Tag: 300-400

On August 2, 2018, Qian, Yimin; Crew, Andrew P.; Crews, Craig M.; Dong, Hanqing; Hornberger, Keith R.; Wang, Jing published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of substituted benzothiophenes as modulators of estrogen receptor proteolysis and associated methods of use. And the patent contained the following:

The disclosure relates to bifunctional compounds of formulas I and II, which find utility as modulators of estrogen receptor (target protein). In particular, the disclosure is directed to bifunctional compounds of formulas I and II, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the resp. E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. Compounds of formulas I and II wherein ULM is a small mol. E3 ubiquitin ligase binding moiety that binds or targets and E3 ubiquitin ligase; L is a chem. linker; X is O and CO; X1 and X2 are independently N and HC; R1 is OH, alkanoyloxy, aroyloxy and lower alkoxy; R2 and R4 are independently H, OH, halo, CN, CF3, etc.; R3 and R5 are independently H and halo; with provisions; and pharmaceutically acceptable salts, enantiomers, stereoisomers, solvates, polymorphs and prodrugs thereof, are claimed. The disclosure exhibits a broad range of pharmacol. activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the disclosure. Example compound III was prepared by a general procedure (procedure given). The invention compounds were evaluated for their estrogen receptor proteolysis modulatory activity. From the assay, it was determined that compound III exhibited IC50 value of 12.7 nM. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0

The Article related to benzothiophene preparation estrogen receptor proteolysis modulator, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Related Products of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shin, Hyeong-Moo; Moschet, Christoph; Young, Thomas M.; Bennett, Deborah H. published an article in 2020, the title of the article was Measured concentrations of consumer product chemicals in California house dust: Implications for sources, exposure, and toxicity potential.Recommanded Product: 6197-30-4 And the article contains the following content:

Household dust is a reservoir of various consumer product chems. Thus, characterizing comprehensive chem. profiles of house dust may help improve our understanding of residential chem. exposure. We have previously developed a method for detecting a broad spectrum of chems. in dust by applying a combination of target, suspect screening, and non-target methods with mass spectrometry preceded by liquid chromatog. and gas chromatog. Building upon a previous study that detected 271 compounds in 38 dust samples, we presented concentrations of 144 compounds that were confirmed and quantified by standards in the same set of samples. Ten compounds were measured with median concentrations greater than 10 000 ng/g of dust: cis-hexadec-6-enoic acid, squalene, cholesterol, vitamin E, bis(2-ethylhexyl) phthalate, dioctyl terephthalate, linoleic acid, tricaprylin, tris(1-chloroisopropyl) phosphate, and oxybenzone. We also reviewed in vitro toxicity screening data to identify compounds that were not previously detected in indoor dust but have potential for adverse health effects. Among 119 newly detected compounds, 13 had endocrine-disrupting potential and 7 had neurotoxic potential. Toxicity screening data were not available for eight biocides, which may adversely affect health. Our results strive to provide more comprehensive chem. profiles of house dust and identified information gaps for future health studies. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to consumer product chem concentration house dust toxicity pollution california, concentration, dust, in vitro bioactivity assays, non-target, suspect screening, target, Air Pollution and Industrial Hygiene: Air Pollutants and Air Pollution and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2022, An, Di; Xing, Xiangyang; Tang, Zhenwu; Li, Yonghong; Sun, Jiazheng published an article.Computed Properties of 6197-30-4 The title of the article was Concentrations, distribution and potential health risks of organic ultraviolet absorbents in street dust from Tianjin, a megacity in northern China. And the article contained the following:

The distribution of organic UV absorbers (OUVAs) in outdoor dust remains poorly understood, especially in megacities. We measured the concentrations of 11 OUVAs in street dust from Tianjin, China, by a gas chromatog.-mass spectrometry, and found total concentrations in the range of 10.3-129 ng/g. These OUVAs were prevalent in the study street dust, but their concentrations were much lower than those in indoor dust reported in other areas previously. Benzophenone and octocrylene were the dominant OUVAs, representing medians of 15.5% and 13.1% of total OUVA concentrations, resp. Total concentrations of dust OUVAs in the industrial area were higher than the residential, cultural and new urban areas. Source assessment indicated that the OUVAs likely originated mainly from the manufacture and consumption of cosmetics and personal care products, and some may have been from the production and use of OUVA-containing consumer products. The calculated non-carcinogenic risks of OUVAs in street dust were low. Our results further confirmed that the OUVAs were prevalent in the environment, provide useful information for understanding potential risks of these chems. and developing risk management strategies. Further studies are needed to investigate the occurrence, environmental behaviors and potential risks of these emerging contaminants in outdoor environment. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Computed Properties of 6197-30-4

The Article related to organic uv absorbent street dust health risk air pollution, distribution, health risks, organic ultraviolet absorbers (ouvas), sources, street dust, Air Pollution and Industrial Hygiene: Air Pollutants and Air Pollution and other aspects.Computed Properties of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhuang, Chen; Tao, Fu-Rong; Cui, Yue-Zhi published an article in 2016, the title of the article was Preparation and properties of gelatin films incorporated with N-hydroxysuccinimide-activated end-bit binary acid.Recommanded Product: 79642-50-5 And the article contains the following content:

A series of novel crosslinkers, N-hydroxysuccinimide (NHS)-activated end-bit binary acid (NHS- C4, C5, C6, C8, C10, C14), were synthesized to modify gelatin films and the crosslinking effects were compared. Homogeneous films with the exception of the film crosslinked by NHS-C14 were observed and the thickness was measured using a scanning electron microscope. The section feature influenced by different film-treatment conditions was also recorded. The differential scanning calorimetry results indicated higher thermal stability. The water contact angles confirmed enhanced hydrophobicity. NHS-C6, which was used as a probe crosslinker, exhibited the best crosslinking effect that the content of the free -NH2 achieved was the lowest out of all the crosslinkers. The biodegradation results of gelatin films modified by NHS-C6 exhibited better degradation-resistance and excellent stability. In addition, the optimal exptl. conditions were 45° C for 12 h when [NHS-C6]/[-NH2] = 2.5. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: 79642-50-5

The Article related to hydroxysuccinimide binary acid preparation gelatin film property, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Recommanded Product: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 2, 2021, Zhou, Haibing; Wu, Shuwen; Xu, Zhichao published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of oseltamivir PROTAC compound and application in anti-influenza virus drugs. And the patent contained the following:

The present invention relates to the preparation of oseltamivir PROTAC compound and application in antiinfluenza virus drugs. In particular, oseltamivir PROTAC compound I and II, wherein ( E3 ligase = VHL or CRBN ligand; linker = alkylene or alkoxy) was prepared The compound provided by the invention can effectively degrade influenza virus neuraminidase so as to exert the activity of inhibiting influenza virus replication, not only has the inhibitory activity on wild strain influenza virus, but also has a good inhibitory effect on oseltamivir-resistant strains, and has low toxicity on cells, the compound of the present invention, or a pharmacol. or physiol. acceptable salt thereof, can be used for the preparation of a medicament against influenza virus. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0

The Article related to oseltamivir protac compound preparation antiinfluenza virus, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 24, 2020, Ren, Yanwei; Yue, Chenglong; Jiang, Huanfeng published a patent.Category: esters-buliding-blocks The title of the patent was Zirconium-based MOF catalyst loaded with dual active sites, preparation method thereof and application in catalyzing tandem alcohol oxidation/aldehyde cyanosilicate reaction. And the patent contained the following:

The invention discloses a zirconium based MOF catalyst loaded dual active sites, a preparation method and application thereof, which has high-efficiency catalytic activity in series alc. oxidation/aldehyde cyanosilicate reaction. The method includes: adding zirconium salt and organic ligand into organic solvent, using organic acid as regulator, self-assembly reaction, obtaining metal organic framework; adding salicylaldehyde to carry out aldehyde amine condensation to obtain chelating coordination site, adding palladium salt, carrying out coordination by immersion method; reducing the obtained MOF in hydrogen to obtain MOF loaded with Pd nanoparticles; reacting MOF with zinc salt in organic solvent, the catalyst is obtained. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Category: esters-buliding-blocks

The Article related to load zinc zirconium metal organic framework catalyst preparation, zirconium metal organic framework catalyst alc oxidation aldehyde cyanosilicate, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoshino, Ken-ichi; Nakajima, Tasuku; Matsuda, Takahiro; Sakai, Takamasa; Gong, Jian Ping published an article in 2018, the title of the article was Network elasticity of a model hydrogel as a function of swelling ratio: from shrinking to extreme swelling states.HPLC of Formula: 79642-50-5 And the article contains the following content:

In this work, we intended to investigate the relationship between the swelling ratio Q and Young’s modulus E of hydrogels from their contracted state to extreme swelling state and elucidate the underlining mol. mechanism. For this purpose, we used tetra-poly(ethylene glycol) (tetra-PEG) gel, whose network parameters are well known, as the polymer backbone, and we succeeded in tuning the swelling of the gel by a factor of 1500 times while maintaining the topol. structure of the network unchanged, using an approach combining a mol. stent method and a PEG dehydration method. A master curve of Q-E, independent of the method of obtaining Q, was obtained. Using the worm-like chain model, the exptl. determined master curve can be well reproduced. We also observed that the uniaxial stress-strain curve of the hydrogel can be well predicted by the worm-like chain model using the structure parameters determined from the fitting of the Q-E exptl. curve. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).HPLC of Formula: 79642-50-5

The Article related to tetraarm peg model hydrogel network elasticity swelling youngs modulus, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.HPLC of Formula: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Gonglin; Zhang, Yan; Zeng, Hongkun; Feng, Xiaoming; Su, Zhishan; Lin, Lili published an article in 2022, the title of the article was Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones.Product Details of 227940-70-7 And the article contains the following content:

A diastereodivergent asym. Mannich reaction of cyclic N-sulfonyl ketimines I (R1 = Me, Et, i-Pr, Bn, etc.; R2 = H, 5-OMe, 7-Cl, 6-Me, etc.) with ketones such as cyclohexanone, tert-Bu 4-oxopiperidine-1-carboxylate, thian-4-one, etc. catalyzed by a bispidine-based chiral amine catalyst, in which addnl. water switches the diastereoselectivity efficiently was reported. Synthesis of chiral anti- benzosultams and syn-benzosultams II (X = CH2, O, NCO2t-Bu, etc.) with potential anti-HIV-1 activity is obtained in excellent yields and good to excellent ee values. Control experiments and d. functional theory (DFT) calculations were applied to study the diastereodivergent mechanism, which reveal that the diastereodivergent catalysis should be state-determined, and the water reverses the energies of states to realize the diastereodivergency. The findings are quite new and might inspire more diastereodivergent asym. synthesis. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Product Details of 227940-70-7

The Article related to benzosultam preparation diastereoselective enantioselective, cyclic sulfonyl ketimine ketone mannich reaction bispidine amine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Product Details of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2016, Bulygina, L. A.; Khrushcheva, N. S.; Peregudov, A. S.; Sokolov, V. I. published an article.SDS of cas: 227940-70-7 The title of the article was Cyclopalladate complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane. And the article contained the following:

A new (C,N,N)-pincer cyclopalladate unsym. complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane (3-benzyl-7-methylbispidine) was synthesized and characterized. Catalytic performance of this complex was examined in the Heck and Suzuki reactions and in the norbornene hydroarylation. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).SDS of cas: 227940-70-7

The Article related to benzylmethyldiazabicyclononane cyclopalladate complex preparation coupling catalyst, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.SDS of cas: 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2022, Jayaraman, Vijay; Lee, D. John; Elad, Nadav; Vimer, Shay; Sharon, Michal; Fraser, James S.; Tawfik, Dan S. published an article.Product Details of 79642-50-5 The title of the article was A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. And the article contained the following:

Abstract: Multi-enzyme assemblies composed of metabolic enzymes catalyzing sequential reactions are being increasingly studied. Here, we report the discovery of a 1.6 megadalton multi-enzyme complex from Bacillus subtilis composed of two enzymes catalyzing opposite (counter-enzymes) rather than sequential reactions: glutamate synthase (GltAB) and glutamate dehydrogenase (GudB), which make and break glutamate, resp. In vivo and in vitro studies show that the primary role of complex formation is to inhibit the activity of GudB. Using cryo-electron microscopy, we elucidated the structure of the complex and the mol. basis of inhibition of GudB by GltAB. The complex exhibits unusual oscillatory progress curves and is necessary for both planktonic growth, in glutamate-limiting conditions, and for biofilm growth, in glutamate-rich media. The regulation of a key metabolic enzyme by complexing with its counter enzyme may thus enable cell growth under fluctuating glutamate concentrations [graphic not available: see fulltext]. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Product Details of 79642-50-5

The Article related to bacillus glutamate metabolism gltab gudb, Microbial, Algal, and Fungal Biochemistry: Metabolism and Microbial Nutrition and other aspects.Product Details of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics