Tag: M.W=250-300

Zhou, Jie; Tan, Yong; Wang, Xudong; Zhu, Meihong published the artcile< Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway in vivo>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is TGF-β1/Smads signaling pathway; ovarian fibrosis; paeoniflorin; polycystic ovary syndrome.

Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrine disorders which are involved in complicated and unknown pathogenic mechanisms. Paeoniflorin (PAE) plays a significant anti-fibrotic role according to previous studies. The aim of the present study was to investigate the effect of PAE on ovarian fibrosis and its underlying mechanism in PCOS development. An animal model of PCOS was established by s.c. injection of 60mg/kg/d dehydroepiandrosterone (DHEA) for 35 consecutive days. Rats in PAE-L, PAE-M and PAE-H groups were administrated by gavage with PAE (20, 40, 80 mg/kg/d) for 4 wk. Our results indicated that DHEA-induced PCOS rats showed similar phenotypes with PCOS patients. PAE could significantly block the DHEA-induced decline of ovary weight and organ coefficient, shorten the prolonged diestrus period, and regulate the irregular estrous cycle of PCOS rats. Moreover, PAE regulated reproductive hormone levels and improved ovarian fibrosis induced by DHEA. PAE treatment could also reduce the expression levels of TGF-β1 and Smad3, and increase the expression levels of Smad7 and MMP2. In conclusion, PAE significantly attenuated the ovarian fibrosis in PCOS, which could be mediated by TGF-β1/Smads signaling pathway. Herein, PAE can be used for the treatment of ovarian fibrosis in PCOS progression.

Aging published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Climans, Seth A.; Mason, Warren P.; Grunfeld, Eva; Chan, Kelvin published the artcile< Clinical features of glioma patients who develop pneumocystis pneumonia with temozolomide chemoradiotherapy>, Electric Literature of 112-63-0, the main research area is Glioma; Pneumocystis pneumonia; Temozolomide.

Abstract: Introduction: The treatment of glioma with temozolomide chemoradiotherapy predisposes patients to pneumocystis pneumonia (PCP). Because PCP is a rare outcome, very little is known about specific clin. risk factors for its development in patients with glioma. Methods: We performed a population-based retrospective cohort study of glioma patients undergoing temozolomide chemoradiotherapy 2005 to 2019 in Ontario, Canada. We compared clin. features of patients who did not vs. did develop PCP within one year of chemoradiotherapy. We examined the overall survival of patients by PCP status. Results: There were 5130 patients with glioma treated with temozolomide chemoradiotherapy. Ultimately, 38 patients (0.74%) were diagnosed with PCP within 1 yr of chemoradiotherapy. Most (71%) infections occurred between 0-90 days and 29% occurred between 91-365 days. Median survival was 12.3 mo in patients who did not develop PCP and 8.6 mo in those who did develop PCP (P < 0.001). Trough 90-day lymphocyte counts were lower in the PCP group. When the lymphocytes fell below 0.19 x 109/L (or 0.25 x 109/L among patients without PCP prophylaxis), the risk of PCP was > 3.5%. Conclusions: Pneumocystis pneumonia is rare in glioma patients who receive temozolomide chemoradiotherapy. Infection is associated with shorter survival and the development of lymphopenia. Reserving PCP prophylaxis for patients whose lymphocyte counts drop below 0.25 x 109/L may be a reasonable strategy.

Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Song; Liu, Na; Ding, Wei; Pang, Xiaoyan; Ding, Zhiwen; Chen, Yongfang published the artcile< Graphene oxide modified waterborne polyurethane-based dye with high color-fastness performance>, COA of Formula: C19H34O2, the main research area is graphene oxide waterborne polyurethane dye color fastness.

Graphene oxide (GO) was incorporated into waterborne polyurethane-based polymeric dyes to prepare GO modified polymeric dyes for further improving the performances of waterborne polyurethane-based dyes. Structure properties of the prepared polymeric dyes were analyzed using FTIR and UV-Vis spectrophotometers. The fastnesses to dry-wet rubbing, thermal migration, light, and the mech. properties of the GO modified polymeric dye films were further investigated. The introduction of GO might lower the tensile strength and the elongation at break of polymeric dye films. Meanwhile, the color of modified polymeric dye films turned to be darker as the GO dosage increased. Moreover, most of the above-mentioned properties could be enhanced considerably. In particular, the dry-wet rubbing and thermal migration fastness of modified polymeric dye films could be enhanced up to grade 5. This suggests that the GO modified waterborne polyurethane-based dye has the potential to be used in leather finishing coloring with high performance.

Journal of Applied Polymer Science published new progress about Color. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smith, Hilton A.; Scrogham, Kenneth G.; Stump, Billy L. published the artcile< The kinetics of the acid-catalyzed hydrolysis of the methyl esters of cyclohexanedicarboxylic acids>, Formula: C19H34O2, the main research area is .

Isomeric cyclohexane dicarboxylic acids (I) were made by reduction of phthalic acids: cis-1,2 (II), m. 194°; trans-1,2 (III), m. 227.5-9.4°; cis-1,3 (IV), m. 167.2-8.2°; cis-1,4 (V), m. 170-2°; and trans-1,4 (VI), m. 312-13°. Di-Me esters made by acid-catalyzed esterification with MeOH were: II, b12 124.4°; III, m. 30.2-30.8°; V, b10 131°; and VI, m. 69°. IV di-Me ester, b10 130.6°, was made from the Ag salt and MeI, whereas trans-1,3-di-Me ester (VII), b20 140°, was made from H and 1,3-C6H4(CO2Me)2 with Adams Pt catalyst. Mono-Me derivative of II, m. 68.5-9.0°, was made similarly from 2-HO2CC6H4CO2Me and H. Mono-Me derivative of III, m. 94.5-95°, was made from the acid and MeOH. Mono-Me derivative of IV, m. 66.2-7.0°, was made from the acid chloride and MeOH. By treatment of the di-Me esters with 1 equivalent KOH, mono-Me derivative of V, m. 106.6-8.6°, mono-Me derivative of VI, m. 125.6-6.8°, and mono-Me derivative of trans-1,3-I were prepared Acid-catalyzed rate constants for these esters were determined at 25°, 35°, 45°, and 55° and the heats of activation calculated Me and di-Me esters of II and III hydrolyzed most slowly, those of IV and VI most rapidly, and those of V and VII at an intermediate rate.

Journal of Organic Chemistry published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ren, Linjing; Ran, Maogang; Fang, Xuehong; Zhao, Ling; Yao, Qiuli published the artcile< An efficient synthesis of 1-arylvinylphosphonates via direct functionalization of C(sp3)-H bond>, Category: esters-buliding-blocks, the main research area is phosphonate arylvinyl preparation green chem; green chem tetrabutylammonium iodide catalyst benzylic phosphonate paraformaldehyde reaction.

The direct functionalization of the C(sp3)-H bond adjacent to the phosphonate group for the preparation of vinyl phosphonates was rarely developed. Herein, a simple and efficient tetrabutylammonium iodide catalyzed protocol for the preparation of vinyl phosphonates from benzylic phosphonates and paraformaldehyde is achieved under mild conditions in air. Moderate to high yields can be obtained for a broad scope of substrates.

Youji Huaxue published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strelyaeva, Angelina V.; Larina, Olga A.; Antsyshkina, Alla M.; Kuznetsov, Roman M.; Bondar, Alina A.; Sorokin, Vladimir A. published the artcile< The study of external signs, microscopy and chemical composition of medicinal plant materials of Verinica beccabunga L. Herb>, HPLC of Formula: 112-63-0, the main research area is external sign microscopy chem composition Verinica beccabunga.

Veronica beccabunga L. belongs to the class dicotyledons, order Lamiáles, family Scrophulariaceae. Representatives of the genus Veronica have long been used in folk medicine as antiinflammatory, antibacterial, antiseptic, wound healing, hemostatic, choleretic and antispasmodic drugs. Widely studied species are Veronica officinalis and Veronica chamaedrys. Veronica beccabunga L., which is the object of our study, remains a poorly studied plant. The study of external signs, microscopy and chem. composition of medicinal plant materials of Veronica beccabunga L. herb. Chromato-mass spectrometry was used in the work. When describing external signs and microscopy, diagnostic signs of Veronica beccabunga were revealed. 27 compounds were identified by chromatog.-mass spectrometry. The maximum content falls on: Citronellol epoxide (R or S) (30.5%), Linolenic acid, Et ester (15.18), Di-Et succinate (12.17%), Et palmitate (6.43%), Phytol (4.89%), Acetaldehyde Et amyl acetal (3.94%), Dibenzylamine (3.01%), Oleamide (2.77%), 2-(1-Methylbutyl)oxirane (2.7%), Bu octyl phthalate(1.7%), Et 10-bromodecanoate (1.68), Valeric acid, 4-methyl-, Et ester (1.58), Glycoside detected : 1-Benzyl-1H-benzimidazole 3-oxide (0.76%). The revealed morphol. and anatomical signs of Veronica beccabunga herb can be used to diagnose this species and develop authenticity indicators for promising medicinal herbs. 27 compounds were identified by chromatographymass spectrometry. Using the method of simple normalization, the relative percentage of identified compounds was determined

Pharmacognosy Journal published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kandil, Heba; El-Sawy, Eslam R.; Awad, Hanem M.; E. El. Nashar, Doaa; Amin, Amal published the artcile< RAFT Terminated Hyperbranched Functionalized Nano Rice Husk Powder / EPDM Nanocomposite for Biomedical Applications>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polymer modified rice husk EPDM nanocomposite cytotoxicity.

Modified nanosize rice husk powder (i.e. mod.nRHP; mod.nRHP-MA-RAFT-H)/ethylene propylene diene monomer (EPDM) nanocomposite was prepared by solvent casting method. The surface of nano rice husk (n-RHP) was treated with maleic anhydride (MA) to yield n-RHP-MA, then, aliphatic hyperbranched polyester (H) was end capped with RAFT agent to obtain H-RAFT. Afterward, H-RAFT-was successfully anchored onto nRHP-MA via RAFT polymerization technique to afford nRHP-MA-RAFT-H (mod.nRHP). The mech. and thermal properties were studied for nRHP-MA-RAFT-H (mod.nRHP)/EPDM nanocomposite with different loadings of mod.nRHP. The cytotoxicity activities of the prepared mod.nRHP/EPDM nanocomposites were investigated toward human cell lines in vitro.

Polymer-Plastics Technology and Materials published new progress about Adhesion, physical, interfacial. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qiu-yan; Huang, Jin-lin; Hou, Hai-sheng; Chen, Shao-chuan published the artcile< Influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance>, Category: esters-buliding-blocks, the main research area is hypertension impaired glucose tolerance endothelin enhanced external counterpulsation.

The effects of enhanced external counterpulsation (EECP) on the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance (IGT) were explored. Eighty hypertensive patients complicated by IGT were divided into treatment group (n = 44, conventional treatment + EECP) and control group (n = 36, conventional treatment). Both groups received conventional antihypertensive treatment, but EECP was added in the treatment group based on the conventional treatment. Blood pressure, pulse wave velocity, endothelin (ET) and nitric oxide (NO) were measured and compared between groups. Blood pressure in the two groups after treatment was dramatically reduced, but there was no significant difference between groups. The ba PWV of patients in treatment group (1602±214) vs. (1890±251) cm/s and control group (1704±221) vs. (1893±243) cm/s after treatment decreased significantly. The ET level of patients in the treatment group (63±21) vs. (90±24) ng/L and control group (75±20) vs. (90±24) ng/L also decreased significantly after treatment. However, NO level of patients in treatment group (79±17) vs. (51±19) mmol/L and control group (68±17) vs. (51±18) μmol/L increased significantly after treatment. However, the ba PWV, ET and NO of patients in treatment group improved more significantly compared with those in the control group. Enhanced external counterpulsation can improve the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance.

Xinzang Zazhi published new progress about Blood triglycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recinella, Lucia; Chiavaroli, Annalisa; Masciulli, Fabrizio; Fraschetti, Caterina; Filippi, Antonello; Cesa, Stefania; Cairone, Francesco; Gorica, Era; De Leo, Marinella; Braca, Alessandra; Martelli, Alma; Calderone, Vincenzo; Orlando, Giustino; Ferrante, Claudio; Menghini, Luigi; Di Simone, Simonetta Cristina; Veschi, Serena; Cama, Alessandro; Brunetti, Luigi; Leone, Sheila published the artcile< Protective Effects Induced by a Hydroalcoholic Allium sativum Extract in Isolated Mouse Heart>, Synthetic Route of 112-63-0, the main research area is ethanol eugenol Allium cardioprotective agent PGE2 COX2 oxidative stress; CIEL*a*b*; HS-SPME/GC–MS; bioinformatics; garlic; inflammation; multimethodological evaluation; oxidative stress.

The aim of the present study was to investigate the possible protective effects of a garlic hydroalcoholic extract on the burden of oxidative stress and inflammation occurring on mouse heart specimens exposed to E. coli lipopolysaccharide (LPS), which is a well-established inflammatory stimulus. Headspace solid-phase microextraction combined with the gas chromatog.-mass spectrometry (HS-SPME/GC-MS) technique was applied to determine the volatile fraction of the garlic powder, and the HS-SPME conditions were optimized for each of the most representative classes of compounds CIEL*a*b* colorimetric analyses were performed on the powder sample at the time of delivery, after four and after eight months of storage at room temperature in the dark, to evaluate the color changing. Freshly prepared hydroalcoholic extract was also evaluated in its color character. Furthermore, the hydroalcoholic extract was analyzed through GC-MS. The extract was found to be able to significantly inhibit LPS-induced prostaglandin (PG) E2 and 8-iso-PGF2α levels, as well as mRNA levels of cyclooxygenase (COX)-2, interleukin (IL)-6, and nuclear factor-kB (NF-kB), in heart specimens. Concluding, our findings showed that the garlic hydroalcoholic extract exhibited cardioprotective effects on multiple inflammatory and oxidative stress pathways.

Nutrients published new progress about Allium sativum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Kong Mun; Ng, Seik Weng published the artcile< Di-μ-hydroxido-bis[bromidodi-p-tolyltin(IV)]>, SDS of cas: 112-63-0, the main research area is crystal structure tin tolyl bromo hydroxo dinuclear complex; mol structure tin tolyl bromo hydroxo dinuclear complex; hydrogen bond tin tolyl bromo hydroxo dinuclear complex.

The Sn atoms in dinuclear di-μ-hydroxo-bis[bromodi-p-tolyltin], [Sn2Br2(C7H7)4(OH)2], exist in distorted trigonal-bipyramidal BrSnC2O2 coordination geometries. Each of the 2 independent dinuclear mols. comprising the asym. unit is disposed about a center of inversion. In the crystal, mols. are linked by an O-H···H bond. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics