On April 22, 1992, Kulagowski, Janusz J.; Rowley, Michael; Leeson, Paul D.; Mawer, Ian Michael published a patent.Recommanded Product: Methyl 2-(3-formylphenyl)acetate The title of the patent was Preparation of 3-aryl-4-hydroxy-2-quinolones as NMDA and AMPA antagonists. And the patent contained the following:
Title compounds (I; R1-R6 = H, hydrocarbyl, heterocyclyl, halo, cyano, CF3, NO2, OR7, SR7, SOR7, SO2R7, SO2NR7R8, NR7R8, etc.; R1R2 = atoms to form a hetero- or carbocycle; R7, R8 = H, hydrocarbyl, heterocyclyl), were prepared Thus, 3-methoxyphenylacetyl chloride and Me 2-amino-4-chlorobenzoate were refluxed 18 h in CH2Cl2 to give Me 4-chloro-3-(3-methoxyphenyl)acetamidobenzoate. The latter was stirred with KN(SiMe3)2 in THF/PhMe to give title compound II. All I prepared displaced 3H-trans-3-carboxy-5,7-dichloro-4-(phenylaminocarbonylamino)-1,2,3,4-tetrahydroquinoline from strychnine-insensitive sites of NMDA receptors in rat forebrain membranes with IC50 < 50 μM. Dosage forms were prepared containing several specific I. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Recommanded Product: Methyl 2-(3-formylphenyl)acetate
The Article related to arylhydroxyquinolone preparation nmda antagonist, ampa antagonist arylhydroxyquinolone antagonist, quinolone arylhydroxy arylhydroxyquinolone antagonist, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: Methyl 2-(3-formylphenyl)acetate
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