Tag: 200-300

On November 30, 2021, Bozbay, Rabia; Orakdogen, Nermin published an article.Related Products of 2358-84-1 The title of the article was Multifunctional poly(methacrylate ester)s-based terpolymer cryogels with basic amino groups: Correlation of elasticity and structural properties with composition. And the article contained the following:

Dual-responsive cryogel-structured materials open up a whole new field of bio-applications. Either dimethylaminoethyl methacrylate (DMAEMA) as a carrier of basic amino groups or glycidyl methacrylate (GMA) as a carrier of epoxy rings was introduced into hydroxypropyl methacrylate (HPMA) skeleton. pH/thermo-responsive cationic terpolymer cryogels were successfully prepared by varying the feeding DMAEMA/GMA mol percent ratio from 80/0 to 0/80. The presence of GMA imparts hydrophobic character that reduces swelling and provides addnl. crosslinks leading to a significant increase in the flexibility. Reducing the polymerization temperature below the f.p. of the solvent resulted in harder and non-brittle cryogels. Up to 48% reduction in hydration was observed for terpolymer cryogels containing 70 mol% DMAEMA upon increasing pH of bathing medium from 2.1 to 8.0. This trend confirmed pH-modulated swelling of amine-containing terpolymer gels, and pH-dependent transition point was found to be 7.7. Oscillating swelling/deswelling in response to pH cycles was studied. The water transport was strongly affected by incorporation of hydrophobic component GMA and protonation of amine functional groups. The swelling mechanism was shifted from anomalous to diffusion controlled with increasing GMA and overall swelling processes followed Schott second order dynamic equation. Lower equilibrium volume swelling at constant temperature was achieved by increasing GMA content of the terpolymers. In low temperature range, while DMAEMA-rich terpolymer gels were swollen, swelling decreased significantly when the gels were enriched in GMA and the temperature was raised above 55°C. Regardless of salt type and Na+ or K+ hydrated ion radii, a significant difference was observed in salt-sensitive swelling in dilute salt solution (below about 10-3 M), which is controlled by the amount of DMAEMA in terpolymer structure. This study would provide novel ideas for the design of (meth)acrylate ester-based cationic terpolymer cryogels and elucidate the relationship between the gel matrix and their special swelling behavior. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Related Products of 2358-84-1

The Article related to polymethacrylate ester cryogel amino elasticity structure swelling thermal, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Related Products of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 14, 2022, Cheng, Fei; Chen, Tao; Huang, Yin-Qiu; Li, Jia-Wei; Zhou, Chen; Xiao, Xiao; Chen, Fen-Er published an article.Category: esters-buliding-blocks The title of the article was Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters. And the article contained the following:

Authors have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale. The experimental process involved the reaction of Ethyl 2-(4-(trifluoromethoxy)phenyl)acetate(cas: 1206550-93-7).Category: esters-buliding-blocks

The Article related to aryl ester preparation copper catalyst, arylhalide malonate tandem ullmann type coupling decarboxylation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 3, 2003, Hewawasam, Piyasena; Fan, Wenhong; Ding, Min; Flint, Kim; Cook, Deborah; Goggins, Gregory D.; Myers, Robert A.; Gribkoff, Valentin K.; Boissard, Christopher G.; Dworetzky, Steven I.; Starrett, John E. Jr.; Lodge, Nicholas J. published an article.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction. And the article contained the following:

Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-ones I [R1 = HO, MeO; R2 = HO(CH2)n, n = 1 – 3; R2 = (E)-HOCH2CH:CH] were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiol. methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. A potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinolinone hydroxyalkyl preparation corporal smooth muscle relaxant erectile disfunction, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 10, 2006, Leroux, Frederic; Lefebvre, Olivier; Schlosser, Manfred published an article.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was The “off-shore” construction of optionally substituted 4-trifluoromethyl-2-quinolinones. And the article contained the following:

Treatment of ortho-lithiated tert-Bu N-arylcarbamates (i.e., BOC-protected anilines) with N-(trifluoroacetyl)piperidine provides 2-(N-BOC-amino)aryl trifluoromethyl ketones which, upon reaction with an α-alkoxycarbonyl-substituted phosphorus ylide and acid (or base) yields 4-trifluoromethyl-2-quinolinones which may bear addnl. substituents at any available position. The method is convenient and expedient. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to quinoline trifluoromethyl preparation trifluoroacetylphenyl carbamate phosphorus ylide, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application In Synthesis of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 29, 2011, Brooks, Carl A.; Cheung, Mui; Eidam, Hilary S.; Fox, Ryan M.; Hilfker, Mark A.; Manas, Eric S.; Ye, Guosen published a patent.Recommanded Product: 141940-37-6 The title of the patent was 4-Quinolinecarboxamide derivatives as TRPV4 antagonists and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to 4-quinolinecarboxamide derivatives of formula I, which are TRPV4 antagonists and which are useful in the treatment of diseases. Compounds of formula I wherein R1 is C1-6 alkyl and C3-6 cycloalkyl; each R2 is independently OH, C1-4 alkoxy, C1-4 alkyl, etc.; R3 is (un)substituted morpholinyl, (un)substituted piperidinyl, (un)substituted pyrrolidinyl, etc.; each R4 is independently CF3, halo, C1-3 alkyl and C1-3 alkoxy; each R5 is independently (un)substituted 2-oxopyrrolidin-1-yl, halo, CN, etc.; two adjacent R5 taken together to form OCH2O and O(CH2)2O; each R6 is independently halo, Me and methoxy; X is N and CH; each n is independently 0 to 2; each p is independently 0 to 2; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their TRPV4 antagonistic activity. From the assay, it was determined that all compounds exhibited IC50 values in the range from 1 nM to 10 μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to quinolinecarboxamide preparation trpv4 antagonist treatment disease, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 9, 2008, Kaila, Neelu; Janz, Kristin Marie; Huang, Adrian; Moretto, Allessandro Fabio; Bedard, Patricia Ward published a patent.COA of Formula: C12H14F3NO2 The title of the patent was Preparation of quinoline compounds as selectin inhibitors for disease treatment. And the patent contained the following:

The present teachings relate to novel compounds of formula I wherein R1 is -OR9, -C(O)R10, etc.; R2 is -C(O)OR9, etc.; R3 and R3′ independently are H, -CN, -NO2, halo, etc.; R4-R7 independently are H, C1-10alkyl, etc.; or R3 and R3′ together, R4 and R5 together, and R6 and R7 together form part of a ring; R8 is (un)substituted C6-14 aryl or 5-14 membered heteroaryl; R9 is H, -C(O)R10, etc.; R10 is H, OH, SH, etc. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selectins. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting the appropriate indoline-2,3-dione with the appropriate 2-oxopropyl acetate, caused 37% inhibition in a Biacore P-selectin/PSGL-1 inhibition assay at 250μM. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to quinoline compound preparation selectin inhibitor disease treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2021, Kury, Markus; Ehrmann, Katharina; Harakaly, Gyorgy Attila; Gorsche, Christian; Liska, Robert published an article.Safety of Phenyl Salicylate The title of the article was Low volatile monofunctional reactive diluents for radiation curable formulations. And the article contained the following:

In the last decades the importance of UV curable formulations has increased continuously. Their fast curing speed, solvent-free polymerization conditions, and the formation of hard and highly crosslinked photopolymer networks represent major benefits. Com. UV resins generally consist of multi-functional vinyl oligomers, photoinitiators, additives, and reactive diluents. Mono- and multi-functional reactive diluents serve as thinners to lower the overall resin viscosity and to improve processability. However, many monofunctional reactive diluents like isobornyl (meth)acrylate or benzyl (meth)acrylate exhibit high volatility, often already at room temperature This causes adverse effects such as unpleasant odor, potential health risks, and changing resin composition during processing. A new group of monomers that show high potential for replacing traditional highly volatile reactive diluents are salicylate (meth)acrylates. In this work, salicylate-based thinners are synthesized, polymerized, and characterized with respect to their viscosity, volatility, thermal stability, photoreactivity, and thermomech. properties of their homopolymers. Addnl., a first example of their diluting effect in a highly viscous difunctional polyester urethane methacrylate is demonstrated with 30 wt% of a cycloaliphatically and an aromatically substituted salicylate methacrylate. The polymers of the diluted resin exhibit similarly high glass transition temperatures of 110 and 126°C, which are in the range of the polymers of the undiluted resin. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to methyl salicylate low volatile monofunctional reactive diluent preparation, Coatings, Inks, and Related Products: Polyester and Alkyd Resin Coatings and other aspects.Safety of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 27, 2007, Koppel, Gary A.; Heindel, Ned D. published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of β-lactamylalkanoic acids as vasopressin V2 antagonists. And the patent contained the following:

β-Lactamylalkanoic acids of formula I [A = carboxylic acid, ester or amide; B = carboxylic acid, ester or amide, (substituted) OH, SH; R1 = H, alkyl; R2 = H, alkyl, alkoxy, alkylthio, CN, CHO, etc.; R3 = (substituted) amino, etc.; R4 = alkyl, alkenyl, cycloalkyl, aryl, etc.] are prepared as vasopressin V2 antagonists. Pharmaceutical compositions containing I are described. Thus, II was prepared, and had IC50 value of 2.06 nM against rat vasopressin V2 receptor. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Category: esters-buliding-blocks

The Article related to lactamylalkanoic acid preparation vasopressin v2 antagonist, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2021, Scheiblich, Hannah; Dansokho, Cira; Mercan, Dilek; Schmidt, Susanne V.; Bousset, Luc; Wischhof, Lena; Eikens, Frederik; Odainic, Alexandru; Spitzer, Jasper; Griep, Angelika; Schwartz, Stephanie; Bano, Daniele; Latz, Eicke; Melki, Ronald; Heneka, Michael T. published an article.Synthetic Route of 2358-84-1 The title of the article was Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. And the article contained the following:

Microglia are the CNS resident immune cells that react to misfolded proteins through pattern recognition receptor ligation and activation of inflammatory pathways. Here, we studied how microglia handle and cope with α-synuclein (α-syn) fibrils and their clearance. We found that microglia exposed to α-syn establish a cellular network through the formation of F-actin-dependent intercellular connections, which transfer α-syn from overloaded microglia to neighboring naive microglia where the α-syn cargo got rapidly and effectively degraded. Lowering the α-syn burden attenuated the inflammatory profile of microglia and improved their survival. This degradation strategy was compromised in cells carrying the LRRK2 G2019S mutation. We confirmed the intercellular transfer of α-syn assemblies in microglia using organotypic slice cultures, 2-photon microscopy, and neuropathol. of patients. Together, these data identify a mechanism by which microglia create an “on-demand” functional network in order to improve pathogenic α-syn clearance. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Synthetic Route of 2358-84-1

The Article related to microglia alpha synuclein nanotube, lrrk2, alpha-synuclein, cell-to-cell transfer, clearance, degradation, microglia, synucleinopathies, tunneling nanotubes, Mammalian Pathological Biochemistry: Metabolic and Hereditary Diseases and other aspects.Synthetic Route of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2022, Chang, Jiali; Ji, Xiaojuan; Deng, Tian; Qiu, Jinxin; Ding, Zhaoyun; Li, Zhao; Ma, Yanhui; Hu, Xiaoyu; Li, Li; Qiu, Ju published an article.Electric Literature of 2358-84-1 The title of the article was Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. And the article contained the following:

Subsets of group 3 innate lymphoid cells (ILC3s) are heterogeneous in development and function and play differential roles in intestinal immunity. Histone modifications are involved in the fate commitment of immune cells, including ILC3s. Here, we report that deletion of Setd2, histone H3K36 methyltransferase, in ILC3s results in increased generation of NKp46+ ILC3s with enhanced cytotoxic signatures and tumor-suppressive capacity. Meanwhile, Rag1-/-RorcCreSetd2flox/flox mice have fewer CCR6+ ILC3s and less defective solitary intestinal lymphoid tissue formation, accompanied by reduced granulocyte-macrophage colony-stimulating factor (GM-CSF) production by NKp46- ILC3s and decreased CD11b+ CD103+ dendritic cell accumulation. The deficiency of Setd2-/-NKp46- ILC3s may contribute to disturbed RORγt+ Treg homeostasis and intestinal inflammation in Rag1-/-RorcCreSetd2flox/flox mice upon T cell reconstitution. Setd2 regulates genome accessibility imprinting gene mRNA expression, with a more profound effect on NKp46+ ILC3s than NKp46- ILC3s. Therefore, Setd2 determines distinct chromatin status and transcriptomic programs of ILC3 subsets to affect their function and intestinal immunity. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Electric Literature of 2358-84-1

The Article related to setd2 ilc3 intestinal cell immunity distinct property, cp: immunology, setd2, group 3 innate lymphoid cells, intestinal immunity, regulatory t cells, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.Electric Literature of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics