On June 30, 1984, Sohda, Takashi; Meguro, Kanji; Kawamatsu, Yutaka published an article.Category: esters-buliding-blocks The title of the article was Studies on antidiabetic agents. IV. Synthesis and activity of the metabolites of 5-[4-(1-methylcyclohexylmethoxy)benzyl]-2,4-thiazolidinedione (ciglitazone). And the article contained the following:
5-[4-(1-Methylcyclohexylmethoxy)benzyl]-2,4-thiazolidinedione (ciglitazone) analogs I [RR1 = COCH2CH2, CH(OH)CH2CH2, CH2COCH2, CH2CH(OH)CH2, CH2CH2CO, CH2CH2CHOH] were synthesized to clarify the structure of the metabolites of I [RR1 = (CH2)3] and for studies of their pharmacol. properties. Of the metabolites identified, 5-[4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)benzyl]-2,4-thiazolidinedione exhibited extremely potent antidiabetic activity compared to I [RR1 = (CH2)3]. Stereoselective syntheses of 3- or 4-hydroxy-1-methylcyclohexanecarboxylic acids required for the preparation of 3′- or 4′-hydroxylated compounds are described. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Category: esters-buliding-blocks
The Article related to ciglitazone metabolite preparation, cyclohexylmethoxybenzylthiazolidinone oxo hydroxy, thiazolidinone cyclohexylmethoxybenzyl oxo hydroxy, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: esters-buliding-blocks
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