Tag: M.W=150-200

Sawano, Takahiro; Ogihara, Kei; Sagawa, Jun; Ono, Masaki; Takeuchi, Ryo published the artcile< Iridium-Catalyzed Hydroalkylation of Aliphatic Alkenes with β-Ketoesters: Formal Hydroalkylation with Methyl Ketones>, Application of C11H12O3, the main research area is iridium catalyzed hydroalkylation alkene beta ketoester; ketone preparation one pot dealkoxycarbonylation hydroalkylated intermediate.

Transition-metal-catalyzed hydroalkylation of alkenes with 1,3-dicarbonyl compounds is a useful reaction to construct a C-C bond under neutral reaction conditions in a highly atom-economical manner. We found that hydroalkylation of aliphatic alkenes with β-ketoesters proceeded with the use of a cationic iridium complex and bidentate phosphine ligand to give selectively branched α-substituted β-ketoesters in high yields. The obtained hydroalkylated compounds can be converted to β-substituted ketones through one-pot Krapcho dealkoxycarbonylation.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wallace, David M.; Leung, Sam H.; Senge, Mathias O.; Smith, Kevin M. published the artcile< Rational tetraarylporphyrin syntheses: tetraarylporphyrins from the MacDonald route>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is tetraarylporphyrin; porphyrin tetraaryl; condensation MacDonald tetraarylporphyrin.

Four new synthetic routes to meso-tetraarylporphyrins using a MacDonald-type [2 + 2] condensation are described. Self-condensation of a 5-aryldipyrromethane, e.g., 5-(4-tolyl)dipyrromethane, with an aryl-substituted one-carbon bridging unit affords a mixture of tetraarylporphyrins due to acid-catalyzed redistribution reactions. The second and third methods presented here show wide applicability for the preparation of 5,10,15,20-tetraaryl-substituted porphyrins, e.g., I, with 2-fold rotational symmetry and involves self-condensation of 5-aryl-1-aryldipyrromethanecarbinols, e.g., II. Finally, the 4th approach involves a [2 + 2] approach in which one of the 2 dipyrromethanes bears both of the bridging carbons in the porphyrin products, affording a porphyrin which possesses 3 different aryl rings, with one pair of uniquely opposite identical aryl groups. The last two [2 + 2] methods are further extended to give a tetraarylporphyrin bearing four different aryl groups in a predesignated array, the structure of which is confirmed by a single-crystal X-ray study.

Journal of Organic Chemistry published new progress about Condensation reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sefkow, M. published the artcile< Synthesis of (+)-wikstromol by double alkylation of malic acid>, SDS of cas: 617-55-0, the main research area is lactone lignan wikstromol preparation stereoselective benzylation malic acid derivative.

The synthesis of (+)-wikstromol (I) in six steps, based on two stereoselective benzylations of unnatural malic acid derivatives, is presented. The influence of the alkyl ester on yield and selectivity in the alkylation of malic acid esters is examined

Tetrahedron: Asymmetry published new progress about Benzylation (stereoselective). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guerfi, Meriem; Berredjem, Malika; Bahadi, Rania; Djouad, Seif-Eddine; Bouzina, Abdeslem; Aissaoui, Mohamed published the artcile< An efficient synthesis, characterization, DFT study and molecular docking of novel sulfonylcycloureas>, Formula: C8H18ClNO2, the main research area is sulfonylcyclourea preparation DFT mol docking; sulfonamide ethyl bis chloroethyl carbamate cyclization.

Sulfonylcycloureas derivatives I (R = H, i-Bu, Bn, etc.) are novel heterocyclic compounds synthesized by condensation reaction of several sulfonamides derived from aminoesters with Et bis(2-chloroethyl)carbamate. Series of these desired products are obtained from good to excellent yields within 3-4 h in all cases. Mol. docking are used to study the anticancer activity of the most active compounds Mol. docking of the mol.s into the AKR1C1 crystal structure reveals the key interactions with the active site. The theor. calculations for the compounds I were performed using DFT/B3LYP/6-31 G (d,p) method. The optimized structural parameters, Frontier MOs (FMO’s) and global reactivity descriptors were determined The dipole moment (μ), polarizability (α) and first order hyperpolarizability (β) values of the title compound have been computed at the same level of theory on the finite field approach.

Journal of Molecular Structure published new progress about Amino acid esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Formula: C8H18ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed Fouad, Manar; Ferretti, Francesco; Formenti, Dario; Milani, Fabio; Ragaini, Fabio published the artcile< Synthesis of Indoles by Reductive Cyclization of Nitro Compounds Using Formate Esters as CO Surrogates>, Quality Control of 30095-98-8, the main research area is indole preparation; nitrostyrene formate ester reductive cyclization palladium ruthenium catalyst.

Alkyl and aryl formate esters were evaluated as CO sources in the Pd- and Pd/Ru-catalyzed reductive cyclization of 2-nitrostyrenes to give indoles. Whereas the use of alkyl formates requires the presence of a ruthenium catalyst such as Ru3(CO)12, the reaction with Ph formate can be performed by using a Pd/phenanthroline complex alone. Ph formate was found to be the most effective CO source and the desired products were obtained in excellent yields, often higher than those previously reported using pressurized CO. The reaction tolerates many functional groups, including sensitive ones like a free aldehydic group or a pendant pyrrole. Detailed experiments and kinetic studies allow to conclude that the activation of Ph formate is base-catalyzed and that the metal doesn’t play a role in the decarbonylation step. The reactions can be performed in a single thick-walled glass tube with as little as 0.2 mol-% palladium catalyst and even on a 2 g scale. The same protocol can be extended to other nitro compounds, affording different heterocycles.

European Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Quality Control of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jamshaid, Sana; Devkota, Shreedhar; Lee, Yong Rok published the artcile< Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters>, Formula: C11H12O3, the main research area is hydroxy indolyl acrylate preparation diastereoselective regioselective; alkoxy oxoethoxy indolyl acrylate preparation diastereoselective regioselective; formylindole diazo ester addition reaction Lewis Acid catalyst.

A facile and efficient In(OTf)3- and BF3.OEt2-catalyzed direct transformation of 3-formylindoles I (R = Me, prop-2-en-1-yl, Ph, Bn, etc.; R1 = H, Me, Et, Ph; R2 = H, Ph, OBn; R3 = H, Me, Ph, naphthalen-2-yl, etc.; R4 = H, Me, Br, Cl, F; R5 = H, Me; R4R5 = -(CH2)3-, -CH=CH-CH=CH-) with diazo esters N2=CHC(O)OR6 (R6 = Et, allyl, Bn, cyclohexyl, etc.) has been developed for synthesizing diverse and functionalized indolyl acrylates II, III and IV. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates II, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates III, and (Z)-3-hydroxy-2-indolyl acrylates IV by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds II, III and IV can be further converted into diversely functionalized materials.

Organic Letters published new progress about C-H bond activation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Wei; Gu, Qiangshuai; Li, Zhongliang; Yang, Dan published the artcile< Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)-H Functionalization>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is palladium catalyst intramol oxidative tandem aminoalkylation divergent functionalization; fused indoline preparation green chem.

We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)-H functionalization, affording three- and five-membered-ring fused indolines, e.g. I and II, in good yields under two optimized conditions, resp. The mechanism studies have indicated that the benzylic C-H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C-H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)-H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles.

Journal of the American Chemical Society published new progress about Aminoalkylation (oxidative). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xueguo; Wang, Peigen; Zhu, Liangwei; Chen, Baohua published the artcile< Rhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C-H activation>, Application of C11H12O3, the main research area is isocoumarin preparation regioselective chemoselective; isoquinolinone preparation regioselective chemoselective; diazo compound phenyloxazole carboxylic acid cyclization rhodium catalyst.

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins I (R = t-Bu, 4-bromophenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Et, t-Bu) and isoquinolinones II (R3 = t-Bu, heptyl, furan-2-yl, etc.) have been realized via Rh(III)-catalyzed C-H activation. Diazo compounds R1C(O)C(=N2)C(O)OR2 act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations.

Chinese Chemical Letters published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lucia; Lin, Shengjia; Santos, Emmanuel; Pralat, Jenna; Spotton, Kaylyn; Sharma, Abhishek published the artcile< Boron-Promoted Deprotonative Conjugate Addition: Geminal Diborons as Soft Pronucleophiles and Acyl Anion Equivalents>, Application In Synthesis of 94-02-0, the main research area is diboryl ketone preparation; geminal diboron alkene deprotonative conjugate addition.

The 1,4-addition of α,α-diboryl carbanions generated via deprotonation of the corresponding geminal diborons R1CH(Bpin)2 (R1 = prop-2-en-1-yl, thiophen-3-ylmethyl, cyclopropylmethyl, etc.) has been reported. The methodol. provided a general route to highly substituted and synthetically useful γ,γ-diboryl ketones R1C(Bpin)2CH(R3)C(O)R2 (R2 = C6H5, 4-ClC6H4, cyclohexyl, etc.; R3 = Me, Ph, Et, etc.). The development of geminal diborons as soft pronucleophiles also enabled their use as acyl anion equivalent via a one-pot tandem conjugate addition-oxidation sequence.

Journal of Organic Chemistry published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent) (diboryl). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kato, Makoto; Toshima, Kazunobu; Matsumura, Shuichi published the artcile< Direct Enzymatic Synthesis of a Polyester with Free Pendant Mercapto Groups>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hexanediol dimethyl mercaptosuccinate enzymic polymerization polyester preparation property; stereochem monomer effect enzymic polym dimethylmercaptosuccinate.

An aliphatic polyester with free pendant mercapto groups was prepared by direct lipase-catalyzed polycondensation of hexane-1,6-diol and di-Me 2-mercaptosuccinate. The polycondensation reaction using immobilized lipase from Candida antarctica (lipase CA) was carried out in bulk at 70 °C without any formation of disulfide or thioester linkages to produce the corresponding polyester with Mw = 14000 g/mol in high yield. The content of free mercapto groups in the polyester could be controlled by copolymerization with other monomers. The obtained polyester was easily crosslinked to form gels by the air oxidation of the pendant thiols to disulfides in DMSO. The effect of stereochem. of the monomers was studied.

Biomacromolecules published new progress about Crosslinking. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics