On August 23, 2018, Zhou, Guo Qiang published a patent.SDS of cas: 1198284-94-4 The title of the patent was Preparation of diazaspirodecanyl pyrimidines useful as SSAO inhibitors. And the patent contained the following:
The invention provides compound of formula I and pharmaceutically acceptable salts of the compounds, methods of treating patients for liver disease, and processes for preparing the compounds Example compound (E)-Iâ?HCl was prepared by BOC-deprotection of tert-Bu N-[(E)-3-fluoro-2-[[2-(2-methyl-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-5-yl]oxymethyl]allyl]carbamate. The invention compounds were evaluated for their SSAO inhibitory activities. From the assay, it was determined that compound I(E)-Iâ?HCl exhibited IC50 value of less than 60 nM. The experimental process involved the reaction of tert-Butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate(cas: 1198284-94-4).SDS of cas: 1198284-94-4
The Article related to diazaspirodecanyl pyrimidine preparation ssao inhibitor nonalcoholic steatohepatitis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 1198284-94-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics