Tag: M.W=150-200

Haag, Franziska published the artcileThe key food odorant receptive range of broadly tuned receptor OR2W1, HPLC of Formula: 103-26-4, the publication is Food Chemistry (2022), 131680, database is CAplus and MEDLINE.

Mammals perceive a multitude of odorants by their chem. sense of olfaction, a high-dimensional stimulus-detection system, with hundreds of narrowly or broadly tuned receptors, enabling pattern recognition by the brain. Cognate receptor-agonist information, however, is sparse, and the role of broadly tuned odorant receptors for encoding odor quality remains elusive. Here, we screened IL-6-HaloTag-OR2W1 and haplotypes against 187 out of 230 defined key food odorants using the GloSensor system in HEK-293 cells, yielding 48 new agonists. Altogether, key food odorants represent about two-thirds of now 153 reported agonists of OR2W1, the highest number of agonists known for a mammalian odorant receptor. In summary, we characterized OR2W1 as a human odorant receptor, with a chem. diverse but exclusive receptive range, complementary to chem. subgroups covered by evolutionary younger, highly selective receptors. Our data suggest OR2W1 to be suited for participating in the detection of many foodborne odorants.

Food Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Boran published the artcileMolecular mechanism of Gleditsiae Spina for the treatment of high-grade serous ovarian cancer based on network pharmacology and pharmacological experiments, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is BioMed Research International (2022), 5988310, database is CAplus and MEDLINE.

Gleditsiae Spina, widely used in traditional Chinese medicine, has a good curative effect on malignant tumors such as ovarian cancer, but the mechanism is not clear. So, we aimed to analyze the pharmacol. mechanism of Gleditsiae Spina in the treatment of high-grade serous ovarian cancer (HGSC) based on network pharmacol. and biol. experiments The main active ingredients of Gleditsiae Spina were identified by high performance liquid chromatog. (HPLC) and mass spectrometry (MS), and the active ingredients were performed by ADME screening. The component targets of Gleditsiae Spina were screened using the PharmMapper platform, and differentially expressed genes in normal and HGSC tissues were identified through the GEO database. Thereafter, the network of “active ingredient-targets” was constructed by cytoscape 3.7.2 software. The protein-protein interaction network was established by the BioGenet database to mine the potential protein function. Biol. processes and pathways were analyzed through Gene Ontol. and Kyoto Encyclopedia of Genes and Genomes anal. The binding ability of the core components of the Gleditsiae Spina and the core target of HGSC was verified by mol. docking and mol. dynamics simulation, and the therapeutic effect of Gleditsiae Spina was proved in vitro through cytotoxicity experiments The effect of Gleditsiae Spina on the core pathway is obtained by western blotting. Gleditsiae Spina had cytotoxicity on HGSC based on network pharmacol. and biol. experiments Luteolin, genistein, D-(+)-tryptophan, ursolic acid, and berberine are the identified core active ingredients of Gleditsiae Spina for regulating HGSC, with HPSE, PI3KCA, AKT1, and CTNNB1as the ideal targets. The prediction results were verified by mol. docking, mol. dynamic simulation, cell viability, and western blot anal. Gleditsiae Spina mainly downregulates the expression of heparanase and β-catenin to affect the composition of tumor cytoplasmic matrix and can regulate the PI3K-AKT pathway, integrating multiple targets and multiple pathways to play a therapeutic role. It also provides a theor. basis for the prevention of ovarian cancer and its treatment using traditional Chinese medicine in the future.

BioMed Research International published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C20H17FO4S, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Diego, Rosa published the artcileDesigned asymmetric coordination helicates with bis-β-diketonate ligands, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Dalton Transactions (2019), 48(45), 16844-16847, database is CAplus and MEDLINE.

A new bis-(β-diketone) ligand featuring built-up structural asymmetry yields non-sym. Fe(III) and Ga(III) dinuclear, triple-stranded helicates by design. Their structural properties have been studied, both in solid state and in solution, and compared with their corresponding sym. analogs. The robustness observed shows the potential of this synthetic strategy to develop non-sym. helicoidal motifs with specific functional groups.

Dalton Transactions published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kwak, Se Hun published the artcileN-Aminopyridinium Ylide-Directed, Copper-Promoted Amination of sp² C-H Bonds, Quality Control of 1877-71-0, the publication is Journal of Organic Chemistry (2019), 84(20), 13022-13032, database is CAplus and MEDLINE.

N-Aminopyridinium ylides were used as monodentate directing groups for copper-promoted C-H/N-H coupling of sp² C-H bonds with pyrazoles, imidazoles, and sulfonamides. Reactions proceed in fluorinated alc. solvents at elevated temperatures and require use of 1.3-3 equiv of copper(II) acetate. This appears to be the first method for copper-promoted C-H/N-H coupling directed by a removable monodentate auxiliary in absence of added ligands.

Journal of Organic Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kwak, Se Hun published the artcileN-Iminopyridinium ylide-directed, cobalt-catalysed coupling of sp² C-H bonds with alkynes, HPLC of Formula: 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(75), 11070-11073, database is CAplus and MEDLINE.

N-Iminopyridinium ylides were competent monodentate directing groups for cobalt-catalyzed annulation of sp² C-H bonds with internal alkynes. The pyridine moiety in the ylide serves as an internal oxidant and was cleaved during the reaction. The annulation reactions possess excellent compatibility with heterocyclic substrates, tolerating furan, thiophene, pyridine, pyrrole, pyrazole, and indole functionalities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, HPLC of Formula: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Savoji, Houman published the artcile3D Printing of Vascular Tubes Using Bioelastomer Prepolymers by Freeform Reversible Embedding, Application In Synthesis of 617-52-7, the publication is ACS Biomaterials Science & Engineering (2020), 6(3), 1333-1343, database is CAplus and MEDLINE.

Bioelastomers have been extensively used in tissue engineering applications because of favorable mech. stability, tunable properties, and chem. versatility. As these materials generally possess low elastic modulus and relatively long gelation time, it is challenging to 3D print them using traditional techniques. Instead, the field of 3D printing has focused preferentially on hydrogels and rigid polyester materials. To develop a versatile approach for 3D printing of elastomers, we used freeform reversible embedding of suspended prepolymers. A family of novel fast photocrosslinakble bioelastomer prepolymers were synthesized from di-Me itaconate, 1,8-octanediol, and tri-Et citrate. Tensile testing confirmed their elastic properties with Young’s moduli in the range of 11-53 kPa. These materials supported cultivation of viable cells and enabled adhesion and proliferation of human umbilical vein endothelial cells. Tubular structures were created by embedding the 3D printed microtubes within a secondary hydrogel that served as a temporary support. Upon photocrosslinking and porogen leaching, the polymers were permeable to small mols. (TRITC-dextran). The polymer microtubes were assembled on the 96-well plates custom made by hot-embossing, as a tool to connect multiple organs-on-a-chip. The endothelialization of the tubes was performed to confirm that these microtubes can be utilized as vascular tubes to support parenchymal tissues seeded on them.

ACS Biomaterials Science & Engineering published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fuller, Ioan D. published the artcileChemical diversity of kanuka: Inter- and intraspecific variation of foliage terpenes and flavanones of Kunzea (Myrtaceae) in Aotearoa/New Zealand, Synthetic Route of 103-26-4, the publication is Phytochemistry (Elsevier) (2022), 113098, database is CAplus and MEDLINE.

Kunzea (Myrtaceae) trees and shrubs, generally called kanuka, grow across most of Aotearoa/New Zealand (NZ). With the exception of K. sinclairii, an offshore island endemic, kanuka had been treated as an Australasian species K. ericoides. However, a 2014 taxonomic revision recognized ten species, all endemic to NZ. Kanuka chem. is less studied than that of its closest relative in NZ, manuka (Leptospermum scoparium), which shows very distinct regional foliage chemotypes. We have used a miniaturized method with GC and 1H NMR to analyze foliage chem. of voucher specimens from across the geog. ranges of the ten NZ Kunzea species. We found common mono- and sesquiterpenes, with α-pinene dominant in all samples, but only traces of antimicrobial triketones. Two unusual flavanones, with unsubstituted B-rings and known bioactivity against Phytophthora, did distinguish some of the samples. 5,7-Dihydroxy-6,8-dimethyl flavanone was only found at high concentrations in the three K. sinclairii samples in this study’s sample set, but this compound has sep. been reported in K. robusta samples from a nearby region. Therefore none of the NZ Kunzea species was distinguished by the chem. analyzed in this study, but there is a possibility of regional flavonoid chemotypes cutting across the species boundaries.

Phytochemistry (Elsevier) published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fugolin, A. P. P. published the artcileProbing stress relaxation behavior in glassy methacrylate networks containing thio-carbamate additives, Product Details of C11H15NO2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(13), 3015-3024, database is CAplus and MEDLINE.

The incorporation of thiourethane prepolymer (TU) into either the organic phase or as a surface treatment for filler particles in composites reduces polymerization stress and improves fracture toughness. The aim of this study was to gain insight into the influence of the inclusion of thiourethanes on the resulting network of methacrylate-based materials polymerized via free-radical mechanisms. Dynamic mech. anal. was used to elucidate network parameters and potential stress relaxation behavior of these networks. TU oligomers were synthesized using a combination of trimethylol-tris-3-mercaptopropionate and dicyclohexylmethane 4,4′-diisocyanate and added into composite formulations at 20 wt% replacing part of the organic matrix and/or as TU-silanes used to functionalize filler particles (TU-matrix, TU-Sil or TU-matrix/sil). Materials not containing any form of TU were used as the control (in those cases, 3-(trimethoxysilyl)propyl methacrylate was used as the silane agent). Filler was added at 50 wt%. Degree of conversion was evaluated by near-IR spectroscopy, mech. properties by 3-point bending and rotational rheometry. Dynamic mech. anal. was used to obtain network parameters (glass transition temperature (T_g), storage modulus, crosslink d., and breadth of tan delta a proxy for network homogeneity – temperature sweep experiments) and to evaluate the potential for network relaxation (stress relaxation). TU-containing formulations showed 10% higher DC than the control. The time to reach storage/loss modulus crossover in the rheometer experiments was significantly longer for TU-matrix and TU-matrix/sil in comparison with the control (21.6, 27.9, and 5.1 s, resp.). TU-matrix and TU-matrix/sil presented significant lower T_g than the control (151.5, 153.8, and 161.3°C, resp.). There were no statistical differences among the groups in terms of shear modulus, crosslink d., breadth of tan delta, flexural strength/modulus, and toughness. For at least one group (TU-matrix/sil), the relaxation time was four times faster than for the control at 105°C. The addition of TU additives into dental polymers resulted in a stark reduction in the stress relaxation time. This behavior, in tandem with the network characterization and mech. properties seems to indicate the TU networks undergo a variety of reversible associative and dissociative chem. reactions which facilitate enhanced stress relief.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Product Details of C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pereira, Leonardo Duarte Eiras published the artcileInfluence of resin matrix on the rheology, translucency, and curing potential of experimental flowable composites for bulk-fill applications, Synthetic Route of 10287-53-3, the publication is Dental Materials (2021), 37(6), 1046-1053, database is CAplus and MEDLINE.

To propose monomer formulations that show an optimal degree of conversion as a function of depth for bulk-fill applications.Four resin blends were formulated with methacrylate-based monomers: BisGMA + TEGDMA (control); BisEMA + BisGMA + TEGDMA (BisEMA-based); UDMA + BisGMA + TEGDMA (UDMA-based) and BisEMA + UDMA + BisGMA + TEGDMA (BisEMA + UDMA-based). For each material, a photoinitiating system and silanized filler particles were added. The rheol. analyses were performed with a rotational rheometer using the cone/plate geometry. CIELab coordinates were assessed over black and white backgrounds using a bench spectrophotometer (SP60, X-Rite) to calculate the translucency parameter (TP) for samples with 0.5, 4, and 6 mm thickness. The degree of C = C conversion (DC) was determined by IR spectroscopy (FTIR/ATR) at 0.05 mm (top), 4, and 6 mm depths (bottom), and the bottom-to-top ratio was considered. A broad spectrum-based LED was used for light activation. Anal. of variance and Tukey′s test (95%) were performed on the results.The materials tested showed pseudoplastic and thixotropic behavior and a predominance of viscous effects over elastics. The control resin yielded the lowest viscosity for the entire shear rate investigated, followed by the BisEMA-based, BisEMA + UDMA-based, and UDMA-based group, which had the highest viscosity. The UDMA-based material showed the lowest TP as a function of thickness. Both the materials′ formulations and depths significantly influenced the DC. The UDMA-based group promoted the highest DC on the top (71 ± 1%) and 4 mm depth (68 ± 1%) but exhibited lower bottom-to-top DC ratio. The BisEMA + UDMA-based material promoted the highest bottom-to-top DC ratio at 4 mm (99%) and 6 mm (97%). The resin matrix interferes in the rheol. behavior, translucency parameter, and polymerization capacity as a function of depth. The material formulated with the addition of UDMA and BisEMA demonstrated the highest curing potential as a function of depth and can be useful for bulk-fill applications.

Dental Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chiloeches, A. published the artcileAntibacterial and compostable polymers derived from biobased itaconic acid as environmentally friendly additives for biopolymers, Application In Synthesis of 617-52-7, the publication is Polymer Testing (2022), 107541, database is CAplus.

In this work, a series of antibacterial cationic copolymers derived from bio-sourced itaconic acid was studied as potential biobased active components in biodegradable formulations based on poly(butylene adipate-co-terephthalate) (PBAT) for packaging applications. These copolymers were first characterized by testing their antimicrobial activity against resistant bacterial strains, their biodegradability in compost conditions, and their thermal properties by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA). The antibacterial properties showed potent activity against Methicillin-resistant Staphylococcus aureus (MRSA), with MIC values as low as 78μg mL^-1. Related to their biodegradability, the cationic polymers biodegraded fast under compost conditions and even a priming effect was observed in the compost. Thermal properties, characterized by DSC and TGA, showed that the copolymers thermally degraded at temperature relatively low; nevertheless, they are able to be processed at temperatures up to _~150°C. Subsequently, these antibacterial polymers were successfully blended as minor active component (10 wt%) with PBAT by melt-extrusion and press-compression molding. The resulting biopolymeric films exhibit potent antibacterial activity. Therefore, these antibacterial biobased polymers derived from itaconic acid seem to be good candidates for applications related to active food packaging or even for biomedical devices.

Polymer Testing published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics