Tag: M.W=250-300

Kandil, Heba; El-Sawy, Eslam R.; Awad, Hanem M.; E. El. Nashar, Doaa; Amin, Amal published the artcile< RAFT Terminated Hyperbranched Functionalized Nano Rice Husk Powder / EPDM Nanocomposite for Biomedical Applications>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polymer modified rice husk EPDM nanocomposite cytotoxicity.

Modified nanosize rice husk powder (i.e. mod.nRHP; mod.nRHP-MA-RAFT-H)/ethylene propylene diene monomer (EPDM) nanocomposite was prepared by solvent casting method. The surface of nano rice husk (n-RHP) was treated with maleic anhydride (MA) to yield n-RHP-MA, then, aliphatic hyperbranched polyester (H) was end capped with RAFT agent to obtain H-RAFT. Afterward, H-RAFT-was successfully anchored onto nRHP-MA via RAFT polymerization technique to afford nRHP-MA-RAFT-H (mod.nRHP). The mech. and thermal properties were studied for nRHP-MA-RAFT-H (mod.nRHP)/EPDM nanocomposite with different loadings of mod.nRHP. The cytotoxicity activities of the prepared mod.nRHP/EPDM nanocomposites were investigated toward human cell lines in vitro.

Polymer-Plastics Technology and Materials published new progress about Adhesion, physical, interfacial. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qiu-yan; Huang, Jin-lin; Hou, Hai-sheng; Chen, Shao-chuan published the artcile< Influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance>, Category: esters-buliding-blocks, the main research area is hypertension impaired glucose tolerance endothelin enhanced external counterpulsation.

The effects of enhanced external counterpulsation (EECP) on the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance (IGT) were explored. Eighty hypertensive patients complicated by IGT were divided into treatment group (n = 44, conventional treatment + EECP) and control group (n = 36, conventional treatment). Both groups received conventional antihypertensive treatment, but EECP was added in the treatment group based on the conventional treatment. Blood pressure, pulse wave velocity, endothelin (ET) and nitric oxide (NO) were measured and compared between groups. Blood pressure in the two groups after treatment was dramatically reduced, but there was no significant difference between groups. The ba PWV of patients in treatment group (1602±214) vs. (1890±251) cm/s and control group (1704±221) vs. (1893±243) cm/s after treatment decreased significantly. The ET level of patients in the treatment group (63±21) vs. (90±24) ng/L and control group (75±20) vs. (90±24) ng/L also decreased significantly after treatment. However, NO level of patients in treatment group (79±17) vs. (51±19) mmol/L and control group (68±17) vs. (51±18) μmol/L increased significantly after treatment. However, the ba PWV, ET and NO of patients in treatment group improved more significantly compared with those in the control group. Enhanced external counterpulsation can improve the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance.

Xinzang Zazhi published new progress about Blood triglycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recinella, Lucia; Chiavaroli, Annalisa; Masciulli, Fabrizio; Fraschetti, Caterina; Filippi, Antonello; Cesa, Stefania; Cairone, Francesco; Gorica, Era; De Leo, Marinella; Braca, Alessandra; Martelli, Alma; Calderone, Vincenzo; Orlando, Giustino; Ferrante, Claudio; Menghini, Luigi; Di Simone, Simonetta Cristina; Veschi, Serena; Cama, Alessandro; Brunetti, Luigi; Leone, Sheila published the artcile< Protective Effects Induced by a Hydroalcoholic Allium sativum Extract in Isolated Mouse Heart>, Synthetic Route of 112-63-0, the main research area is ethanol eugenol Allium cardioprotective agent PGE2 COX2 oxidative stress; CIEL*a*b*; HS-SPME/GC–MS; bioinformatics; garlic; inflammation; multimethodological evaluation; oxidative stress.

The aim of the present study was to investigate the possible protective effects of a garlic hydroalcoholic extract on the burden of oxidative stress and inflammation occurring on mouse heart specimens exposed to E. coli lipopolysaccharide (LPS), which is a well-established inflammatory stimulus. Headspace solid-phase microextraction combined with the gas chromatog.-mass spectrometry (HS-SPME/GC-MS) technique was applied to determine the volatile fraction of the garlic powder, and the HS-SPME conditions were optimized for each of the most representative classes of compounds CIEL*a*b* colorimetric analyses were performed on the powder sample at the time of delivery, after four and after eight months of storage at room temperature in the dark, to evaluate the color changing. Freshly prepared hydroalcoholic extract was also evaluated in its color character. Furthermore, the hydroalcoholic extract was analyzed through GC-MS. The extract was found to be able to significantly inhibit LPS-induced prostaglandin (PG) E2 and 8-iso-PGF2α levels, as well as mRNA levels of cyclooxygenase (COX)-2, interleukin (IL)-6, and nuclear factor-kB (NF-kB), in heart specimens. Concluding, our findings showed that the garlic hydroalcoholic extract exhibited cardioprotective effects on multiple inflammatory and oxidative stress pathways.

Nutrients published new progress about Allium sativum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Kong Mun; Ng, Seik Weng published the artcile< Di-μ-hydroxido-bis[bromidodi-p-tolyltin(IV)]>, SDS of cas: 112-63-0, the main research area is crystal structure tin tolyl bromo hydroxo dinuclear complex; mol structure tin tolyl bromo hydroxo dinuclear complex; hydrogen bond tin tolyl bromo hydroxo dinuclear complex.

The Sn atoms in dinuclear di-μ-hydroxo-bis[bromodi-p-tolyltin], [Sn2Br2(C7H7)4(OH)2], exist in distorted trigonal-bipyramidal BrSnC2O2 coordination geometries. Each of the 2 independent dinuclear mols. comprising the asym. unit is disposed about a center of inversion. In the crystal, mols. are linked by an O-H···H bond. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Larcher, Adele; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves; van der Lee, Arie; Vasseur, Jean-Jacques; Laurencin, Danielle; Smietana, Michael published the artcile< Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors>, Application of C19H34O2, the main research area is dicarboxamide linked benzoxaborole preparation carbonic anhydrase inhibitor.

The synthesis, characterization, and biol. evaluation of a series of compounds incorporating two or three benzoxaborole moieties is reported. Three different synthetic strategies were used to explore within this series as much chem. space as possible, all starting from the 6-aminobenzoxaborole reagent: amide coupling, imine bond formation, and squarate coupling. Eleven new compounds were isolated in pure form, and single crystals were obtained for two of them. These compounds were then evaluated as carbonic anhydrase inhibitors against the cytosolic hCA I and II and the transmembrane hCA IV, IX, and XII isoforms. While the benzoxaborole scaffold has been recently introduced as a new chemotype for carbonic anhydrase inhibition, these new multivalent derivatives exhibited superior inhibitory activity against the tumor-associated isoform hCA IX. In particular, compared to monovalent 6-aminobenzoxaborole (KI = 813 nM) and 6-carboxybenzoxaborole (KI = 400 nM), derivative 2h characterized by a glutamic acid structural core and two benzoxaborole moieties was found to be more potent (KI = 64 nM) and more selective over human hCA II.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Suk Bong; Raushel, Frank M. published the artcile< Inhibitors directed towards the binuclear metal center of phosphotriesterase>, COA of Formula: C19H34O2, the main research area is phosphotriesterase cadmium zinc phosphonate phosphoramidate.

The potential roles in binding and catalysis for the binuclear metal center found within bacterial phosphotriesterase were evaluated by characterization of the inhibitory properties of 26 substrate and product mimetics. Phosphonates bearing monofluoro, difluoro, or hydroxyl substituents at the methylene position were noncompetitive inhibitors with Ki values ranging from 0.6-9 mM vs. the substrate paraoxon. Phosphoramidates did not inhibit the enzyme. Di-Et phosphate and di-Et dithiophosphate inhibited the Cd-substituted enzyme with Ki values of 10 and 130 μM, resp. The most effective inhibitor for either the Cd or Zn substituted enzyme was found di-Et thiomethyl-phosphonate. The competitive inhibition constants for this compound were 60 nM and 2.8 μM for the Cd- and Zn-substituted enzyme, resp. The tight binding is attributed to chelation of both metal ions simultaneously.

Journal of Enzyme Inhibition published new progress about Metalloenzymes Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ni, Haiwei; Ruan, Guojing; Sun, Cheng; Yang, Xuan; Miao, Zhenyan; Li, Jifei; Chen, Ying; Qin, Hai; Liu, Yichen; Zheng, Lufeng; Xing, Yingying; Xi, Tao; Li, Xiaoman published the artcile< Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is tanshinone IIA gastric cancer cell stemness ferroptosis; SLC7A11; Tanshinone IIA; ferroptosis; gastric cancer; stemness.

Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found that Tanshinone IIA could reduce gastric cancer cell stemness through detecting spheroid-forming, flow cytometry anal., and the expression of stemness markers (OCT3/4, ALDH1A1, and CD44). Mechanistically, Tanshinone IIA increased the level of lipid peroxides and decreased glutathione level in gastric cancer cells, both of which are the markers of ferroptosis. Similarly, ferroptosis inducers (erastin, sulfasalazine, and sorafenib) reduced gastric cancer cell stemness. Addnl., the inhibitory effects of Tanshinone IIA on GC cell stemness were reversed by ferroptosis inhibitor (Fer-1) or overexpression of SLC7A11, which is a critical ferroptosis inhibitor. Therefore, we revealed that Tanshinone IIA inhibited the stemness of gastric cancer cells partly through inducing ferroptosis.

Environmental Toxicology published new progress about CD44 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Yi; Zhang, Ruoqi; Zhao, Wenguang; Wen, Sha; Xiang, Yanping; Liu, Xianxiang published the artcile< A New Sulfonic Acid-Functionalized Organic Polymer Catalyst for the Synthesis of Biomass-Derived Alkyl Levulinates>, HPLC of Formula: 112-63-0, the main research area is sulfonate functionalized organic polymer catalyst biomass alkyl levulinate.

Alkyl levulinates are important biobased chems. with great fuel-blending properties and good reactivity. In this work, a new functionalized nitrogen-containing organic polymer bearing sulfonic acid groups (PDVTA-SO3H) was successfully prepared and studied for the esterification of levulinic acid with alcs. to produce alkyl levulinates. The results showed that this sulfonic acid-functionalized organic polymer possessed high catalytic activity, and the yield of Bu levulinate reached 97.4% under the mild conditions. PDVTA-SO3H exhibited strong acidic sites and high stability, and would be well expected to be a potential candidate better than some com. sulfonic solid catalysts for alkyl levulinates production The catalyst had been reused without any treatment for five times and the results proved its potential for industrial applications.

Catalysis Letters published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cooper, G.; Irwin, W. J. published the artcile< 1-styrylimidazoles>, Application In Synthesis of 112-63-0, the main research area is styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Styrene oxide reacted with imidazole, its 2-methyl, 2-phenyl, and 4,5-diphenyl derivatives and benzimidazole in DMF in the presence of catalytic quantities of K at room temperature to give 45-98% of the corresponding 1-(2-hydroxy-2-phenylethyl)imidazole, which on heating with SOCl2 and KOH were dehydrated to give 51-90% trans-1-styrylimidazoles.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Turco, Rosa; Di Serio, Martino published the artcile< Sustainable synthesis of epoxidized Cynara C. seed oil>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cardoon seed oil epoxidation hydrogen peroxide phys chem property.

The use of non-edible vegetable oils to produce oleochems. has been attracting more attention in recent years. Cardoon seed oil, derived from the Cynara C. plant, growing in marginal and contaminated lands, represents a non-edible alternative to soybean oil to obtain plasticizers through epoxidation reaction. The use of hydrogen peroxide as oxidant and in the presence of a heterogeneous catalyst allows overcoming the limits of epoxidation with peracids. γ-Alumina has been shown to have an active catalyst epoxidation reaction with hydrogen peroxide, mainly using acetonitrile as solvent. However, the use of acetonitrile as solvent is widely debated due to its hazardous character and health issues. For these reasons, the influence of solvent on the reaction was studied in this work to find a more environmentally friendly and stable solvent. The study showed that the epoxidation reaction takes place also in the absence of solvent although with lower selectivity. The type of solvent influences both the epoxidation and decomposition reactions of hydrogen peroxide. γ-Valerolactone was found to be the most promising solvent for cardoon oil epoxidation reaction. This finding represents a noteworthy novelty in the field of epoxidation of vegetable oils with hydrogen peroxide, opening the way to greener and cleaner process. Finally, an optimization study showed that the most effective molar ratio between hydrogen peroxide and double bonds for better selectivity was 4.5 and the need to use the highest possible initial concentration of hydrogen peroxide (approx. 60 weight%).

Catalysts published new progress about Artichoke. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics