On April 2, 2021, Zhou, Haibing; Wu, Shuwen; Xu, Zhichao published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of oseltamivir PROTAC compound and application in anti-influenza virus drugs. And the patent contained the following:
The present invention relates to the preparation of oseltamivir PROTAC compound and application in antiinfluenza virus drugs. In particular, oseltamivir PROTAC compound I and II, wherein ( E3 ligase = VHL or CRBN ligand; linker = alkylene or alkoxy) was prepared The compound provided by the invention can effectively degrade influenza virus neuraminidase so as to exert the activity of inhibiting influenza virus replication, not only has the inhibitory activity on wild strain influenza virus, but also has a good inhibitory effect on oseltamivir-resistant strains, and has low toxicity on cells, the compound of the present invention, or a pharmacol. or physiol. acceptable salt thereof, can be used for the preparation of a medicament against influenza virus. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0
The Article related to oseltamivir protac compound preparation antiinfluenza virus, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 882518-89-0
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