On February 17, 2021, Hess, Stephan N.; Mo, Xiaobin; Wirtz, Conny; Fuerstner, Alois published an article.Formula: C12H16O7 The title of the article was Total Synthesis of Limaol. And the article contained the following:
A nonthermodynamic array of four skipped methylene substituents on the hydrophobic tail renders limaol (I), a C40-polyketide of marine origin, unique in structural terms. This conspicuous segment was assembled by a two-directional approach and finally coupled to the polyether domain by an allyl/alkenyl Stille reaction under neutral conditions. The core region itself was prepared via a 3,3′-dibromo-BINOL-catalyzed asym. propargylation, a gold-catalyzed spirocyclization, and introduction of the southern sector via substrate-controlled allylation as the key steps. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7
The Article related to limaol total synthesis stille asym propargylation spirocyclization, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Formula: C12H16O7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics