Tag: M.W=150-200

Yao, Zhiyi; Zeng, Xin; Yi, Wei; Jiang, Sheng published the artcile< Stereoselective synthesis of (S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio)hept-4-enoate>, Name: (S)-Dimethyl 2-hydroxysuccinate, the main research area is heptenoate tritylthio hydroxy trimethylsilylethyl preparation stereoselective.

(S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio)hept-4-enoate was synthesized from com. available L-malic acid by the Julia-Kocienski olefination coupling method. This method provides a concise synthetic strategy for (S,E) -3-hydroxy-7-mercaptohept-4-enoic acid.

Letters in Organic Chemistry published new progress about Diastereoselective synthesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Name: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Eric J.; Williams, Andrew C. published the artcile< Development of a synthesis of lankacidins: stereoselective synthesis of the δ-lactone fragment>, Product Details of C6H10O5, the main research area is lankacidin delta lactone stereoselective preparation.

Electrophiles react at C(3) stereoselectivity on the less hindered face of the enolate derived from the 4-substituted azetidinone I to give products in which the new substituent is trans to the (tert-butyldimethylsilyloxymethyl) group at C(4). Aldol addition with 3-(tert-butyldimethylsilyloxy)propanal gave the alcs. II and III, ratio 80:20, which were separated as mixtures of C(1′). Oxidation, followed by exchange of protecting groups, gave the 3-(1′-oxopropyl)azetidinones which, on selective monodesilylation, were converged into the δ-lactones IV and V. The stereochem. of the major δ-lactone IV corresponds to that of the lankacidins at C(2) and C(3).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Paterson, Ian; Anderson, Edward A.; Dalby, Stephen M.; Lim, Jong Ho; Genovino, Julien; Maltas, Philip; Moessner, Christian published the artcile< Total synthesis of spirastrellolide A methyl ester-part 1: synthesis of an advanced C17-C40 bis-spiroacetal subunit>, Synthetic Route of 617-55-0, the main research area is asym synthesis spirastrellolide A methyl ester fragment Suzuki coupling; bis spiroacetal fragment asym synthesis Suzuki coupling.

The marine macrolide spirastrellolide A is a potent and selective inhibitor of protein phosphatase 2A and a lead for anticancer therapies. A flexible and modular synthetic strategy has been developed with two routes for the construction of the DEF bis-spiroacetal subunit I and II. The optimized Suzuki coupling approach results in the efficient preparation of a C17-C40 aldehyde that forms the cornerstone II of the first total synthesis.

Angewandte Chemie, International Edition published new progress about Olefination (Julia olefination). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki published the artcile< Synthesis of thromboxane A2 analogs: DL-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is thromboxane A2 analog; dideoxadiepithiothromboxane A2.

Thromboxane A2(TXA2), one of the major products formed from arachidonic acid, possesses powerful biol. effects, i.e., platelet aggregation and vasoconstriction. In spite of these very important biol. actions, this substance is too unstable to be isolated. Therefore synthesis of the stable TXA2 analogs with potent biol. activities is of great importance in thromboxane research. However, only a few stable analogs of TXA2 have been reported because of its chem. unusual structure. The total synthesis of the stable TXA2 analogs, dl-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2 Me ester (I; R = Me) and the Na salt (I; R = Na), has been achieved starting from (MeO)2CHCOCH2CO2Me. The ester was converted to the key intermediate II in high yield, which was efficiently transformed into the precursor III leading to the main framework, 2,6-dithiabicyclo[3.1.1]heptane, via the compound IV. III was treated with base to afford the desired bicyclic product. The TXA2 analogs thus obtained showed very potent biol. activities.

Journal of the American Chemical Society published new progress about Blood platelet. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seebach, Dieter; Aebi, Johannes; Wasmuth, Daniel published the artcile< Diastereoselective α-alkylation of β-hydroxycarboxylic esters through alkoxide enolates: (+)-diethyl (2S,3R)-3-allyl-2-hydroxysuccinate from (-)-diethyl S-malate (butanedioic acid, 2-hydroxy-3-(2-propenyl)-, diethyl ester, [S-(R,S)])>, Application In Synthesis of 617-55-0, the main research area is diastereoselective alkylation hydroxycarboxylate; alkylation diastereoselective ethyl malate; alkoxide enolate alkylation diastereoselective.

The reaction of di-Et (S)(-)-malate with LiN(CHMe2)2 at -78 to -20° under 100 mm Hg argon pressure, followed by treatment with CH2:CHCH2Br gave 92% u-CH2:CHCH2CH(CO2Et)CH(OH)CO2Et (u-I) and 8% l-I. Similarly prepared were 14 other I analogs.

Organic Syntheses published new progress about Alkylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Murakami, Saeko; Aoki, Nobuyoshi published the artcile< Synthesis and ring-oligomer recovery of an environmentally benign malate-containing polyurethane using enzymatic process>, HPLC of Formula: 617-55-0, the main research area is ring oligomer malate polyurethane enzyme catalyzed polymerization lipase.

Oligo[(hexanediol-L-malate)-co-(hexanediol-succinate)] [oligo(HM-co-HS)] was prepared by the lipase-catalyzed polymerization of di-Me L-malate, di-Me succinate and 1,6-hexanediol in an environmentally benign bioprocess. These monomers can be derived from biomass resources. The contents of free hydroxyl groups in the oligomers was varied by changing the feed ratio of L-malate and succinate. Polyurethanes containing malic acid were synthesized by the reaction of enzymically prepared oligo(HM-co-HS) and hexamethylene diisocyanate. The thermal properties of polyurethanes with different contents of L-malate and succinate were evaluated. Melting was observed for polyurethanes containing the oligomers with less than 20% L-malate. The glass transition temperatures of the polyurethanes increased with increasing contents of L-malate having a free hydroxyl group. The malate-containing polyurethanes were enzymically degraded by lipase and the degradation products exclusively contained cyclic oligomers which may be repolymd.

Kobunshi Ronbunshu published new progress about Biomass. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Daisuke; Kimura, Hiroyuki; Kawashima, Hidekazu; Yagi, Yusuke; Arimitsu, Kenji; Ono, Masahiro; Saji, Hideo published the artcile< Development of 99mTc radiolabeled A85380 derivatives targeting cerebral nicotinic acetylcholine receptor: Novel radiopharmaceutical ligand 99mTc-A-YN-IDA-C4>, Product Details of C6H12ClNO4, the main research area is technetium 99m A85380 derivative preparation cerebral nicotinic receptor; A85380 derivatives; Docking simulation; Nicotinic acetylcholine receptors; Single-photon emission computed tomography; Technetium-99m.

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that have been implicated in higher brain functions. To elucidate the functional mechanisms underlying nAChRs and contribute significantly to development of drugs targeting neurol. and neuropsychiatric diseases, non-invasive nuclear medical imaging can be used for evaluation. In addition, technetium-99m (99mTc) is a versatile radionuclide used clin. as a tracer in single-photon emission computed tomog. Because A85380 is known as a potent α4β2-nAChR agonist, we prepared A85380 derivatives labeled with 99mTc using a bifunctional chelate system. A computational scientific approach was used to design the probe efficiently. We used non-radioactive rhenium (Re) for a 99mTc analog and found that one of the derivatives, Re-A-YN-IDA-C4, exhibited high binding affinity at α4β2-nAChR in both the docking simulation (-19.3 kcal/mol) and binding assay (Ki = 0.4 ± 0.04 nM). Further, 99mTc-A-YN-IDA-C4 was synthesized using microwaves, and its properties were examined Consequently, we found that 99mTc-A-YN-IDA-C4, with a structure optimized by using computational chem. techniques, maintained affinity and selectivity for nAChR in vitro and possessed efficient characteristics as a nuclear medicine mol. imaging probe, demonstrated usefulness of computational scientific approach for mol. improvement strategy.

Bioorganic & Medicinal Chemistry published new progress about Brain. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Product Details of C6H12ClNO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Shiqun; Fan, Weibin; Zhang, Wei; Li, Yinghua; Guo, Shiwei; Huang, Deguang published the artcile< Aqueous CO2 fixation: construction of pyridine skeletons in cooperation with ammonium cations>, Quality Control of 94-02-0, the main research area is pyridine preparation green chem; ketone carbon dioxide cycloaddition.

A simple and green method is explored for the synthesis of fused pyridines e.g., 3,7-dimethyl-10,12-dihydrodiindeno[1,2-b:2′,1′-e]pyridine by [2 + 2 + 1 + 1] the cycloaddition of ketones e.g., 6-methyl-1-indanone with an ammonium cation under a CO2 atmosphere. The reactions employed ammonium cation as a nitrogen source and CO2 gas as a carbon source in an aqueous solution Monoethanolamine (MEA) was used as an additive to increase the solubility of CO2 in an aqueous solution The scope and versatility of the method are demonstrated with examples e.g., 3,7-dimethyl-10,12-dihydrodiindeno[1,2-b:2′,1′-e]pyridine. Products are found to be photosensitive and show potential applications as organic optoelectronic materials. A selectfluor-promoted reaction mechanism is proposed based on the exptl. studies. This work is superior as it is a metal-free system, uses CO2 as a carbon source and MEA as an additive in aqueous synthesis.

Green Chemistry published new progress about Cycloaddition reaction. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Quality Control of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rawal, Viresh H.; Cava, Michael P. published the artcile< Thermolytic removal of tert-butyloxycarbonyl (BOC) protecting group on indoles and pyrroles>, COA of Formula: C8H9NO3, the main research area is butyloxycarbonyl protective group thermolytic removal; pyrrole butoxycarbonyl thermal decomposition; indole butoxycarbonyl thermal deacylation.

The tert-butyloxycarbonyl (BOC) group on indoles and pyrroles can be removed cleanly and in high yield by simple thermolysis: no acid, base or solvent is required. Thus, heating I (R = Me3CO2C) at ∼180° gave 94% I (R = H).

Tetrahedron Letters published new progress about Deacylation. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, COA of Formula: C8H9NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lorenz, Peter; Duckstein, Sarina; Conrad, Juergen; Knoedler, Matthias; Meyer, Ulrich; Stintzing, Florian C. published the artcile< An Approach to the Chemotaxonomic Differentiation of Two European Dog's Mercury Species: Mercurialis annua L. and M. perennis L.>, Reference of 617-55-0, the main research area is chemotaxonomy Mercurialis.

Mercurialis annua and M. perennis are medicinal plants used in complementary medicine. In the present work, anal. methods to allow a chemotaxonomic differentiation of M. annua and M. perennis by means of chem. marker compounds were established. In addition to previously published compounds, the exclusive presence of pyridine-3-carbonitrile and nicotinamide in CH2Cl2 extracts obtained from the herbal parts of M. annua was demonstrated by GC/MS. Notably, pyridine-3-carbonitrile was identified for the first time as a natural product. Further chromatog. separation of the CH2Cl2 extracts via polyamide yielded a MeOH fraction exhibiting a broad spectrum of side-chain saturated n-alkylresorcinols. While the n-alkylresorcinol pattern was similar for both plant species, some specific differences were observed for particular n-alkylresorcinol homologs. Finally, the investigation of H2O extracts by LC/MS/MS revealed the presence of depside constituents. Whereas, in M. perennis, a mixture of mercurialis acid (=(2R)-[(E)-caffeoyl]-2-oxoglutarate) and phaselic acid (=(E)-caffeoyl-2-malate) could be detected, in M. annua solely phaselic acid was found. By comparison with synthesized enantiomerically pure (2R)- and (2S)-phaselic acids, the configuration of the depside could be determined as (2S) in M. annua and as (2R) in M. perennis.

Chemistry & Biodiversity published new progress about Configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics