Tag: 200-300

On May 6, 2016, Pasternak, Alexander; Dong, Shuzhi; Gu, Xin; Jiang, Jinlong; Shi, Zhi-Cai; Walsh, Shawn P.; Wu, Zhicai; Yu, Yang; Ferguson, Ronald, II; Guo, Zhiqiang; Frie, Jessica; Suzuki, Takao; Blizzard, Timothy A.; Fu, Qinghong; Vangelder, Kelsey F. published a patent.Recommanded Product: tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate The title of the patent was Spiro[piperidine-azacycle] derivatives as inhibitors of the renal outer medullary potassium channel and their preparation. And the patent contained the following:

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof, which are inhibitor of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Compounds of formula I wherein A is CH2, CH2CH2 and CH2CH2CH2; B is CH2 and CH2; X is (un)substituted 4-(tetrazol-1-yl)phenyl, (un)substituted oxoisobenzofuranyl, (un)substituted (tetrazol-1-yl)pyridinyl, etc.; Y is O, NH and a bond; Z is (un)substituted Ph, (un)substituted pyridinyl, (un)substituted pyrimidinyl, etc.; n is 0, 1 and 2; R1 is H, D and OH; R2 is H and D; R3 is H, D and alkyl; R4 is H and D; each R5 is independently oxo and (un)substituted alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by arylation of 5-[(1R)-2-(2,8-diazaspiro[4.5]dec-8-yl)-1-hydroxyethyl]-4-methyl-2-benzofuran-1(3H)-one with 5-chloro-3-methyl-1,2,4-thiadiazole. The invention compounds were evaluated for their ROMK channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.2508 μM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Recommanded Product: tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

The Article related to spiropiperidine azacycle preparation romk channel inhibitor, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Recommanded Product: tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 6, 2016, Pasternak, Alexander; Dong, Shuzhi; Gu, Xin; Jiang, Jinlong; Shi, Zhi-Cai; Walsh, Shawn P.; Wu, Zhicai; Yu, Yang; Ferguson, Ronald, II; Guo, Zhiqiang; Frie, Jessica; Suzuki, Takao; Blizzard, Timothy A.; Fu, Qinghong; Vangelder, Kelsey F. published a patent.Related Products of 1198284-94-4 The title of the patent was Spiro[piperidine-azacycle] derivatives as inhibitors of the renal outer medullary potassium channel and their preparation. And the patent contained the following:

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof, which are inhibitor of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Compounds of formula I wherein A is CH2, CH2CH2 and CH2CH2CH2; B is CH2 and CH2; X is (un)substituted 4-(tetrazol-1-yl)phenyl, (un)substituted oxoisobenzofuranyl, (un)substituted (tetrazol-1-yl)pyridinyl, etc.; Y is O, NH and a bond; Z is (un)substituted Ph, (un)substituted pyridinyl, (un)substituted pyrimidinyl, etc.; n is 0, 1 and 2; R1 is H, D and OH; R2 is H and D; R3 is H, D and alkyl; R4 is H and D; each R5 is independently oxo and (un)substituted alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by arylation of 5-[(1R)-2-(2,8-diazaspiro[4.5]dec-8-yl)-1-hydroxyethyl]-4-methyl-2-benzofuran-1(3H)-one with 5-chloro-3-methyl-1,2,4-thiadiazole. The invention compounds were evaluated for their ROMK channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.2508 μM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).Related Products of 1198284-94-4

The Article related to spiropiperidine azacycle preparation romk channel inhibitor, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Related Products of 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2022, Yashima, Takumi; Tani, Marie; Kurita, Rei published an article.HPLC of Formula: 118-55-8 The title of the article was Filamentous crystal growth in organic liquids and selection of crystal morphology. And the article contained the following:

Filamentous crystals such as whisker crystals are often seen not only in metallic liquids, but also in organic liquids and solutions They are interesting as reinforce materials. However, it remains challenging to induce filamentous crystals due to an incomplete understanding of the mechanisms behind their formation. In this paper, we investigate filamentous crystal growth in viscous organic liquids It is found that filamentous crystals grow via an extraordinary dynamical path, where the mols. locally evaporate to bubbles and then redeposite to the tip of growing crystalline filaments. We also succeeded in controlling whether filamentous or faceted crystal growth is selected by inducing or suppressing the bubbles. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).HPLC of Formula: 118-55-8

The Article related to filamentous crystal growth organic liquid morphol, Crystallography and Liquid Crystals: Crystal Morphology (Habit), Orientation, Crystallinity and other aspects.HPLC of Formula: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 7, 2011, Lu, Shoufu; Yu, Xinmin published a patent.HPLC of Formula: 1198284-94-4 The title of the patent was Method for preparing diazaspirocyclic compounds. And the patent contained the following:

The invention relates to a process for the preparation of diazaspirocyclic compounds (e.g., I). For instance, substitution of compound II with 1-bromo-3-chloro-propane followed by azidation, heterocyclization, and reduction gave compound I as a white solid. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).HPLC of Formula: 1198284-94-4

The Article related to diazaspirocyclic compound preparation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.HPLC of Formula: 1198284-94-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 5, 1986, Iwasaki, Genji; Saeki, Seitaro; Hamana, Masatomo published an article.Safety of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Nucleophilic substitution of p-dinitrobenzene with some carbanions. Formation of p-substituted nitrobenzenes. And the article contained the following:

Treatment of p-O2NC6H4NO2 with RH (R = CH2COMe, CHMeCOEt, CHEtCOMe, CMe2COCHMe2, CH2CO2Et, CH2CO2CMe3, CH2CN, CHPhCN, CMePhCN, PhNH 2-oxocyclopentyl, 2-oxocyclohexyl, cyano-1-naphthylmethyl, 2-pyridylamino) in the presence of Me3COK in liq NH3 at -70° gave p-O2NC6H4R in 18-97.6% yields. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Safety of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to nitrobenzene nucleophile substitution, carbanion substitution dinitrobenzene, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Safety of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 20, 2020, Greis, Kim; Kirschbaum, Carla; Leichnitz, Sabrina; Gewinner, Sandy; Schoellkopf, Wieland; von Helden, Gert; Meijer, Gerard; Seeberger, Peter H.; Pagel, Kevin published an article.SDS of cas: 2873-29-2 The title of the article was Direct Experimental Characterization of the Ferrier Glycosyl Cation in the Gas Phase. And the article contained the following:

The Ferrier rearrangement reaction is crucial for the synthesis of pharmaceuticals. Although its mechanism was described more than 50 years ago, the structure of the intermediate remains elusive. Two structures have been proposed for this Ferrier glycosyl cation: a 1,2-unsaturated cation that is resonance-stabilized within the pyranose ring or a cation that is stabilized by the anchimeric assistance of a neighboring acetyl group. Using a combination of gas-phase cryogenic IR spectroscopy in helium nanodroplets and first-principles d. functional theory, we provide the first direct structural characterization of Ferrier cations. The data show that both acetylated glucal and galactal lead to glycosyl cations of the dioxolenium type. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to ferrier glycosyl cation gas phase structure exptl characterization, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2011, Jang, Yoon-Seok; Kim, Sung-Hyun; Yoo, Ki-Pung; Byun, Hun-Soo published an article.Related Products of 1985-51-9 The title of the article was Phase behavior measurement for the binary mixture of CO2 + neopentyl glycol diacrylate and CO2 + neopentyl glycol dimethacrylate systems at high pressure. And the article contained the following:

In this work, the solubility curves for the CO2 + neopentyl glycol diacrylate (NPGDA) and CO2 + neopentyl glycol dimethacrylate (NPGDMA) systems are measured in static method at five temperatures of (313.2, 333.2, 353.2, 373.2 and 393.2) K and pressures up to 25.28 MPa. Both CO2 + di(meth)acrylate systems have continuous critical mixture (locus) curves that exhibit maximum in pressure-temperature space between the critical temperatures of CO2 and neopentyl glycol di(meth)acrylate. The solubility of CO2 in the CO2 + neopentyl glycol di(meth)acrylate mixture decreases as the temperature increases at a constant pressure. The CO2 + NPGDA and CO2 + NPGDMA systems exhibit type-I phase behavior. The exptl. results for the CO2 + NPGDA and CO2 + NPGDMA systems are correlated with Peng-Robinson equation of state using a mixing rule including two adjustable parameters. The critical properties of NPGDA and NPGDMA are predicted with Joback-Lyderson and Lee-Kesler method. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Related Products of 1985-51-9

The Article related to carbon dioxide npgda npgdma binary mixture phase transition, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Related Products of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2022, Bai, Hualong; Zhang, Liwei; Sun, Peng; Wu, Haoliang; Li, Mingxing; Gu, Yulei; Zhang, Cong; Lou, Chunyang; Li, Jing’an published an article.Application of 2358-84-1 The title of the article was ADAM17: A novel treatment target for aneurysms. And the article contained the following:

The mechanisms underlying abdominal aortic aneurysms (AAAs) are still not fully understood, previous researches showed ADAM17 is increased in aneurysm. We hypothesized that inhibiting ADAM17 can decrease AAA formation and progression. Aneurysm models were established in mouses and rats by aortic adventitial CaCl2 incubation and aortic pericardial patch angioplasty resp. In mouse, control (no treatment) or SA/HA hydrogel loaded with TAPI-1 (ADAM17 inhibitor) were adventitial applied; in rat, control and TAPI-1 coated pericardial patch were used in rat aortic pericardial patch angioplasty. Samples were harvested on day 14 or 30 and analyzed by immunofluorescence. Bioinformatics anal. and immunostaining anal. were carried out to confirm the therapeutic potential of ADAM17 in the human AAA. ADAM17 was highly expressed in mouses, rats and human aneurysms. Adventitial application of SA/HA hydrogel loaded TAPI-1 or TAPI-1 conjugated pericardial patch can decrease AAA formation and progression in mouses and rats, resp. Bioinformatic anal. showed ADAM17 promotes transformation of M1 macrophages and synthetic vascular smooth muscle cells, together with immunostaining anal. and results from animal models, the therapeutic potential of ADAM17 in the human AAA were confirmed. We showed that local delivery of ADAM17 inhibitor can inhibit aneurysm formation and progression in mouse and rat, these results showed ADAM17 plays an important role in the aneurysm formation and may be a potential treatment target. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to adam aneurysm treatment target, adam17, aneurysm, macrophage, smooth muscle cells, Mammalian Pathological Biochemistry: Hematology and Reticuloendothelial System Diseases and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Tao; Yuan, Xiaoxue; Zhang, Gang; Zeng, Yi; Chen, Tong; Wang, Gongying published an article in 2019, the title of the article was Influence of coordinating groups of organotin compounds on the Fries rearrangement of diphenyl carbonate.Reference of Phenyl Salicylate And the article contains the following content:

In this paper, the Fries rearrangement of di-Ph carbonate (DPC) catalyzed by organotin compounds with different coordination groups was studied for the first time. The electronic effect and steric hindrance of the coordinating groups were discussed with respect to the reactivity of DPC rearrangement. The results showed that both the electronic effect and steric hindrance of the coordinating groups influenced the acidity of the active tin centers and then affected the catalytic performance of organotin as a Lewis acid for the rearrangement of DPC, and the influence of the electronic effect is greater than that of steric hindrance. The catalytic activity is in the order of BuSnO(OH) > Bu2SnO > Bu2Sn(OCOC11H23)2 > BuSnCl3 > Bu3SnOSnBu3 > Bu3SnCl, and Bu2SnO showed the best catalytic activity due to its strong electron absorption effect, small steric hindrance, and good stability. Under the optimum reaction conditions, the conversion of DPC was up to 93%, and the yields of Ph salicylate (PS) and xanthone (XA) were 62% and 28%, resp. In addition, a reaction mechanism of DPC rearrangement catalyzed by the organotin compounds was speculated. This research can provide vigorous theor. data support to control the byproducts produced by DPC rearrangement in the process of DPC synthesis. It also provides a new route for the preparation of PS and XA. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Reference of Phenyl Salicylate

The Article related to diphenyl carbonate organotin catalyst fries rearrangement mechanism, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Reference of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khodeir, Miriam; Jia, He; Vlad, Alexandru; Gohy, Jean-Francois published an article in 2021, the title of the article was Application of redox-responsive hydrogels based on 2,2,6,6-tetramethyl-1-piperidinyloxy methacrylate and oligo(ethyleneglycol) methacrylate in controlled release and catalysis.Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Hydrogels have reached momentum due to their potential application in a variety of fields including their ability to deliver active mols. upon application of a specific chem. or phys. stimulus and to act as easily recyclable catalysts in a green chem. approach. In this paper, we demonstrate that the same redox-responsive hydrogels based on polymer networks containing 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) stable nitroxide radicals and oligoethylene glycol Me ether methacrylate (OEGMA) can be successfully used either for the electrochem. triggered release of aspirin or as catalysts for the oxidation of primary alcs. into aldehydes. For the first application, we take the opportunity of the pos. charges present on the oxoammonium groups of oxidized TEMPO to encapsulate neg. charged aspirin mols. The further electrochem. reduction of oxoammonium groups into nitroxide radicals triggers the release of aspirin mols. For the second application, our hydrogels are swelled with benzylic alc. and tert-Bu nitrite as co-catalyst and the temperature is raised to 50°C to start the oxidation reaction. Interestingly enough, benzaldehyde is not miscible with our hydrogels and phase-sep. on top of them allowing the easy recovery of the reaction product and the recyclability of the hydrogel catalyst. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to tetramethyl piperidinyloxy oligo ethyleneglycol methacrylate hydrogel catalysis, tempo, catalysis, encapsulation-release, hydrogels, redox-responsive polymers, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Reference of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics