Category: esters-buliding-blocks

Lee, Yong-Pyo; Jung, Hyun Ae; Lee, Min-Sang; Choi, Jung Won; Kong, Doo-Sik; Seol, Ho Jun; Nam, Do-Hyun; Lee, Jung-Il; Lee, Se-Hoon published the artcile< Bevacizumab plus irinotecan with or without gamma knife radiosurgery after failure of concurrent chemo-radiotherapy for high-grade glioma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is bevacizumab irinotecan anticancer agent high grade glioma; Bevacizumab; Gamma knife radiosurgery; High-grade glioma; Irinotecan.

Introduction: Concurrent chemo-radiotherapy (CCRT) with temozolomide (TMZ) is a standard first-line treatment for high-grade glioma. However, if CCRT with TMZ treatment fails, second-line treatment options have limited value. Bevacizumab plus irinotecan is the only available treatment option for such patients. The role of gamma knife radiosurgery (GKS) in patients with high-grade gliomas is not well-established. In this study, we evaluated the efficacy and safety of bevacizumab plus irinotecan with or without GKS in the treatment of high-grade glioma patients who progressed after initially being treated with CCRT with TMZ. We collected clin. data of patients with biopsy-proven high-grade glioma (glioblastoma multiforme (GBM) or anaplastic astrocytoma) who were treated at Samsung Medical Center from Jan. 2015 to Dec. 2020, retrospectively. We evaluated the overall survival (OS), progression-free survival (PFS), and safety of bevacizumab plus irinotecan with or without GKS. In total, 203 patients were diagnosed with high-grade glioma, including GBM and anaplastic astrocytoma. The median OS was 8.73 mo (95% confidence interval [CI]: 7.27-10.18), and the median PFS was 4.36 mo (95% CI: 3.75-4.97). Sixty-eight (33.4%) patients underwent GKS prior to bevacizumab plus irinotecan treatment, which led to a significantly prolonged OS (10.13 mo, 95% CI: 8.65-11.60 vs. 8.26 mo, 95% CI: 7.01-9.51, p = 0.012). The most common adverse events of any grade were neutropenia (36.9%) and thrombocytopenia (22.6%). However, the incidence of adverse events in patients who underwent GKS prior to bevacizumab plus irinotecan was not different compared with those in patients who did not undergo GKS. Bevacizumab plus irinotecan was well-tolerated and moderately effective in patients with high-grade gliomas. The addition of GKS prior to bevacizumab plus irinotecan led to a significant OS benefit with a manageable safety profile. GKS prior to bevacizumab plus irinotecan can therefore be considered a potential treatment option for these patients.

Journal of Neuro-Oncology published new progress about Anaplastic astrocytoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Westerberg, Goran; Langstrom, Bengt published the artcile< Online production of [11C]cyanogen bromide>, Computed Properties of 112-63-0, the main research area is cyanogen bromide 11C labeled preparation.

The electrophilic labeling precursor [11C]cyanogen bromide was produced in 95% radiochem. yield (decay-corrected) from hydrogen [11C]cyanide within 3 min from the end of bombardment using a simple and convenient solid-phase online procedure. The [11C]cyanogen bromide was used in the synthesis of a number of labeled compounds for use in positron emission tomog.

Applied Radiation and Isotopes published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Bing; Hu, Xiongtao; Hu, Xiaofeng; Hu, Libin; Ma, Wencheng; Li, Wenrong; Liu, Xiaoyu; Zhang, Jiujun; Jiang, Yong published the artcile< Thermal initiation/ultraviolet cross-linking process in polyethylene oxide@Li6·75La3Zr1·75Ta0·25O12-based composite electrolyte with high room-temperature ionic conductivity and long life cycle>, Category: esters-buliding-blocks, the main research area is solid state lithium metal battery polymer electrolyte.

Organic-inorganic composite electrolytes (PL-SCEs) based on polyethylene oxide (PEO) and Li6·75La3Zr1·75Ta0·25O12 (LLZTO) are considered to be one of the most promising solid electrolytes. However, the low room-temperature ionic conductivity caused by the inherent high crystallinity of PEO severely hinders its practical application. Herein, a novel PL-SCE is synthesized through a facile thermal induction and UV crosslinking process, using fluoroethylene carbonate (FEC) and 4-methylbenzophenone as thermal/UV triggers, and tetraethylene glycol di-Me ether (TEGDME) as an ion conductive plasticizer. The F atom in the FEC can attack the C-O bond in the PEO chain and abstract the hydrogen attached to the C atom to form an active site, prompt TEGDME and PEO to achieve a higher degree of crosslinking, thus endowing PL-SCE with high Li-ion conductivity of 5.35 x 10-4 S cm-1 at 25°C. Besides, the obtained PL-SCE exhibits excellent wettability and compatibility with Li metal anodes, the interfacial impedance is only 44 Ω cm2. The LiFePO4||Li full cell based on the proposed PL-SCE exhibits an excellent room-temperature cycling performance with a capacity retention rate up to 88% and the average Coulombic efficiency above 98% upon 450 cycles at 1 C. Prospectively, this work provides a promising alternative method for the practical application of PL-SCEs.

Journal of Power Sources published new progress about Crosslinking. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhijun; Bao, Haiying published the artcile< Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic>, Product Details of C19H34O2, the main research area is Inonotus hepatic carcinoma petroleum ether extract amino acid antitumor; Anti-tumor; Inonotus hispidus petroleum-ether-extract (IPE); Mechanisms; Serum metabonomic; UPLC-MS/MS.

The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear. This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics. The model of H22 tumor-bearing mice was constructed according to the histopathol. data and biochem. parameters, while the serum metabolomics was analyzed by non-targeted ultra-high performance liquid chromatog. and high-resolution mass spectrometry (UPLC-MS/MS) to study the potential anti-tumor mechanisms of IPE. These results indicated that IPE has significant anti-tumor effect on H22 tumor-bearing mice and no obvious adverse reactions were observed After the intervention of IPE, the biosynthesis of cortisol and corticosterone as the metabolics in the downstream of steroid biosynthesis pathway and the biosynthesis of succinate, fumarate and malate as the metabolics in the downstream of tricarboxylic acid cycle pathway were inhibited; but the metabolic pathways of the amino acids as tryptophan, lysine degradation, alanine, aspartate and glutamate and other amino acid were activated. IPE has significant anti-tumor effect in H22 tumor-bearing mice, and the anti-tumor activity of IPE is main through the regulation of energy, amino acids, and steroid hormone biosynthesis pathways expression.

Journal of Ethnopharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (metabolism). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mahankali, Kiran; Gottumukkala, Sundeep Varma; Masurkar, Nirul; Thangavel, Naresh Kumar; Jayan, Rahul; Sawas, Abdulrazzag; Nagarajan, Sudhan; Islam, Mahbubul Md; Arava, Leela Mohana Reddy published the artcile< Unveiling the Electrocatalytic Activity of 1T'-MoSe2 on Lithium-Polysulfide Conversion Reactions>, Computed Properties of 112-63-0, the main research area is unveiling electrocatalytic molybdenum selenide lithium polysulfide conversion reaction; 2D material; electrocatalysis; lithium−sulfur; phase transformation; transition metal dichalcogenide.

The dissolution of intermediate lithium polysulfides (LiPS) into an electrolyte and their shuttling between the electrodes have been the primary bottlenecks for the commercialization of high-energy d. lithium-sulfur (Li-S) batteries. While several two-dimensional (2D) materials have been deployed in recent years to mitigate these issues, their activity is strictly restricted to their edge-plane-based active sites. Herein, for the first time, we have explored a phase transformation phenomenon in a 2D material to enhance the number of active sites and electrocatalytic activity toward LiPS redox reactions. Detailed theor. calculations demonstrate that phase transformation from the 2H to 1T’ phase in a MoSe2 material activates the basal planes that allow for LiPS adsorption. The corresponding transformation mechanism and LiPS adsorption capabilities of the as-formed 1T’-MoSe2 were elucidated exptl. using microscopic and spectroscopic techniques. Further, the electrochem. evaluation of phase-transformed MoSe2 revealed its strong electrocatalytic activity toward LiPS reduction and their oxidation reactions. The 1T’-MoSe2-based cathode hosts for sulfur later provide a superior cycling performance of over 250 cycles with a capacity loss of only 0.15% per cycle along with an excellent Coulombic efficiency of 99.6%.

ACS Applied Materials & Interfaces published new progress about Battery electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lahuta, Leslaw Bernard; Szablinska-Piernik, Joanna; Glowacka, Katarzyna; Stalanowska, Karolina; Railean-Plugaru, Viorica; Horbowicz, Marcin; Pomastowski, Pawel; Buszewski, Boguslaw published the artcile< The Effect of Bio-Synthesized Silver Nanoparticles on Germination, Early Seedling Development, and Metabolome of Wheat (Triticum aestivum L.)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Triticum aestivum silver nanoparticle germination early seedling development metabolome; ROS; metabolic profiles; seedling; silver nanoparticles; wheat.

Changes in the metabolome of germinating seeds and seedlings caused by metal nanoparticles are poorly understood. In the present study, the effects of bio-synthesized silver nanoparticles ((Bio)Ag NPs) on grains germination, early seedlings development, and metabolic profiles of roots, coleoptile, and endosperm of wheat were analyzed. Grains germinated well in (Bio)Ag NPs suspensions at the concentration in the range 10-40 mg/L. However, the growth of coleoptile was inhibited by 25%, regardless of (Bio)Ag NPs concentration tested, whereas the growth of roots gradually slowed down along with the increasing concentration of (Bio)Ag NPs. The deleterious effect of Ag NPs on roots was manifested by their shortening, thickening, browning of roots tips, epidermal cell death, progression from apical meristem up to root hairs zone, and the inhibition of root hair development. (Bio)Ag NPs stimulated ROS production in roots and affected the metabolic profiles of all tissues. Roots accumulated sucrose, maltose, 1-kestose, phosphoric acid, and some amino acids (i.e., proline, aspartate/asparagine, hydroxyproline, and branched-chain amino acids). In coleoptile and endosperm, contrary to roots, the concentration of most metabolites decreased. Moreover, coleoptile accumulated galactose. Changes in the concentration of polar metabolites in seedlings revealed the affection of primary metabolism, disturbances in the mobilization of storage materials, and a translocation of sugars and amino acids from the endosperm to growing seedlings.

Molecules published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kolar, David; Kleteckova, Lenka; Skalova, Katerina; Brozka, Hana; Kalous, Martin; Vales, Karel published the artcile< Glycolytic and Krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated NMDA inhibition by MK-801>, Synthetic Route of 112-63-0, the main research area is MK801 NMDA antagonist glycolytic Krebs cycle enzyme schizophrenia brain; Citrate synthase; Energy metabolism; Hexokinase; Lactate dehydrogenase; Malate dehydrogenase; Schizophrenia.

Psychosis is a state of altered thoughts which often accompanies schizophrenia. It was suggested that changes in energetic metabolism accompany psychosis and post-psychosis states. Here, author use the N-methyl–aspartate (NMDA) receptor antagonist MK-801 to exptl. induce psychosis-like behavior in rats. Author addressed an effect of single and repeated (5x) MK-801 application (0.3 mg/kg; i.p.) on the energy metabolism in homogenates and crude mitochondrial fraction (CMF) of the striatum (STR), prefrontal cortex (PFC), and the hippocampus (HIP) of the adult male Wistar rat (n = 39). In each brain region, author assessed activity of glycolytic (hexokinase (HK) and lactate dehydrogenase (LDH)) and Krebs cycle enzymes (citrate synthase (CS) and malate dehydrogenase (MDH)) 2 h and 3 days (3d) after the last MK-801 application together with relative respiratory rates assessment in tissue homogenate. In STR, a single MK-801 application led to a decrease in the LDH (p = 0.0035) and the increase of the MDH (p = 0.0043) activities following 3d. Therein, repeated MK-801 doses evoked increased LDH (p = 0.0204) and CS (p = 0.0019) activities in the homogenate 2 h and increased HK (p = 0.0007) 3d after the last application. Elevated HK activity within CMF was observed after 3d (p = 0.0054). In PFC, repeated MK-801 application decreased HK activity in the homogenate 3d after the final application (p = 0.0234). Correspondingly, PFC HK activity in CMF of repeated administration samples dropped (p = 0.003). In HIP, repeated MK-801 administration led to increased respiration of SDH (p = 0.0475) only 2 h after the last application and decreased CS activity (p = 0.0160) was observed 3d after the last application. Author result indicate a progressive metabolic dysregulation of glycolytic and Krebs cycle enzymes following repeated inhibition of NMDA receptors activity in a region-specific manner. Energetic alterations may form a basis for persisting cognitive problems during and following a psychosis in schizophrenia patients.

NeuroToxicology published new progress about Brain corpus striatum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Otsuji, Yoshio; Koda, Yoshiki; Kubo, Masaru; Furukawa, Masaaki; Imoto, Eiji published the artcile< Reactivities of the heterocyclic compounds. VI. Application of the Hammett equation to pyridine compounds>, Product Details of C19H34O2, the main research area is .

5-Ethylpyridine-2-carboxylic acid (I) (12 g.) dissolved in 100 ml. AcOH and 10 g. H2SO4, 11 g. CrO3 added at 15°, and the product purified through the Cu salt gave 42% 5-acetylpyridine-2-carboxylic acid (II), m. 179-80°. Et ester of II was prepared similarly in 72% yield, b5 143-5°; 2,4-dinitrophenylhydrazone m. 226°. H2O2 (30%) (20 ml.) added to 50 ml. H2SO4 at 0-5° and 5 g. 2-aminopyridine-5-carboxylic acid in 50 ml. H2SO4 added gave after 2 days 63% 2-nitropyridine-5-carboxylic acid (III), m. 187-8°. Compounds used in this study were picolinic acid (IV), I, 5-iodo-2-carboxylic acid, II, nicotinic acid, and their Et esters, 2-methylpyridine-5-carboxylic acid, 2-chloropyridine-5-carboxylic acid, and III. The hydrolysis rates of Et 5-substituted pyridine-2-carboxylates at 25° were studied and found to be linear with Hammett σp values except for Et ester of II. Deviation of the Ac group was attributed to enolization and ionization when the Ac group was attached to an electron-drawing group. ρ was obtained as 1.56 and the small ρ was attributed to the electronegativity of N. Hydrolysis rate of 3 Et pyridinecarboxylates was in good agreement with the π-electron distribution. Dissociation constants of 5-substituted pyridine-2-carboxylic acids (V) and 2-substituted pyridine-5-carboxylic acids (VI) were obtained. V gave always higher pKa than VI, indicating that IV and its derivatives existed as zwitterions. The Hammett equation was also applicable to the dissociation and ρ was obtained as 2.31 and 1.60 for V and VI, resp., while substituted benzoic acids had 1.60 under the similar conditions. Greater ρ than that expected from ester hydrolysis must be attributed to the existence of a zwitterion of which H+ on N influences the σ values. From the ρ value the ratio of zwitterion in V was estimated as 30% in 50% EtOH. The σ value was corrected by use of the above zwitterion content and better linear correlation was obtained.

Nippon Kagaku Zasshi published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thiam, Mohamadou; Slassi, Abdelmalik; Chastrette, Francine; Amouroux, Roger published the artcile< Malic acid as a chiral synthon: synthesis of 1,2 and 1,3 optically active diols>, Name: (S)-Dimethyl 2-hydroxysuccinate, the main research area is chiral synthon malic acid; diol optically active.

Com. malic acid is used for the synthesis of substituted 1,2 and 1,3 optically active diols. Thus, diol I was prepared in 70% yield from II via the key intermediate acetonide III.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Name: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Das, Anindita; Theato, Patrick published the artcile< Multifaceted Synthetic Route to Functional Polyacrylates by Transesterification of Poly(pentafluorophenyl acrylates)>, HPLC of Formula: 71195-85-2, the main research area is polyacrylate transesterification polypentafluorophenyl acrylate.

Synthesis of functional polyacrylates by 4-dimethylaminopyridine (DMAP) catalyzed trans-esterification of poly(pentafluorophenyl acrylate) (polyPFPA) is reported. High fidelity and versatility of this strategy was exemplified by near quant. conversion with diverse functional alcs. (primary, secondary as well as phenolic) featuring reactive groups like alkene, alkyne or acrylate, enabling further sequential functionalization using click chem. Co-integrating an equimolar mixture of allyl and propargyl alc. produced an orthogonally clickable copolymer by thiol-ene and 1,3-cycloaddition reaction. Base catalyzed ester exchange allowed installation of acid labile Boc-L-serine to create amino acid pendent polymer keeping both NH2- and COOH-group free, thereby providing a facile route toward zwitterionic polymers. Reaction with 2-dimethylaminoethanol conferred dual pH and CO2 responsive polymers from the same reactive precursor. The synthetic strategy was further extended to attach alcs. obtained from natural resources such as geraniol, L-lactic acid or sesamol to engineer new renewable polymers. Even a graft copolymer with very high (93%) grafting d. could be achieved utilizing PEG350-OH. The trans-esterification was found to be highly selective for primary alcs. over secondary alcs. and also to the activated PFP-ester over a normal ester such as poly(Me acrylate). Using such selectivity, fluorescently tagged polymer could be synthesized by replacing only the PFP-ester of a poly(Me acrylate-co-PFPA) with 1-pyrenemethanol. Further, PFPA was polymerized with 2.0 mol % diacrylate to produce a cross-linked gel network. The PFP-ester groups of the cross-linked gel could be quant. replaced with Boc-L-serine, which upon deprotection of the Boc group resulted in a novel zwitterionic hydrogel exhibiting pH-dependent swelling properties. Time-dependent FTIR experiment suggested fast kinetics of the reaction, making this synthetic route practically applicable for postpolymn. modification. Mechanistic investigation exposed involvement of both DMAP and the nucleophilic solvent N,N-dimethylformamide (DMF) in catalyzing the reaction. This also explains the reason as to why near quant. conversion was achieved in DMF and not in the non-nucleophilic solvent 1,4-dioxane.

Macromolecules (Washington, DC, United States) published new progress about Acrylic polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics