Tag: M.W=250-300

Chernov, Alexandr N.; Tsapieva, Anna; Alaverdian, Diana A.; Filatenkova, Tatiana A.; Galimova, Elvira S.; Suvorova, Mariia; Shamova, Olga V.; Suvorov, Alexander N. published the artcile< In Vitro Evaluation of the Cytotoxic Effect of Streptococcus pyogenes Strains, Protegrin PG-1, Cathelicidin LL-37, Nerve Growth Factor and Chemotherapy on the C6 Glioma Cell Line>, Application In Synthesis of 112-63-0, the main research area is anticancer PG1 LL37 NGF chemotherapy cytotoxicity Streptococcus glioma; LL-37; MTT assay; NGF; PG-1; Streptococcus pyogenes; cathelicidin family peptides; chemotherapy; cytotoxicity; glioma C6; human normal fibroblasts; real-time xCELLigence system; trypan blue assay.

Brain cancer treatment, where glioblastoma represents up to 50% of all CNS malignancies, is one of the most challenging calls for neurooncologists. The major driver of this study was a search for new approaches for the treatment of glioblastoma. We tested live S. pyogenes, cathelicidin family peptides and NGF, assessing the oncolytic activity of these compounds as monotherapy or in combination with chemotherapeutics. For cytotoxicity evaluation, we used the MTT assay, trypan blue assay and the xCELLigence system. To evaluate the safety of the studied therapeutic approaches, we performed experiments on normal human fibroblasts. Streptococci and peptides demonstrated high antitumor efficiency against glioma C6 cells in all assays applied, surpassing the effect of chemotherapeutics (doxorubicin, carboplatin, cisplatin, etoposide). A real-time cytotoxicity anal. showed that the cell viability index dropped to 21% 2-5 h after S. pyogenes strain exposure. It was shown that LL-37, PG-1 and NGF also exhibited strong antitumor effects on C6 glioma cells when applied at less than 10-4 M. Synergistic effects for combinations of PG-1 with carboplatin and LL-37 with etoposide were shown. Combinations of S. pyogenes strain #7 with NGF or LL-37 demonstrated a cytotoxic effect (56.7% and 57.3%, accordingly) on C6 glioma cells after 3 h of exposure.

Molecules published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saini, Nipun; Virdee, Manjot S.; Helfrich, Kaylee K.; Kwan, Sze Ting Cecilia; Mooney, Sandra M.; Smith, Susan M. published the artcile< Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders>, Reference of 112-63-0, the main research area is FASD maternal hepatic glucose amino acid metabolome analysis; amino acids; fetal weight; gluconeogenesis; glucose; hepatic metabolism; maternal–fetal metabolism; pregnancy; prenatal alcohol exposure; untargeted metabolomics.

Prenatal alc. exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alc. (ALC) revealed that the hepatic metabolome of ALC and control (CON) dams were distinct, whereas that of ALC and CON fetuses were similar. Alc. reduced maternal hepatic glucose content and enriched essential amino acid (AA) catabolites, N-acetylated AA products, urea content, and free fatty acids. These alterations suggest an attempt to minimize the glucose gap by increasing gluconeogenesis using AA and glycerol. In contrast, ALC fetuses had unchanged glucose and AA levels, suggesting an adequate draw of maternal nutrients, despite intensified stress on ALC dams. Maternal metabolites including glycolytic intermediates, AA catabolites, urea, and one-carbon-related metabolites correlated with fetal liver and brain weights, whereas lipid metabolites correlated with fetal body weight, indicating they may be drivers of fetal weight outcomes. Together, these data suggest that ALC alters maternal hepatic metabolic activity to limit glucose availability, thereby switching to alternate energy sources to meet the high-energy demands of pregnancy. Their correlation with fetal phenotypic outcomes indicates the influence of maternal metabolism on fetal growth and development.

Nutrients published new progress about Alcohols Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hsu, Day-Shin; Liang, Suz-Ping published the artcile< NHC-Mediated Synthesis of Tricyclic Spirocarbocycles via an Intramolecular Stetter Reaction of Cyclic Enal-Enones>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tricyclic spirocarbocycle preparation; cyclic enal enone intramol Stetter reaction nitrogen heterocyclic carbene.

A general and efficient method for the synthesis of tricyclic spirocarbocycles is described. Various cyclic enal-enones were reacted with an N-heterocyclic carbene and an intramol. Stetter reaction proceeded smoothly to give various tricyclic spiro-1,4-diketones in 31-72% yields. The ring size of the spiro compounds can be easily controlled using different cyclic enals and enones, or by altering the length of the carbon tether.

Journal of Organic Chemistry published new progress about Diketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Haiping; Zhai, Wanchen; Sun, Ke; Zhu, Yunwen; Zhou, Hongli; Wan, Peng published the artcile< Chemical composition and potential bioactivities of essential oil from Quercus mongolica bark>, SDS of cas: 112-63-0, the main research area is Quercus bark essential oil pentadecanoic acid antioxidant anticoagulant.

The chem. composition and potential bioactivities of essential oil from Quercus mongolica bark (EOQMB) were researched for value-added utilization processing byproduct. The results of gas chromatog.-mass spectrometry (GC-MS) anal. showed that 30 components accounting for 98.42% were identified in EOQMB, with pentadecanoic acid the most abundant compound accounting for 34.90%, which was further confirmed by the Fourier transform IR observation. EOQMB exerts antioxidant activities, and the IC50 values for scavenging DPPH radical, ABTS radical, and hydroxyl radical were 8.48, 0.77, and 3.54 mg/mL, resp. The effects of EOQMB on prolonging activated partial thromboplastin time and thrombin time and on decreasing fibrinogen are similar to those of heparin, and the promising anticoagulant activities of EOQMB could be largely contributed by pentadecanoic acid. Herein, the present study uncovered that the waste Q. mongolica bark can serve as a new potential material in pharmaceutical products.

Arabian Journal of Chemistry published new progress about Anticoagulants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Liu; Lu, Pingan; Qu, Song published the artcile< Commentary: Kinesin Family Member C1 Increases Resistance of Glioblastoma to Temozolomide Through Promoting DNA Damage Repair.>, Application of C19H34O2, the main research area is DNA-PK; KIFC1; chemoresistance; neoplasms; normal tissue toxicity.

There is no abstract available for this document.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Carol Sze Ki; Kirpluks, Mikelis; Priya, Anshu; Kaur, Guneet published the artcile< Conversion of food waste-derived lipid to bio-based polyurethane foam>, Formula: C19H34O2, the main research area is polyurethane foam lipid food waste.

Food waste contains complex nutrients such as carbohydrates, fats, proteins which could be broken down into simpler substrates such as sugars (e.g., glucose), lipids and proteins (e.g., free amino nitrogen). These components can be used for conversion into useful bio-based products such as chems., materials and fuels. This research aimed at the development of bio-based polyurethane (PU) materials using food waste-derived lipids. Since the quality of lipid plays an important role in polyol synthesis, optimal extraction procedures were developed to select the most appropriate method for polyol synthesis. From obtained lipids, two polyol synthesis methods were used, lipid transamidation with diethanolamine (DEOA or DEA) and lipid epoxidation and subsequent epoxy ring opening with trimethylolpropane. Bio-polyol obtained in transamidation reaction was used to obtain rigid PU foams with three different isocyanate indexes of 130; 150 and 200 while bio-polyol form epoxy ring opening was used to obtain rigid PU foams with an isocyanate index of 150. The initial formulations were suitable to produce good quality rigid PU foam samples at a laboratory scale. The resultant rigid PU foams are promising for further studies and development of thermal insulation materials.

Case Studies in Chemical and Environmental Engineering published new progress about Enzymic hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guemues, Selcuk; Tuerker, Lemi published the artcile< Substituent effect on the aromaticity of 1,3-azole systems>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxazole imidazole thiazole substituent effect aromaticity.

The effects of substituent type and position on the aromaticity of certain derivatives of oxazole, imidazole and thiazole have been theor. investigated by using d. functional theory at the levels of B3LYP/6-31G(d,p) and B3LYP/6-31++G(d,p) methods. The second heteroatom substitution decreased aromaticity of furan, pyrrole and thiophene. The decreased aromaticity was gained back to some extent by the substitution of strong electron withdrawing groups or atoms (NO2 and F). Nucleus-independent chem. shift (NICS) data have been considered to determine the aromaticity of the systems. The most effective substitution to enhance the aromaticity has been calculated to be at position 4. The variation of the bond lengths of the main skeleton supported the findings through NICS calculations The frontier MO energies have also been reported to draw a general correlation between these energies and the aromaticity of the system.

Heterocyclic Communications published new progress about Aromaticity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhavani, R.; Rathinavel, P. published the artcile< Evaluation of phytochemical profile and in vitro antioxidant properties of Terminalia chebula fruits>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Terminalia chebula fruit phytochem antioxidant property.

The fruit of Terminalia chebula have wide applications in folk medicine since ancient times due to the presence of several bioactive compounds This study aims at the anti-oxidant capacity and the screening of phytochems. from the fruits of the T. chebula. Preliminary phytochem. screening of leaf showed the presence of Carbohydrates, protein, steroids, glycosides, tannins, flavonoids, alkaloids, saponin, starch, terpenoids, anthrocyanin, coumarin, phytosterol, glycosides and chalcogens in the different extracts The ethanol, aqueous and chloroform extracts of the fruit were tested for antioxidant activity using scavenging activities of DPPH radical, Nitric oxide, reducing power, hydrogen peroxide and superoxide methods. Among the three different extracts tested, the ethanol extract has registered noticeable effect in all scavenging assays than other extracts tested. The finding suggests that the three different extracts of T. chebula fruit showed different level of antioxidant activity and it is potential source of natural antioxidants.

International Journal of Current Research in Chemistry and Pharmaceutical Sciences published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huynh, Man P.; Hibbard, Bruce E.; Ho, Khanh-Van; Shelby, Kent S. published the artcile< Toxicometabolomic profiling of resistant and susceptible western corn rootworm larvae feeding on Bt maize seedlings>, Product Details of C19H34O2, the main research area is Zea Diabrotica larva seedling toxicometabolomics.

The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, is the most serious pest of maize (Zea mays L.) in the U. S. Corn Belt and parts of Europe. Transgenic maize hybrids expressing at least one of the four currently available insecticidal toxins from Bacillus thuringiensis (Bt) Berliner, currently the most widely adopted control method in continuous maize, have faltered due to the emergence of resistance. The resistance mechanisms of WCR to Bt toxins are not fully understood. We identified metabolic profiles of susceptible and resistant WCR larvae fed on maize hybrids expressing each of three available Cry3 proteins (eCry3Ab1, mCry3A, and Cry3Bb1) targeting corn rootworms and a control non-Bt maize via an untargeted metabolomics approach. Over 580 unique metabolites found in WCR larvae were classified into different pathways (amino acids, carbohydrates, cofactors and vitamins, energy, lipid, nucleotide, peptide, and xenobiotics). By exploring shifts in WCR larval metabolome exclusively by Bt toxins, several candidate metabolites and metabolic pathways were identified in susceptible and resistant larvae that may be involved in defense against or recovery from Bt ingestion by these larvae. These findings would provide mechanistic insights into altered metabolic pathways associated with the resistance mechanisms of WCR to Bt toxins.

Scientific Reports published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yutong; Xie, Jianchun; Zhang, Chenping; Xu, Yuxia; Yang, Xuelian published the artcile< Effect of lipid on formation of Maillard and lipid-Maillard meaty flavor compounds in heated cysteine-xylose-methyl linoleate system>, Application of C19H34O2, the main research area is cysteine xylose methyl linoleate lipid Maillard meaty flavor compound.

The effect of lipid level and reaction temperature and time on the heated cysteine-xylose reaction to form meaty flavors was investigated. The presence of 1% or 2% Me linoleate inhibited the formation of volatile sulfur-containing compounds and heterocyclic compounds via the Maillard reaction, that is Maillard compounds However, the former was better because of the moderate inhibition and more compounds generated from the lipid-Maillard interaction, that is lipid-Maillard compounds Partial least squares-discriminant anal. suggested the lipid-Maillard compounds were the main markers during varying dosage of Me linoleate, reaction temperature (100-140°C) and reaction time (30-180 min). Lower temperatures increased formation of the Maillard compounds (eg, 2-furfurylthiol) or lipid-Maillard compounds (eg, 2-pentylpyridine) with reaction time. However, high temperatures caused their amounts changed in a curve or irregularly due to the complications from the Maillard and lipid oxidization reactions. By comparing time-courses of the levels of cysteine and Cys-Amadori compounds, and 294 and 420 nm UV absorbance values in the reaction systems under 120°C with or without 2% Me linoleate, it was revealed that the underlying lipid effect mechanism was to initially inhibit and later attend the Maillard reaction, leading to less formation of the Maillard compounds and generation of the lipid-Maillard compounds

Flavour and Fragrance Journal published new progress about Heterocyclic compounds Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics