Tag: M.W=250-300

Cui, Pei H.; Rawling, Tristan; Bourget, Kirsi; Kim, Terry; Duke, Colin C.; Doddareddy, Munikumar R.; Hibbs, David E.; Zhou, Fanfan; Tattam, Bruce N.; Petrovic, Nenad; Murray, Michael published the artcile< Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antitumor antimetastatic monounsaturated fatty acid preparation breast cancer; structure activity antitumor monounsaturated fatty acid preparation breast cancer.

Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E2 (PGE2), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis. We tested the hypothesis that these antitumor actions of n-3 PUFA may involve the n-3 olefinic bond. n-3 Monounsaturated fatty acids (MUFAs) of chain length C16-C22 were synthesized and evaluated in MDA-MB-468 breast cancer cells that stably overexpressed COX-2 (MDA-COX-2 cells). Longer chain (C19-C22) n-3 MUFAs inhibited proliferation, activated apoptosis, decreased PGE2 formation, and decreased cell invasion; C16-C18 analogs were less active. Mol. modeling showed that interactions of Arg120, Tyr355, and several hydrophobic amino acid residues in the COX-2 active site with C19-C22 MUFA analogs were favored. Thus, longer-chain n-3 MUFAs may be prototypes of novel anticancer agents that decrease the formation of PGE2 in tumor cells that contain high levels of COX-2.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Li; Zhu, Huayu; Song, Xingliang; Sun, Aide published the artcile< Analysis of chemical components in essential oil of the Negundo Chastetree fruit of supercritical CO2 fluid extraction by gas chromatography/mass spectrometry>, Related Products of 112-63-0, the main research area is Negundo carbon dioxide GC MS essential oil.

The chem. compositions in essential oil of the Negundo Chastetree Fruit of supercritical CO2 fluid extraction were analyzed. The chem. compositions of the volatile oil of the Negundo Chastetree Fruit extracted by supercritical CO2 fluid were analyzed by capillary gas chromatog.-mass spectrometry (GC-MS) method, and the relative component percentage of each component was determined by GC area normalization method. Ninety-one peaks were separated by capillary GC-MS and of the 60 peaks corresponding compounds were identified, which account for about 96% of the total area. The main chem. compositions were as follows: decanol (71.22%), 2,5,5,8a-tetramethyloctahydro-2H-chromene (4.96%), β-caryophyllene (2.29%), cyclohexene (1.86%), osthole (1.77%), 4-hydroxy-4-methyl-2-pentanone (1.61%) and 9-(3-butenyl) anthracene (1.11%), etc. This study could be served as a scientific basis for the further exploitation and utilization of the Negundo Chastetree Fruit.

Zhongguo Yaofang published new progress about Negundo. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Chunsheng; Zhong, Chongli published the artcile< Chirality factors and their application to QSAR studies of chiral molecules>, Category: esters-buliding-blocks, the main research area is chirality factor QSAR.

Two series of chirality factors that can distinguish enantiomers and diastereomers were developed in this work and the corresponding chiral topol. indexes were proposed. The obtained chiral topol. indexes can be used to perform QSAR studies for chiral mols. The biol. activities of fourteen 3-(3-hydroxyphenyl)- piperidines (seven pairs of enantiomers), the high-pressure thin-layer chromatog. retention indexes of eight hydroxy acids and ten amino acids (nine pairs of enantiomers), the ED50 of 23 ecdysteroids (19 pairs of diastereomers), and the corticosteroid-binding globulins affinities of 31 steroids were used to evaluate the chirality factors and the corresponding chiral topol. indexes. The QSAR models developed give satisfactory predictive accuracy. Compared with the existing methods, the chirality factor method proposed in this work has the advantage of being applicable to the existing topol. indexes directly. This makes good use of the existing topol. indexes, and thus brings convenience to the QSAR studies for chiral mols. Another advantage of the new method is that it can also correctly describe the characteristics of meso compounds

QSAR & Combinatorial Science published new progress about Chirality. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Lu; Zhang, Luxin; Liu, Yuting; He, Yunfei; Zhu, Yujie; Sun, Ruijun; Yi, Simin; Xiang, Junping published the artcile< Clean production of ethyl levulinate from kitchen waste>, Product Details of C19H34O2, the main research area is kitchen waste ethyl levulinate heterogeneous catalyst physicochem property.

A clean and highly efficient catalytic system for the synthesis of Et levulinate (EL) from kitchen waste was developed. A heterogeneous catalyst (Sn/ZrP-SO3H) was prepared and the Bronsted and Lewis acid sites on the surface of the catalyst were evaluated by pyridine FT-IR. Other physicochem. properties were also characterized using XRD, SEM, FT-IR, XPS, BET, NH3-TPD. The yield of EL obtained was 49.27%, when glucose was used as the starting material and subjected to 170°C for 10 h in the presence of the solid acid catalyst, Sn/ZrP-SO3H. The prepared catalyst was also combined with several metal triflates; (Al(OTf)3, Fe(OTf)3, Sm(OTf)3) to form a catalytic system for the efficient preparation of EL from kitchen waste. Sn/ZrP-SO3H/Al(OTf)3 had superior activity compare to other catalyst combinations. In single factor experiments, the yield of EL reached 52.52% after heating at 170°C for 4 h. In addition, four-factor and three-level experiments were performed using response surface methodol. (RSM) to analyze the interaction between each factor. The optimal reaction conditions predicted by the model (163°C, 7.63 h, 20 mg Al(OTf)3, 40 mg Sn/ZrP-SO3H and 79.98 mg of kitchen waste) estimated a maximal yield for EL of 51.24%. The exptl. yield of EL however was 52.03% which confirms the reliability of the model. This work provides a cleaner production technol. for the synthesis of the high value-added chem. EL, and a sustainable route for the utilization of kitchen waste.

Journal of Cleaner Production published new progress about Polymer surface morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Calter, Michael A.; Phillips, Ryan M.; Flaschenriem, Christine published the artcile< Catalytic, Asymmetric, ""Interrupted"" Feist-Benary Reactions>, Formula: C19H34O2, the main research area is hydroxydihydrofuran preparation catalytic asym interrupted Feist Benary.

Pyrimidine derivatives of the cinchona alkaloids function as excellent asym. catalysts for the interrupted Feist-Benary reaction. This reaction produces highly substituted hydroxydihydrofurans from simple starting materials under mild conditions. The asym. reaction gives high enantioselectivities with unsubstituted bromoketones and high enantio- and diastereoselectivities with substituted substrates. Mechanistic experiments suggest that the hydrobromide salt of the alkaloid derivative is the active catalyst for the reaction.

Journal of the American Chemical Society published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gangane, Purushottam Shridhar; Pachpute, Tejas; Mahapatra, Debarshi Kar; Mahajan, Nilesh Manoharrao published the artcile< HPMC polymers and xanthan gum assisted development and characterization of stavudine extended release floating tablets>, HPLC of Formula: 112-63-0, the main research area is xanthan gum assisted development extended release floating tablet.

Stavudine has a low half-life of 0.8-1.5 h and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-d. formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed IR Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped d., bulk d., Hausner’s ratio, Carr’s index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.

Indian Journal of Pharmaceutical Education and Research published new progress about Artificial gastric juice. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Lei; Wang, Hua; Yu, Shanshan; Zhang, Lin; Jiang, Jue; Zhou, Qi published the artcile< Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is herceptin ferroptosis mitochondrial dysfunction heart failure; Herceptin; cardiotoxicity; ferroptosis; mitochondrial dysfunction.

Ferroptosis has been previously implicated in the pathol. progression of cardiomyopathy. Herceptin (trastuzumab), which targets HER2, is commonly applied for the treatment of HER2+ breast cancer. However, its clin. use is limited by its cardiotoxicity. Therefore, the present study aimed to investigate if targeting ferroptosis could protect against Herceptin-induced heart failure in an in vitro model of H9c2 cells after treatment of Herceptin, Herceptin + ferroptosis inhibitor ferrostatin-1 (Fer-1) or Herceptin + Deferoxamine. H9c2 cell viability was measured by MTT assay. Reactive oxygen species (ROS) levels were detected by measuring the fluorescence of DCFH-DA-A and MitoSOX Red. Glutathione (GSH)/oxidized glutathione (GSSG) ratio was measured using the GSH/GSSG Ratio Detection Assay kit. Mitochondrial membrane potential and ATP content were evaluated by JC-1 staining and bioluminescent assay kits, resp. Protein expressions of glutathione peroxidase 4, recombinant solute carrier family 7 member 11, mitochondrial optic atrophy1-1/2, mitofusin, Acyl-CoA synthetase long chain family member 4, cytochrome c, voltage-dependent anion-selective channel, dynamin-related protein, mitochondrial fission 1 protein and mitochondrial ferritin were evaluated by western blotting. It was found that Herceptin reduced H9c2 cell viability while increasing intracellular and mitochondrial ROS levels in a dose- and time-dependent manner. Furthermore, Herceptin decreased glutathione peroxidase (GPX) protein expression and the GSH/GSSG ratio in H9c2 cells in a dose- and time-dependent manner. The Fer-1 abolished this Herceptin-induced reduction in cell viability, GSH/GSSG ratio, mitochondrial membrane potential and ATP content. Fer-1 also reversed the suppressive effects of Herceptin on the protein expression levels of GPX4, recombinant solute carrier family 7 member 11, mitochondrial optic atrophy1-1/2 and mitofusin in H9c2 cells. Subsequently, Fer-1 was found to reverse the Herceptin-induced increase in mitochondrial ROS and iron levels in H9c2 cells, as well as the increased protein expression levels of Acyl-CoA synthetase long chain family member 4, cytochrome c, voltage-dependent anion-selective channel, dynamin-related protein, mitochondrial fission 1 protein and mitochondrial ferritin in H9c2 cells. However, compared with deferoxamine, an iron chelator, the effects of Fer-1 were less effective. Collectively, these findings provided insights into the pathogenic mechanism that underlie Herceptin-induced cardiomyopathy, which potentially provides a novel therapeutic target for the prevention of cardiotoxicity in HER2+ breast cancer treatment.

International Journal of Molecular Medicine published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selvakumar, N.; Azhagan, A. Malar; Srinivas, D.; Krishna, G. Gopi published the artcile< A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline>, Category: esters-buliding-blocks, the main research area is coerulescine synthesis; horsfiline synthesis; arylpropenoic acid ester nitro preparation; propenoic acid ester arylnitro preparation.

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their Ph ring using common and less expensive reagents is described. The usefulness of this methodol. is substantiated by the efficient total syntheses of (±)-coerulescine (I) and (±)-horsfiline from the 2-arylpropenoic acid esters obtained.

Tetrahedron Letters published new progress about Nitro group. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Werner, Maxim; Lyu, Chen; Stadlbauer, Birgit; Schrader, Isabel; Buchner, Alexander; Stepp, Herbert; Sroka, Ronald; Pohla, Heike published the artcile< The role of Shikonin in improving 5-aminolevulinic acid-based photodynamic therapy and chemotherapy on glioblastoma stem cells>, Computed Properties of 112-63-0, the main research area is Glioblastoma; Photodynamic therapy; Shikonin; Stem cells.

Glioblastoma multiforme is a malignant neoplasia with a median survival of less than two years and without satisfactory therapeutic options. The so-called glioblastoma stem cells escape the established radio- and chemotherapies and lead to tumor recurrence in most cases. The alkaloid Shikonin with its various anti stem cell properties and the interstitial photodynamic therapy with 5-aminolevulinic acid seem to be promising new options in the therapy of glioblastoma. In this study, in vitro investigations were performed to observe the influence of Shikonin on viability, proliferation, induction of apoptosis and the capability of forming tumor spheres in U-87 MG and the primary glioblastoma cell line GB14. The combined effect with the chemotherapeutic temozolomide and photodynamic treatment on the mRNA expression of glioma specific stem cell markers and further examined intracellular protoporphyrin IX accumulation under Shikonin treatment was analyzed. Shikonin effectively inhibited the capability of forming tumor spheres and enhanced temozolomide effectiveness in the reduction of proliferation and in the induction of apoptosis. Addnl., Shikonin increased the mRNA expression of the tumor suppressing Neurofibromatosis type 1 (NF1) gene and showed modulating effects on intracellular protoporphyrin IX.

Photodiagnosis and Photodynamic Therapy published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

D’Ambrosio, Valeria; di Bitonto, Luigi; Angelini, Antonella; Gallipoli, Agata; Braguglia, Camilla M.; Pastore, Carlo published the artcile< Lipid extraction from sewage sludge using green biosolvent for sustainable biodiesel production>, Formula: C19H34O2, the main research area is sewage sludge green biosolvent sustainable biodiesel production lipid extraction.

Sewage sludge is a type of urban waste generated as a byproduct of wastewater treatment in quantities ranging from 9 to 9.5 million tons (dry substance) in Europe. This waste can be considered a source of lipids, which can be converted into biofuels. Recovery of lipids from sludge is a critical step in the overall process, and the choice of the extracting solvent should satisfy efficiency as well as sustainability criteria. This study reports exptl. optimization of lipid extraction from sewage sludge using Et butyrate, a green bio-derivable solvent. Extraction conditions were optimized using the desirability function applied to the response surface methodol. anal. of a Box-Behnken factorial design of experimentals. By carrying out the extraction at 70°C for 7 h, using an amount of solvent equal to the wet sludge, and without using any acids, 93.7% of the starting lipids were recovered. The extracted lipids were then efficiently converted into biodiesel (fatty acid Me esters) through direct esterification promoted by AlCl3·6H2O (catalyst). Furthermore, the residual sludge obtained after the extraction, different to that obtained using hexane, was found to be anaerobically digestible without any inhibition.

Journal of Cleaner Production published new progress about Alkalinity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics