Li, Gonglin; Zhang, Yan; Zeng, Hongkun; Feng, Xiaoming; Su, Zhishan; Lin, Lili published an article in 2022, the title of the article was Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones.Product Details of 227940-70-7 And the article contains the following content:
A diastereodivergent asym. Mannich reaction of cyclic N-sulfonyl ketimines I (R1 = Me, Et, i-Pr, Bn, etc.; R2 = H, 5-OMe, 7-Cl, 6-Me, etc.) with ketones such as cyclohexanone, tert-Bu 4-oxopiperidine-1-carboxylate, thian-4-one, etc. catalyzed by a bispidine-based chiral amine catalyst, in which addnl. water switches the diastereoselectivity efficiently was reported. Synthesis of chiral anti- benzosultams and syn-benzosultams II (X = CH2, O, NCO2t-Bu, etc.) with potential anti-HIV-1 activity is obtained in excellent yields and good to excellent ee values. Control experiments and d. functional theory (DFT) calculations were applied to study the diastereodivergent mechanism, which reveal that the diastereodivergent catalysis should be state-determined, and the water reverses the energies of states to realize the diastereodivergency. The findings are quite new and might inspire more diastereodivergent asym. synthesis. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Product Details of 227940-70-7
The Article related to benzosultam preparation diastereoselective enantioselective, cyclic sulfonyl ketimine ketone mannich reaction bispidine amine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Product Details of 227940-70-7
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