Tag: M.W=250-300

Martinez-Pardo, Pablo; Lavios, Adrian; Sanz-Marco, Amparo; Vila, Carlos; Pedro, Jose R.; Blay, Gonzalo published the artcile< Enantioselective Synthesis of Functionalized Diazaspirocycles from 4-Benzylideneisoxazol-5(4H)-one Derivatives and Isocyanoacetate Esters>, Computed Properties of 112-63-0, the main research area is isocyanoacetate methylidene isoxazolone silver oxide squaramide enantioselective diastereoselective cycloaddition; spiro pyrrolidine isoxazolone preparation.

Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high functionalization were obtained through a formal [3+2] cycloaddition reaction catalyzed by a cooperative system. The spiro compounds were synthesized from 4-arylideneisoxazol-5-ones and isocyanoacetate esters using a bifunctional squaramide/Bronsted base organocatalyst derived from a Cinchona alkaloid and silver oxide as Lewis acid. This method afforded two out of the four possible diastereomers with good yields and high enantiomeric excess for both diastereomers.

Advanced Synthesis & Catalysis published new progress about [3+2] Cycloaddition reaction catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Apath, Daniel; Moyo, Mambo; Shumba, Munyaradzi published the artcile< TiO2 nanoparticles decorated graphene nanoribbons for voltammetric determination of an Anti-HIV drug nevirapine>, Product Details of C19H34O2, the main research area is nevirapine graphene titanium oxide nanoparticle nanoribbon voltammetry HIV.

In the present study, electrochem. behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform IR spectroscopy (FT-IR) and SEM (SEM). The electrochem. behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochem. impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (-37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020-0.14μM. The detection limit was calculated as 0.043μM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully.

Journal of Chemistry published new progress about Additive manufacturing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fairweather, Jon K.; Stick, Robert V.; Tilbrook, D. Matthew G. published the artcile< The asymmetric dihydroxylation of some alkenyl 2-acetylamino-2-deoxy-β-D-glucopyranosides: the preparation of optically pure epoxides as putative inhibitors of chitinases>, Product Details of C19H34O2, the main research area is aminodeoxyglucopyranoside epoxide preparation potential chitinase inhibitor; alkenyl aminodeoxyglucopyranoside asym hydroxylation.

Various alkenyl 2-acetylamino-2-deoxy-β-D-glucopyranosides have been subjected to the Sharpless asym. dihydroxylation protocol to yield the corresponding diols, albeit with somewhat disappointing stereoselectivity. An alternative, more traditional approach has yielded the optically pure epoxyalkyl 2-acetylamino-2-deoxy-β-D-glucopyranosides as putative inhibitors of chitinases. As well, an epoxypropyl chito-bioside and -trioside have been prepared, each as mixtures of two diastereoisomers.

Australian Journal of Chemistry published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinogradov, Alexander A.; Nifant’ev, Ilya E.; Vinogradov, Alexey A.; Borisov, Roman S.; Ivchenko, Pavel V. published the artcile< Precision rheological study of the effectiveness of polymer cold flow improvers for corn oil based biodiesel>, Category: esters-buliding-blocks, the main research area is precision rheol effectiveness polymer cold flow improver corn oil.

Combination of the precision rheol. and DSC helps to make an objective assessment of the effectiveness of modified copolymers of maleic anhydride with methylidenealkanes and best known com. pour point depressants as cold flow improvers for corn oil based biodiesel.

Mendeleev Communications published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yebra, Mayra; Bhargava, Shruti; Kumar, Avi; Burgoyne, Adam M.; Tang, Chih-Min; Yoon, Hyunho; Banerjee, Sudeep; Aguilera, Joseph; Cordes, Thekla; Sheth, Vipul; Noh, Sangkyu; Ustoy, Rowan; Li, Sam; Advani, Sunil J.; Corless, Christopher L.; Heinrich, Michael C.; Kurzrock, Razelle; Lippman, Scott M.; Fanta, Paul T.; Harismendy, Olivier; Metallo, Christian; Sicklick, Jason K. published the artcile< Establishment of patient-derived succinate dehydrogenase-deficient gastrointestinal stromal tumor models for predicting therapeutic response>, Product Details of C19H34O2, the main research area is temozolomide anticancer succinate dehydrogenase gastrointestinal stromal tumor.

Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A-D) comprising less than 7.5% (i.e., 150-200/yr) of new cases annually in the United States. Contrary to GISTs harboring KIT or PDGFRA mutations, SDH-mutant GISTs affect adolescents/young adults, often metastasize, and are frequently resistant to tyrosine kinase inhibitors (TKI). Lack of human models for any SDH-mutant tumors, including GIST, has limited mol. characterization and drug discovery. Exptl. Design: We describe methods for establishing novel patient-derived SDH-mutant (mSDH) GIST models and interrogated the efficacy of temozolomide on these tumor models in vitro and in clin. trials of patients with mSDH GIST. Mol. and metabolic characterization of our patient-derived mSDH GIST models revealed that these models recapitulate the transcriptional and metabolic hallmarks of parent tumors and SDH deficiency. We further demonstrate that temozolomide elicits DNA damage and apoptosis in our mSDH GIST models. Translating our in vitro discovery to the clinic, a cohort of patients with SDH-mutant GIST treated with temozolomide (n = 5) demonstrated a 40% objective response rate and 100% disease control rate, suggesting that temozolomide represents a promising therapy for this subset of GIST. We report the first methods to establish patient-derived mSDH tumor models, which can be readily employed for understanding patient-specific tumor biol. and treatment strategies. We also demonstrate that temozolomide is effective in patients with mSDH GIST who are refractory to existing chemotherapeutic drugs (namely, TKIs) in clinic for GISTs, bringing a promising treatment option for these patients to clinic.

Clinical Cancer Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (SDH). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schlienger, Nathalie; Lefebvre, Isabelle; Aubertin, Anne-Marie; Peyrottes, Suzanne; Perigaud, Christian published the artcile< Mononucleoside phosphorodithiolates as mononucleotide prodrugs>, Product Details of C19H34O2, the main research area is HIV1 replication inhibition antiviral mononucleoside phosphorodithiolate; Antiviral; Mononucleotide; Phosphorus; Prodrug.

The synthesis and in vitro anti-HIV activity of a novel series of pronucleotides are reported. These prodrugs were characterized by a phosphorodithiolate structure, incorporating two O-pivaloyl-2-oxyethyl substituents as biolabile phosphate protections. The compounds were obtained following an original one-pot three-step procedure, involving the formation of a phosphorodithioite intermediate which is in situ oxidized. In vitro, comparative anti-HIV evaluations demonstrate that such original prodrugs are able to allow the efficient intracellular release of the corresponding 5′-mononucleotide. The pronucleotide of 2′,3′-dideoxyadenosine (ddA) 3 exhibited a very potent antiretroviral effect with 50% effective concentration (EC50) values in nanomolar concentration range in various cell lines. In primary monocytes/macrophages, this derivative was 500 times more potent in inhibiting HIV replication (EC50 0.23 pM) than ddA and the selectivity index of the prodrug is fifty times higher than the one of the parent nucleoside.

European Journal of Medicinal Chemistry published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bergmann, Ernest; Weizmann, Anna published the artcile< Dipole moment and molcular structure. XVIII. The dipole moments of substituted α-methylstyrenes>, COA of Formula: C19H34O2, the main research area is .

The deviations observed are believed to be due to an inductive effect. Values of μ were determined as follows: o,α-Dimethylstyrene 0.8, α-naphthylmethylethylene 0, o-methoxy-α-methylstyrene 1.48, o-F analog (I) 1.54, o-Br analog (II) 1.87, o-I analog (III) 1.48, m-MeO analog 1.65, m-Cl analog (IV) 1.89, p-MeO analog 1.39, p-Br analog (V) 1.45. o-Fluorophenyl-dimethylcarbinol (VI), b20 102-4°; heating with Ac2O for 8 hrs. gives I, b28 62°, nD30 1.5009. Br analog of VI, b1 87-93°; II, b0.9 55-65°, nD27 1.5530. o-I analog of VI, b0.9 108-10°; III, b0.9 65-70°, nD26 1.5955. m-Cl analog of VI, b18 124-6°; IV, b26 105-8°. V, b1.8 58-60°, nD27 1.5778.

Transactions of the Faraday Society published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baltus, Christine B.; Jorda, Radek; Marot, Christophe; Berka, Karel; Bazgier, Vaclav; Krystof, Vladimir; Prie, Gildas; Viaud-Massuard, Marie-Claude published the artcile< Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azaindole triazole preparation CDK2 inhibitor anticancer activity mol modeling; 1,4-Triazole; 1,5-Triazole; 1H-pyrrolo[2,3-b]pyridine; 3D-QSAR CoMFA; Anti-tumor agent; Cyclin-dependent kinase 2; Kinase inhibitors; [3+2] cycloaddition.

From four mols., inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) and triazole heterocycles. Using a Huisgen type [3 + 2] cycloaddition as the convergent key step, 24 derivatives were synthesized and their biol. activities were evaluated. Comparative mol. field anal. (CoMFA), based on three-dimensional quant. structure-activity relationship (3D-QSAR) studies, was conducted on a series of 30 compounds from the literature with high to low known inhibitory activity towards CDK2/cyclin E and was validated by a test set of 5 compounds giving satisfactory predictive r2 value of 0.92. Remarkably, it also gave a good prediction of pIC50 for our tri-heterocyclic series which reinforce the validation of this model for the pIC50 prediction of external set compounds The most promising compound, I, showed a micro-molar range inhibitory activity against CDK2/cyclin E and also an antiproliferative and proapoptotic activity against a panel of cancer cell lines.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Lang; Lu, Tao; Xu, Gaojie; Zhang, Xiaohu; Jiang, Zhaoxuan; Zhang, Zengqi; Wang, Yantao; Han, Pengxian; Cui, Guanglei; Chen, Liquan published the artcile< Thermal runaway routes of large-format lithium-sulfur pouch cell batteries>, Application In Synthesis of 112-63-0, the main research area is thermal runaway lithium sulfur pouch cell battery.

Lithium-sulfur (Li-S) batteries emerge as one of the most attractive energy storage systems due to their ultra-high theor. energy densities, but the pace of their thermal safety assessment is obviously lagging behind. Herein, by investigating the thermal runaway behavior of Li-S pouch cells from the materials level, we unprecedentedly revealed that the thermal runaway route starts from cathode-induced reactions and then gets accelerated by reactions from the anode. Besides, the solvent vaporization is verified to dominate pressure building up during thermal runaway. Moreover, Li-S batteries employing varied electrolytes with different thermal stabilities, even inorganic all solid-state electrolytes, all undergo rapid thermal runaway at a narrow temperature range due to the intrinsic thermal features of the sulfur cathode and Li metal anode sublimating, melting, and cross-reacting at high temperatures The in-depth depicted thermal runaway routes will deliver great inspiration for mitigating the safety issues of next generation batteries.

Joule published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shah, Sanjit; Manzoor, Saima; Rothman, Yehudit; Hagen, Matthew; Pater, Luke; Golnik, Karl; Mahammedi, Abdelkader; Lin, Andrew L; Bhabhra, Ruchi; Forbes, Jonathan A; Sengupta, Soma published the artcile< Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report.>, COA of Formula: C19H34O2, the main research area is .

BACKGROUND AND IMPORTANCE: Aggressive pituitary adenomas (APAs) are pituitary tumors that are refractory to standard treatments and carry a poor prognosis. Current treatment guidelines are not standardized but combine surgical resection, radiation therapy, and chemotherapy. Temozolomide is the only chemotherapeutic agent with documented effectiveness and is recommended for APA in European Society of Endocrinology clinical guidelines. CLINICAL PRESENTATION: A 57-year-old man presented with visual deterioration and bitemporal hemianopsia. MRI of the brain demonstrated a sellar mass suspected to be pituitary macroadenoma with displacement of the stalk and optic nerve impingement. The patient underwent stereotactic endoscopic transsphenoidal resection of the mass. Postoperative MRI demonstrated gross total resection. Pathology revealed a sparsely granulated corticotroph adenoma with malignant transformation. Immunohistochemistry showed loss of expression of MLH1 and PMS2 in the tumor cells. Proton therapy was recommended given an elevated Ki67 index and p53 positivity. Before radiotherapy, there was no radiographic evidence of residual tumor. Temozolomide therapy was initiated after surveillance MRI showed recurrence at 16 months postoperatively. However, MRI demonstrated marked progression after 3 cycles. Next-generation sequencing using the MSK-IMPACT platform identified somatic mutations in MLH1 Y548lfs*9 and TP53 R337C . Immunotherapy with ipilimumab/nivolumab was initiated, and MRI demonstrated no residual tumor burden 34 months postoperatively. CONCLUSION: APA is a tumor with frequent recurrence and a short median expected length of survival. Here, we demonstrate the utility of immunotherapy in a single case report of APA, with complete resolution of recurrent APA and improved survival compared with life expectancy.

Neurosurgery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics