Tag: M.W=150-200

Gaunt, Matthew J.; Jessiman, Alan S.; Orsini, Paolo; Tanner, Huw R.; Hook, David F.; Ley, Steven V. published the artcile< Synthesis of the C-1-C-28 ABCD Unit of Spongistatin 1>, Reference of 617-55-0, the main research area is asym synthesis spongistatin ABCD fragment anti aldol condensation borinate; beta keto dithiane preparation conjugate addition dithiol ynone.

The synthesis of the C-1-C-28 ABCD fragment I of spongistatin 1 is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment II to an AB spiroketal aldehyde unit III forms the desired C1-C28 advanced intermediate I. Other features include the double conjugate addition of a dithiol to an ynone to generate the key β-keto-dithiane unit required for the synthesis of the AB spiroketal fragment.

Organic Letters published new progress about Aldol condensation (anti-selective boron-mediated aldol coupling). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ameen, K. K. Mohammed; Ahamed, F. M. Mashood; Padusha, M. Syed Ali; Gunasekaran, B. published the artcile< Diethyl 4-(3-chlorophenyl)-2,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylate>, Related Products of 94-02-0, the main research area is diethyl chlorophenyl diphenyl dihydropyridine dicarboxylate hydrogen bond crystal structure.

In the title compound, C29H26ClNO4, the dihydropyridine ring adopts a shallow boat conformation. The mean plane of the dihydropyridine ring (all atoms) subtends dihedral angles of 66.54 (1), 73.71 (1) and 79.47 (1)° with the two Ph rings and the chlorophenyl ring, resp. In the crystal, N-H···O hydrogen bonds link the mols. into [001] chains.

IUCrData published new progress about Bond angle, dihedral. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Related Products of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ossowicz, Paula; Kardaleva, Proletina; Guncheva, Maya; Klebeko, Joanna; Swiatek, Ewelina; Janus, Ewa; Yancheva, Denitsa; Angelov, Ivan published the artcile< Ketoprofen-based ionic liquids: synthesis and interactions with bovine serum albumin>, Application In Synthesis of 2743-40-0, the main research area is ketoprofen based ionic liquid formulation bovine serum albumin; binding constants; bovine serum albumin; ionic liquids; ketoprofen; secondary structure.

The development of ionic liquids based on active pharmaceutical ingredients (API-ILs) is a possible solution to some of the problems of solid and/or hydrophobic drugs such as low solubility and bioavailability, polymorphism and an alternative route of administration could be suggested as compared to the classical drug. Here, we report for the first time the synthesis and detailed characterization of a series of ILs containing a cation amino acid esters and anion ketoprofen (KETO-ILs). The affinity and the binding mode of the KETO-ILs to bovine serum albumin (BSA) were assessed using fluorescence spectroscopy. All compounds bind in a distance not longer than 6.14 nm to the BSA fluorophores. The estimated binding constants (KA) are in order of 105 L mol-1, which is indicative of strong drug or IL-BSA interactions. With respect to the ketoprofen-BSA system, a stronger affinity of the ILs containing l-LeuOEt, l-ValOBu, and l-ValOEt cation towards BSA is clearly seen. Fourier transformed IR spectroscopy experiments have shown that all studied compounds induced a rearrangement of the protein mol. upon binding, which is consistent with the suggested static mechanism of BSA fluorescence quenching and formation of complexes between BSA and the drugs. All tested compounds were safe for macrophages.

Molecules published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Application In Synthesis of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Odham, Goran; Pettersson, Bente; Stenhagen, Einar published the artcile< Use of optically active half-esters of methoxy-substituted succinic acids in the stereospecific synthesis of long chain oxygenated compounds>, Synthetic Route of 617-55-0, the main research area is tetradecanoate ester methoxy; chain lengthening malate ester; electrolytic chain lengthening lauric acid.

The isomeric half-esters of (S)-methoxysuccinic acid have been prepared in the search of suitable intermediates for the synthesis of the β-glycol group of phthiocerol. The half-esters have very similar properties and differ mainly in the mass spectra and ir spectra. Chain-lengthening of (S)-methyl 2-methoxy-3-carboxypropanoate by mixed electrolysis with dodecanoic acid in DMF gave a 21% yield of (S)-methyl 2-methoxytetradecanoate.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Coupling reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hudlicky, Milos published the artcile< Fluorination with diethylaminosulfur trifluoride and related aminofluorosulfuranes>, SDS of cas: 617-55-0, the main research area is review SN; review Defluorination; review Epoxide cleavage; review Heterocycle formation; review Dehydrohalogenation; review Deamination; review Cyclization; review Labeling; review Allylic; review Dearomatization; review Oxidation; review Ether cleavage; review Chemoselective; review Oxygenation; review N Silylation; review Substitution; review Alkoxylation; review Ring formation; review Geoselective; review N Desilylation; review Amination; review Dehalogenation; review Acetal cleavage; review Aromatization; review Acylation; review Dehydrogenation; review Selective; review Ring expansion; review O Debenzylation; review Migration; review Addition; review Heterocyclization; review Dechlorination; review Cleavage; review Alkylation; review Elimination; review Fluorination; review Regioselective; review Deoxygenation; review O Desilylation; review Coupling; review O Sulfonation; review Transhalogenation; review Intramol; review S Oxidation; review C Amination; review S Desilylation; review O Alkylation; review Acetalization; review Ring cleavage; review Rearrangement; review Isomerization; review Etherification; review Sulfonation; review O Acylation; review S Amination; review Stereoselective; review Deiodination; review Retention; review Esterification; review Halogenation; review Dehydration; review Inversion; review Lactonization; review Diastereoselective; review Condensation; review Dehydroxylation; review Desulfurization; review Silylation; review Dealkoxylation; review Dehydrofluorination; review Chlorination; review Debromination; review S Deoxygenation; review Desilylation; review Ring contraction; review Thioacetal cleavage; review Debenzylation; review Desulfonation; review Shift; review P Oxidation; review Sulfurization.

A review of the article Fluorination with diethylaminosulfur trifluoride and related aminofluorosulfuranes.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kang, Qing-Qing; Meng, Ya-Nan; Zhang, Jun-Hao; Li, Long; Ge, Guo-Ping; Zheng, Hongxing; Liu, Hongxin; Wei, Wen-Ting published the artcile< Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds: Facile access to 2,3-dihydrofurans>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is dihydrofuran preparation regioselective; olefinic dicarbonyl compound ketone oxidative cyclization iron catalyst; dicarbonyl compound allyl bromide allylation.

Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds through C-C and C-O bond formations has been described for the first time. A broad substrate scope and ease of scale-up are the attractive features of this synthetic method, which provides a series of potentially bioactive 2,3-dihydrofurans. The reaction pathway is proposed to involve a radical addition of the in situ-formed α-carbonyl radical to the C=C bond of olefinic 1,3-dicarbonyls followed by intramol. 5-endo-trig cyclization.

New Journal of Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (unsaturated). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hajipour, Abdol Reza; Ruoho, Arnold E. published the artcile< Nitric acid in the presence of P2O5 supported on silica gel - a useful reagent for nitration of aromatic compounds under solvent-free conditions>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arene nitric acid silica supported phosphorus oxide nitration solventfree; nitro aromatic preparation.

A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% HNO3 in the presence of P2O5 supported on silica gel. This methodol. is useful for nitration of activated and deactivated aromatic rings.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Ziwei; Tsui, Gavin Chit published the artcile< Radical cyclization/bis(pentafluoroethylation) of 1,6-dienes using HCF2CF3-derived CuCF2CF3>, Application of C11H19NO2, the main research area is pyrrolidine pentafluoropropyl preparation diastereoselective; diallylamine copper pentafluoroethyl radical cyclization pentafluoroethylation; pentafluoropropyl cyclopentane preparation diastereoselective; diallyl malonate copper pentafluoroethyl radical cyclization pentafluoroethylation.

A domino radical cyclization/bis(pentafluoroethylation) of 1,6-dienes CH2=CHCH2N(R)CH2C(=CH2)R1 (R = H, 4-H3CC6H4SO2, 2,6-bis(propan-2-yl)phenyl, CH2CH=CH2, etc.; R1 = H, Me), and CH2=CHCH2C(R2)(R3)CH2CH=CH2 [R2 = R3 = C(O)OEt, C(O)OPh, C(O)Bn, etc. R2R3 = -C(O)(CH2)3C(O)-] for the synthesis of new classes of pyrrolidine I and cyclopentane derivatives II containing two C2F5 groups was described. This reaction is efficient for constructing three carbon-carbon bonds in one step. The reagent [CuCF2CF3] is prepared from inexpensive pentafluoroethane and the reactions conveniently run at room temperature in open air. Moderate to good diastereoselectivities can be obtained favoring the cis products I with X-ray structural proof.

Organic Chemistry Frontiers published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Application of C11H19NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saito, Seiki; Hasegawa, Takashi; Inaba, Masami; Nishida, Ryosuke; Fujii, Toshikazu; Nomizu, Seiya; Moriwake, Toshio published the artcile< Combination of borane-dimethyl sulfide complex with catalytic sodium tetrahydroborate as a selective reducing agent for α-hydroxy esters. Versatile chiral building block from (S)-(-)-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is butanoate dihydroxy preparation lactonization; borane sulfide reduction malate; borohydride dimethyl sulfide reductant; hydroxy ester selective reduction; butanolide hydroxy; butanal dihydroxy isopropylidene ketal.

BH3-Me2S complex in combination with NaBH4 is an efficient and selective reducing agent for α-hydroxy esters. Thus, reduction of di-Me (S)-(-)-malate with this agent afforded 80% (S)-HOCH2CH(OH)CH2CO2Me, which was converted into chiral building blocks I and II.

Chemistry Letters published new progress about Hydroxy esters Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Kenji; Ikunaka, Masaya published the artcile< Pheromone synthesis. 65. Synthesis of all of the four energetically possible stereoisomers of 7-ethyl-2-methyl-1,6-dioxaspiro[4.5]decane. A pheromone produced by bees Paravespura vulgaris L. and Andrena haemorrhoa F>, Related Products of 617-55-0, the main research area is dioxaspirodecane ethylmethyl isomer preparation; pheromone ethymethyldioxaspirodecane isomer preparation.

All 4 energetically possible stereoisomers [(2R,5R,7R)-, (2R,5S,7S)-, (2S,5R,7R)- and (2S,5S,7S)] of 7-ethyl-2-methyl-1,6-dioxaspiro[4.5]decane were synthesized from Et (S)-lactate and di-Me (S)-malate or Me (R)-β-hydroxyvalerate employing dianion alkylation as the key-step.

Tetrahedron published new progress about Plant pheromones Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics