Tag: M.W=150-200

Anthony, Paschal Chidera published the artcileSynthesis of some esters of cinnamic acid and evaluation of their in vitro antidiabetic and antioxidant properties, Safety of Methyl 3-phenyl-2-propenoate, the publication is Tropical Journal of Pharmaceutical Research (2022), 21(1), 131-136, database is CAplus.

To synthesize various ester derivatives of cinnamic acid and to evaluate their in vitro antidiabetic and antioxidant properties. Esters of cinnamic acid were synthesized by refluxing the parent compound (cinnamic acid) with different alcs. using concentrated sulfuric acid as a catalyst. Physicochem. analyses (solubility, b.p., refractive index) and spectrophotometric analyses (UV-visible spectroscopy (UV-VIS), Fourier-transform IR spectroscopy (FT-IR) and gas chromatog.-mass spectroscopy (GC-MS)) were carried out on the synthesized products. The antioxidant inhibitory property, uptake of glucose by yeast, and Hb glycosylation of the synthesized products were also evaluated using standard methods. The identities of methylcinnamate, ethylcinnamate, propylcinnamate, 2-propylcinnamate, butylcinnamate and 2-butylcinnamate were confirmed, at m/z ratios of (131,103,77 and M⁺ of162), (131,103,77 and M⁺ of 176), (147,103,77and M⁺ of 190), (147,103,77 and M⁺ of 204), (143, 103, 77 and M⁺ of 190), and finally (147,103,77 and M⁺ of 204) resp. FT-IR results revealed the following important bonds for the synthesized compounds: C=O, C-C, C-O, C=H, C-H and adjacent H. The results for glucose uptake by yeast and of Hb glycosylation test indicate that all the products facilitated the transport and detachment of glucose at varying concentrations, resp. The DPPH scavenging activity of propylcinnamate, 2-butylcinnamate and methylcinnamate with the absorbance of 63.06, 56.85 and 53.06 at 50μg/mL – 250μg/mL, resp., recorded the highest values when compared with the control (ascorbic acid). The results reveal that the six ester derivatives of cinnamic acid exhibit a certain degree of antidiabetic activity by facilitating the uptake of glucose by yeast and reducing glycation of Hb; thus, showing a reasonable level of inhibition against free radicals.

Tropical Journal of Pharmaceutical Research published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Safety of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Studzian, Maciej published the artcileSynthesis, Internalization and Visualization of N-(4-Carbomethoxy) Pyrrolidone Terminated PAMAM [G5:G3-TREN] Tecto(dendrimers) in Mammalian Cells, Category: esters-buliding-blocks, the publication is Molecules (2020), 25(19), 4406, database is CAplus and MEDLINE.

Tecto(dendrimers) are well-defined, dendrimer cluster type covalent structures. In this article, we present the synthesis of such a PAMAM [G5:G3-(TREN)]-N-(4-carbomethoxy) pyrrolidone terminated tecto(dendrimer). This tecto(dendrimer) exhibits nontraditional intrinsic luminescence (NTIL; excitation 376 nm; emission 455 nm) that has been attributed to three fluorescent components characterized by different fluorescence lifetimes. Furthermore, it has been shown that this PAMAM [G5:G3-(TREN)]-N-(4-carbomethoxy) pyrrolidone terminated tecto(dendrimer) is able to form a polyplex with double stranded DNA, and is nontoxic for HeLa and HMEC-1 cells up to a concentration of 10 mg/mL, even though it accumulates in endosomal compartments as demonstrated by its unique NTIL emission properties. Many of the above features would portend the proposed use of this tecto(dendrimer) as an efficient transfection agent. Quite surprisingly, transfection activity could not be demonstrated in HeLa cells, and the possible reasons are discussed in the article.

Molecules published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C15H20O6, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ranger, Christopher M. published the artcileElectrophysiological and Behavioral Responses of an Ambrosia Beetle to Volatiles of its Nutritional Fungal Symbiont, Name: Methyl 3-phenyl-2-propenoate, the publication is Journal of Chemical Ecology (2021), 47(4-5), 463-475, database is CAplus and MEDLINE.

Ambrosia beetles (Coleoptera: Scolytinae) cultivate their fungal symbiont within host substrates as the sole source of nutrition on which the larvae and adults must feed. To investigate a possible role for semiochems. in this interaction, we characterized electrophysiol. and behavioral responses of Xylosandrus germanus to volatiles associated with its fungal symbiont Ambrosiella grosmanniae. During still-air walking bioassays, X. germanus exhibited an arrestment response to volatiles of A. grosmanniae, but not antagonistic fungi Beauveria bassiana, Metarhizium brunneum, Trichoderma harzianum, the plant pathogen Fusarium proliferatum, or malt extract agar. Solid phase microextraction-gas chromatog.-mass spectrometry identified 2-ethyl-1-hexanol, 2-phenylethanol, Me benzoate and 3-methyl-1-butanol in emissions from A. grosmanniae; the latter two compounds were also detected in emissions from B. bassiana. Concentration-responses using electroantennog. documented weak depolarizations to A. grosmanniae fungal volatiles, unlike the comparatively strong response to ethanol. When tested singly in walking bioassays, volatiles identified from A. grosmanniae elicited relatively weak arrestment responses, unlike the responses to ethanol. Xylosandrus germanus also exhibited weak or no long-range attraction to the fungal volatiles when tested singly during field trials in 2016-2018. None of the fungal volatiles enhanced attraction of X. germanus to ethanol when tested singly; in contrast, 2-phenylethanol and 3-methyl-1-butanol consistently reduced attraction to ethanol. Volatiles emitted by A. grosmanniae may represent short-range olfactory cues that could aid in distinguishing their nutritional fungal symbiont from other fungi, but these compounds are not likely to be useful as long-range attractants for improving detection or mass trapping tactics.

Journal of Chemical Ecology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Name: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Steingass, Christof B. published the artcileInfluence of fruit logistics on fresh-cut pineapple (Ananas comosus [L.] Merr.) volatiles assessed by HS-SPME-GC-MS analysis, Synthetic Route of 103-26-4, the publication is European Food Research and Technology (2021), 247(7), 1617-1630, database is CAplus.

Green-ripe pineapples are shipped overseas by sea freight, while those picked at full maturity need to be transported by airfreight over the same large distance. In this study, fresh-cut pineapple cubes were assessed two, five, and eight days after processing from green-ripe pineapples after mimicked sea freigh (SF) and fully ripe air-freighted (AF) pineapples. The sea-freighted samples displayed elevated titratable acidity (TA), thus resulting in smaller ratios of total soluble solids and TA compared to the AF pineapples. Differences in the carotenoid levels of the two fresh-cut categories were found to be insignificant. By contrast, hierarchical cluster anal. (HCA) and principal component anal. (PCA) calculated on the basis of the volatiles analyzed by headspace solid-phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS) permitted to distinguish all six individual sample types and to segregate them into two major clusters (SF and AF). The effect of storage on the volatiles was further evaluated by partial least squares (PLS) regression. Substantial chem. markers to differentiate the individual samples and to describe the effect of storage were deduced from the PCA and PLS regression, resp. In general, fresh-cut products obtained from fully ripe AF fruit displayed higher concentrations of volatiles, in particular, increased concentrations of diverse Me esters. With progressing storage duration, the concentrations of ethanol and diverse Et esters increased. Moreover, products from AF pineapples displayed lower microbial counts compared to those from SF fruit.

European Food Research and Technology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C12H23N3S, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mau, Alexandre published the artcileConcomitant initiation of radical and cationic polymerizations using new copper complexes as photoinitiators: Synthesis and characterisation of acrylate/epoxy interpenetrated polymer networks, Related Products of esters-buliding-blocks, the publication is European Polymer Journal (2021), 110457, database is CAplus.

Two new copper complexes were investigated in three-component visible light photoinitiating system for both radical and cationic polymerization under air. Their reactivity and efficiency have been compared with that of a highly efficient photoredox catalyst. The formation of acrylate/epoxy interpenetrated polymer networks were successfully performed through concomitant initiation of radical and cationic polymerization with low copper complex content upon either LED@405 nm or LED@455 nm irradiations. Several characterizations of the acrylate/epoxy IPNs final properties, such as the mech. properties, adhesion properties, shrinkage and swelling, indicated the possibilities to adapt or tune their properties compared to radical polymerization of TMPTA.

European Polymer Journal published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sipes, I. G. published the artcileBenzyl derivatives, Product Details of C12H14O2, the publication is WHO Food Additives Series (2011), 189-206, database is CAplus.

The Committee evaluated eight addnl. flavoring agents belonging to the group of benzyl derivatives that was previously evaluated. The structural feature common to all members of the group is a primary oxygenated functional group bonded directly to a benzene ring or a functional group metabolized to a benzyl alc. or benzoic acid derivative Generally, the Committee concluded that these eight flavoring agents, which are additions to the group of benzyl derivatives evaluated previously, would not give rise to safety concerns at current estimated dietary exposures.

WHO Food Additives Series published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C20H12N2O2, Product Details of C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fang, Kun published the artcileDiscovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors, Application In Synthesis of 1877-71-0, the publication is ACS Medicinal Chemistry Letters (2018), 9(4), 312-317, database is CAplus and MEDLINE.

In order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed. The highly active dual inhibitor 10 showed excellent and balanced activity against both IDO1 (IC₅₀ = 69.0 nM) and HDAC1 (IC₅₀ = 66.5 nM), whose dual targeting mechanisms were validated in cancer cells. Compound 10 had good pharmacokinetic profiles as an orally active antitumor agent and significantly reduced the L-kynurenine level in plasma. In particular, it showed excellent in vivo antitumor efficacy in the murine LLC tumor model with low toxicity. This proof-of-concept study provided a novel strategy for cancer treatment. Compound 10 represents a promising lead compound for the development of novel antitumor agents and can also be used as a valuable probe to clarify the relationships and mechanisms between cancer immunotherapy and epigenetics.

ACS Medicinal Chemistry Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Application In Synthesis of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vervliet, Philippe published the artcileIdentification of chemicals leaching from dental resin-based materials after in vitro chemical and salivary degradation, Synthetic Route of 10287-53-3, the publication is Dental Materials (2022), 38(1), 19-32, database is CAplus and MEDLINE.

Only little is known about degradation of methacrylate monomers. Therefore, using in vitro chem. and saliva degradation this study aimed to identify the degradation products of organic compounds present in resin-based dental materials. Ten dental monomers and nine polymerized dental resin-based materials were immersed for 24 h in chem. media (0.1 M HCl, 0.1 M NaOH) and human pooled saliva in order to identify leached monomers and degradation products from chem. and saliva degradation Samples were analyzed using liquid chromatog. coupled to high-resolution mass spectrometry to identify previously unknown degradation products. During in vitro chem. degradation, uncured monomers were rapidly hydrolyzed into mono- and demethacrylated degradation products. During chem. degradation in alk. conditions of polymerized materials, considered the worst-case scenario, only degradation products could be detected. In acidic conditions, monomers and their degradation products were detected. In addition, different additives such as EDMAB, DMPA and HMBP were present in acidic degradation samples. Degradation in human pooled saliva for 24 h to mimic the in vivo situation, resulted in the identification of both monomers and their degradation products. Using state-of-the-art high-resolution mass spectrometry previously unknown degradation products of commonly used monomers were identified for the first time. Patients may be exposed to monomers and their degradation products in the first 24 h after restorative procedures. The results provide a base for further research on the degradation of resin-based dental composites in order to assess their safety using elution and toxicity studies.

Dental Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C3H6O2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bera, Sourav Sekhar published the artcileCp*Co^III-Catalyzed syn-Selective C-H Hydroarylation of Alkynes Using Benzamides: An Approach Toward Highly Conjugated Organic Frameworks, Application of 3-(Methoxycarbonyl)benzoic acid, the publication is Journal of Organic Chemistry (2017), 82(1), 420-430, database is CAplus and MEDLINE.

Hydroarylation of internal alkynes by cost effective CoIII-catalysis, directed by N-tert-Bu amides, is achieved to avail mono- or di-hydroarylated amide products selectively in an atom and step economic way. Several important functional groups were tolerated the reaction conditions, and syn-hydroarylation products were exclusively isolated. Notably, a fourfold C-H hydroarylation provided a highly conjugated organic framework (I) in one step. Kinetic study with extensive deuterium labeling experiments were performed to support the proposed mechanism.

Journal of Organic Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Application of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vasconcelos e Cruz, Joana published the artcileImproving Properties of an Experimental Universal Adhesive by Adding a Multifunctional Dendrimer (G-IEMA): Bond Strength and Nanoleakage Evaluation, Related Products of esters-buliding-blocks, the publication is Polymers (Basel, Switzerland) (2022), 14(7), 1462, database is CAplus and MEDLINE.

A vast number of adhesive formulations exist currently. However, available adhesives still have several drawbacks such as increased hydrophilicity, polymerization deficiency, potential cytotoxicity and limited monomer interdiffusion within dentin. To improve material properties, a Bisphenol A-free adhesive containing a novel dendrimer G(2)-isocyanatoethyl methacrylate (G-IEMA) in replacement of Bis-GMA was made and tested. Sound human molars were sectioned to expose mid-coronal dentin, which was bonded using four adhesives-Futurabond, Scotchbond Universal and experimentals EM1 and EM2. The exptl. adhesive EM2 contained G-IEMA, while EM1 had Bis-GMA. Groups were further allocated to two different adhesive strategies: etch-and-rinse (20 s etching) or self-etch. Immediate (24 h) microtensile bond strength to dentin (n = 5) was tested using a universal testing machine (1 mm/min, 5 kN; Shimadzu AGS-X Autograph, Tokyo, Japan), while the ultrastructure of the interface (n = 2) was assessed using SEM-energy dispersive spectroscopy (SEM-EDS). Nanoleakage expression was evaluated using silver nitrate penetration and posterior SEM-EDS anal. (n = 3). Linear mixed models/Generalized models were used for inferential statistics (5% significance level). Bond strength results did not depend on the adhesive choice, although differences were found between strategies (p < 0.001). Regarding nanoleakage, when applied in an etch-and-rinse mode, exptl. adhesives scored lower nanoleakage means than Futurabond and Scotchbond Universal. The novel adhesive shows interesting interfacial properties, with favorable nanoleakage results and a bond strength to dentin that matches current com. adhesives.

Polymers (Basel, Switzerland) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C15H24S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics