehensive Cancer Center in India.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Elderly; Fractionation; Glioblastoma; Radiotherapy; Survival; Temozolomide.

BACKGROUND: There is lack of consensus regarding optimal adjuvant therapy in elderly glioblastoma (GBM). We have been treating elderly (≥60 years) GBM patients with normofractionated or hypofractionated radiotherapy (RT) plus temozolomide (TMZ) based on Karnofsky performance status (KPS). Herein we report clinical outcomes in this cohort treated at our institute using this approach. METHODS: Medical records of elderly GBM patients (≥60 years) treated between 2013 and 2017 with either normofractionated RT (59.4-60 Gy/30-33 fractions/6-6.5 weeks) or hypofractionated RT (35 Gy/10 fractions/2 weeks) plus TMZ were reviewed retrospectively. Outcomes of interest included progression-free survival (PFS), overall survival (OS), and ≥grade 3 myelotoxicity. Time-to-event outcomes were analyzed with Kaplan-Meier methods, compared using log-rank test, and reported as point estimates with 95% confidence interval (CI). RESULTS: The normofractionated cohort (n = 126) was characterized by a higher proportion of patients younger than age 65 years, KPS ≥70, methylated O6-methylguanine DNA methyltransferase (MGMT), and receiving adjuvant TMZ including extended adjuvant TMZ (>6 cycles) compared with the hypofractionated cohort (n = 20), confirming selection bias. At a median follow-up of 13 months, 1-year Kaplan-Meier estimates of PFS and OS were 43% (95% CI: 36%-52%) and 56% (95% CI: 48%-64%), yielding median PFS and OS of 11.0 months and 13.1 months, respectively. Higher KPS, methylated MGMT, normofractionated RT, and extended adjuvant TMZ emerged as favorable prognostic factors. TMZ was well tolerated with a low risk of ≥grade 3 myelotoxicity. CONCLUSIONS: Our single-institution clinical audit confirms poor survival in elderly GBM with suboptimal performance status but demonstrates acceptably fair outcomes in patients with preserved KPS comparable with the nonelderly cohort.

World neurosurgery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Shuai; Deng, Youmei; Xu, Feng published the artcile< An inorganic-organic hybrid MnIII{MnII6}2 cluster consisting of rare Lindqvist-like Mn6 subunits with high proton conductivity>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tris hydroxymethylpropane organic hybrid manganese cluster Lindqvist preparation structure; proton conductivity tris hydroxymethylpropane organic hybrid manganese cluster Lindqvist.

A new inorganic-organic hybrid MnIII{MnII6}2 with rare Lindqvist-like Mn6 subunits was synthesized. Authors studies reveal the distinct advantages of the MnIII{MnII6}2 compound as a potential material of proton exchange membranes, including its facile and cost-effective synthesis, insolubility in water, and most importantly, its maximum proton conductivity of 4.69 x 10-3 S cm-1 at 368 K and 97% RH.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ming-Shuang; Quan, Mao; Yang, Xi-Ran; Jiang, Wei published the artcile< Cucurbit[n]urils (n = 7, 8) can strongly bind neutral hydrophilic molecules in water>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cucurbituril crown ether dioxane inclusion reaction kinetics hydrogen bond.

It is challenging to recognize neutral hydrophilic mols. in water. Effective use of hydrogen bonds in water is generally accepted to be the key to success. In contrast, hydrophobic cavity is usually considered to play an insignificant role or only to provide a nonpolar microenvironment for hydrogen bonds. Herein, we report that hydrophobic cavity alone can also strongly bind neutral, highly hydrophilic mols. in water. We found that cucurbit[n]urils (n = 7, 8) bind 1,4-dioxane, crown ethers and monosaccharides in water with remarkable affinities. The best binding constant reaches 107 M-1 for cucurbit[8]uril, which is higher than its binding affinities to common organic cations. D. functional theory (DFT) calculations and control experiments reveal that the hydrophobic effect is the major contributor to the binding through releasing the cavity water and/or properly occupying the weakly hydrated cavity. However, hydrophobic cavity still prefers nonpolar guests over polar guests with similar size and shape.

Science China: Chemistry published new progress about Enthalpy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Blauenstein, Peter; Remy, Nathalie; Buck, Alfred; Ametamey, Simon; Haberli, Marc; Schubiger, P. August published the artcile< In vivo properties of N-(2-aminoethyl)-5-halogeno-2-pyridinecarboxamide 18F- and 123I-labeled reversible inhibitors of monoamine oxidase B>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iodo 123 pyridinecarboxylate brain imaging; fluoro 18 pyridinecarboxylate brain imaging; brain PET single photon emission tomog; MAO inhibitor brain imaging.

The reversible and highly selective monoamine oxidase B (MAO-B) inhibitor Ro 19-6327, a picolinic acid derivative, was selected for the development of new radiopharmaceuticals, whereby in place of Cl either 123I or 18F was introduced. The resp. labeling procedures have been described earlier. In this study, some metabolic properties were investigated. Blood and urine samples were analyzed, and halogenated picolinylglycine, a more hydrophilic compound, was identified as the main metabolite. This shows that the amine is oxidized to the resp. carboxylate, but the intermediate imine or aldehyde that was proposed earlier could not be detected. First experiments with single photon emission tomog. and positron emission tomog. (PET) showed that the iodo compound can be used to investigate MAO-B in vivo while the fluoro compound is accumulated in the brain to such a low degree that no PET studies can be performed. We conclude that the main reason for the poor uptake of the fluoro compound is its lower lipophilicity as compared to the iodo compound and, to a lesser degree, its metabolism, which is similar for both compounds

Nuclear Medicine and Biology published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, MouPing; Chen, YuanMao; Ke, Xi; Huang, ZeXi; Chen, YouChen; Wu, WenLi; Qu, XiaoFeng; Shi, ZhiCong; Guo, ZaiPing published the artcile< In situ growth of NiS2 nanosheet array on Ni foil as cathode to improve the performance of lithium/sodium-sulfur batteries>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nickel disulfide nanosheet foil growth lithium sodium sulfur battery.

The NiS2 nanosheet array on Ni foil (NiS2/NF) was prepared using an in situ growth strategy and sulfidation method and was used as the cathode of lithium sulfur battery. The unique nanostructure of the NiS2nanosheet array can provide abundant active sites for the adsorption and chem. action of polysulfides. Compared with the sulfur powder coated pure NF (pure NF-S) for lithium sulfur battery, the sulfur powder coated NiS2/NF (NiS2/NF-S) electrode exhibits superior electrochem. performance. Specifically, the NiS2/NF-S delivered a high reversible capacity of 1007.5 mAh g-1 at a c.d. of 0.1 C (1 C= 1675 mA g-1) and kept 74.5% of the initial capacity at 1.0 C after 200 cycles, indicating the great promise of NiS2/NF-S as the cathode of lithium sulfur battery. In addition, the NiS2/NF-S electrode also showed satisfactory electrochem. performance when used as the cathode for sodium sulfur battery.

Science China: Technological Sciences published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thakur, Subhash; Kumar, Narendra; Salunke, Pravin; Ahuja, Chirag; Madan, Renu published the artcile< A randomized study of short course (one week) radiation therapy with or without temozolomide in elderly and/or frail patients with newly diagnosed glioblastoma (GBM)>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Glioblastoma; Short Course Radiotherapy; Temozolomide.

Objective: Short-course radiotherapy (25 Gy in 5 fractions) has been shown to be non-inferior to standard course radiotherapy in elderly and frail patients (60 Gy in 30 fractions). The purpose of this study was to determine the effects of temozolomide combined with short-course radiotherapy on the outcome of elderly and frail patients. Methods: Between Jan. 2017 and Nov. 2018, 90 patients (65 years old and KPS score of 50-70; 65 years old and KPS score of 80-100; and 65 years old and KPS score of 50-70) were assessed for eligibility. Nine patients were excluded because they did not meet the inclusion criteria, six patients declined to participate, and four patients were unable to complete the quality-of-life questionnaire. The remaining 71 patients were divided into two arms at random in a 1:1 ratio. Short-course radiotherapy with concurrent temozolomide and adjuvant temozolomide was given to Arm 1, while short-course radiotherapy alone was given to Arm 2. Results: In terms of overall survival and progression-free survival, radiotherapy with concurrent temozolomide and adjuvant temozolomide outperformed short-course radiotherapy alone. The median overall survival in arm 1 was 146 days and 121 days in arm 2 (P=0.146). The median progression-free survival in arm 1 was 109.50 days, while it was 77 days in arm 2 (P=0.028). With a median follow-up time of 6 mo, the quality of life at 4 wk and 12 wk after treatment was not different between the two arms. Conclusion: We concluded that adding temozolomide to short-course radiotherapy significantly improved progression-free survival and showed an increasing trend in overall survival without compromising the quality of life.

Asian Pacific Journal of Cancer Prevention published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jozsef, Janos; Juhasz, Laszlo; Somsak, Laszlo published the artcile< Thio-click reaction of 2-deoxy-exo-glycals towards new glycomimetics: stereoselective synthesis of C-2-deoxy-D-glycopyranosyl compounds>, COA of Formula: C12H16O7, the main research area is deoxyglycal Bamford Stevens deoxyglycopyranosylmethyl sulfide disaccharide; configuration deoxyglycopyranosyl cyanide anhydroaldose tosylhydrazone reduction tosylhydrazine.

A series of 2-deoxy-glycopyranosyl cyanides with D-arabino, D-lyxo, D-erythro, and D-threo configurations was synthesized from the corresponding glycals via 2-deoxy-glycopyranosyl acetates. The cyanides were transformed to anhydro-aldose tosyl-hydrazones by reduction with NaH2PO2/Ra-Ni in the presence of tosylhydrazine. The tosyl-hydrazones furnished 2-deoxy-exo-glycals under modified Bamford-Stevens conditions. Photo-initiated thiol-ene additions of these exo-glycals resulted in the corresponding C-(2-deoxy-D-glycopyranosyl)methyl sulfides in medium to good yields with exclusive regio- and stereoselectivities in most cases. Several disaccharide mimics with a C-S moiety in place of the glycosidic oxygen were also obtained.

New Journal of Chemistry published new progress about Aldoses Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, COA of Formula: C12H16O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bendjeddou, Lyamin Z.; Loaec, Nadege; Villiers, Benoit; Prina, Eric; Spath, Gerald F.; Galons, Herve; Meijer, Laurent; Oumata, Nassima published the artcile< Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor>, Category: esters-buliding-blocks, the main research area is imidazopyridazine preparation antileishmanial cytotoxicity protein kinase inhibitor human; CLKs; Imidazo[1,2-b]pyridazine; Kinase inhibitor; Leishmania, DYRK1A; Unicellular parasites.

3,6-Disubstituted imidazo[1,2-b]pyridazine derivatives were synthesized to identify new inhibitors of various eukaryotic kinases, including mammalian and protozoan kinases. Among the imidazo[1,2-b]pyridazines tested as kinase inhibitors, several derivatives were selective for DYRKs and CLKs, with IC50 < 100 nM. The characterization of the kinome of several parasites, such as Plasmodium and Leishmania, has pointed out profound divergences between protein kinases of the parasites and those of the host. The activities of the prepared compounds against 11 parasitic kinases was investigated. 3,6-Disubstituted imidazo[1,2-b]pyridazines showed potent inhibition of Plasmodium falciparum CLK1 (PfCLK1). Compound I was found to be the most selective product against CLK1 (IC50 = 82 nM), CLK4 (IC50 = 44 nM), DYRK1A (IC50 = 50 nM), and PfCLK1 (IC50 = 32 nM). The compounds were also tested against Leishmania amazonensis. Several compounds showed anti-leishmanial activity at rather high (10 μM) concentration, but were not toxic at 1 μM or 10 μM, as judged by viability assays carried out using a neuroblastoma cell line. European Journal of Medicinal Chemistry published new progress about Cytotoxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics