On September 27, 2007, Koppel, Gary A.; Heindel, Ned D. published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of β-lactamylalkanoic acids as vasopressin V2 antagonists. And the patent contained the following:
β-Lactamylalkanoic acids of formula I [A = carboxylic acid, ester or amide; B = carboxylic acid, ester or amide, (substituted) OH, SH; R1 = H, alkyl; R2 = H, alkyl, alkoxy, alkylthio, CN, CHO, etc.; R3 = (substituted) amino, etc.; R4 = alkyl, alkenyl, cycloalkyl, aryl, etc.] are prepared as vasopressin V2 antagonists. Pharmaceutical compositions containing I are described. Thus, II was prepared, and had IC50 value of 2.06 nM against rat vasopressin V2 receptor. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Category: esters-buliding-blocks
The Article related to lactamylalkanoic acid preparation vasopressin v2 antagonist, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
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