Tag: M.W=150-200

Pan, Bo-Wen; Shi, Yang; Li, Wen-Chao; Wang, Qing; Pan, Meng; Wu, Qiong; Fu, Hong-Zheng published the artcile< Synthesis and biological evaluation of Vinpocetine derivatives>, Application In Synthesis of 19241-24-8, the main research area is vinpocetine derivative preparation PDE1A inhibitor vasorelaxant; PDE1A; Structural modification; Vinpocetine.

A new series of Vinpocetine derivatives were synthesized and evaluated for their inhibitory activity on PDE1A in vitro. Seven compounds with higher inhibitory activity were selected for surface plasmon resonance (SPR) binding experiments Compared with Vinpocetine, these high potency compounds presented a higher binding affinity with PDE1A, which was consistent with inhibitory activity. After further screening, four compounds and Vinpocetine were selected to examine the vasorelaxant effects on endothelium-intact rat thoracic aortic rings. The study suggested that the effects of compounds I (R1 = 4-fluorophenyl) and I (R1 = 3-fluorophenyl) were the most significant with the maximum value of 93.46 ± 0.77% and 92.90 ± 0.78% (n = 5) at a concentration of 100μM resp. Based on these studies, compounds I (R1 = 4-fluorophenyl) and I (R1 = 3-fluorophenyl) were considered for further development as hit compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Cerebrovascular disease. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoelzel, Conner A.; Hu, Hang; Wolstenholme, Charles H.; Karim, Basel A.; Munson, Kyle T.; Jung, Kwan Ho; Zhang, Han; Liu, Yu; Yennawar, Hemant P.; Asbury, John B.; Li, Xiaosong; Zhang, Xin published the artcile< A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents>, Reference of 39987-25-2, the main research area is triazole donor acceptor mol substituent; amines; charge transfer; donor-acceptor systems; fluorescence; solvent effects.

While organic donor-acceptor (D-A) mols. are widely employed in multiple areas, the application of more D-A mols. could be limited because of an inherent polarity sensitivity that inhibits photochem. processes. Presented here is a facile chem. modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and exptl. analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophys. properties of commonly used D-A fluorophores and their enhanced performance in biol. imaging are shown.

Angewandte Chemie, International Edition published new progress about Absorption. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Reference of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brain, Christopher T.; Chen, Anqi; Nelson, Adam; Tanikkul, Nongluk; Thomas, Eric J. published the artcile< Synthesis of macrocyclic precursors of lankacidins using Stille reactions of 4-(2-iodo-alkenyl)azetidinones and related compounds for ring closure>, Quality Control of 617-55-0, the main research area is lankacidin precursor synthesis Stille coupling iodoalkenylazetidinone ring closure; stereoselective acylation azetidinone lankacidin intermediate preparation; selective cleavage silyl azetidinone lankacidin intermediate preparation; regioselective monodeprotection silyl ether.

In the context of a proposed total synthesis of lankacidins, the synthesis of 4-(2-iodo-alkenyl)azetidinones and their participation in Stille coupling reactions have been investigated. 1-Tert-Butyldimethylsilyl-4-(2-iodoethenyl)azetidinone was found to undergo a Stille coupling reaction with a 3-hydroxy-1-(tributylstannyl)hepta-1,5-diene to give an acceptable yield of the corresponding conjugated diene; but the analogous reaction with a 3-tert-butyldimethylsilyloxy-1-(tributylstannyl)hepta-1,5-diene was unsuccessful. A series of 4-[(E)-2-iodoprop-1-enyl]azetidinones, a ring-opened ester and a lactone were also found to undergo Stille reactions with 3-tributylstannylprop-2-enol albeit with variable yields. Asym. syntheses of Me (2R,3R,5S)-3-tert-butyldimethylsilyloxy-2-methyl-5-(2-trimethylsilylethoxy)methoxy-6-oxohexanoate, (3R,4S)-1-tert-butyldimethylsilyl-4-[(E)-2-iodoprop-1-enyl]-3-methylazetidin-2-one, and (5S,2E,6E)-5-tert-butyldimethylsilyloxy-2-methyl-1-phenylsulfonyl-7-tributylstannylhepta-2,6-diene and their incorporation into macrocyclic precursors of the lankacidins were then investigated. Key reactions were a Julia reaction between the aldehyde and the sulfone to form the 12,13-double-bond, a stereoselective acylation of the azetidinone, and formation of macrocycles using intramol. Stille reactions in the presence of a free hydroxyl group at C(8) (lankacidin numbering).

Tetrahedron published new progress about Acylation, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei; Huang, Tingting; Gao, Liqian; Yang, Xianfeng; Deng, Wenbin; Zhou, Rui; Liu, Hongjun published the artcile< Textile-supported silver nanoparticles as a highly efficient and recyclable heterogeneous catalyst for nitroaromatic reduction at room temperature>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is nitroarom reduction silver nanoparticle textile support recyclable heterogeneous catalyst.

A novel textile-based nanosilver catalyst was prepared with a facile synthetic method. The textile-supported nanosilver (TsNS) proved to be an excellent heterogeneous catalyst for the reduction of nitroaroms. with a broad substrate scope. It can be recycled for up to 6 times without significantly compromising its catalytic efficacy. The TsNS catalyst was developed into a column reactor, demonstrating its practical application with the advantages of low cost, ease of operation and large scale synthesis capabilities. SEM (SEM) showed that there were few changes to the catalyst’s surface after the reaction. Besides, inductively coupled plasma (ICP) anal. showed that few silver particles leaked, and the interactions between the nitro groups of the nitroaroms. and the nanosilver particles were characterized by XPS, which lead to the proposal of a four-step mechanism for the reduction reaction.

RSC Advances published new progress about Aromatic amines Role: IMF (Industrial Manufacture), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Hongyun; Khanal, Hari Datta; Lee, Yong Rok published the artcile< Base-Promoted Direct Cascade Transformation of Chromones to Coumarins via Benzannulation and Transesterification>, Electric Literature of 94-02-0, the main research area is alkenyl chromone acetoacetate cesium carbonate promoter tandem benzannulation transesterification; acyl phenylcoumarin preparation.

A mild base-promoted reaction between 3-substituted chromones and β-keto esters for the easy access to various coumarins with structural diversity was described. This protocol provided highly functionalized 3-acyl-4-arylcoumarins in good-to-excellent yield via benzannulation and transesterification. A reaction mechanism containing Michael addition, 1,5-H shift and intramol. transesterification was proposed.

Asian Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Electric Literature of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ogawa, Toshihisa; Matsumoto, Keita; Yoshimura, Misa; Hatayama, Katsuo; Kitamura, Kunihiro; Kita, Yasuyuki published the artcile< Stereochemistry of the 2-hydroxy-1,2,3,4-tetrahydropyridine intermediate of Hantzsch cyclization>, Computed Properties of 60705-25-1, the main research area is crystal structure nitrophenyl hydroxytetrahydropyridine; mol structure nitrophenyl hydroxytetrahydropyridine; cyanoethyl aminocrotonate Hantzsch cyclization dialkoxymethylbenzylidene acetoacetate.

Hantzsch cyclization of cyanoethyl 3-aminocrotonate and (E,Z)-4-dialkoxymethyl-2-benzylideneacetoacetates (alkoxy = Me, Et) afforded 3,4-trans-2-hydroxy-1,2,3,4-tetrahydropyridines, e.g., I, in high stereoselectivity.

Tetrahedron Letters published new progress about Crystal structure. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zurwerra, Didier; Glaus, Florian; Betschart, Leo; Schuster, Julia; Gertsch, Juerg; Ganci, Walter; Altmann, Karl-Heinz published the artcile< Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives>, Synthetic Route of 617-55-0, the main research area is zampanolide asym total synthesis antitumor structure activity relationship; dactylolide asym total synthesis antitumor structure activity relationship.

A new total synthesis of the marine macrolide (-)-zampanolide (I) and the structurally and stereochem. related non-natural levorotatory enantiomer (II) of (+)-dactylolide was developed. The synthesis features a high-yielding, selective intramol. Horner-Wadsworth-Emmons (HWE) reaction to close the 20-membered macrolactone ring of I and II. The β-keto phosphonate/aldehyde precursor for the ring-closure reaction was obtained by esterification of a ω-di-Et phosphono carboxylic acid fragment and a secondary alc. fragment incorporating the THP ring that is embedded in the macrocyclic core structure of I and II. THP ring formation was accomplished through a segment coupling Prins-type cyclization. Employing the same overall strategy, 13-desmethylene-II as well as the monocyclic desTHP derivatives of I and II were prepared Synthetic I inhibited human cancer cell growth in vitro with nanomolar IC50 values, while II, which lacks the diene-containing hemiaminal-linked side-chain of I, is 25- to 260-fold less active. 13-Desmethylene-II as well as the reduced versions of II and 13-desmethylene-II all showed similar cellular activity as II itself. The same activity level was attained by the monocyclic desTHP derivative of I. Oxidation of the aldehyde functionality of II gave a carboxylic acid that was converted into the corresponding N-hexyl amide. The latter showed only micromolar antiproliferative activity, thus being several 100-fold less potent than I.

Chemistry – A European Journal published new progress about Antitumor agents. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shimizu, Hiroaki; Yoshinaga, Kohei; Yokoshima, Satoshi published the artcile< Nitrone Formation by Reaction of an Enolate with a Nitro Group>, SDS of cas: 30095-98-8, the main research area is quinolinedione preparation dipolar cycloaddition; isoxazoloquinolinone preparation; base mediated cyclocondensation ketonitroarene mechanism transition state structure; intramol dipolar cycloaddition alkenyl isoxazoloquinolinone nitrone.

Ketones with a 2-nitrophenyl group at the α-position such as I were treated with sodium hydroxide in methanol at 60 °C. Under these conditions, enolates derived from the ketones intramolecularly reacted with the nitro group to form a variety of nitrones such as II. Addnl. exptl. results, including the unexpected isolation of N-hydroxyindolinone as a byproduct, led to a proposed reaction mechanism, occurring via an α-hydroxyketone. The resultant nitrones underwent inter- and intramol. 1,3-dipolar cycloaddition with olefins to afford polycyclic isoxazolidines such as III.

Organic Letters published new progress about 1,3-Dipolar cycloaddition reaction. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, SDS of cas: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuthan, J.; Musil, L.; Jehlicka, V. published the artcile< The use of dipole moments in the conformational analysis of nicotinic acid derivatives>, Product Details of C8H9NO2, the main research area is nicotinic acid derivative conformation; pyrrolopyridine dipole moment MO; dipole moment nicotinamide derivative; furopyridinone dipole moment MO.

The apparent dipole moments in C6H6 of Me nicotinate (I), nicotinamide (II), 6-oxo-7H-furo[2,3-b]pyridine, 6-oxo-7H-pyrrolo[2,3-b]pyridine, 2-oxo-7H-furo[3,4-c]pyridine, and 2-oxo-7H-pyrrolo[3,4-c]pyridine along with theor. moments of their CNDO/2 models were used in a semiquant. estimate of conformational population in I and II. With nicotinic acid, this approach did not lead to unequivocal conclusions.

Collection of Czechoslovak Chemical Communications published new progress about CNDO/2 (molecular orbital method). 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Product Details of C8H9NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Budama-Kilinc, Yasemin; Kecel-Gunduz, Serda; Ozdemir, Burak; Bicak, Bilge; Akman, Gizem; Arvas, Busra; Aydogan, Feray; Yolacan, Cigdem published the artcile< New nanodrug design for cancer therapy: Its synthesis, formulation, in vitro and in silico evaluations>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is antitumor cancer; DNA binding; anticancer; coumarin derivative; molecular docking; nanoparticle.

The aim of this study was to develop a novel nanosize drug candidate for cancer therapy. For this purpose, (S)-Me 2-[(7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-yl)methyleneamino]-3-(1H-indol-3-yl)propanoate (ND3) was synthesized by the condensation reaction of 8-formyl-7-hydroxy-4-phenylcoumarin with L-tryptophan Me ester. Its controlled release formulation was prepared and characterized by different spectroscopic and imaging methods. The cytotoxic effects of ND3 and its controlled release formulation were evaluated against MCF-7 and A549 cancer cell lines, and it was found that both of them have a toxic effect on cancer cells. For drug design and process development, the mol. docking anal. technique helps to clarify the effects of some DNA-targeted anticancer drugs to determine the interaction mechanisms of these drugs on DNA in a shorter time and at a lower cost. By using the mol. docking anal. and DNA binding assays, the interaction between the synthesized compound and DNA was elucidated and non-binding interactions were also determined To predict the pharmacokinetics, and thereby accelerate drug discovery, the absorption, distribution, metabolism, excretion and toxicity values of the synthesized compound were determined by in silico methods.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antitumor agents. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics