Tag: M.W=150-200

Dong, Jun; Du, Hongguang; Xu, Jiaxi published the artcile< Regiospecific synthesis of polysubstituted furans with mono- to tricarboxylates from various sulfonium acylmethylides and acetylenic esters>, COA of Formula: C11H12O3, the main research area is polysubstituted furan preparation regioselective; ylide alkyne tandem Michael addition nucleophilic ring opening elimination.

Polysubstituted furans I [R1 = CO2Me, CO2Et; R2 = H, CF3, CO2Me, CO2Et; R3 = H, CO2Me, CO2Et; R4 = Me, Ph, 1-naphthyl, etc.] were prepared in moderate to good yields from sulfur ylides and acetylenic esters. The direct reactions of dimethylsulfonium acylmethylides with acetylenic esters afforded furans I through a tandem sequence of Michael addition, intramol. nucleophilic addition, 4π ring opening, intramol. Michael addition and elimination. The method was extended to synthesize furan-3-carboxylate, -2,4-dicarboxylates, and -2,3,4-tricarboxylates as well. The current method provided a direct and simple strategy in synthesis of structurally diverse polysubstituted furans with mono- to tricarboxylate groups from safe and readily available dimethylsulfonium acylmethylides and different acetylenic esters.

RSC Advances published new progress about Elimination reaction. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hanaya, Tadashi; Schurrle, Karsten; Yamamoto, Hiroshi published the artcile< Synthesis of functionalized phospholane oxides and phosphorinane oxides from 1,4- and 1,5-di-O-mesyloxy compounds>, Related Products of 617-55-0, the main research area is threitol cyclization oxidation phenylphosphine; mesoxylitol cyclization oxidation phenylphosphine; phospholane oxide methoxyphenyl preparation; phosphorinane oxide methoxyphenyl preparation.

Treatment of 1,4-di-O-mesyl-2,3-di-O-methyl-L-threitol with phenylphosphine in the presence of Na hydride in DMSO, followed by the action of H2O2, afforded 3,4-dimethoxy-1-phenylphospholane 1-oxide, while the same treatment of 1,5-di-O-mesyl-2,3,4-tri-O-methyl-mesoxylitol provided 2,3,4-trimethoxy-1-phenylphosphorinane 1-oxide.

Heterocycles published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bunce, Richard A.; Herron, Derrick M.; Ackerman, Matthew L. published the artcile< Aryl-fused nitrogen heterocycles by a tandem reduction-Michael addition reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is nitrogen heterocycle aryl fused preparation; quinolineacetate tetrahydro preparation; benzoxazineacetate dihydro preparation; quinoxalineacetate tetrahydro preparation; nitrophenylpentenoate preparation tandem reduction Michael addition; nitrophenoxybutenoate preparation tandem reduction Michael addition; nitroanilinobutenoate preparation tandem reduction Michael addition.

The tetrahydroquinolines, benzoxazines, and quinoxalines I (X = CH2, O, NH; R = H, Me) were prepared from the nitrobenzenes II by tandem iron/HOAc reduction-Michael addition reactions.

Journal of Organic Chemistry published new progress about Heterocyclic compounds, nitrogen Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maki, Toshikatsu; Ishihara, Kazuaki; Yamamoto, Hisashi published the artcile< New boron(III)-catalyzed amide and ester condensation reactions>, Quality Control of 617-55-0, the main research area is boron catalysis carboxylic acid esterification amidation green chem; polystyrene bound alkylated boronopyridinium salt preparation catalysis esterification amidation; Ritter addition catalysis benzodioxaborole; crystal structure cyclocondensed dodecamer quaternized boronopyridinium iodide; mol structure cyclocondensed dodecamer quaternized boronopyridinium iodide.

In 1996, the authors reported that benzeneboronic acids bearing electron-withdrawing groups at the meta- or para-position are highly effective catalysts for the amide condensation reaction in less-polar solvents. The authors now report that N-alkyl-4-boronopyridinium halides are more effective catalysts than the previous ones in more polar solvents. N-Alkyl-4-boronopyridinium halides are effective not only for amide condensation between equimolar mixtures of carboxylic acids and amines but also for the esterification of α-hydroxycarboxylic acids in alc. solvents. Furthermore, perchlorocatecholborane is more effective than areneboronic acids for the amide condensation of sterically demanding carboxylic acids. Lewis acid-assisted Bronsted acid (LBA), which was prepared from a 1:2 M mixture of boric acid and tetrachlorocatechol, is effective for the Ritter reaction from alcs. and nitriles to amides. The crystal and mol. structures of a cyclocondensed dodecamer of 4-borono-1-methylpyridinium iodide were determined by x-ray crystallog.

Tetrahedron published new progress about Addition reaction catalysts (Ritter). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choudary, B. M.; Reddy, G. Vidya Sagar; Rao, K. Koteswara published the artcile< Vanadium-catalyzed novel oxidation of arylacetic esters for the synthesis of arylglyoxylic esters>, Electric Literature of 30095-98-8, the main research area is arylacetate oxidation vanadium montmorillonite catalyst; arylglyoxylate; glyoxylate aryl.

Direct synthesis of arylglyoxylic esters RC6H4COCO2Me (R = H, 2-, 4-OMe, 4-Me, 4-NH2, 4-NO2, 2-, 4-Cl) in excellent yields (24-88%) from inexpensive arylacetic esters RC6H4CH2CO2Me is realized for the first time by the oxidation of activated methylene using vanadium pillared clay as the catalyst and tert-Bu hydroperoxide as an oxidant.

Journal of the Chemical Society, Chemical Communications published new progress about Oxidation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lyons, Demelza J. M.; Dinh, An H.; Ton, Nhan N. H.; Crocker, Reece D.; Mai, Binh Khanh; Nguyen, Thanh Vinh published the artcile< Ring Contraction of Tropylium Ions into Benzenoid Derivatives>, HPLC of Formula: 94-02-0, the main research area is benzenoid preparation; tropylium ion ring contraction.

Authors report a method to convert substituted tropylium ions into benzenoid derivatives

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, HPLC of Formula: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rombouts, Frederik J. R.; Tresadern, Gary; Buijnsters, Peter; Langlois, Xavier; Tovar, Fulgencio; Steinbrecher, Thomas B.; Vanhoof, Greet; Somers, Marijke; Andres, Jose-Ignacio; Trabanco, Andres A. published the artcile< Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors>, Computed Properties of 33402-75-4, the main research area is pyrido triazolo pyrazine brain phosphodiesterase inhibitor; PDE2 inhibitor; Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazine; phosphodiesterase 2 inhibitor; selective; tricycle.

A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the Ph ring pending from the triazole. The SAR and protein flexibility were explored with free energy perturbation calculations Rat pharmacokinetic data and in vivo receptor occupancy data are given for two representative compounds 6 and 12.

ACS Medicinal Chemistry Letters published new progress about Drug bioavailability. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Computed Properties of 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Hao-Nan; Cao, Hao-Qiang; Cheung, Chi Wai; Ma, Jun-An published the artcile< Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis>, Synthetic Route of 94-02-0, the main research area is aryldiazonium salt alkyl aminoacrylate preparation copper heterocyclization; alkyl aryltriazole carboxylate preparation.

A Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts was described, both of which were readily available substrates. Furthermore, alkyl 2-aminoacrylates were also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogs was rapidly prepared under mild conditions. Especially, this protocol allowed one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Organic Letters published new progress about Amino esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vodicka, Petr; Streinz, Ludvik; Vavra, Jan; Koutek, Bohumir; Budesinsky, Milos; Ondracek, Jan; Cisarova, Ivana published the artcile< Synthesis of (R)- and (S)-3,3,3-trifluoro-2-phenylpropanoyl isocyanates and their use as reactive analogues of Mosher's acid>, SDS of cas: 617-55-0, the main research area is isocyanate trifluorophenylpropanoyl Mosher preparation alc addition; carbamate preparation.

The title isocyanates have been prepared from the resp. 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acids (MTPA) by a three-step synthesis with MTPA chloride and MTPA amide as reaction intermediates. The requested compounds were obtained in high chem. yields without any change in optical purity during the preparation To ascertain the usefulness of this auxiliary agent in the chiral anal., both 3,3,3-trifluoro-2-phenylpropanoyl isocyanates were subjected in NMR tubes to non-catalyzed reactions with 16 different com. available chiral alcs. The steric arrangement of all diastereomers prepared correlated well with their NMR spectral nonequivalence data (Δδ), thus demonstrating the regular sign distribution of Δδ of particular groups according to the devised mol. model.

Chirality published new progress about Alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Amit; Sharma, Gaurav; Shukla, Sanjeev K.; Panda, Gautam published the artcile< A Tandem Semipinacol Rearrangement/aldehyde Arylation or Alkylation of Trisubstituted 2,3-Epoxy Alcohols with Grignard reagents for Functionalized 1,3-diols>, Quality Control of 30095-98-8, the main research area is anti diol preparation diastereoselective DFT; epoxy alc Grignard reagent tandem semipinacol rearrangement arylation alkylation.

A tandem semipinacol rearrangement/aldehyde arylation or alkylation reaction leading to formation of functionalized 1,3-diols bearing three consecutive tertiary stereocenters anti-R1CH(OH)R2CHR3C(OH) (R1 = Ph, 2-methoxyphenyl, 6-bromo-2-methoxyquinolin-3-yl, etc.; R2 = Ph, naphth-1-yl; R3 = iso-Pr, Ph, thiophen-2-yl, etc.) is identified from the reaction of various new trisubstituted 2,3-epoxy alcs. I with numerous Grignard reagents R3MgX. This reaction is useful for stereoselective construction of three consecutive tertiary stereocenters. The observed 1,3-diols exist in anti-configuration which is confirmed by the 2D-NOESY, crystal structure of acetonide of one of the 1,3-diol analog 3ai and further DFT studies.

Journal of Organic Chemistry published new progress about Alcohols, epoxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Quality Control of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics