Tag: M.W=150-200

Feenstra, R. W.; Stokkingreef, E. H. M.; Nivard, R. J. F.; Ottenheijm, H. C. J. published the artcile< An efficient synthesis of N-hydroxy α-amino acid derivatives of high optical purity>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxy amino acid; substitution hydroxy ester triflate benzylhydroxylamine.

(S)-HOCHRCO2R1 (R = Me, R1 = Et; R = CH2Ph, CH2CHMe2, CH2CO2Me, R1 = Me) were treated with (CF3SO2)2O (Tf2O) to give (S)-TfOCHRCO2R1, which were treated in situ with PhCH2ONH2 to give 78-89% (R)-PhCH2ONHCHRCO2R1 via a SN2 reaction. (S)-PhCH2ONHCHPhCO2Me was prepared similarly from (R)-HOCHPhCO2Me. The optical purity of the products ranged from 76 to 100%.

Tetrahedron Letters published new progress about Nucleophilic substitution reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao, Yujie; Zhao, Weijie published the artcile< Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors>, Computed Properties of 39987-25-2, the main research area is neolamellarin A derivative preparation HIF1 inhibitory activity SAR; Anti-tumor; Hypoxia inducible factor (HIF)-1; Marine alkaloids; Neolamellarin A; Structure-activity relationship.

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A (I) and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, resp. The results showed that neolamellarin A (IC50 = 10.8 ± 1.0 μM) and compound II (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biol. activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small mol. probes for target protein identification.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkaloids Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (pyrrole). 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Computed Properties of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Palladium-Catalyzed Decarboxylative Vinylation of Potassium Nitrophenyl Acetate: Application to the Total Synthesis of (±)-Goniomitine>, Product Details of C9H9NO4, the main research area is vinylation palladium catalyst decarboxylative potassium nitrophenyl acetate; goniomitine total synthesis decarboxylative vinylation potassium nitrophenyl acetate; oxidation reduction cyclization stereoselective total synthesis goniomitine.

A seven step total synthesis of (±)-goniomitine has been accomplished via novel palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates and vinyl triflates and a one-pot multiple bond forming integrated oxidation/reduction/cyclization process. Thus, reacting potassium (2-nitrophenyl)acetate with cyclohex-1-en-1-yl triflate in the presence of [{PdCl(allyl)}2]/XPhos in DMF gave 1-[(2-nitrophenyl)methyl]-1-cyclohexene.

Angewandte Chemie, International Edition published new progress about Cyclization, stereoselective. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xinying; Mi, Tongge; Guo, Wenjing; Ruan, Zhongrui; Guo, Yu; Ma, Yan-Na; Chen, Xuenian published the artcile< KB3H8: an environment-friendly reagent for the selective reduction of aldehydes and ketones to alcohols>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is aldehyde ketone reduction; alc preparation green chem.

Selective reduction of aldehydes and ketones to their corresponding alcs. with KB3H8, an air- and moisture-stable, nontoxic, and easy-to-handle reagent, in water and THF has been explored under an air atm. for the first time. Control experiments illustrated the good selectivity of KB3H8 over NaBH4 for the reduction of 4-acetylbenzaldehyde and aromatic keto esters.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Laha, Joydev K.; Sharma, Shubhra; Kirar, Seema; Banerjee, Uttam C. published the artcile< Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams>, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is heteroarylfused vinyl sultam preparation Michael addition hydrogenation cycloaddition.

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chem. reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

Journal of Organic Chemistry published new progress about Cycloaddition reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kammel, Richard; Tarabova, Denisa; Broz, Bretislav; Hladikova, Veronika; Hanusek, Jiri published the artcile< Formation of 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones involving ring transformation of 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles>, Product Details of C9H9NO4, the main research area is Hammett correlation kinetics ring transformation aryl aminophenyl hydroxythiazole; amino arylmethylidene indolone preparation Eschenmoser coupling; ring transformation aryl aminophenyl hydroxythiazole kinetics.

The reaction of 3-bromooxindole with substituted (hetero)aromatic thioamides in acetonitrile was studied. At room temperature the reaction preferably gives products of ring transformation i.e. 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles whereas at elevated temperature products of an Eschenmoser coupling reaction, i.e. 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones, are formed exclusively. There exist only two exceptions (4-methoxy and 2-pyridinthioamide) in which the Eschenmoser coupling reaction always takes place. Also N-methylation of the starting 3-bromooxindole completely prevents formation of thiazoles. The prepared thiazoles are unstable in solution and they undergo slow ring transformation to the expected Eschenmoser coupling products. The rate limiting step of this rearrangement involves cleavage of an intermediary thiirane ring, which is slowed down by electron-withdrawing substituents on the thioamide (ρ = -1.15).

Tetrahedron published new progress about C-S bond (cleavage). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Homma, Chihiro; Yamanaka, Masahiro; Kano, Taichi; Maruoka, Keiji published the artcile< Synthesis of alkynyl Z-ketimines and their application in amine-catalyzed asymmetric Mannich reactions and conjugate addition>, Computed Properties of 120157-98-4, the main research area is alkynyl ketimine amine catalyst enantioselective Mannich reaction conjugate addition.

A facile and practical synthesis of various alkynyl Z-ketimines, which was used as a synthetic equivalent of alkyl ketimines was developed. The obtained alkynyl Z-ketimines was successfully applied in enantioselective Mannich reaction and conjugate addition catalyzed by a chiral amine with an acid functionality.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 120157-98-4 belongs to class esters-buliding-blocks, and the molecular formula is C7H13NO3, Computed Properties of 120157-98-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ushio, Kazutoshi; Nakagawa, Kouzou; Nakagawa, Katsuhiko; Watanabe, Kunio published the artcile< An easy access to optically pure (R)-malic acid via enantioselective hydrolysis of diethyl malate by Rhizopus lipase>, Quality Control of 617-55-0, the main research area is malate enzymic resolution lipase; malic acid optically active.

(±)-Di-Et malate was enantioselectively hydrolyzed by crude Rhizopus lipase (Saiken) to leave optically pure (≥99% enantiomeric excess) (R)-(+)-malic acid in 20% recovery. The combination of di-Pr malate and lipase AY (Amano) also gave the (R)-enantiomer with an enantiomeric excess of ≥95% and about 20% recovery in a short reaction time.

Biotechnology Letters published new progress about Enzymic resolution. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Dong Ung; Mayer, Klaus K.; Wiegrebe, Wolfgang; Lauber, Rolf; Schlunegger, Urs P. published the artcile< Mass-spectrometric investigations on derivatives of phenylacetic acid. II. Ortho effects of ionized phenylacetates>, Safety of Methyl 2-(2-nitrophenyl)acetate, the main research area is mass spectra benzeneacetate substituent effect; metastable ion mass spectra phenylacetate; collisional activation mass spectra benzeneacetate.

The mol. ions of 2-RC6H4CH2CO2R1 (I; R = Cl, R1 = Me, Et; R = Br, NO2, R1 = Me) lost R to give strong [M-R]+ signals. I (R = Me2N, R1 = Me; R = MeO, R1 = Et) did not lose R, and 3-ClC6H4CH2CO2Me did not lose Cl. The metastable-ion and collisional-activation spectra were discussed.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Mass spectra. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Safety of Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kamal, Ahmed; Balakrishna, Moku; Reddy, Papagari Venkat; Rahim, Abdul published the artcile< First total synthesis of the E- and Z-isomers of cytospolide-D>, Quality Control of 617-55-0, the main research area is cytospolide D synthesis.

A simple, convergent, and efficient approach for the total synthesis of the bioactive E- and Z-isomers of cytospolide-D is described. The key features of the synthetic strategy include stereoselective methylation, regioselective epoxide opening, olefin cross-metathesis, and a Yamaguchi protocol reaction for the formation of the E-olefinic geometry of the 10 membered ring; Steglich esterification and ring-closing metathesis reaction for the formation of the 10 membered ring with a Z-olefinic geometry in the skeleton. L-Malic acid was used as a chiral pool starting material for the construction of the olefinic acid fragment while D-mannitol was used as a chiral pool starting material for the building of the olefinic alc. fragment.

Tetrahedron: Asymmetry published new progress about Cross-metathesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics