Tag: M.W=150-200

Gao, Jing; Wang, Jian; Wang, Dandan; Pan, Li; Cheng, Maosheng published the artcile< Synthesis of tert-butyl (3R,5S)-6-oxo-3,5-O-isopropylidene-3,5-dihydroxyhexanoate>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is rosuvastatin intermediate synthesis.

The title compound [i.e., 3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexuronic acid 1,1-dimethylethyl ester] was synthesized from L-(-)-malic acid by esterification, reduction, hydroxy protection, condensation, carbonyl group reduction, hydroxyl protection, deprotection and Swern oxidation with an overall yield of 25%. The title compound is a key intermediate of rosuvastatin.

Zhongguo Yiyao Gongye Zazhi published new progress about Condensation reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Zhenli; Wan, Shanhong; Pan, Yixiao; Yao, Zhen; Zhang, Xin; Li, Bohan; Li, Jiajie; Xu, Lijin; Fan, Qing-Hua published the artcile< Metal-Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 · Et2O Catalysis>, Synthetic Route of 94-02-0, the main research area is ketone amine formic acid boron trifluoride etherate reductive amination; alkylamine preparation.

BF3·Et2O was found to effectively catalyze reductive amination of ketones with amines employing formic acid as the reductant under metal-free conditions. This transformation tolerated a broad range of primary and secondary amines and differently decorated ketones, delivering N-alkylated amines in good to excellent yields with high compatibility of functional groups. The synthetic potential of this protocol was demonstrated by its application in the preparation of biol. and pharmaceutically relevant compounds

Asian Journal of Organic Chemistry published new progress about Amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prasad, Girija; Hanna, Patrick E.; Noland, Wayland E.; Venkatraman, Shankar published the artcile< 18-Crown-6 as a catalyst in the dialkylation of o-nitrophenacyl derivatives>, Related Products of 30095-98-8, the main research area is alkylation nitrophenacyl compound 18crown6 catalyst; catalyst crown ether dialkylation nitrophenacyl.

The dialkylation of o-nitrophenacyl ketones, o-nitrophenylacetate esters, and o-nitrophenylacetonitrile with alkyl halides and potassium tert-butoxide proceeds in good yields with 18-crown-6 as catalyst.

Journal of Organic Chemistry published new progress about Alkylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reddy, Angula Chandra Shekar; Anbarasan, Pazhamalai published the artcile< Rhodium-Catalyzed Rearrangement of S/Se-Ylides for the Synthesis of Substituted Vinylogous Carbonates>, Category: esters-buliding-blocks, the main research area is sulfur seleno vinylogous carbonate preparation chemo regioselective; seleno sulfur ylide oxa sigmatropic rearrangement rhodium catalyst.

An efficient rhodium-catalyzed unprecedented oxa-[2,3]-sigmatropic rearrangement of sulfur ylide derived from α-thioesters/ketones and diazo carbonyl compounds has been accomplished for the synthesis of various sulfur-tethered vinylogous carbonates in good to excellent yields. Important features of the developed reaction include wide functional group tolerance, excellent chemo- and regioselectivity, and efficient rearrangement involving the carbonyl motif. The present reaction also equally works well with α-selenoesters for the synthesis of seleno-containing vinylogous carbonates.

Organic Letters published new progress about Carbonates Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thyrann, Thomas; Lightner, David A. published the artcile< Oxidation of methylpyrrole to formylpyrrole with ceric ammonium nitrate>, Quality Control of 7126-50-3, the main research area is oxidation ceric ammonium nitrate methylpyrrole; pyrrolecarboxaldehyde; pyrrolecarboxylic acid formyl.

1H-pyrrole-2-carboxaldehydes can be prepared in high yield by oxidation of 2-methyl-1H-pyrrole with ceric ammonium nitrate when the pyrrole ring also contains a carboxylic acid ester group. The regioselective oxidation of 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid Me ester with ceric ammonium nitrate gave 4-acetyl-5-formyl-3-methyl-1H-Pyrrole-2-carboxylic acid Me ester (88% yield).

Tetrahedron Letters published new progress about Oxidation, regioselective. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Quality Control of 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hirama, Masahiro; Nakamine, Takeshi; Ito, Sho published the artcile< Synthesis of the C11-C28 subunit of the avermectins>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is avermectin fragment preparation; dioxaspiroundecanehexenol.

Construction of the trisubstituted double bond of the C(11)-C(28) subunit I of avermectin A1a and B1a has been achieved in 5 steps from the sulfone II and the aldehyde III.

Tetrahedron Letters published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Winterson, Bethan; Rennigholtz, Tim; Wirth, Thomas published the artcile< Flow electrochemistry: a safe tool for fluorine chemistry>, Category: esters-buliding-blocks, the main research area is fluoro compound preparation; allyl amide electrochem fluorination hypervalent iodine mediated; alc allyl electrochem fluorination hypervalent iodine mediated; carbonyl compound electrochem fluorination hypervalent iodine mediated.

A scalable, versatile and safe electrochem. fluorination protocol was conferred and strategy proceeded through a transient (difluoroiodo)arene, generated by anodic oxidation of an iodoarene mediator. Even the isolation of iodine(III) difluorides was facile since electrolysis was performed in the absence of other reagents. A broad range of hypervalent iodine mediated reactions afforded 5-(fluoromethyl)-aryl-oxazolines [R = Ph, 2-furanyl, 4-MeOC6H4, etc.], ((2,3-difluoropropoxy)methyl)-aromatic compounds [R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.; R2 = H, Me] and some fluoro compounds R3-F [R3 = 1,3-diphenylpropanyl-1,3-dione, 1-phenyl-1-propanone, 3-phenyldihydrofuran-2(3H)-one, etc.] in high yields by coupling the electrolysis step with downstream reactions in flow, surpassing limitations of batch chem. (Difluoroiodo)arenes were toxic and suffered from chem. instability, so the uninterrupted generation and immediate use in flow was highly advantageous. High flow rates facilitated productivities of up to 834 mg h-1 with vastly reduced reaction times. Integration into a fully automated machine and in-line quenching was key in reducing the hazards surrounding the use of hydrofluoric acid.

Chemical Science published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Xiao; Huang, Pei Qiang; Ruan, Yuan Ping; Lee, Albert W. M.; Chan, Wing Hong published the artcile< A new asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids starting from (S)-malic acid>, Formula: C6H10O5, the main research area is methylpyrrolidine alkaloid asym synthesis malate; pyrrolidine methyl alkaloid asym synthesis; leptothoracine synthesis.

Diastereoselective methylation of di-Me (S)-malate followed by two three-step reductive dehydroxylation procedures afforded di-Me (R)-2-methylsuccinate in 80.2% and 84.7% ee resp., the later was further transformed into the natural enantiomers of ant venom alkaloids (R)-leptothoracine (I) and (R)-3-methyl-N-(2-phenylethyl)pyrrolidine and (3R,2’S)-3-methyl-N-(2-methylbutyl)pyrrolidine.

Heterocycles published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (pyrrolidine). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Negishi, Shoko; Ishibashi, Hiroyuki; Matsuo, Jun-ichi published the artcile< Asymmetric Synthesis of 2,3-Dihydro-4-pyranones by Reaction of Chiral 3-Alkoxycyclobutanone and Aldehydes>, COA of Formula: C6H10O5, the main research area is asym dihydropyranone preparation diastereoselective cycloaddition; diastereoselective cycloaddition chiral alkoxycyclobutanone aldehyde reactant dihydropyranone preparation; titanium tin chloride mediated diastereoselective cycloaddition enantioselective dihydropyranone preparation.

Chiral cyclobutanone I, which has Et L-lactate as a chiral auxiliary at the 3-position, reacted with aldehydes to give 2,3-dihydro-4-pyranones, e.g. II, in up to 93% ee by combined use of titanium(IV) chloride and tin(II) chloride.

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Clericuzio, Marco; Tabasso, Silvia; Garbarino, Juan A.; Piovano, Marisa; Cardile, Venera; Russo, Alessandra; Vidari, Giovanni published the artcile< Non-phenolic dicinnamamides from Pholiota spumosa: isolation, synthesis and antitumour activity>, Application of C6H10O5, the main research area is dicinnamamide isolation structure preparation Pholiota spumosa antitumor.

Two new amides derived from cinnamic acid, namely, (R)-2-hydroxyputrescine dicinnamamide and pholiotic acid {(2R)-2-[(S)-3-hydroxy-3-methylglutaryloxy]putrescine dicinnamamide}, in addition to the known compound maytenine (N1,N8-dicinnamoyl spermidine) were isolated from the fruiting bodies of the Basidiomycete Pholiota spumosa. The absolute configuration of (R)-2-hydroxyputrescine dicinnamamide was established as (R) by its total synthesis starting from (S)-di-Me malate, whereas that of pholiotic acid was determined by conversion into the known compound Me (S)-4-[(S)-1-(1-naphthalen-1-yl)-ethylcarbamoyl]-3-hydroxy-3-methylbutanoate. Maytenine and pholiotic acid exhibited an inhibitory effect on cell growth of the androgen-insensitive DU-145 prostate cancer cells, which suggests that these fungal polyamine conjugates, like other polyamine analogs, might have chemotherapeutic potential against androgen-independent prostatic cancer.

European Journal of Organic Chemistry published new progress about Amides Role: NPO (Natural Product Occurrence), PAC (Pharmacological Activity), PRP (Properties), PUR (Purification or Recovery), BIOL (Biological Study), OCCU (Occurrence), PREP (Preparation) (dicinnamamides). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics