Tag: M.W=250-300

Leng, Haijun; Zhao, Qian; Mao, Qing; Liu, Shuaijiang; Luo, Menglan; Qin, Rui; Huang, Wei; Zhan, Gu published the artcile< NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles>, HPLC of Formula: 112-63-0, the main research area is spirocyclopentaneoxindole preparation diastereo enantioselective solvent controlled stereodivergent NHC catalyst; oxindole unsaturated aldehyde Michael retro aldol tandem reaction.

An N-heterocyclic carbene (NHC)-catalyzed retro-aldol/aldol cascade reaction of spirooxindole-based β-hydroxyaldehydes has been developed. The ring opening-closure process enables the diastereodivergent synthesis of spirocyclopentaneoxindole products I (R’ = Bn, allyl; R1 = H, 5-Me, 6-Br, etc.; R2 = C6H5, 4-MeC6H4, 4-FC6H4; R3 = C6H5, 4-MeC6H4, 3-FC6H4, etc.) and II with four consecutive stereocenters by simply changing the reaction solvents (THF or DCE). The Michael/aldol/retro-aldol/aldol sequential protocol allows the diastereodivergent synthesis of spirocyclopentaneoxindoles from 3-substituted oxindoles and α,β-unsaturated aldehydes under the relay catalysis of a chiral secondary amine and an NHC catalyst. Moreover, four stereoisomers of the product can be selectively provided by using different combinations of a chiral secondary amine and a solvent.

Chinese Chemical Letters published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Kai; Li, Hong; Li, Xingang; Han, Wentao; Guo, Chunkai; Gao, Xin published the artcile< Inter-integration reactive distillation with vapor permeation for ethyl levulinate production: Modeling, process analysis and design>, Product Details of C19H34O2, the main research area is reactive vapor permeation distillation ethyl levulinate production modeling design.

The reactive-vapor permeation-distillation (R-VP-D) hybrid configuration is a newly designed inter-integration concept firstly proposed for the production of Et levulinate (EL) by esterification of ethanol and levulinic acid in this paper. In the R-VP-D configuration, the VP membrane module is inserted to the reaction section of the reactive distillation (RD) column, of which the product water is in-situ removed by the vapor permeation (VP) to promote the performance of esterification RD process. The proposed R-VP-D configuration is modeled by Aspen Plus V8.4 using the two-dimensional VP model built in ACM, and the inserting position of single or double VP modules is found by contrast trials, where both the conversion rate and purity of product can reach the industrial production standards As a result, the proposed novel R-VP-D configuration is feasible, with > 21.6% and 31.4% reduction in total annual cost and total duty as compared to the configuration which only applies an extra distillation column to separation and recycle the excess ethanol without azeotrope separation, and with 13.5 and 21.5% reduction in TAC and total duty as compared to the hybrid configuration where the vapor permeation is coupled outside the RD column. The result also shows the advantage of the proposed R-VP-D process for potentially leading to the development of new integration processes and applications.

Chemical Engineering Science published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Murray, Michael; Roseblade, Ariane; Chen, Yongjuan; Bourget, Kirsi; Rawling, Tristan published the artcile< Carbon Chain Length Modulates MDA-MB-231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl-Urea Fatty Acids>, Electric Literature of 112-63-0, the main research area is aryl urea fatty acid preparation structure breast cancer mitochondrion; antitumor agents; apoptosis; breast cancer; fatty acids; lipid drugs.

Targeting the tumor cell mitochondrion could produce novel anticancer agents. We designed an aryl-urea fatty acid (1 g; 16({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid) that disrupted the mitochondrion and decreased MDA-MB-231 breast cancer cell viability. To optimize the aryl-ureas the present study evaluated mitochondrial targeting by 1 g analogs containing alkyl chains between 10-17 carbons. Using the dye JC-1, the C12-C17 analogs efficiently disrupted the mitochondrial membrane potential (IC50s 3.5±1.2 to 7.6±1.1μM) and impaired ATP production; shorter analogs were less active. 7-Aminoactinomycin D/annexin V staining and flow cytometry showed that these agents activated the killing mechanisms of necrosis and apoptosis to varying extents (7-aminoactinomycin D/annexin V staining ratios 4.3-6.0). Indeed, 1 g and its C17 analog preferentially activated necrosis and apoptosis, resp. (ratios 2.1 and 16). Taken together, alkyl chain length is a determinant of mitochondrial targeting by aryl-ureas and can be varied to develop analogs that activate apoptosis or necrosis in a regulated fashion.

ChemMedChem published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shahabuddin, Mohammad; Akutsu, Akira; Kimura, Takao; Karikomi, Michinori published the artcile< Synthesis of Helical Quinone Derivatives by Oxidative Coupling of Substituted 2-Hydroxybenzo[c]phenanthrenes>, Product Details of C19H34O2, the main research area is crystal mol structure bibenzo phenanthrylidene dione; hydroxybenzo phenanthrene electrocyclization oxidative aromatization coupling; helical quinone preparation electrocyclization oxidative aromatization coupling.

A concise synthesis of novel substituted quinone derivatives from com. available starting materials was developed. For this synthesis, classical photo-induced 6π-electrocyclization was utilized, followed by oxidative aromatization reaction, and subsequent oxidative coupling reactions in the presence of CuCl(OH)-TMEDA. The unique quinone derivatives were characterized by IR, 1H, and 13C NMR spectroscopies, and mass spectroscopic data anal. In some cases, the keto dimers were obtained as significant intermediates for the quinone synthesis.

Synthesis published new progress about Aromatization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shekari, Nafiseh; Vosough, Maryam; Tabar Heidar, Kourosh published the artcile< Chromatographic fingerprinting through chemometric techniques for herbal slimming pills: A way of adulterant identification>, HPLC of Formula: 112-63-0, the main research area is sibutramine amfepramone caffeine herbal slimming pill adulterant GC MS; Adulteration; Fingerprinting; GC–MS; Herbal slimming pills; MCR-ALS.

In the current study, gas chromatog.-mass spectrometry (GC-MS) fingerprinting of herbal slimming pills assisted by chemometric methods has been presented. Deconvolution of two-way chromatog. signals of nine herbal slimming pills into pure chromatog. and spectral patterns was performed. The peak clusters were resolved using multivariate curve resolution-alternating least squares (MCR-ALS) by employing appropriate constraints. It was revealed that more useful chem. information about the composition of the slimming pills can be obtained by employing sophisticated GC-MS method coupled with proper chemometric tools yielding the extended number of identified constituents. The thorough fingerprinting of the complex mixtures proved the presence of some toxic or carcinogen components, such as toluene, furfural, furfuryl alc., styrene, itaconic anhydride, citraconic anhydride, tri-Me phosphate, phenol, pyrocatechol, p-propenylanisole and pyrogallol. In addition, some samples were shown to be adulterated with undeclared ingredients, including stimulants, anorexiant and laxatives such as phenolphthalein, amfepramone, caffeine and sibutramine.

Forensic Science International published new progress about Adulterants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nowak, Anna; Cybulska, Krystyna; Makuch, Edyta; Kucharski, Lukasz; Rozewicka-Czabanska, Monika; Prowans, Piotr; Czapla, Norbert; Bargiel, Piotr; Petriczko, Jan; Klimowicz, Adam published the artcile< In vitro human skin penetration, antioxidant and antimicrobial activity of ethanol-water extract of fireweed (Epilobium angustifolium L.)>, Formula: C19H34O2, the main research area is ethanol water human skin penetration antioxidant antimicrobial activity extract; Franz cell; antibacterial activity; antioxidants; herbal extract; phenolic acids; skin.

Epilobium angustifolium L. is applied as an antiseptic agent in the treatment of skin diseases. However, there is a lack of information on human skin penetration of active ingredients with antioxidative potential. It seems crucial because bacterial infections of skin and s.c. tissue are common and partly depend on oxidative stress. Therefore, we evaluated in vitro human skin penetration of fireweed ethanol-water extracts (FEEs) by determining antioxidant activity of these extracts before and after penetration study using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Folin-Ciocalteu methods. Microbiol. tests of extracts were done. The qual. and quant. evaluation was performed using gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC-UV) methods. The in vitro human skin penetration using the Franz diffusion chamber was assessed. The high antioxidant activity of FEEs was found. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), and caffeic acid (CA) were identified in the extracts The antibacterial activities were found against Serratia lutea, S. marcescens, Bacillus subtilis, B. pseudomycoides, and B. thuringiensis and next Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and P. fluorescens strains. In vitro penetration studies showed the penetration of some phenolic acids and their accumulation in the skin. Our results confirm the importance of skin penetration studies to guarantee the efficacy of formulations containing E. angustifolium extracts

Molecules published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lakouraj, Moslem M.; Ghodrati, Keivan published the artcile< A facile and convenient method for the conversion of thioamides into amides using pyridinium hydrobromide perbromide>, Computed Properties of 112-63-0, the main research area is thioamide oxidation pyridinium hydrobromide perbromide; amide preparation.

Selective transformation of thioamides to their corresponding carbonyl compounds are performed in high to excellent yields under mild conditions using pyridinium hydrobromide perbromide as a mild and efficient reagent.

Monatshefte fuer Chemie published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussain, Nazar; Babu Tatina, Madhu; Mukherjee, Debaraj published the artcile< Cross dehydrogenative coupling of sugar enol ethers with terminal alkenes in the synthesis of pseudo-disaccharides, chiral oxadecalins and a conjugated triene>, Synthetic Route of 4098-06-0, the main research area is Diels Alder cycloaddition oxadecalin stereoselective dehydrogenative coupling disaccharide; maleic anhydride cycloaddition oxadecalin stereoselective dehydrogenative coupling disaccharide preparation; oxadecalin disaccharide dehydrogenative stereoselective coupling alkene triene.

An efficient strategy for the synthesis of C-2 and C-3 branched sugar dienes via cross dehydrogenative coupling of sugar enol ethers with terminal alkenes was developed. Both pyran and furan based enol ethers coupled smoothly with electron rich as well as deficient alkene sources yielding sugar dienes with complete E-stereoselectivity. This coupling reaction was applied successfully for the synthesis of orthogonally protected pseudo-C-saccharides as an alternative to olefin metathesis. Substrate scope was further enhanced by reacting exo-glycals with Me acrylate to generate C-5 branched sugars with moderate diastereoselectivity. These diene subunits were reacted with maleic anhydride under [4+2] cycloaddition conditions to generate highly functionalized chiral oxadecalin cores. Finally, utilizing this C-C bond formation, a sugar based conjugated triene was synthesized in excellent yield and selectivity.

Organic & Biomolecular Chemistry published new progress about Coupling reaction. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Aline M.; Yang, Ethan; Smith, Matthew D.; Chu, Chengyan; Calabresi, Peter A.; Glunde, Kristine; van Zijl, Peter C. M.; Bulte, Jeff W. M. published the artcile< CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice>, Synthetic Route of 112-63-0, the main research area is CEST MRI MALDI imaging cervical lymph node metabolic alteration; CEST MRI; Lymph nodes; Multiple sclerosis; Neuroinflammation.

Multiple sclerosis (MS) is a neurodegenerative disease, wherein aberrant immune cells target myelin-ensheathed nerves. Conventional magnetic resonance imaging (MRI) can be performed to monitor damage to the central nervous system that results from previous inflammation; however, these imaging biomarkers are not necessarily indicative of active, progressive stages of the disease. The immune cells responsible for MS are first activated and sensitized to myelin in lymph nodes (LNs). Here, we present a new strategy for monitoring active disease activity in MS, chem. exchange saturation transfer (CEST) MRI of LNs. We studied the potential utility of conventional (T2-weighted) and CEST MRI to monitor changes in these LNs during disease progression in an exptl. autoimmune encephalomyelitis (EAE) model. We found CEST signal changes corresponded temporally with disease activity. CEST signals at the 3.2 ppm frequency during the active stage of EAE correlated significantly with the cellular (flow cytometry) and metabolic (mass spectrometry imaging) composition of the LNs, as well as immune cell infiltration into brain and spinal cord tissue. Correlating primary metabolites as identified by matrix-assisted laser desorption/ionization (MALDI) imaging included alanine, lactate, leucine, malate, and phenylalanine. Taken together, we demonstrate the utility of CEST MRI signal changes in superficial cervical LNs as a complementary imaging biomarker for monitoring disease activity in MS. CEST MRI biomarkers corresponded to disease activity, correlated with immune activation (surface markers, antigen-stimulated proliferation), and correlated with LN metabolite levels.

Journal of Neuroinflammation published new progress about Antigen-presenting cell. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Chengke; Hu, Zhenhua; Shi, Lanlan; Wang, Chen; Yue, Fengxia; Li, Suxiang; Zhang, Han; Lu, Fachuang published the artcile< Profiling of the formation of lignin-derived monomers and dimers from Eucalyptus alkali lignin>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Eucalyptus alkali lignin monomer dimer fraction chem pulping.

Lignin is a renewable and the most abundant aromatic source that can be used for extensive chems. and materials. Although approx. 50 million tons of lignin are produced annually as a byproduct of the pulp and paper industry, it is currently underutilized. It is important to know the structural features of tech. lignin when considering its application. In this work, we have demonstrated the formation of low-mol.-weight constituents from hardwood (Eucalyptus) lignin, which produces much more low-mol.-weight constituents than softwood (spruce) lignin, after a chem. pulping process, and analyzed the micromol. compositions in the alkali lignin after fractionation by dichloromethane (DCM) extraction By applying anal. methods (gel-permeation chromatog., 2D NMR and GC-MS) with the aid of evidence from authenticated compounds, a great treasure trove of lignin-derived phenolic compounds from Eucalyptus alkali lignin were disclosed. Except for some common monomeric products, as many as 15 new lignin-derived monomers and dimers including syringaglycerol, diarylmethane, 1,2-diarylethanes, 1,2-diarylethenes, (arylvinyl ether)-linked arylglycerol dimers and isomeric syringaresinols were identified in the DCM-soluble fraction. Regarding the formation and evolution of the Cα-condensed β-aryl ether structure, a novel route that is potentially responsible for the high content of β-1 diarylethenes and diarylethanes in the lignin low-mol.-weight fraction, in addition to the β-1 (spirodienone) pathway, was proposed. This work not only provides novel insights into the chem. transformation of S-G lignin during the alkali pulping process, but also discovered lignin-derived phenolic monomers and dimers that can potentially be used as raw materials in the chem. or pharmaceutical industries.

Green Chemistry published new progress about Bond energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics