Category: 112-63-0

Takiyama, Mikina; Matsumoto, Takashi; Sanechika, Sho; Watanabe, Junko published the artcile< Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is shimotsuto medicine gynecol disease pharmacokinetics; Active ingredients; Blood and circulatory system; Gynecological disease; Pharmacokinetics; Shimotsuto.

Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecol. diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of the pharmacol. actions of shimotsuto is traditionally considered to be exerted by an improvement effect of the blood and the circulatory system. Multiple ingredients (e.g., catalpol and paeoniflorin) contained in shimotsuto have been reported to have pharmacol. activities on the blood and circulatory system, and thus been considered to contribute to the pharmacol. actions of shimotsuto. However, it remains unclear whether the ingredients can be absorbed into the body following oral administration of shimotsuto. The aim in the present study was to specify shimotsuto ingredient absorbed into the systemic circulation in rats. Seven candidate active ingredients (catalpol, paeoniflorin, albiflorin, ligustilide, senkyunolide A, butylphthalide, and ferulic acid) in plasma after oral administration of shimotsuto were quantified by targeted liquid chromatog.-tandem mass spectrometry (LC-MS/MS) anal. This study also performed nontargeted LC-MS/MS anal. of plasma following administration of constituent crude drugs of shimotsuto to find extensively blood-absorbed ingredients of shimotsuto. Among detected peaks in the nontargeted anal., two peaks could be identified as bergapten and 8-debenzoylpaeoniflorin, subsequently their concentrations in shimotsuto-treated rat plasma were quantified. These pharmacokinetic studies indicated that catalpol showed the highest plasma concentration following administration of shimotsuto, followed by 8-debenzoylpaeoniflorin. This study suggests that all nine ingredients are absorbed into the blood following oral administration of shimotsuto and possibly contribute to its pharmacol. action.

Journal of Natural Medicines published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ampong, Isaac published the artcile< Metabolic and Metabolomics Insights into Dilated Cardiomyopathy>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review metabolomics dilated cardiomyopathy population sex difference; Biomarkers; Dilated cardiomyopathy; Metabolites; Metabolomics.

A review. Metabolomics is an emerging and powerful discipline that provides a global information on the phenotype of mammalian systems via the study of endogenous and exogenous metabolites in cells, tissues, and biofluids. These studies aid in the identification of biomarkers to prevent diseases in later life or help to early detect onset of diseases as well as aiding in the elucidation of disease mechanisms. Metabolomics provides a unique opportunity to discover novel biomarkers for DCM. This review demonstrates evidence of metabolite-based biomarkers useful for predicting, diagnosing, and monitoring therapeutic interventions of DCM. Key metabolites identified as potential biomarkers for diagnosing DCM include acylcarnitines, succinic acid, malate, methylhistidine, aspartate, methionine, and phenylalanine. In terms of differentiating DCM from ischemic cardiomyopathy, potential biomarkers including 1-pyrroline-2-carboxylate, norvaline, lysophosphatidylinositol (16:0/0:0), phosphatidylglycerol, fatty acid esters of hydroxy fatty acid, and phosphatidylcholine were identified. Acylcarnitines, isoleucine and linoleic acid, and tryptophan were the main biomarkers to monitor treatment response to DCM. Mapping metabolites to metabolic pathways revealed dysregulation of branch-chain amino acid, glycolysis, tricarboxylic acid cycle, and triacylglycerol and pentose phosphate metabolism, which have the therapeutic potential for DCM. This review shows several limitations including the use of small sample sizes, lack of interpretation of age and sex differences in most studies, and the fact that studies have so far been limited to case-control study designs. Metabolites have close proximity to disease phenotype. With recent advances in metabolomics field, potential biomarkers for DCM have been identified based on studies using different biol. and metabolomics technologies. However, multicenter studies with larger populations that will lead to validation of these identified biomarkers to enable their clin. translation and utilization are still needed. Dilated cardiomyopathy (DCM) is the most common form of heart muscle disease characterized by progressive dilatation and ventricular dysfunction.

Annals of Nutrition & Metabolism published new progress about Acylcarnitines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

O’Toole, Sarah E.; Rose, Christopher A.; Gundala, Sivaji; Zeitler, Kirsten; Connon, Stephen J. published the artcile< Highly chemoselective direct crossed aliphatic-aromatic acyloin condensations with triazolium-derived carbene catalysts>, Synthetic Route of 112-63-0, the main research area is hydroxylketone derivative preparation; aliphatic aldehyde aromatic aldehyde acyloin condensation triazolium precatalyst.

It has been shown for the first time that triazolium precatalysts promote (in the presence of base) highly chemoselective crossed acyloin condensation reactions between aliphatic and ortho-substituted aromatic aldehydes. An o-bromine atom can serve as a temporary directing group to ensure high chemoselectivity (regardless of the nature of the other substituents on the aromatic ring) which then can be conveniently removed. The process is of broad scope and is operationally simple as it does not require the preactivation of any of the coupling partners to ensure selectivity. Preliminary data indicate that highly enantioselective variants of the reaction are feasible using chiral precatalysts.

Journal of Organic Chemistry published new progress about Acyloin condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Shoulei; Zhang, Enge; Feng, Junjun; Li, Xin published the artcile< An enantioselective conjugate addition reaction of 3-substituted benzothiophen-2-ones and 2-phthalimidoacrylates>, Synthetic Route of 112-63-0, the main research area is chiral benzothiophenone preparation; benzothiophenone phthalimidoacrylate enantioselective conjugate addition.

A highly enantioselective conjugate addition reaction of 3-substituted benzothiophen-2-ones to 2-phthalimidoacrylates has been developed using a bifunctional tertiary-amine thiourea catalyst. A number of chiral 3-substituted benzothiophen-2-one compounds I (R1 = Bn, i-Bu, (CH2)2COOMe, etc.; R2 = CH3, C2H5, Bn, etc.) were obtained with excellent yields (up to 99%) and very good stereoselectivities (up to >19 : 1 dr and up to 92% ee). The reaction was proved to be an efficient strategy for the synthesis of enantioenriched α-amino acid derivatives with 1,3-nonadjacent stereogenic centers.

Organic Chemistry Frontiers published new progress about Aromatic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trang, Nguyen Thi Quynh; Long, Dang Thanh; Hong, Hoang Thi Kim published the artcile< Phytocomponents and antioxidant activity in the methanol extract of seed lotus (Nelumbo Nucifera Gaernt.) from Viet Nam>, HPLC of Formula: 112-63-0, the main research area is phytocomponent antioxidant activity methanol extract Nelumbo Nucifera.

In this study, we determined the phytocomponents using GC-MS and evaluated antioxidant activity by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the methanolic extract of six lotus varieties seed in Viet Nam (N.Nucifera). GC-MS chromatogram of the methanolic extract of six lotus varieties seed in Viet Nam showed 27 peaks which indicate the presence of 27 phytochem. constituents. The major phytochem. constituent is methyl-alpha-d-galactopyranoside (66,86-78,69%) in all lotus varieties. Antioxidant activity of liquid extract and condensed extract was found as 8.20-15.67 mg/mL and 0.850-1.286 mg/mL in comparison with IC50 of ascorbic acid (3.2μg/mL). Moreover, 50% of the DPPH scavenging ability of liquid and condensed extract differed from each other. From obtained results, the seeds of six lotus varieties in Viet Nam were found to be potential for bioactive compounds and antioxidant activity.

Research Journal of Biotechnology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Michael D.; Murray, William V. published the artcile< Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones>, Related Products of 112-63-0, the main research area is cyclic enone preparation; phosphonium salt activator palladium catalyst coupling reaction cycloalkanedione.

Phosphonium salt-activated, Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the synthesis of β-substituted cyclic enones are described. These transformations exhibit good isolated yield and high generality with respect to both substrates and coupling partners. Extension of the substrate scope to cyclic 1,3-dione equivalent, such as 2-cyanocyclohexanone (4), is also briefly examined

Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matsufuji, Tetsuyoshi; Shimada, Kousei; Kobayashi, Shozo; Kawamura, Asuka; Fujimoto, Teppei; Arita, Tsuyoshi; Hara, Takashi; Konishi, Masahiro; Abe-Ohya, Rie; Izumi, Masanori; Sogawa, Yoshitaka; Nagai, Youko; Yoshida, Kazuhiro; Takahashi, Hisashi published the artcile< Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration>, Formula: C19H34O2, the main research area is diazepine chiral preparation bombesin receptor subtype 3 agonist; structure activity chiral diazepine bombesin receptor subtype 3 agonist; Bombesin receptor subtype-3 (BRS-3) agonists; Brain penetration; Diazepine.

The discovery and optimization of a novel series of BRS-3 agonists are described. We explored a potent BRS-3 agonist with low brain penetration to avoid an adverse effect derived from central nervous system exposure. Through the derivatization process, chiral diazepines I (R1 = iso-Bu, 2-methylpyridin-5-yl) were identified as possessing low brain penetration as well as potent in vitro activity against human and mouse BRS-3s.

Bioorganic & Medicinal Chemistry Letters published new progress about Bombesin receptor BB3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Collins, Jon L.; Blanchard, Steven G.; Boswell, G. Evan; Charifson, Paul S.; Cobb, Jeff E.; Henke, Brad R.; Hull-Ryde, Emily A.; Kazmierski, Wieslaw M.; Lake, Debra H.; Leesnitzer, Lisa M.; Lehmann, Juergen; Lenhard, James M.; Orband-Miller, Lisa A.; Gray-Nunez, Yolanda; Parks, Derek J.; Plunkett, Kelli D.; Tong, Wei-Qin published the artcile< N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonists. 2. Structure-Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety>, Application of C19H34O2, the main research area is benzoylphenyltyrosine analog preparation structure PPARgamma agonist; peroxisome proliferator receptor benzoylphenyltyrosine analog antidiabetic.

We previously reported the identification of (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}propanoic acid (I) (PPARγ pKi = 8.94, PPARγ pEC50 = 9.47) as a potent and selective PPARγ agonist. We now report the expanded structure-activity relationship around the Ph alkyl ether moiety by pursuing both a classical medicinal chem. approach and a solid-phase chem. approach for analog synthesis. The solution-phase strategy focused on evaluating the effects of oxazole and Ph ring replacements of the 2-(5-methyl-2-phenyloxazol-4-yl)ethyl side chain of I with several replacements providing potent and selective PPARγ agonists with improved aqueous solubility Specifically, replacement of the Ph ring of the phenyloxazole moiety with a 4-pyridyl group to give (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-pyridin-4-yloxazol-4-yl)ethoxy]phenyl}propionic acid (PPARγ pKi = 8.85, PPARγ pEC50 = 8.74) or a 4-methylpiperazine to give (2S)-((2-benzoylphenyl)amino)-3-(4-{2-[5-methyl-2-(4-methylpiperazin-1-yl)thiazol-4-yl]ethoxy}phenyl)propionic acid (PPARγ pKi = 8.66, PPARγ pEC50 = 8.89) provided two potent and selective PPARγ agonists with increased solubility in pH 7.4 phosphate buffer and simulated gastric fluid as compared to I. The second strategy took advantage of the speed and ease of parallel solid-phase analog synthesis to generate a more diverse set of Ph alkyl ethers which led to the identification of a number of novel, high-affinity PPARγ ligands (PPARγ pKi’s 6.98-8.03). The combined structure-activity data derived from the two strategies provide valuable insight on the requirements for PPARγ binding, functional activity, selectivity, and aqueous solubility

Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ortiz-Rivero, Elisa; Prorok, Katarzyna; Skowickl, Michal; Lu, Dasheng; Bednarkiewicz, Artur; Jaque, Daniel; Haro-Gonzalez, Patricia published the artcile< Single-Cell Biodetection by Upconverting Microspinners>, Electric Literature of 112-63-0, the main research area is single cell biodetection upconverting microspinner; bacteria; candida cell; optical trapping; spinner; upconversion.

Near-IR-light-mediated optical tweezing of individual upconverting particles has enabled all-optical single-cell studies, such as intracellular thermal sensing and minimally invasive cytoplasm studies. Furthermore, the intrinsic optical birefringence of upconverting particles renders them light-driven luminescent spinners with a yet unexplored potential in biomedicine. The use of upconverting spinners is showcased for the accurate and specific detection of single-cell and single-bacteria attachment events, through real-time monitoring of the spinners rotation velocity of the spinner. The phys. mechanisms linking single-attachment to the angular deceleration of upconverting spinners are discussed. Concomitantly, the upconversion emission generated by the spinner is harnessed for simultaneous thermal sensing and thermal control during the attachment event. Results here included demonstrate the potential of upconverting particles for the development of fast, high-sensitivity, and cost-effective systems for single-cell biodetection.

Small published new progress about Bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xing, Da; Bawol, Pawel P.; Abd-El-Latif, Abd-El-Aziz A. A.; Zan, Lingxing; Baltruschat, Helmut published the artcile< Insertion of Magnesium into Antimony Layers on Gold Electrodes:Kinetic Behaviour>, Electric Literature of 112-63-0, the main research area is magnesium antimony layer gold electrode kinetic behavior diffusion coefficient.

Magnesium based secondary batteries are regarded as a viable alternative to the immensely popular Li-ion systems. One of the largest challenges is the selection of a Mg anode material since the insertion/extraction processes are kinetically slow because of the large ionic radius and high charge d. of Mg2+. In an attempt to bridge the gap between insertion measurements in 3D composite electrode materials and that in an idealized pure model system, we studied the insertion and diffusion of Mg in a thin, massive layer of Sb deposited on Au by using PITT, CV, and potential step experiments Sb has been suggested as an insertion material because magnesium can form intermetallic compound with it. The layered crystal structure of Sb leads should facilitate formation of such an intermetallic phase. Mg insertion from a MACC/tetraglyme electrolyte into Sb starts 300 mV pos. of the onset potential of Mg deposition as shown by cyclic voltammetry. The molar ratio of Mg to Sb agrees well with the stoichiometry of Mg3Sb2 alloy (Zintl-phase). The diffusion coefficient of Mg-insertion into Sb – layers and the charge transfer rate have been estimated by the above techniques. Such diffusion coefficients, albeit still somewhat “”apparent””, are much more closely related to the true diffusion coefficient in the metal or alloy. The solid-state diffusion coefficient of Mg into the Sb layers is in the range of 4-8×10-14 cm2 s-1. A very high Tafel slope of 370 mV/dec was found in potential step experiments Mg insertion was further investigated by XPS measurements. Besides Mg and Sb, Al and Cl signals were also detected, particularly at the outer parts of the layer.

ChemElectroChem published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics