Tag: 200-300

On May 6, 2010, Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:

Title compounds, e.g., I [or pharmaceutically acceptable salts or solvates thereof], etc., were prepared For example, reaction of compound II (preparation given) with NH2NH2·H2O followed by in-situ treatment with trifluoroacetic anhydride, de-allylation, ethylation, and hydrolysis afforded compound I. In squalene synthase inhibition assays, the IC50 of I was 0.98 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 17, 2005, Mutti, Stephane; Malpart, Joel; Lavigne, Michel published a patent.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Method for preparation of thiazolo[3,4,5-de][4,1]benzothiazepines via direct cyclization of tert-butyl 2-hydroxymethylphenylcarbamates with thioglycolic acid in the presence of p-toluenesulfonic acid. And the patent contained the following:

The invention is related to the preparation of the well-known anticonvulsants thiazolo[3,4,5-de][4,1]benzothiazepine derivatives, in particular I•MeSO3H and II•MeSO3H, and their enantiomers and pharmaceutically acceptable salts via direct cyclization of 2-hydroxymethyl phenylcarbamates, e.g. tert-Bu 2-hydroxymethylphenylcarbamate (III) with thioglycolic acid (IV) in the presence of p-toluenesulfonic acid. The advantages include reduced number of steps and simple purification Thus, was prepared, in 58% global yield, in 8 steps: (1) BOC-protection of 4-trifluoromethylaniline with di-tert-Bu dicarbonate; (2) formylation with DMF; (3) reduction of the aldehyde with NaBH4; (4) cyclization of III with IV in the presence of p-toluenesulfonic acid in toluene; (5) reduction of amide V with NaBH4 in the presence of MeSiCl/THF; (6) cyclization of tetrahydrobenzothiazepine with KSCN in the presence of Br2/AcOH; (7) oxidation of thiazolobenzothiazepine with O3 in CH3CN/H2O; (8) methanesulfonate formation by treatment with MeSO3H in acetone/H2O. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to thiazolobenzothiazepine preparation cyclization hydroxymethylphenylcarbamate thioglycolic acid toluenesulfonic acid catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Okten Besli, Nur Sena; Orakdogen, Nermin published an article in 2020, the title of the article was Charge-balanced terpolymer poly(diethylaminoethyl methacrylate-hydroxyethyl methacrylate-2-acrylamido-2-methyl-propanesulfonic acid) hydrogels and cryogels: scaling parameters and correlation with composition.COA of Formula: C12H18O5 And the article contains the following content:

The scaling laws relating the preparation conditions to the swelling degree, reduced modulus and effective crosslinking d. of poly(diethylaminoethyl methacrylate-co-hydroxyethyl methacrylate-co-2-acrylamido-2-methyl-propanesulfonic acid), henceforth designated as PDHA, gels prepared by radical crosslinking copolymerization in a solvent mixture were reported. Charge-balanced terpolymer PDHA hydrogels and cryogels (PDHA-Hgs and Cgs) were prepared in different monomer feed compositions The swelling dependence of the reduced modulus was described by a power law relationship Gr â‰?(φv)mwith an exponent of m = -0.30 at low swelling degree, while in the high swelling region the scaling becomes 0.21, indicating the finite extensibility of the network chains. The scaling exponent for the swelling degree and terpolymer composition, φv â‰?(Nν2)m, was found to be -0.13, indicating the increasing extent of the topol. constraints arising from the trapped entanglements. By combining elasticity and swelling results, the scaling relationship between the apparent crosslink d. and HEMA content used in the terpolymer feed was obtained as a cubic polynomial of the mol% of HEMA. In the HEMA-rich terpolymer PDHA Hgs and Cgs, the swelling degree was possibly controlled by the HEMA part of the terpolymer network, while the presence of DEAEM units in the network triggered the thermoresponsive swelling behavior. The dependence of interaction parameter χ on the volume fraction of the crosslinked terpolymer network in the swollen gel ν2 was evaluated and the results revealed extremely strong concentration dependence of χ for all terpolymer samples. Because of their inherent properties, the resulting terpolymer gels might contribute to the improvement of the loading capacity of polymers used in anticancer drug delivery systems. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to hydroxylethyl methacrylate dmaem acrylamidomethyl propanesulfonic acid hydrogel cryogel swelling, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, T. E. Mohan; Saritha, S. Reena; Shamshuddin, S. Z. Mohamed; Vasantha, V. T.; Pratap, S. R. published an article in 2018, the title of the article was Synthesis of salicylate esters over cordierite honeycomb monoliths coated with zirconia based solid acids in vapour phase.Safety of Phenyl Salicylate And the article contains the following content:

Solid acid catalysts such as ZrO2, Mo(VI)/ ZrO2, Pt-SO42-/ ZrO2 has been coated on honeycomb monoliths and characterized for their physico-chem. properties such as total surface acidity by NH3-TPD, crystalinity by powder XRD, functionality by FT-IR and morphol. by SEM techniques. These solid acid catalytic materials are employed in the vapor phase transesterification of Me salicylate with different alcs. The catalytic property of these solid acids has been correlated with their physico-chem. properties. These catalytic materials are found to be very efficient in the transesterification reaction with up to �8% yield of the desired transester. Reaction conditions are optimized to get highest possible yield of the desired transester. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to zirconia coated honeycomb monolith catalyst crystalinity salicylate ester transesterification, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.Safety of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 28, 2021, Okten Besli, Nur Sena; Orakdogen, Nermin published an article.Synthetic Route of 2358-84-1 The title of the article was Design of weakly cationic alco-cryogels consisting of poly(alkylmethacrylates)-based sulfonated terpolymer network with tunable multiresponsive assembly. And the article contained the following:

Cryogels with ion-, and solvent-responsiveness have been designed by cryogelation of 2-(diethylamino)ethyl methacrylate (DEAEMA) as weakly cationic monomer, hydroxyethyl methacrylate as neutral comonomer and 2-acrylamido-2-methyl-1-propanesulfonic acid as anionic termonomer in ethanol-water mixture (50:50 volume/volume), which had been proved to offer a good miscibility of monomers. Influence of composition of terpolymer and polymerization temperature on the properties of terpolymer cryogels (Cgels) and hydrogels (Hgels) were evaluated by swelling kinetics, and response against rapid ionic strength change. Swelling of terpolymer networks in the form of Cgel and Hgel decreased with increase in the size of ions present in swelling medium and followed the order of swelling behavior Cl- > Br- > I-. Terpolymer alcogels exhibited salting-out behavior in the presence of Cl- and Br- ions, while “salting-in” behavior was observed in KI solutions of high concentrations Sensitivity sequence of terpolymer alcogels to mono- and di-valent cations with a common anion (SO42-) on swelling was Na+ > K+ > Mg2+> Zn2+. Swelling data agree well with second-order kinetic model and with increasing amount of DEAEMA in terpolymer feed, diffusion mechanism changed from non-Fickian type to Fickian diffusion. In ionic environments, the salt-sensitivity and excellent water absorption/retention capability give this intelligentized terpolymer gels wide potential applications. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to polyalkylmethacrylate sulfonated terpolymer cryogel hydrogel salting out swelling kinetics, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khodeir, Miriam; Antoun, Sayed; van Ruymbeke, Evelyne; Gohy, Jean-Francois published an article in 2020, the title of the article was Temperature and Redox-Responsive Hydrogels Based on Nitroxide Radicals and Oligoethyleneglycol Methacrylate.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

A temperature and redox-responsive polymer hydrogel is constructed by randomly incorporating 2,2,6,6-tetramethyl-1-piperidinyloxy-methacrylate (TEMPO) stable nitroxide radicals and oligoethyleneglycol methacrylate (OEGMA) groups in a polymer network. TEMPO can be reversibly oxidized into an oxoammonium cation (TEMPO+) providing the redox-responsive properties while the lower critical solubility temperature (LCST) of OEGMA results in temperature-responsive properties. Since a rather low amount of di(ethylene glycol) dimethacrylate (OEGMA2) is used to chem. crosslink the polymer network, the accordingly formed hydrogels obtained after swelling with water consist of microgel particles with entangled polymer chains that are not chem. crosslinked. By varying the amount of TEMPO in the polymer network, it is demonstrated that the radical form of TEMPO aggregates into hydrophobic domains acting as phys. crosslinking nodes in the hydrogels and further increasing the cohesion between microgel particles. Increasing the temperature results in two opposite effects on the solubility of TEMPO and OEGMA units. The oxidation of TEMPO into TEMPO+ also results in a deep change in the hydrogel properties since TEMPO+ units are essentially hydrophilic and do not aggregate into phys. crosslinking nodes. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to temperature redox responsive nitroxide radical oligoethyleneglycol methacrylate hydrogel, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanc, Beril; Orakdogen, Nermin published an article in 2020, the title of the article was Influence of gel preparation concentration on statistical mechanics of poly(dialkylaminoethyl methacrylate) gels on the basis of scaling concept: Toward tunable elasticity and thermomechanical parameters.Product Details of 2358-84-1 And the article contains the following content:

To evaluate the scaling parameters of weakly cationic crosslinked network structures, poly(dialkylaminoethyl methacrylate)-based hydrogels were synthesized via free-radical crosslinking in aqueous solution varying systematically concentration of pregel solution Based on the gel-preparation concentration, variation in structural properties, effective crosslinking d., average mol. weight of polymer chains, and thermodn. parameters from combined swelling and elasticity results were discussed using the scaling theory to predict various exponent identities. The concentration dependence of compressive elastic modulus as-prepared state was described by a power-law relation G0â‰?ν20)m with the exponent of m = 3.55 indicating the importance of the trapped entanglements. Two structural characteristics, the network chain length N and the average mol. weight of polymer chains have inverse dependence on the gel-preparation concentration in the matrix, while the compressive moduli and effective crosslinking d. show completely direct dependence. Exptl. determined N values of PDMAEMA hydrogels first decrease with increasing ν20 up to 0.2972 and the dependence of N on the gel-preparation concentration gives the relation N≈X-1(ν20)n with a scaling parameter n = -1.80, which coincides with the prediction of scaling theory. Acceptable agreement was found between the estimate of crosslink d. fluctuations deduced from mech. measurements and the results derived from independent swelling observations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48350. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to polydialkylaminoethyl methacrylate network hydrogel crosslink d compressive modulus, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 31, 2022, Bozbay, Rabia; Orakdogen, Nermin published an article.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Temperature-regulated elasticity and multifunctionality in n-alkyl methacrylate ester-based ternary gels: optimizing adsorption and pH/temperature dual sensitivity. And the article contained the following:

An attempt was made to correlate the gelation temperature with elasticity and pH/temperature dual sensitivity of n-alkyl methacrylate ester-based cationic gels. Ternary gels were prepared by free-radical crosslinking of HPMA, DMAEMA, and GMA in water at fixed monomer and crosslinker concentrations, while gel preparation temperature Tprep was varied from – 18 to 60°C. The structure and phys. properties of ternary gels were fully characterized using thermal gravimetric anal., Fourier transform IR spectroscopy, and X-ray diffraction. Tprep has been shown to be an effective independent variable to adjust both macroscopic and microscopic properties of ternary gels as desired. Gelation temperature dependence of swelling and compressive elasticity was investigated. Ternary gels synthesized at 5°C showed maximum swelling capacity. The equilibrium swelling ratio increased first slightly up to 5°C and then decreased continuously with increasing Tprep. This trend indicated that swelling is influenced by properties of both crosslinking region and the main constituent amorphous region. In swollen state, elastic modulus of gels changed from 0.9 to 108 kPa and increased 120 times as Tprep decreased from 60 to – 18°C. Terpolymer gels showed pH-sensitive swelling characteristic of cationic DMAEMA monomer and exhibited high swelling ratio in acidic solutions induced by electrostatic repulsion between quaternary amine groups. The swelling ratio decreased due to hydrophobic effect of the alkyls when environmental pH is higher than 7.7. Regardless of Tprep, the gels gradually contracted as swelling temperature increased from 25 to 75°C. Flory-Huggins interaction parameter χ ranged from 0.4005 to 0.5358 and increased with the degree of intermol. hydrophobic interactions. The effectiveness of ternary gels for removing methyl orange from aqueous solution was tested, and the results showed that the gels prepared under low-temperature conditions were promising for removing anionic dyes. The adsorption was spontaneous and found to be a multistep process with surface adsorption followed by intraparticle diffusion. This knowledge will aid the future design of n-alkyl methacrylate ester-based ternary gels as an effective adsorbent for dye removal from wastewater and pharmaceutical preparations The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to alkyl methacrylate ester ternary gel preparation temperature regulated elasticity, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.Name: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 15, 2010, Sugita, Kazuyuki; Haginoya,noriyasu published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Preparation of substituted tricyclic heteroaryl compound as squalene and cholesterol synthetase inhibitors. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = (halo)alkoxy; R2 = halo, (halo)alkyl or alkoxy; R3 = halo, (halo)alkyl or (halo)alkoxy; R4 = hydroxyhaloalkyl; m = 0-4; -X-Y- = a single bond, alkylenecarbonyl-heterocyclyl or alkylene-heterocyclyl; and pharmaceutically acceptable salts thereof] were prepared as squalene and cholesterol synthetase inhibitors. For example, II was provided in a multi-step synthesis starting from 2-bromo-3-hydroxybenzaldehyde. I were tested for inhibition of rat squalene synthetase and rat liver cholesterol synthetase, e.g. II had an IC50 value of 1.7 nM on squalene synthetase and 84% inhibition rate on cholesterol synthetase. Thus, I are useful as squalene and cholesterol synthetase inhibitors for the treatment of hyperlipemia including hypercholesterolemia, hypertriglyceridemia and hypo-HDL cholesterolemia and/or arteriosclerosis in mammals including human. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to triazolobenzoxazepine preparation squalene cholesterol synthetase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2019, Lafuente, Leticia; Rochetti, Maria Florencia; Bravo, Rodolfo; Sasiambarrena, Leandro; Santiago, Cintia C.; Ponzinibbio, Agustin published an article.SDS of cas: 2873-29-2 The title of the article was Cu-Fe Spinels: First Heterogeneous and Magnetically Recoverable Catalyst for the Ferrier Rearrangement of 2-Nitroglycals. And the article contained the following:

Cu-Fe spinels promoted the Ferrier rearrangement of 2-nitroglycals with several O-nucleophiles. 2,3-Unsaturated carbohydrate derivatives were prepared by the reaction of 3,4,6-tri-Oacetyl- 2-nitroglucal and alcs. in the presence of 5% of CuFe2O4. After separation of the catalyst with an external magnet, the reaction products were obtained in good yields and high stereo and regioselectivity. Also, S- and heterocyclic C-3 substituted 2-nitro-endo-glycals could be prepared by this method. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).SDS of cas: 2873-29-2

The Article related to nitroglycal ferrier rearrangement structural morphol catalytic property, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.SDS of cas: 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics