Category: esters-buliding-blocks

Bristow, Tony; Harrison, Mark; Sims, Martin published the artcile< The application of gas chromatography/atmospheric pressure chemical ionisation time-of-flight mass spectrometry to impurity identification in Pharmaceutical Development>, Synthetic Route of 112-63-0, the main research area is gas chromatog atm pressure impurity pharmaceutical development.

Accurate mass measurement (used to determine elemental formulas) is an essential tool for impurity identification in pharmaceutical development for process understanding. Accurate mass liquid chromatog./mass spectrometry (LC/MS) is used widely for these types of analyses; however, there are still many occasions when gas chromatog. (GC)/MS is the appropriate technique. Therefore, the provision of robust technol. to provide accurate mass GC/MS (and GC/MS/MS) for this type of activity is essential. In this report we describe the optimization and application of a newly available atm. pressure chem. ionization (APCI) interface to couple GC to time-of-flight (TOF) MS. To fully test the potential of the new interface the APCI source conditions were optimized, using a number of standard compounds, with a variety of structures, as used in synthesis at AstraZeneca. These compounds were subsequently analyzed by GC/APCI-TOF MS. This study was carried out to evaluate the range of compounds that are amenable to anal. using this technique. The range of compounds that can be detected and characterized using the technique was found to be extremely broad and include apolar hydrocarbons such as toluene. Both protonated mols. ([M + H]+) and radical cations (M+.) were observed in the mass spectra produced by APCI, along with addnl. ion signals such as [M + H + O]+. The technique has been successfully applied to the identification of impurities in reaction mixtures from organic synthesis in process development. A typical mass accuracy of 1-2 mm/zunits (m/z 80-500) was achieved allowing the reaction impurities to be identified based on their elemental formulas. These results clearly demonstrate the potential of the technique as a tool for problem solving and process understanding in pharmaceutical development. The reaction mixtures were also analyzed by GC/electron ionization (EI)-MS and GC/chem. ionization (CI)-MS to understand the capability of GC/APCI-MS relative to these two firmly established techniques. Copyright © 2010 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about Drugs. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Han; Xu, Qiong; Li, Hui; Liu, Jian; Liu, Xianxiang; Huang, Geng; Yin, Dulin published the artcile< Catalytic Transfer Hydrogenation of Ethyl Levulinate to γ-Valerolactone Over Ni Supported on Equilibrium Fluid-Catalytic-Cracking Catalysts>, SDS of cas: 112-63-0, the main research area is catalytic transfer hydrogenation ethyl levulinate gamma valerolactone.

Nickel supported on equilibrium fluid-catalytic-cracking catalysts (Ni/E-cats) were prepared by a simple grinding-pyrolysis method and employed for the transfer hydrogenation of Et levulinate (EL) to γ-valerolactone (GVL). 96.2% selectivity of GVL and 90.3% conversion of EL were obtained at 180°C for 6 h over 30-Ni/E-cat. Through XRD, N2 adsorption-desorption, NH3-TPD and SEM anal., the high activity of the 30-Ni/E-cat catalyst was attributed to its dispersed Ni metal active centers and available acidic sites. Catalytic probe test revealed that metal and acid sites of Ni/E-cat played a synergistic catalytic role in the synthesis of GVL in 2-propanol, where Ni metal sites contribute to the hydrogenation of ketone group in EL, and acid sites of E-cat promoted the lactonization of intermediate ethyl- or iso-Pr 4-hydroxyvalerate. Two reaction pathways and synergistic mechanism were proposed in this catalytic system. Moreover, Ni/E-cat catalyst exhibited good stability up to four cycles without obvious loss of catalytic activity.

Catalysis Letters published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Grayson, James D.; Partridge, Benjamin M. published the artcile< Mild Cu-Catalyzed Oxidation of Benzylic Boronic Esters to Ketones>, SDS of cas: 94-02-0, the main research area is benzylic boronic ester preparation copper complex catalyzed oxidation; ketone preparation.

The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atm. of air as the terminal oxidant and is notably chemoselective. Oxidation of the C-B bond occurs selectively, even in the presence of unprotected alcs. Initial study suggests the reaction proceeds through an alkylboron to Cu transmetalation, peroxide formation, and rearrangement to give the carbonyl.

ACS Catalysis published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (benzylic boronic esters). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasulov, N. Sh.; Goyushov, R. D.; Bairamov, G. M.; Guseinov, S. A. published the artcile< Monoalkyl hexahydroterephthalates>, Formula: C19H34O2, the main research area is hexahydroterephthalate monoalkyl ester; terephthalate hexahydro diacid chloride esterification.

The title esters were obtained in high yield (≤65%) from the esterification of hexahydroterephthalic diacid chloride with ROH (R = Me, Et, Pr).

Azerbaidzhanskii Khimicheskii Zhurnal published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Congxiao; Liu, Chao; Chen, Jun; Jiang, Han; Zhang, Wei; Yang, Lili; Li, Xueda; Li, Zixiang; Peng, Lijing; Hu, Xiaokun; Sun, Peng published the artcile< Effect of neoadjuvant iodine-125 brachytherapy upon resection of glioma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is neoadjuvant iodine125 brachytherapy glioma resection; Combination therapy; Glioma; Neoadjuvant 125I brachytherapy; Surgical resection; Tumor shrinkage.

A more extensive surgical resection of glioma contributes to improved overall survival (OS) and progression-free survival (PFS). However, some patients miss the chance of surgical resection when the tumor involves critical structures. The present study aimed to assess the feasibility of neoadjuvant 125I brachytherapy followed by total gross resection for initially inoperable glioma. Six patients diagnosed with inoperable glioma due to invasion of eloquent areas, bihemispheric diffusion, or large tumor volume received 125I brachytherapy. Surgical resection was performed when the tumor shrank, allowing a safe resection, assessed by the neurosurgeons. Patients were followed up after surgery. Shrinkage of the tumor after adjuvant 125I brachytherapy enabled a total gross resection of all six patients. Four patients were still alive at the last follow-up, with the longest survival time of more than 50 mo, two of which returned to everyday life with a KPS of 100. Another two patients had neurol. injuries with KPSs of 80 and 50, resp. One patient with grade II glioma died 34 mo, and another with grade IV glioma died 40 mo after the combined therapy. In the present study, the results demonstrated that 125I brachytherapy enabled a complete resection of patients with initially unresectable gliomas. The 125I brachytherapy may offer a proper neoadjuvant therapy method for glioma.

BMC Cancer published new progress about Brachytherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surakanti, Ramu; Sanivarapu, Sumalatha; Thulluri, Chiranjeevi; Iyer, Pravin S.; Tangirala, Raghuram S.; Gundla, Rambabu; Addepally, Uma; Murthy, Y. L. N.; Velide, Lakshmi; Sen, Subhabrata published the artcile< Corrigendum: Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis [Erratum to document cited in CA159:742720]>, Related Products of 30095-98-8, the main research area is pyrrolidine indoline cyclotryptamine preparation anticancer antibacterial erratum; spiro indoline preparation anticancer antibacterial erratum.

In the Supporting Information, spectra for 1, 5, 7, 8, 11, 16, 17, 18a, 20, 21and 24 were found to have been edited to remove solvents and minor impurities. Original spectra were located and replaced for all the compounds The spectra editing does not affect the conclusions of the published paper and all yields were found to be correct.

Chemistry – An Asian Journal published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinet, Julien; Treguier, S.; Levasseur-Garcia, C.; Calmon, A.; Violleau, F. published the artcile< Iodine and Peroxide Index Rapid Determination by Mid- and Near-infrared Spectroscopy in Ozonated Sunflower Oil and Ozonated Fats>, Product Details of C19H34O2, the main research area is iodine peroxide index IR spectroscopy ozonated sunflower oil fat.

Ozone can react with fatty species such as vegetable oils to form oxidized compounds with interesting antibacterial activity. The iodine and peroxide indexes of these ozonated products are two crucial antibacterial characteristics. Currently, these two parameters are determined by chem. methods, which is disadvantageous because it requires long handling time, sample destruction and the use of toxic products. Spectroscopic analyses coupled with chemometric evaluations have already shown their usefulness for characterizing virgin oils via rapid, chem.-free methods. In addition, IR spectroscopy is widely used to characterize ozonated compounds The present study evaluates the possibility of coupling IR spectroscopy with chem. analyses of ozonated compounds We subjected 187 fat samples of varying compositions to different ozonation conditions to determine their chem. parameters. We analyzed the samples by IR spectroscopy and modeled the results by combining chem. data with spectral anal. The model results are quantified by the coefficient of determination R2, the root-mean-square error, and the residual predictive deviation (RPD). The model produces RPDs greater than 3.5 for the mid-IR spectral range, which means that they may be used to estimate indexes. In addition, with RPDs between 2 and 3, partial least squares near-IR models demonstrate a capacity for rough screening of ozonated fats.

Ozone: Science & Engineering published new progress about Corn oil Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghalib, Raza Murad; Hashim, Rokiah; Sulaiman, Othman; Mehdi, Sayed Hasan; Anis, Zurida; Rahman, Syed Ziaur; Ahamed, B. M. Khadeer; Abdul Majid, Amin Malik Shah published the artcile< Phytochemical analysis, cytotoxic activity and constituents-activity relationships of the leaves of Cinnamomum iners (Reinw. ex Blume-Lauraceae)>, SDS of cas: 112-63-0, the main research area is Cinnamomum antitumor leaf tumor.

The leaves of Cinnamomum iners (Reinw. ex Blume-Lauraceae) have been refluxed successively with chloroform and alc. to get chloroform extract and alc. extract Both the extracts have been assayed for cytotoxicity against human colorectal tumor cells. The chloroform extract exhibited significant cytotoxicity with IC50 31 μg mL-1 (p < 0.01). However, ethanol extract was found to be much less cytotoxic with IC50 > 200 μg mL-1. The chloroform extract has been further proceeded for chem. anal. by GC-TOFMS and 178 components were identified including acids, amines, amides, aldehydes, alcs., esters, benzene derivatives, bicyclic compounds, terpenes, hydrocarbons, naphthalene derivatives, furan derivatives, azulenes, etc. Nine components representing 51.73% of the total chloroform extract were detected as major components. Caryophyllene (14.41%) and Eicosanoic acid Et ester (12.17%) are the most prominent components of the chloroform extract Components of the chloroform extract β-Caryophyllene (14.41%) as most abundant compound supports potent cytotoxicity as shown by chloroform extract

Natural Product Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rehman, Fawad Ur; Liu, Yang; Yang, Qingshan; Yang, Haoying; Liu, Runhan; Zhang, Dongya; Muhammad, Pir; Liu, Yanjie; Hanif, Sumaira; Ismail, Muhammad; Zheng, Meng; Shi, Bingyang published the artcile< Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma synergistic therapy heme oxygenase exosome; Exosome; Glioblastoma; HMOX1; Temozolomide resistance; siRNA.

Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete prevailing remedy. Although the synthetic nanotechnol.-based approaches exhibit excellent therapeutic potential, the associated cytotoxic effects and organ clearance failure rest major obstacles from bench to clinics. Here, we explored allogeneic bone marrow mesenchymal stem cells isolated exosomes (BMSCExo) decorated with heme oxygenase-1 (HMOX1) specific short peptide (HSSP) as temozolomide (TMZ) and small interfering RNA (siRNA) nanocarrier for TMZ resistant glioblastoma therapy. The BMSCExo had excellent TMZ and siRNA loading ability and could traverse the blood-brain barrier (BBB) by leveraging its intrinsic brain accumulation property. Notably, with HSSP decoration, the TMZ or siRNA encapsulated BMSCExo exhibited excellent TMZ resistant GBM targeting ability both in vitro and in vivo due to the overexpression of HMOX1 in TMZ resistant GBM cells. Further, the HSSP decorated BMSCExo delivered the STAT3 targeted siRNA to the TMZ resistant glioma and restore the TMZ sensitivity, consequently achieved the synergistically drug resistant GBM treatment with TMZ. Our results showed this biomimetic nanoplatform can serve as a flexible, robust and inert system for GBM treatment, especially emphasizing the drug resistant challenge.

Journal of Controlled Release published new progress about Antibiotic resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Zhiwei; Liu, Xiaofeng; Liu, Juntao; Tao, Jingchao published the artcile< Highly enantioselective Michael addition catalyzed by new primary amine-squaramide organocatalysts>, Electric Literature of 112-63-0, the main research area is enantioselective Michael addition primary amine squaramide organocatalyst.

The asym. Michael addition reaction of α,α-disubstituted aldehydes to maleimides catalyzed by new bifunctional primary amine-squaramides has been developed. This organocatalytic asym. reaction provides easy access to functionalized succinimides with a broad substrate scope. Both enantiomers of desired succinimide derivatives were obtained in good to excellent yields (up to 98%) with excellent enantioselectivities (up to > 99% ee).

Youji Huaxue published new progress about Michael reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics