Tag: M.W=150-200

Talukder, Mahabubur Rahman Md.; Min, Puah Sze; Jae, Choi Won published the artcile< Integration of cell permeabilization and medium engineering for enhanced enantioselective synthesis of ethyl-S-3-hydroxy-3-phenylpropanoate (S-EHPP)>, Product Details of C11H12O3, the main research area is Kluyveromyces SEHPP cell permeabilization.

Low permeability of microbial cells and mass transfer limitations are major problems for efficient whole-cell biocatalysis. In this work, a method for enhanced enantioselective synthesis of S-EHPP, an intermediate for antidepressant drug fluoxetine via Kluyveromyces lactis whole-cell-catalyzed reduction of Et benzoyl acetate (EBA) was developed by the integration of cell permeabilization and medium engineering. Intracellular EBA reductase of K. lactis was found to be growth associated enzyme and 3-day grown cells that showed the highest activity, were permeabilized by pretreating them with different permeabilizing agents. Among the permeabilizing agents tested, acetone was the most effective and improved the whole-cell activity by 1.7-fold. The medium engineering by the addition of iso-Pr alc. (IPA) further enhanced the reaction rate through increasing mass transfer. Therefore, the integration of cell permeabilization with acetone and medium engineering with IPA, enhanced the activity of whole-cells by 2.0-fold while maintaining S-EHPP enantiomeric excess (EE) of >99.5%. This integration approach led to a S-EHPP yield of 86% within 13 h while only a 70% yield was achieved after 24 h by using untreated cells in IPA free reaction medium. These results demonstrated that the developed method could be applied to improve the performance of other whole-cell biocatalysts.

Biochemical Engineering Journal published new progress about Antidepressants. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuan; Fu, Lulu; Sun, Baobao; Qian, Cheng; Pangannaya, Srikala; Zhu, Hong; Ma, Jing; Jiang, Juli; Ni, Zhigang; Wang, Ruibing; Lu, Xiancai; Wang, Leyong published the artcile< Selection of Planar Chiral Conformations between Pillar[5,6]arenes Induced by Amino Acid Derivatives in Aqueous Media>, COA of Formula: C8H18ClNO2, the main research area is selection planar chiral conformation pillararene induced amino acid derivative; amino acids; chiral conformations; chiral induction; chiral inversion; pillararenes.

Chiral α-amino acids play critical roles in the metabolic process in nearly all life forms. So far, chiral recognition of α-amino acids has mainly focused on the determination of L/D enantiomers. Herein, selection of planar chiral conformations between water-soluble pillar[5]arene WP5 and pillar[6]arene WP6 was observed due to α-side chain or Et ester moieties of L-α-amino acid Et ester hydrochlorides binding with WP5 and WP6, resp. Therefore, α-side chain and Et ester moieties of L-α-amino acid Et ester hydrochlorides were recognized by observing the induced CD signal and its inversion. This is a rare example of being able to detect the chiral region around α-carbon of a chiral α-amino acid mol.

Chemistry – A European Journal published new progress about Chiral amino acids Role: ANT (Analyte), ANST (Analytical Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, COA of Formula: C8H18ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Rahul; Joshi, Abhisek; Rawat, Deepa; Adimurthy, Subbarayappa published the artcile< Synthesis of thiazolidinimines/thiazinan-2-imines via three-component coupling of amines, vic-dihalides and isothiocyanates under metal-free conditions>, Category: esters-buliding-blocks, the main research area is amine vicinal dihalide isothiocyanate tandem regioselective three component coupling; thiazolidinimine preparation; thiazinanimine preparation.

An expeditious approach for the synthesis of thiazolidin-2-imines and 1,3-thiazinan-2-imines through three-components coupling (TCC) of amines, isothiocynates and dihalides under metal-free conditions was described. Dichloroethane (DCE) employed as two carbon (C2) source for the annulation and obtained saturated five membered heterocycles. With 1,3-dibromopropane, six membered heterocycles were obtained in good yields. The metal-free, broad substrate scope, functional group tolerance and applicability at gram scale synthesis were the advantages of the present protocol.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Su Ho; Yoon, Hee Kyoon; Lee, Hyo Won published the artcile< Metal-mediated diastereoselective allylation reaction of chiral α,β-epoxy aldehyde. Part 2>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is homoallylic alc chiral preparation zinc epoxy aldehyde allylation.

A general method for a metal-promoted stereoselective allylation of chiral epoxy aldehydes using methallyl bromide is reported here. The asym. synthesis of chiral 3-[(2S)-3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-[(4-methoxyphenyl)methoxy]-2-oxiranecarboxaldehyde using (S)-malic acid as starting material was achieved. A subsequent zinc-mediated allylation of this aldehyde provided a homoallylic alc. having anti-configuration as the major product.

Bulletin of the Korean Chemical Society published new progress about Alcohols, homoallylic Role: SPN (Synthetic Preparation), PREP (Preparation) (epoxy, chiral). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sumiya, Tatsunobu; Ishigami, Ken; Watanabe, Hidenori published the artcile< Determination of the absolute configuration of nodulisporacid A by the concise synthesis of four stereoisomers via three-component reaction and one-pot construction of the framework>, Quality Control of 617-55-0, the main research area is malate diketene protected hydroxyaldehyde three component coupling; nodulisporacid A preparation absolute configuration.

Four stereoisomers of nodulisporacid A (I) were synthesized by the concise approach, which includes three-component reaction and subsequent one-pot construction of the whole framework. The 1H NMR comparison of amide derivatives revealed the absolute configuration of natural I to be 4R,4’R,6’R.

Tetrahedron Letters published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pihko, Petri M.; Rissa, Terhi K.; Aksela, Reijo published the artcile< Enantiospecific synthesis of isomers of AES, a new environmentally friendly chelating agent>, Related Products of 617-55-0, the main research area is aspartic acid ethoxysuccinate hexasodium enantioselective synthesis biodegradable chelating agent; malic aspartic acid reductive amination saponification.

Three four-step enantiospecific syntheses of different diastereomers of aspartic acid ethoxysuccinate (AES), a new biodegradable chelating agent, are described. The stereocenters in each of the isomers are accessible from L- and D-malic and aspartic acids.

Tetrahedron published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Howarth, Nicola M.; Wakelin, Laurence P. G.; Walker, David M. published the artcile< α-cycloPNA: 1-Aminocyclopentane-1-carboxylic Acid-Derived Peptide Nucleic Acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is aminocyclopentanecarboxylic peptide nucleic acid preparation conference; cyclopentanecarboxylic acid amino peptide nucleic acid preparation conference.

A conference report. All four diastereoisomers of 3-thymine-1-[(tert-butoxycarbonyl)amino]cyclopentane-1-carboxylic acid have been synthesized from (S)-di-Me malate and one of the thymine monomer diastereoisomers has been incorporated into an α-cycloPNA oligomer.

Nucleosides, Nucleotides & Nucleic Acids published new progress about Peptide nucleic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Feng; Wang, Tengfei; Gao, Meixiang; Zhang, Xia; Liu, Zhuqing; Zhao, Shi Jia; Lv, Zao Sheng; Xiao, Jiaqi published the artcile< Benzofuran-isatin-imine hybrids tethered via different length alkyl linkers: Design, synthesis and in vitro evaluation of anti-tubercular and anti-bacterial activities as well as cytotoxicity>, Product Details of C11H12O3, the main research area is benzofuran isatin imine preparation antitubercular antibacterial cytotoxicity; Anti-bacterial; Anti-tubercular; Benzofuran; Hybrid compounds; Imine; Isatin; Multi-drug resistant; Structure-activity relationship.

The design and synthesis of twenty-two novel benzofuran-isatin-imine hybrids I [R1 = H, F, OCH3; X = (CH2)n; Y = NOCH3, NOC2H5, NNHC(S)NH2, NOH; R3 = H, OCH3, F; n = 1, 2, 3, 4] tethered through propylene, butylene, pentylene and hexylene, and for the evaluation of their in vitro anti-tubercular and anti-bacterial activities as well as cytotoxicity were reported. All benzofuran-isatin-imine hybrids exhibited considerable in vitro anti-TB (MIC: <0.016-0.218 μg/mL and 0.062-14.15 μg/mL against drug-sensitive and MDR MTB, resp.) and anti-bacterial (MIC: 0.25-64 μg/mL and 0.06-16 μg/mL against Gram-pos. and Gram-neg. strains, resp.) activities. All of them also showed acceptable cytotoxicity towards VERO (CC50: 8-128 μg/mL). The most active hybrid I (R1 = H; X = CH2CH2; Y = NOCH3; R3 = OCH3) (MIC: <0.016, 0.062 and 0.16 μg/mL, resp.) was >4.8 and >48 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H37Rv and MDR-TB isolates, resp. Moreover, hybrid I (R1 = H; X = CH2CH2; Y = NOCH3; R3 = OCH3) also demonstrated promising anti-bacterial activities with MIC values of ≤1 μg/mL against the majority of the tested Gram-neg. and Gram-pos. pathogens, which was comparable to vancomycin (MIC: 0.5-4 μg/mL) and CPFX (MIC: 0.125-8 μg/mL) against Gram-pos. bacteria, but slightly less potent than CPFX (MIC: ≤0.03-0.5 μg/mL) against Gram-neg. bacteria. The results indicated that benzofuran-isatin-imine hybrids could act as candidates for the development of anti-TB and anti-bacterial agents.

European Journal of Medicinal Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Widmer, Ulrich published the artcile< A convenient benzylation procedure for β-hydroxy esters>, Formula: C6H10O5, the main research area is benzylation hydroxy ester; ether benzyl.

Benzylation of β-hydroxy esters, containing primary and secondary alc. functions, with benzyl 2,2,2-trichloroacetamidate (I) gives the corresponding benzyl ethers in good yield. In the case of chiral substrates non racemization is observed Treatment of Me(CH2)10CH(OH)CH2CO2Me with I in the presence of a catalytic amount of F3CSO3H gave 79% Me(CH2)10CH(OCH2Ph)CH2CO2Me. Among the 5 other compounds similarly prepared were MeO2CCH2CH(OCH2Ph)CO2Me and PhCH2OCH2CH(Me)CO2Me.

Synthesis published new progress about Benzylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Rahul; Ginoya, Vaibhavkumar; Semwal, Rashmi; Adimurthy, Subbarayappa published the artcile< BF3·Et2O catalyzed transannulation of pyridotriazoles with isothiocyanates: synthesis of thiazolo[3,4-a]pyridin-3-imines>, Category: esters-buliding-blocks, the main research area is pyridotriazole isothiocyanat boron trifluoride diethyl etherate catalyst diastereoselective transannulation; thiazolopyridinimine preparation.

The synthesis of thiazolo[3,4-a]pyridin-3-imines through the denitrogenative transannulation of pyridotriazoles with isothiocyanates using BF3·Et2O as a catalyst was described. A combination of solvents (dichlorobenzene-dichloroethane) played a crucial role in obtaining the desired products under transition metal-free conditions.

New Journal of Chemistry published new progress about Cyclization catalysts, stereoselective. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics