Category: 112-63-0

Mohammad, Shabbair; Dhambri, Sabrina; Gori, Didier; Vaxelaire, Carine; Sorin, Geoffroy; Ardisson, Janick; Lannou, Marie-Isabelle published the artcile< Asymmetric Sharpless dihydroxylation reaction of chiral bishomoallylic alcohols: Application to the synthesis of the C1-C10-C5 fragment of FR225654>, Computed Properties of 112-63-0, the main research area is asym Sharpless dihydroxylation chiral bishomoallylic alc pyrimidine ligand.

Toward the synthesis of FR225654, an antidiabetic natural product, the Sharpless asym. dihydroxylation of chiral bishomoallylic alcs., never reported in the literature, was examined Employing the pyrimidine class of ligands, a high level of matched diastereoselectivity was obtained. An application to the stereoselective synthesis of the C1-C10-C5 fragment I of FR225654 was performed.

Synlett published new progress about Alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent) (bishomoallylic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Mei-xiang; Lei, Bo; Song, Xin; Huang, Yong-mei; Ma, Xiao-qin; Hao, Chen-xia; Yang, Wan-hua; Pan, Man-li published the artcile< Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products>, Electric Literature of 112-63-0, the main research area is compound XiongShao capsule plant extract neuroprotective agent apoptosis; nitroxidative stress diabetic peripheral neuropathy; Advanced glycation end products; BAX/BCL2–caspase-3; Compound XiongShao Capsule; Diabetic peripheral neuropathy; Oxidative – nitrosative stress.

Compound XiongShao Capsule (CXSC), a traditional herb formula, has been approved for using to treat diabetic peripheral neuropathy (DPN) by the Shanghai Food and Drug Administration, with significant efficacy in clinic. This study aimed to investigate the multidimensional pharmacol. mechanisms and synergism of CXSC against DPN in rats. The quality anal. of CXSC was performed by high-performance liquid chromatog. (HPLC) and thin-layer chromatog. Rats with DPNinduced by streptozotocin/high-fat diet for 4 wk were treated with CXSC at three doses (1.2 g/kg, 0.36 g/kg, and 0.12 g/kg), or epalrestat (15 mg/kg) daily for 8 wk continuously. During the treatment period, body weight, serum glucose levels, and nerve function, including nerve conduction velocity (NCV), and mech. and thermal hyperalgesia were tested and assessed every 4 wk. In the 13th week, the histopathol. examination in the sciatic nerve was performed using a transmission electron microscope. The expression of apoptosis-related proteins of BAX, BCL2, and caspase-3 in the sciatic nerve was examined using hematoxylin and eosin staining. The serum levels of advanced glycation end products (AGEs), oxidative-nitrosative stress biomarkers of superoxide dismutase (SOD), and nitric oxide synthase (NOS) were measured using a rat-specific ELISA kit. CXSC had no significant effect on body weight or serum glucose levels (P > 0.05), but it significantly improved mech. hyperalgesia (F5,36 = 18.24, P < 0.0001), thermal hyperalgesia (F5,36 = 8.45, P < 0.0001), and NCV (motor NCV: F5,36 = 7.644, P < 0.0001, sensory NCV: F5,36 = 12.83, P < 0.0001). Besides, it maintained myelin and axonal structure integrity, downregulated the expression of apoptosis-related proteins in the sciatic nerve tissue, reduced AGEs and NOS levels, and enhanced antioxidant enzyme SOD activities in the serum. CXSC exerted neuroprotective effects against rats with DPN through multidimensional pharmacol. mechanisms including antiapoptotic activity in the sciatic nerve and downregulation of the level of serum NOS, SOD and AGEs. Journal of Ethnopharmacology published new progress about Advanced glycosylation end products Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shalmani, Armin Azadkhah; Ghahremani, Mohammad Hossein; Jeivad, Fereshteh; Shadboorestan, Amir; Hassanzadeh, Gholamreza; Beh-Pajooh, Abbas; Ganbari-Erdi, Mikhriy; Kasirzadeh, Sara; Mojtahedzadeh, Mojtaba; Sabzevari, Omid published the artcile< Monomethyl fumarate alleviates sepsis-induced hepatic dysfunction by regulating TLR-4/NF-κB signalling pathway>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sepsis hepatic dysfunction monomethyl fumarate TLR 4 NF kappaB; Hepatic impairment; Monomethyl fumarate; NF-κB; Sepsis; TLR-4.

Sepsis is a potentially fatal illness that can lead to impairment of multiple organs such as liver. The condition is deeply associated with oxidative stress and inflammation. The aim of current study was to evaluate protective effects of MMF in sepsis-induced hepatic dysfunction. Wistar rats were assigned to one of sham, CLP, CLP + dexamethasone (as pos. control of inflammation) and CLP + MMF groups. Levels of serum IL-1β, IL-6, IL-10, AST, ALT and γ-GT were quantified. Furthermore, Hepatic levels of GSH and MDA and mRNA expression of TNF and NFKBIA along with hepatic protein level of TLR-4 were assessed. Septic rats demonstrated risen levels of IL-1β, IL-6, IL-10, AST, ALT and γ-GT, while treatment with dexamethasone or MMF attenuated these levels. Moreover, enhancements in protein level of TLR-4 and mRNA levels of TNF and NFKBIA were observed in CLP rats. These elevations were mitigated in CLP-induced rats that were treated with either dexamethasone or MMF. Treatment with dexamethasone or MMF also shifted sepsis-induced disturbance in the levels of GSH and MDA towards sham levels. Hepato-protective effects of dexamethasone and MMF were further confirmed by histopathol. observations. Our findings imply that MMF alleviates sepsis-induced hepatic dysfunction by mitigating the inflammatory and oxidative state and this effect is at least partly mediated by the inhibition of TLR-4/NF-κB signalling pathway.

Life Sciences published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Himmelstrup, Jonas; Buendia, Mikkel B.; Sun, Xing-Wen; Kramer, Soeren published the artcile< Enantioselective aryl-aryl coupling facilitated by chiral binuclear gold complexes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is chiral binuclear gold complex preparation; enantioselective aryl coupling arylbornic acid binuclear gold catalyst.

Herein, we report stoichiometric investigations embodying the first highly enantioselective aryl-aryl coupling facilitated by a gold complex. With up to 91% ee, this is the first demonstration of a transmetalation and C(sp2)-C(sp2) reductive elimination sequence with high enantioselectivity using a gold complex. The results offer a basis for development of enantioselective gold-catalyzed aryl-aryl coupling reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Atropisomers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Ming; Fan, Jiakun; Liu, Qianting; Luo, Hui; Tang, Qingyan; Li, Chongping; Zhao, Jurun; Zhang, Xinfeng published the artcile< Phytochemical profiles of edible flowers of medicinal plants of Dendrobium officinale and Dendrobium devonianum>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Dendrobium medicinal plant flower phytochem antioxidant activity; Dendrobium devonianum; Dendrobium officinale; edible flowers; fatty acids; metabonomics; phytochemicals.

The discovery of new edible flowers that are nontoxic, innocuous flowers having human health benefits, surveys of their phytochems. and utilization are of great scientific and com. interest. Dendrobium officinale and Dendrobium devonianum are precious Traditional Chinese Medicine. During the massive com. cultivation, a lot of flowers were produced and certified as edible flowers, and the phytochem. profiles and bioactivities warrant evaluate. The present study aimed to investigate the phytochems. and antioxidative activities in flowers of D. officinale (DOF) and D. devonianum (DDF). In total, 474 metabolites were identified using a widely targeted metabonomics method, 16 amino acids and 6 flavonoids were measured using high-performance liquid chromatog. (HPLC), and 8 fatty acids were detected using gas chromatog.-mass spectrometry (GC-MS). Both flowers contained various amino acids, including 7 essential amino acids, diverse flavonoids, especially quercetin, kaempferol and their derivatives, and high levels of Me linoleate and Me linolenate. The relative levels of quercetin, kaempferol and their glycosides were higher in DDF than in DOF, whereas the relative levels of several flavonoids C-glycosides were high in DOF. Ethanol extracts of both DOF and DDF showed antioxidative capacities including the scavenging of 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals. Both edible flowers contained flavonoids, amino acids, and fatty acids and have antioxidative activities, which should be explored for use in functional foods and pharmaceuticals.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sharma, Ranjana; Rana, Ajay; Kumar, Sanjay published the artcile< Phytochemical investigation and bioactivity studies of flowers obtained from different cultivars of Camellia sinensis plant>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Camellia phytochem antioxidant antifungal flower; Camellia sinensis flowers; GC/GC-MS; HPLC; bioactivity; non-volatile; phytochemicals; volatile.

Investigation of major volatile and non-volatile phytochems. from flowers of different cultivars of Camellia sinensis was performed. A total of 21 volatile constituents and 9 fatty acids were identified by gas chromatog. -mass spectrometry (GC-MS). For evaluation of non-volatile constituents, reverse-phase high-performance liquid chromatog. with diode array detection (RP-HPLC-DAD) is used. Spectral quantification of polyphenols revealed 48.88 – 60.01 mg/gm gallic acid equivalent polyphenols. Catechins estimated up to 1.14%, while theanine and caffeine content varies from 0.13% to 0.41% and 0.07% to 0.13%, resp. Further assessment of antioxidant activity by different assays (DPPH, FRAP, RPA and FIC) showed commendable antioxidant potential. The results of antimicrobial studies showed growth inhibition of Candida albicans (17.0 ± 0.00-10.0 ± 0.00 mm) and Aspergillus niger (5 ± 0.00 to 12.5 ± 0.70 mm), indicating antifungal potential. The antiglycation assay also showed inhibition of BSA up to 94%. This study of C. sinensis flowers indicated their immense prospective as sustainable source of bioactive natural compounds

Natural Product Research published new progress about Alcohols Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Sunhui; Qiu, Qiujun; Wang, Dongdong; She, Dejun; Yin, Bo; Gu, Guolong; Chai, Meihong; Heo, Dong Nyoung; He, Huining; Wang, Jianxin published the artcile< Dual-sensitive drug-loaded hydrogel system for local inhibition of post-surgical glioma recurrence>, Category: esters-buliding-blocks, the main research area is post surgical glioma recurrence drug loaded hydrogel local inhibition; Glioma recurrence; Magnetic resonance imaging; Reactive oxygen species-sensitive nanoparticles; Synergistic effect; Thermo-sensitive hydrogel.

Local treatment after resection to inhibit glioma recurrence is thought to able to meet the real medical needs. However, the only clin. approved local glioma treatment-wafer containing bis(2-chloroethyl) nitrosourea (BCNU) showed very limited effects. Herein, in order to inhibit tumor recurrence with prolonged and synergistic therapeutic effect of drugs after tumor resection, an in situ dual-sensitive hydrogel drug delivery system loaded with two synergistic chemo-drugs BCNU and temozolomide (TMZ) was developed. The thermosensitive hydrogel was loaded with reactive oxygen species (ROS)-sensitive poly (lactic-co-glycolic) acid nanoparticles (NPs) encapsulating both BCNU and TMZ and also free BCNU and TMZ. The in vitro synergistic effect of BCNU and TMZ and in vivo presence of ROS at the residual tumor site were confirmed. The prepared ROS-sensitive NPs and thermosensitive hydrogel, as well as the long-term release behavior of drugs and NPs, were fully characterized both in vitro and in vivo. After >90% glioblastoma resection, the dual-sensitive hydrogel drug delivery system was injected into the resection cavity. The median survival time of the exptl. group reached 65 days which was twice as long as the Resection only group, implying that this in situ drug delivery system effectively inhibited tumor recurrence. Overall, this study provides new ideas and strategies for the inhibition of postoperative glioma recurrence.

Journal of Controlled Release published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamijala, Sharma S. R. K. C.; Kwon, Hyuna; Guo, Juchen; Wong, Bryan M. published the artcile< Stability of Calcium Ion Battery Electrolytes: Predictions from Ab Initio Molecular Dynamics Simulations>, Electric Literature of 112-63-0, the main research area is calcium ion battery electrolyte ab initio mol dynamics simulation; Born−Oppenheimer molecular dynamics; ab initio molecular dynamics; calcium ion batteries; electrolyte stability; time-dependent PDOS.

Multivalent batteries, such as magnesium-ion, calcium-ion, and zinc-ion batteries, have attracted significant attention as next-generation electrochem. energy storage devices to complement conventional lithium-ion batteries (LIBs). Among them, calcium-ion batteries (CIBs) are the least explored due to difficult reversible Ca deposition-dissolution In this work, we examined the stability of four different Ca salts with weakly coordinating anions and three different solvents commonly employed in existing battery technologies to identify suitable candidates for CIBs. By employing Born-Oppenheimer mol. dynamics (BOMD) simulations on salt-Ca and solvent-Ca interfaces, we find that the tetraglyme solvent and carborane salt are promising candidates for CIBs. Due to the strong reducing nature of the calcium surface, the other salts and solvents readily decompose We explain the microscopic mechanisms of salt/solvent decomposition on the Ca surface using time-dependent projected d. of states, time-dependent charge-transfer plots, and climbing-image nudged elastic band calculations Collectively, this work presents the first mechanistic assessment of the dynamical stability of candidate salts and solvents on a Ca surface using BOMD simulations, and provides a predictive path toward designing stable electrolytes for CIBs.

ACS Applied Materials & Interfaces published new progress about Battery capacity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Huai-Wei; Deng, Cheng-Long; Li, Dan-Dan; Liu, Dan-Dan; Chai, Shao-Meng; Wang, Wei; Zhang, Yan; Chen, Kai; Li, Xin; Wang, Jian; Song, Shao-Jiang; Song, Hong-Rui published the artcile< Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Kα>, SDS of cas: 112-63-0, the main research area is amino quinazoline preparation dual EGFR PI3K inhibitor cancer; 4-aminoquinazolines; Anticancer agents; Antiproliferative effects; Dual target; EGFR; PI3K.

The overexpression of EGFR correlates with rapidly progressive disease, resistance to chemotherapy and poor prognosis. In certain human cancers, PI3K works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development of dual-target drugs against EGFR and PI3K has therapeutic advantage and was an attractive approach against tumors. In this work, based on the mol. docking and previous studies, a series of 4-aminoquinazolines derivatives containing 6-sulfonamide substituted pyridyl group were rationally designed and identified as potent EGFR and PI3K dual inhibitors. The cytotoxicity experiment results showed that this series of compounds could effectively inhibit cell growth. The kinase assay demonstrated that 6c and 6i had high inhibition for EGFR and selectivity for PI3Kα distinguished from other isoforms. Further experiments showed that 6c could induce cell cycle arrest in G1 phase and apoptosis in BT549 cells. The western blot assay indicated that 6c inhibited the proliferation of BT549 cell through EGFR and PI3Kα/Akt signaling pathway. Our study suggested that compound 6c was a potential dual inhibitors of EGFR and PI3Kα.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Sheng; Zhu, Jinxing; Tian, Saiqi published the artcile< Polyurethane-based retanning agents with antimicrobial properties>, Category: esters-buliding-blocks, the main research area is polyurethane retanning agent antimicrobial property.

Polyurethane-based retanning agents with antimicrobial properties were synthesized by the chem. incorporation of ciprofloxacin (CPFX) units into polyurethane chains. The chem. structures were characterized by Fourier transform IR (FTIR) and gel permeation chromatog. (GPC). Then, the retanning agents were applied in the leather retanning process. Owing to the conjugation of CPFX into polyurethane chains, the mol. weight increases, further leading to the decrease in hydroxyl value and increase in particle size. The shrinkage temperature was improved after retanning. Owing to the filling of retanning agents in the gap of collagen fibers, the average thickness of leather increased by 65.8%. The mech. properties of leather were visibly improved because of the large number of -COOH coordinate with Cr3+ and more hydrogen crosslinking with carboxyl group, amino group, and hydroxyl group of leather collagen. Furthermore, leather retanned by these polyurethane-based retanning agents presented good antimicrobial properties. The antibacterial activity could be conserved above 89% even after rinsing for ten times.

e-Polymers published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics